|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combination of iTRAQ proteomics and RNA-seq transcriptomics reveals multiple levels of regulation in phytoplasma-infected Ziziphus jujuba Mill显示文摘Jujube witches’broom(JWB)is caused by infection with a phytoplasma.A multi-omics approach was taken during graft infection of jujube by JWB-infected scion through the analysis of the plant transcriptome,proteome and phytohormone levels.A high number of differentially expressed genes(DEGs)were identified 37 weeks after grafting(WAG),followed by observation of typical symptoms of JWB at 48 WAG.At 37 WAG,the majority of the upregulated DEGs and differentially expressed proteins(DEPs)were related to flavonoid biosynthesis,phenylalanine metabolism and phenylpropanoid biosynthesis.Two of the four upregulated proteins were similar to jasmonate-induced protein-like.Among the downregulated genes,the two most populated GO terms were plant–pathogen interaction and plant hormone signal transduction(mainly for tryptophan metabolism).Moreover,phytoplasma infection resulted in reduced auxin content and increased jasmonate content,indicating that auxin and jasmonic acid have important roles in regulating jujube responses during the first and second stages of phytoplasma infection.At 48 WAG,the two largest groups of upregulated genes were involved in phenylpropanoid biosynthesis and flavonoid biosynthesis.Both genes and proteins involved in carbon metabolism and carbon fixation in photosynthetic organisms were downregulated,indicating that photosynthesis was affected by the third stage of phytoplasma infection. | Xia Ye Huiyu Wang Peng Chen Bing Fu Mengyang Zhang Jidong Li Xianbo Zheng Bin Tan Jiancan Feng | 2017 | Horticulture Research2017，4，1： | 9 |
| 2 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 3 | A five-fold pig bacterial artificial chromosome library:a resource for positional cloning and physical mapping显示文摘一个猪用绳子拖的平底渡船图书馆从一头 maleErhualian 猪与 genomic DNA 被构造。在有后部的 III 片 384 井盘子的部分消化以后(20 个盘子每超级水池) 。屏蔽系统的二拍子的圆舞 4 尺寸 PCR 被建立屏蔽积极克隆。一般水准插入 128 kb 的尺寸从 105 随机孤立的克隆被估计,它显示图书馆是超过五次 genomic 范围。为概率到的示范从图书馆选出任何唯一的基因或 DNA 标记, 10 单个拷贝的基因外面被屏蔽,积极克隆与 3.6 的一般水准在 1 和 8 之间被产出。积极超级水池为从猪染色体的不同区域选择的 32 个微卫星标记被获得。为每个标记的积极超级水池的数字与 4.78 的一般水准从 1 ~ 9 变化。这个用绳子拖的平底渡船图书馆为猪提供一个另外的资源物理印射和基因鉴定。 | LIU Wei ZHANG Ying LIU Zhaoliang GUO Li WANG Xiaobo FEI Jing FENG Jidong ZHAO Rui HU Xiaoxiang LI Ning | 2006 | Progress in Natural Science:Materials International2006，16，8： | 4 |
| 4 | Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer显示文摘Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors(WHO).Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall(Gofman and Lindgren,1950).Tremendous clinical and experimental efforts have | Chong Feng Xiaomin Wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 5 | Evaluation of menopausal status among breast cancer patients with chemotherapy-induced amenorrhea显示文摘Objective: In patients with chemotherapy-induced amenorrhea(CIA), the menopausal status is ambiguous and difficult to evaluate. This study aimed to establish a discriminative model to predict and classify the menopausal status of breast cancer patients with CIA.Methods: This is a single center hospital-based study from 2013 to 2016. The menopausal age distribution and accumulated incidence rate of CIA are described. Multivariate models were adjusted for established and potential confounding factors including age, serum concentration of estradiol(E2) and follicle-stimulating hormone(FSH),feeding, pregnancy, parity, abortions, and body mass index(BMI). The odds ratio(OR) and 95% confidence interval(95% CI) of different risk factors were estimated.Results: A total of 1,796 breast cancer patients were included in this study, among whom, 1,175(65.42%) were premenopausal patients and 621(34.58%) were post-menopause patients. Five hundred and fifty patients were included in CIA analysis, and a cumulative CIA rate of 81.64% was found in them. Age(OR: 1.856, 95% CI:1.732-1.990), serum concentration