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| 1 | Sparse Kernel Locality Preserving Projection and Its Application in Nonlinear Process Fault Detection显示文摘Locality preserving projection (LPP) is a newly emerging fault detection method which can discover local manifold structure of a data set to be analyzed, but its linear assumption may lead to monitoring performance degradation for complicated nonlinear industrial processes. In this paper, an improved LPP method, referred to as sparse kernel locality preserving projection (SKLPP) is proposed for nonlinear process fault detection. Based on the LPP model, kernel trick is applied to construct nonlinear kernel model. Furthermore, for reducing the computational complexity of kernel model, feature samples selection technique is adopted to make the kernel LPP model sparse. Lastly, two monitoring statistics of SKLPP model are built to detect process faults. Simulations on a continuous stirred tank reactor (CSTR) system show that SKLPP is more effective than LPP in terms of fault detection performance. | DENG Xiaogang TIAN Xuemin | 2013 | Chinese Journal of Chemical Engineering2013，21，2： | 26 |
| 2 | Effect on glycemia in rats with type 2 diabetes induced by streptozotocin: low-frequency electro-pulse needling stimulated Weiwanxiashu(EX-B 3) and Zusanli(ST 36)显示文摘OBJECTIVE: To investigate the effect of low frequency electro-pulse acupuncture(EA) on blood glucose in rats with streptozotocin-induced type 2diabetes, and the possible mechanism underlying the action.METHODS: Rat models were established with high fat feeding and intraperitoneal injection of streptozotocin(STZ)(30 mg/kg). Rats with a random blood glucose > 16.7 mmol/L and blood glucose at 2 h-point of oral glucose tolerance test(OGTT) > 11.1 mmol/L were included as diabetic rats, and randomly divided into model group, EA Weiwanxiashu(EX-B 3) group, EA Zusanli(ST 36)group, glimepiride group, and EA non-acupoint group(n = 12). EA(2 Hz continuous wave, 2 m A,20 min/day, 6 days/week, 4 weeks) and intra-gastric administration of glimepiride were applied as interventions. With fasting blood glucose and OGTT tested at the end of the intervention, thestudy observed the patterns of hypoglycemic effects. For mechanism study, it observes hematoxylin and eosin staining and Masson staining of pancreas paraffin sections, protein expression of glucagon-like peptide 1 receptor(GLP-1R) in the pancreas and skeletal muscle, glucose transporter 4(GLUT4) protein expression in skeletal muscle membrane, to detect whether EA controls blood glucose via regulation of GLP-1R.RESULTS: EA Weiwanxiashu(EX-B 3) significantly increased model rats' pancreas GLP-1R, and GLUT4 of skeletal muscle membrane; the therapy significantly decreased model rats' skeletal muscle GLP-1R, restored pancreas morphology, and reduced fasting blood glucose and insulin resistance indices.CONCLUSION: EA Weiwanxiashu(EX-B 3) alone has significant effect on glycemia. EA Weiwanxiashu(EX-B 3) plus glimepiride further strengthen the effect. The regulation of the GLP-1R in pancreas and skeletal muscle might be mechanism underpinning the effect. | Cao Bingyan Li Rui Tian Huanhuan Ma Yanjia Hu Xiaogang Jia Ning Wang Yueying | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 4 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | Yizhining elixation improves sustained attention deficit and impulsiveness of spontaneous hypertensive rats显示文摘BACKGROUND: The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders (ADHD) can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE: To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN: Observational and controlled analysis. SETTING: Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS: Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi, etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS: This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups: Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by '5-choice serial response time task' method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining high-dose and low-dose groups were drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation (diluted to 25 mL/kg) respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response: Ratio of correct response=[times of correct response/(times of correct response + times of incorrect response)]; impulsiveness was evaluated with the ratio of immature response: ratio of immature response=[times of immature response/ (times of correct response+times of incorrect response+times of omission+times of immature response)]. MAIN OUTCOME MEASURES: The effects of different doses of Yizhining elixation on the sustained attention (ratio of correct response) and impulsiveness (ratio of immature response) of spontaneous hypertensive rats. RESULTS: Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was (98.9±2.30)% and (96.6±4.00)%, respectively, which was significantly higher than that before administration [(80.4±11.5)%, (83.9±8.90)%,P < 0.01] and that in the blank control group[(83.3±6.30)%,P < 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after administration was (5.04±1.04)%, (7.23±1.22)%, respectively, which was lower than that before administration [(9.85±2.50)%,(9.40±1.73)%,P < 0.05] and that in the blank control group [(9.42±1.64)%,P < 0.01]. CONCLUSION: Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats. | Xiaogang Chen Hui Tian Donglan Lai Yan Tang Honglan Jiang Hualun Zeng Yirui Li | 2007 | Neural Regeneration Research2007，2，1： | 2 |
