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| 1 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 2 | Surface Polishing of 6H-SiC Substrates显示文摘为硅碳化物擦亮的表面(原文如此)底层被调查 andresults 为机械擦亮被介绍( MP )并且chemo机械的擦亮( CMP ) .High qualitysurfaces 在 CMP 期间在物理的 MP anddetailed 和化学过程与擦伤的胶体的 silica.The 移动机制在 CMP 以后被获得是 MP 和 CMP 的 analyzed.The 效果在 thesurface 上,粗糙被光显微镜学( OM )估计,原子力量显微镜学( AFM )和高分辨率 | Xiufang CHEN Xiangang XU Juan LI Shouzhen JIANG Lina NING Yingmin WANG Deying MA Xiaobo HU Minhua JIANG | 2007 | Journal of Materials Science & Technology2007，23，3： | 4 |
| 3 | A five-fold pig bacterial artificial chromosome library:a resource for positional cloning and physical mapping显示文摘一个猪用绳子拖的平底渡船图书馆从一头 maleErhualian 猪与 genomic DNA 被构造。在有后部的 III 片 384 井盘子的部分消化以后(20 个盘子每超级水池) 。屏蔽系统的二拍子的圆舞 4 尺寸 PCR 被建立屏蔽积极克隆。一般水准插入 128 kb 的尺寸从 105 随机孤立的克隆被估计,它显示图书馆是超过五次 genomic 范围。为概率到的示范从图书馆选出任何唯一的基因或 DNA 标记, 10 单个拷贝的基因外面被屏蔽,积极克隆与 3.6 的一般水准在 1 和 8 之间被产出。积极超级水池为从猪染色体的不同区域选择的 32 个微卫星标记被获得。为每个标记的积极超级水池的数字与 4.78 的一般水准从 1 ~ 9 变化。这个用绳子拖的平底渡船图书馆为猪提供一个另外的资源物理印射和基因鉴定。 | LIU Wei ZHANG Ying LIU Zhaoliang GUO Li WANG Xiaobo FEI Jing FENG Jidong ZHAO Rui HU Xiaoxiang LI Ning | 2006 | Progress in Natural Science:Materials International2006，16，8： | 4 |
| 4 | Real-time grain breakage sensing for rice combine harvesters using machine vision technology显示文摘Breakage rate is one of the most important indicators to evaluate the harvesting performance of a combine harvester.It is affected by operating parameters of a combine such as feeding rate,the peripheral speed of the threshing cylinder and concave clearance,and shows complex non-linear law.Real-time acquisition of the breakage rate is an effective way to find the correlation of them.In addition,real-time monitoring of the breakage rate can help the driver optimize and adjust the operating parameters of a combine harvester to avoid the breakage rate exceeding the standard.In this study,a real-time monitoring method for the grain breakage rate of the rice combine harvester based on machine vision was proposed.The structure of the sampling device was designed to obtain rice kernel images of high quality in the harvesting process.According to the working characteristics of the combine,the illumination and installation of the light source were optimized,and the lateral lighting system was constructed.A two-step method of“color training-verification”was applied to identify the whole and broken kernels.In the first step,the local threshold algorithm was used to get the edge of kernel particles in a few training images with binary transformation,extract the color spectrum of each particle in color-space HSL and output the recognition model file.The second step was to verify the recognition accuracy and the breakage rate monitoring accuracy through grabbing and processing images in the laboratory.The experiments of about 2300 particles showed that the recognition accuracy of 96%was attained,and the monitoring values of breakage rate and the true artificial monitoring values had good trend consistency.The monitoring device of grain breakage rate based on machine vision can provide technical supports for the intellectualization of combine harvester. | Jin Chen Yi Lian Rong Zou Shuai Zhang Xiaobo Ning Mengna Han | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 3 |