of E2(OR: 0.976, 95% CI: 0.972-0.980) and FSH(OR: 1.060, 95% CI:1.053-1.066), and menarche age(OR: 1.074, 95% CI: 1.009-1.144) were found to be associated with the patients' menopausal status. According to multivariate analysis, the discriminative model to predict the menopausal status is Logit(P)=-28.396+0.536 Age-0.014 E2+0.031 FSH. The sensitivities for this model were higher than 85%, and its specificities were higher than 89%.Conclusions: The discriminative model obtained from this study for predicting menstrual state is important for premenopausal patients with CIA. This model has high specificity and sensitivity and should be prudently used. | Bailin Zhang Jinqi Wu Rongshou Zheng Qian Zhang Margaret Zhuoer Wang Jun Qi Haijing Liu Yipeng Wang Yang Guo Feng Chen Jing Wang Wenyue Lyu Jidong Gao Yi Fang Wanqing Chen Xiang Wang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 2 |
| 6 | PpTCP18 is upregulated by lncRNA5 and controls branch number in peach (Prunus persica) through positive feedback regulation of strigolactone biosynthesis显示文摘Branch number is an important agronomic trait in peach(Prunus persica)trees because plant architecture affects fruit yield and quality.Although breeders can select varieties with different tree architecture,the biological mechanisms underlying architecture remain largely unclear.In this study,a pillar peach(‘Zhaoshouhong’)and a standard peach(‘Okubo’)were compared.‘Zhaoshouhong’was found to have significantly fewer secondary branches than‘Okubo’.Treatment with the synthetic strigolactone(SL)GR24 decreased branch number.Transcriptome analysis indicated that PpTCP18(a homologous gene of Arabidopsis thaliana BRC1)expression was negatively correlated with strigolactone synthesis gene expression,indicating that PpTCP18 may play an important role in peach branching.Yeast one-hybrid,electrophoretic mobility shift,dual-luciferase assays and PpTCP18-knockdown in peach leaf buds indicated that PpTCP18 could increase expression of PpLBO1,PpMAX1,and PpMAX4.Furthermore,transgenic Arabidopsis plants overexpressing PpTCP18 clearly exhibited reduced primary rosette-leaf branches.Moreover,lncRNA sequencing and transient expression analysis revealed that lncRNA5 targeted PpTCP18,significantly increasing PpTCP18 expression.These results provide insights into the mRNA and lncRNA network in the peach SL signaling pathway and indicate that PpTCP18,a transcription factor downstream of SL signaling,is involved in positive feedback regulation of SL biosynthesis.This role of PpTCP18 may represent a novel mechanism in peach branching regulation.Our study improves current understanding of the mechanisms underlying peach branching and provides theoretical support for genetic improvement of peach tree architecture. | Xiaobei Wang Qiuping Wang Lixia Yan Yuhang Hao Xiaodong Lian Haipeng Zhang Xianbo Zheng Jun Cheng Wei Wang Langlang Zhang Xia Ye Jidong Li Bin Tan Jiancan Feng | 2023 | Horticulture Research2023，10，1： | 2 |
| 7 | Layer-by-layer slot-die coated high-efficiency organic solar cells processed using twin boiling point solvents under ambient condition显示文摘Layer-by-layer (LbL) strategy has been developed to form bulk heterojunction (BHJ) structure for processing efficient organic solar cells (OSCs). Herein, LbL slot-die coating with twin boiling point solvents (TBPS) strategy was developed to fabricate highly efficient OSCs, which matches with large-scale, high throughput roll-to-roll (R2R) industrialized mass process. The TBPS strategy could produce high-quality thin film without any additive, leading to the optimized vertical phase separation with interpenetrating nanostructures, as well as the enhanced charge transport and extraction. Thus, the power conversion efficiency up to 14.42% was achieved for [(2,6-(4,8-bis(5-(2-ethylhexyl-3-fluoro)thiophen-2-yl)-benzo [1,2-b:4,5-b′]dithiophene))-alt-(5,5-(1′,3′-di-2-thienyl-5′,7′-bis(2-ethylhexyl)benzo[1′,2′-c:4′,5′-c′]dithiophene-4,8-dione)]:2,2′-((2Z,2′Z)-((12,13-bis(2-ethylhexyl)-3,9-diundecyl-12,13-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2″,3″:4″,5″]thieno[2′,3′:4,5]pyrrolo[3,2-g]thieno[2′,3′:4,5]thieno[3,2-b]indole-2,10-diyl)bis(methanylylidene)) bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (PM6:Y6) OSCs fabricated via sequentially LbL slot-die coating using the TBPS strategy under ambient condition. The research provides a potential route for industrialized production of high-efficiency and large-area OSC devices. | Yu Yang Erming Feng Hengyue Li Zichao Shen Wanrong Liu Jingbo Guo Qun Luo Jidong Zhang Guanghao Lu Changqi Ma Junliang Yang | 2021 | Nano Research2021，14，11： | 1 |
| 8 | Understanding energetic disorder in electron-deficient-core-based non-fullerene solar cells显示文摘Recent advances in material design for organic solar cells(OSCs)are primarily focused on developing near-infrared nonfullerene acceptors,typically A-DA′D-A type acceptors(where A abbreviates an electron-withdrawing moiety and D,an electron-donor moiety),to achieve high external quantum efficiency while maintaining low voltage loss.However,the charge transport is still constrained by unfavorable molecular conformations,resulting in high energetic disorder and limiting the device performance.Here,a facile design strategy is reported by introducing the'wing'(alkyl chains)at the terminal of the DA′D central core of the A-DA′D-A type acceptor to achieve a favorable and ordered molecular orientation and therefore facilitate charge carrier transport.Benefitting from the reduced disorder,the electron mobilities could be significantly enhanced for the'wing'-containing molecules.By carefully changing the length of alkyl chains,the mobility of acceptor has been tuned to match with that of donor,leading to a minimized charge imbalance factor and a high fill factor(FF).We further provide useful design strategies for highly efficient OSCs with high FF. | Jun Yuan Chujun Zhang Honggang Chen Can Zhu Sin Hang Cheung Beibei Qiu Fangfang Cai Qingya Wei Wei Liu Hang Yin Rui Zhang Jidong Zhang Ye Liu Huotian Zhang Weifang Liu Hongjian Peng Junliang Yang Lei Meng Feng Gao Shukong So Yongfang Li Yingping Zou | 2020 | Science China Chemistry2020，63，8： | 1 |
| 9 | Grape berry plasma membrane proteome analysis and its differential expression during ripening显示文摘 | ZHANG Jiangwei MA Huiqin FENG Jidong | 2008 | Journal of Experimental Botany2008，59，11： | 1 |
| 10 | Characterizing and optimizing TPC-C workloads on large-scale systems using SSD arrays显示文摘Transaction processing performance council benchmark C(TPC-C) is the de facto standard for evaluating the performance of high-end computers running on-line transaction processing applications. Differing from other standard benchmarks, the transaction processing performance council only defines specifications for the TPC-C benchmark, but does not provide any standard implementation for end-users. Due to the complexity of the TPC-C workload, it is a challenging task to obtain optimal performance for TPC-C evaluation on a large-scale high-end computer. In this paper, we designed and implemented a large-scale TPC-C evaluation system based on the latest TPC-C specification using solid-state drive(SSD) storage devices. By analyzing the characteristics of the TPC-C workload, we propose a series of system-level optimization methods to improve the TPC-C performance. First, we propose an approach based on Small File table space to organize the test data in a round-robin method on all of the disk array partitions; this can make full use of the underlying disk arrays.Second, we propose using a NOOP-based disk scheduling algorithm to reduce the utilization rate of processors and improve the average input/output service time. Third, to improve the system translation lookaside buffer hit rate and reduce the processor overhead, we take advantage of the huge page technique to manage a large amount of memory resources. Lastly, we propose a locality-aware interrupt mapping strategy based on the asymmetry characteristic of non-uniform memory access systems to improve the system performance. Using these optimization methods, we performed the TPC-C test on two large-scale high-end computers using SSD arrays. The experimental results show that our methods can effectively improve the TPC-C performance. For example, the performance of the TPC-C test on an Intel Westmere server reached 1.018 million transactions per minute. | Jidong ZHAI Feng ZHANG Qingwen LI Wenguang CHEN Weimin ZHENG | 2016 | Science China(Information Sciences)2016，59，9： | 1 |