| 5 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 6 | APPLICATION OF GIS IN REGIONAL ECOLOGICAL RISK ASSESSMENT OF WATER RESOURCES 显示文摘 | Yin Ge Liu Ning Lian Wang Lin Gang Wang Ya Qian Zhao XiaoBo Wu | 2013 | Environmental Engineering and Management Journal2013，12，7： | 1 |
| 7 | Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling显示文摘 | Chang Liu Lin Chen Jing Zeng Jian Cui Jiao-nin Ning Guan-song Wang Karine Belguise Xiaobo Wang Gui-sheng Qian Kai-zhi Lu Bin Yi | 2015 | Experimental Cell Research2015，，1： | 1 |
| 8 | MechanisticStudyonFlameRetardanceof Polycarbonate with a Small Amount of Potassium Perfluorobutane Sulfonate by TGA-FTIR/XPS显示文摘 | Huang Xiaobo Ouyang Xiaoyue Ning Fanglin | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 9 | Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRα activation显示文摘 | Pohsheng Yeong Yanxia Ning Yali Xu Xiaobo Li Lianhua Yin | 2010 | BBA - Molecular and Cell Biology of Lipids2010，，： | 1 |
| 10 | Magnetic reso- nance image reconstruction using trained geometric direc- tions in 2D redundant wavelets domain and non-convex op- timization 显示文摘 | Ning Bende Qu Xiaobo Guo Di | 2013 | Magnetic Resonance Imaging2013，31，9： | 1 |
| 11 | Undersampled MRI reconstruction with patch-based directional wavelets 显示文摘 | Qu Xiaobo Guo Di Ning Bende | 2012 | Magnetic Resonance Imaging2012，30，7： | 1 |
| 12 | Effect of Mo addition on the microstructure and mechanical properties of ultra-free grade TiC- TiN-WC-Mo2C-Co cermets显示文摘 | Li Yan Liu Ning Zhang Xiaobo Rong Chunlan | 2008 | International Journal of Refractory Metals & Hard Materials2008，26，： | 1 |
| 13 | Effect of WC content on the microstructure and mechanical properties of (Ti,W) (C,N)-Co cermets 显示文摘 | Li Yart Liu Ning Zhang Xiaobo Rong Chunlan | 2008 | International Journal of Refractory Metals & Hard Materials2008，26，： | 1 |
| 14 | Effect of WC content on the microstructure and mechanical properties of ( Ti, W) ( C, N )-Co eermets 显示文摘 | Li Yan Liu Ning Zhang Xiaobo | 2008 | International Journal of Refractory Metals and Hard Materials2008，26，1： | 1 |
| 15 | A New Surgical Innovation for Chronic Constipation (Jinling Procedure):2 Years Follow-up显示文摘 | Ning L Jun J Xiaobo F | | 0，，2： | 1 |
| 16 | Long-term Follow-up of the Jinling Procedure for Combined Slow-Transit Constipation and Obstructive Defecation显示文摘 | Ning L Jun J Xiaobo F | | 0，，1： | 1 |
| 17 | Effect of WC content on the microstructure and mechanical properties of (Ti,W)(C, N)–Co cermets显示文摘 | Yan Li Ning Liu Xiaobo Zhang Chunlan Rong | 2007 | International Journal of Refractory Metals and Hard Materials2007，，1： | 1 |
| 18 | Effect of car-bon content on the microstructure and mechanical properties of superfine Ti(C,N)-based cermets显示文摘 | Liu Ning Liu Xuesong Zhang Xiaobo | 2008 | Mater Charact2008，59，： | 1 |
| 19 | Effect of carbon content on the microstructure and mechanical properties of superfine Ti (C,N)-based cermets 显示文摘 | Liu Ning Liu Xuesong Zhang Xiaobo Zhu Longwei | 2008 | Materials Characterization2008，，： | 1 |
| 20 | Effect of WC content on the microstructure and mechanical properties of(Ti,W)(C,N)-Co cermets显示文摘 | Li Yan Liu Ning Zhang Xiaobo etc | 2008 | International Joumal of Refractory Metals&Hard Materials2008，26，： | 1 |
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