| 11 | Hybrid hydrovoltaic electricity generation driven by water evaporation显示文摘Water evaporation is a ubiquitous natural process exploiting thermal energy from ambient environment.Hydrovoltaic technologies emerged in recent years offer one prospective route to generate electricity from water evaporation,which has long been overlooked.Herein,we developed a hybrid hydrovoltaic generator driven by natural water evaporation,integrating an“evaporation motor”with an evaporation-electricity device and a droplet-electricity device.A rotary motion of the“evaporation motor”relies on phase change of ethanol driven by water-evaporation induced temperature gradient.This motion enables the evaporation-electricity device to work under a beneficial water-film operation mode to produce output of~4 V and~0.2μA,as well as propels the droplet-electricity device to convert mechanical energy into pulsed output of~100 V and~0.2 mA.As different types of hydrovoltaic devices require distinctive stimuli,it was challenging to make them work simultaneously,especially under one single driving force.We here for the first time empower two types of hydrovoltaic devices solely by omnipresent water evaporation.Therefore,this work presents a new pathway to exploiting water evaporation-associated ambient thermal energy and provides insights on developing hybrid hydrovoltaic generators. | Xuemei Li Gu Feng Yiding Chen Jidong Li Jun Yin Wei Deng Wanlin Guo | 2024 | Nano Research Energy2024，3，2： | 0 |
| 12 | Chicken QTL mapping by multiplex PCR | HUANG Yinhua HU Xiaoxiang DENG Xuemei XU Weizhuo LI Ning FENG Jidong SUN Han WU Changxin | 2002 | Progress in Natural Science:Materials International2002，12，1： | 0 |
| 13 | Topic Model Based Text Similarity Measure for Chinese Judgment Document显示文摘In the recent informatization of Chinese courts, the huge amount of law cases and judgment documents, which were digital stored,has provided a good foundation for the research of judicial big data and machine learning. In this situation, some ideas about Chinese courts can reach automation or get better result through the research of machine learning, such as similar documents recommendation, workload evaluation based on similarity of judgement documents and prediction of possible relevant statutes. In trying to achieve all above mentioned, and also in face of the characteristics of Chinese judgement document, we propose a topic model based approach to measure the text similarity of Chinese judgement document, which is based on TF-IDF, Latent Dirichlet Allocation (LDA), Labeled Latent Dirichlet Allocation (LLDA) and other treatments. Combining with the characteristics of Chinese judgment document,we focus on the specific steps of approach, the preprocessing of corpus, the parameters choices of training and the evaluation of similarity measure result. Besides, implementing the approach for prediction of possible statutes and regarding the prediction accuracy as the evaluation metric, we designed experiments to demonstrate the reasonability of decisions in the process of design and the high performance of our approach on text similarity measure. The experiments also show the restriction of our approach which need to be focused in future work. | Yue Wang Jidong Ge Yemao Zhou Yi Feng Chuanyi Li ZhongjinLi Xiaoyu Zhou Bin Luo | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 14 | Build Evidence Chain Relational Model Based on Chinese Judgment Document显示文摘The reasoning of judgment documents is the touchstone of justice. Attaching importance to the reasoning of judgment documents is essentially the embodiment of judiciary civilization. In order to promote the reform of judgment documents reasoning and improve the level of it, the technology of automated judgment documents reasoning evaluation has to be studied on. How to build evidence chain relational model is the basis and key to this technology.An approach is proposed to build evidence chain relational model based on Chinese judgment documents. Using automated text preprocessing for Chinese judgment documents creates semi-structured XML documents and extracts evidence set and fact set. The method of key elements extraction is used to obtain the keywords of evidence and facts. Calculating the degree of association can work out the connection points of evidence chain relational model. Tabular display and graphical display of evidence chain relational model can be realized. | Siyuan Kong Yemao Zhou1,2 Jidong Ge Zhongjin Li Chuanyi Li Yi Feng Xiaoyu Zhou Bin Luo | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 15 | Overexpression of peach NAC25 promotes anthocyanin biosynthesis in poplar shoots显示文摘Anthocyanins,a categories of metabolites derived from flavonoid biosynthesis pathway,are responsible for the red color of peach.Anthocyanin metabolism is modulated by a complicated regulatory network.In this study,our results demonstrated that PpNAC25 was a component of anthocyanin regulatory network in peach.PpNAC25 showed a closed relationship with the well-known ripening-related gene NOR(no-ripening)and was highly expressed in peach fruit.Overexpression of PpNAC25 in poplar resulted in a redder shoot tips compared with EV control.PpNAC25 overexpression upregulated the anthocyanin biosynthetic and transportation genes in transcript levels and then increased anthocyanin contents.In Y1H and Luc/Ren assay,PpNAC25 bound to the promoter of the anthocyanin-activator PpMYB10.1 and PpMYB10.2 and activated its transcript.Moreover,PpNAC25 formed a heterodimer with PpNAC1,an anthocyanin-regulator.Our researches provide evidence that PpNAC25 may be a positive regulator of anthocyanin biosynthesis in peach fruit. | Mingxi Geng Yun Shao Mengmeng Zhang Xianbo Zheng Bin Tan Wei Wang Langlang Zhang Xia Ye Ming Li Jidong Li Jun Cheng Jiancan Feng | 2022 | Fruit Research2022，2，1： | 0 |
| 16 | Statute Recommendation Based on Word Embedding显示文摘The statute recommendation problem is a sub problem of the automated decision system, which can help the legal staff to deal with the process of the case in an intelligent and automated way. In this paper, an improved common word similarity algorithm is proposed for normalization. Meanwhile, word mover’s distance (WMD) algorithm was applied to the similarity measurement and statute recommendation problem, and the problem scene which was originally used for classification was extended. Finally, a variety of recommendation strategies different from traditional collaborative filtering methods were proposed. The experimental results show that it achieves the best value of Fmeasure reaching 0.799. And the comparative experiment shows that WMD algorithm can achieve better results than TF-IDF and LDA algorithm. | Peitang Ling Zian Wang Yi Feng Jidong Ge Mengting He Chuanyi Li Bin Luo | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
| 17 | 香菇引起的小肠梗阻两例报道显示文摘The shiitake mushroom(Lentinula edodes),known as Xiang-gu in China,has been an important component of Asian cuisine for hundreds of years.Although not easily digestible,there are few reports of them causing bowel obstruction.We present two cases of small bowel obstruction due to a shiitake mushroomrequiring surgical intervention.Two patients who did not have any teeth and did not use dentures presented with intestinal bowel obstruction and were referred to the Emergency Department of our hospital after eating a meal including shiitake mushrooms without cutting.The first patient underwent an emergency laparotomy and a semental small bowel resection and the other underwent laparoscopic small bowel incision for removal of a foreign body.The causes of the small bowel obstruction for the two patients were uncut shiitake mushrooms in the small bowel.The two patients recovered uneventfully post-operatively. | Jinfu Tan Kaitao Yuan Jidong Zuo Weigang Dai Yujie Yuan Weidong Feng Min Tan Jinping Ma | 2019 | Gastroenterology Report2019，7，4： | 0 |
| 18 | 26.75 cm^(2) organic solar modules demonstrate a certified efficiency of 14.34%显示文摘Organic solar cells(OSCs)have been developed rapidly in past years,due to the fast evolution of wide-bandgap copoly-mer donors and low-bandgap non-fullerene acceptors[1−9].At present,the highest power conversion efficiencies(PCEs)for single-junction OSCs and tandem OSCs exceed 19%and 20%,respectively[10,11].These OSCs are typically fabricated by us-ing low-boiling-point solvent chloroform(CF)with an effect-ive area<0.1 cm^(2).The doctor-blading deposition is the most advantageous technique to fabricate OSCs with low-boiling-point solvent for upscaling lab cells to industrial-scale mod-ules[12],exhibiting simple operation,low cost,and high materi-al utilization[13−15].Herein,a typical OSC material system PM6:Y6(Fig.1(a))was used to fabricate OSCs modules via doc-tor-blading deposition in ambient condition,and the influ-ence of the ambient temperature and substrate temperature on the film quality was investigated. | Erming Feng Yunfei Han Jianhui Chang Hengyue Li Keqing Huang Lixiu Zhang Qun Luo Jidong Zhang Changqi Ma Yingping Zou Liming Ding Junliang Yang | 2022 | Journal of Semiconductors2022，43，10： | 0 |
| 19 | 优化经直肠前列腺重复穿刺(英文)显示文摘Objective: Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer remains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods: In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45° angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontally inwardly inclined 45°. Results: A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8%(8/45), and prostate intraepithelial neoplasm(PIN) was 6.7%(3/45). The patients receiving repeat transrectal prostate biopsies were pathologically diagnosed as lower Gleason grade prostate cancers. Conclusion: The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrectal prostate biopsies patients. | Xiaojun Deng Jianwei Cao Feng Liu Weifeng Wang Jidong Hao Jiansheng Wan Hui Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，4： | 0 |
| 20 | 扩大穿刺对PSA≥20ng/mL的患者合适吗?(英文)显示文摘Objective: The aim of this study was to investigate whether it was necessary to increase the number of cores at initial prostate biopsy with patients of prostate-specific antigen(PSA) ≥ 20 ng/mL and to explore an appropriate individualized transrectal ultrasonograhpy(TRUS)-guided prostate biopsy for the detection of prostate cancer in men suspicious of prostate cancer. Methods: A total of 115 patients with PSA ≥ 20 ng/mL and suspicious of prostate cancer were prospectively randomized to perform TRUS-guided biopsy. Patients were randomized to a '6 + X' cores or a '10 + X' cores protocol. The primary end point was cancer detection rate. Secondary end points were cancer characteristics, rate of complications and the level of pain experienced by patients during TRUS-guided prostate biopsy. Results: Preoperative variables were similar in both groups. The overall prostate cancer detection rate was 73.9%. The '10 + X' cores strategy increased cancer detection rate only 9.7% in patients with PSA ≥ 20 ng/mL but < 50 ng/mL, while there was no difference between the two strategies for cancer detection in patients with PSA ≥ 50.1 ng/mL. The number of extended biopsy cores and pain score of extended biopsy in prostate cancer patients increased significantly(P < 0.001). Conclusion: Our findings suggest that there is no significant advantage in using extended biopsy protocol in all patients with PSA ≥ 20 ng/mL. | Xiaojun Deng Jian Chu Bo Yang Feng Liu Weifeng Wang Jidong Hao Jiansheng Wan Hui Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员