| 5 | Anomalous tremor before 2008 Ms8.0 Wenchuan earthquake: a review显示文摘In this paper we give a review of several previously published papers on anomalous tremors observed before the 2008 Ms8.0 Wenchuan earthquake. Based on the observed time and frequency shifts between coastal and inland stations, we discussed some methods to distinguish different kinds of microseisms, and speculated that a pre-earthquake typhoon might have caused a 'mainland-originated microseism' which in turn triggered the earthquake. | Hao Xiaoguang Hu Xiaogang Tian Lianghui | 2011 | Geodesy and Geodynamics2011，2，3： | 2 |
| 6 | Multiway kernel independent component analysis based on feature samples for batch process monitoring显示文摘 | Xuemin Tian Xiaoling Zhang Xiaogang Deng Sheng Chen | 2008 | Neurocomputing2008，，7： | 2 |
| 7 | Hybrid total arch repair without deep hypothermic circulatory arrest for acute type A aortic dissection (R1)显示文摘 | Qian Chang Chuan Tian Yizhen Wei Xiangyang Qian Xiaogang Sun Cuntao Yu | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 1 |
| 8 | Developing a new grey dynamic modeling system for evaluation of biology and pollution indicators of the marine environment in coastal areas显示文摘 | Xiaogang Tian Meiting Ju Chaofeng Shao Zili Fang | 2011 | Ocean and Coastal Management2011，，10： | 1 |
| 9 | A genome wide association study between copy number variation (CNV) and human height in Chinese population显示文摘Copy number variation (CNV) is a type of genetic variation which may have important roles in phenotypic variability and disease susceptibility. To hunt for genetic variants underlying human height variation, we performed a genome wide CNV association study for human height in 618 Chinese unrelated subjects using Affymetrix 500K array set. After adjusting for age and sex, we found that four CNVs at 6p21.3, 8p23.3-23.2, 9p23 and 16p12.1 were associated with human height (with borderline significant p value: 0.013, 0.011, 0.024, 0.049; respectively). However, after multiple tests correction, none of them was associated with human height. We observed that the gain of copy number (more than 2 copies) at 8p23.3-23.2 was associated with lower height (normal copy number vs. gain of copy number: 161.2 cm vs. 153.7 cm, p = 0.011), which accounted for 0.9% of height variation. Loss of copy number (less than 2 copies) at 6p21.3 was associated with 0.8% lower height (loss of copy number vs. normal copy number: 154.5 cm vs. 161.1 cm, p = 0.013). Since no important genes influencing height located in CNVs at loci of 8p23.3-23.2 and 6p21.3, the two CNVs may cause the structural rear- rangements of neighbored important candidate genes, thus regulates the variation of height. Our results expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Xi Li Lijun Tan Xiaogang Liu Shufeng Lei Tielin Yang Xiangding Chen Fang Zhang Yue Fang Yan Guo Liang Zhang Han Yan Feng Pan Zhixin Zhang Yumei Peng Qi Zhou Lina He Xuezhen Zhu Jing Cheng Lishu Zhang Yaozhong Liu Qing Tian Hongwen Deng | 2010 | Journal of Genetics and Genomics2010，37，12： | 1 |
| 10 | Modified kernel principal component analysis based on local structure analysis and its application to nonlinear process fault diagnosis显示文摘 | Deng Xiaogang Tian Xuemin Chen Sheng | 2013 | Chemometrics ~ Intelli- gent Laboratory Systems2013，127，15： | 1 |
| 11 | Multiway kernel independent component analysis based on feature samples for batch process monitoring 显示文摘 | TIAN Xuemin ZHANG Xiaoling DENG Xiaogang | 2009 | Neurocomputing2009，72，7： | 1 |
| 12 | Developing a new grey dynamic modeling system for evaluation of biology and pollution indicators of the marine environment in coastal areas显示文摘 | Xiaogang Tian Melting Ju Chaofeng Shao Zili Fang | 2011 | Ocean & Coastal Management2011，54，10： | 1 |
| 13 | Effect of fluorine content on the crystallization of fluorsilicic mica glass显示文摘 | TIAN Jiemo CAO Xiaogang ZHANG Yong | 2002 | J Mater Sci2002，37，： | 1 |
| 14 | Current climate overrides past climate change in explaining multi-site beta diversity of Lauraceae species in China显示文摘Background:We aimed to characterise the geographical distribution of Sørensen-based multi-site dissimilarity(β_(sor))and its underlying true turnover(β_(sim))and nestedness(βsne)components for Chinese Lauraceae and to analyse their relationships to current climate and past climate change.Methods:We used ensembles of small models(ESMs)to map the current distributions of 353 Lauraceae species in China and calculated β_(sor) and its β_(sim) and β_(sne) components.We tested the relationship between β_(sor),β_(sne) and β_(sim) with current climate and past climate change related predictors using a series of simultaneous autoregressive(SAR_(err))models.Results:Spatial distribution of β_(sor)of Lauraceae is positively correlated with latitude,showing an inverse rela-tionship to the latitudinalα-diversity(species richness)gradient.High β_(sor) occurs at the boundaries of the warm temperate and subtropical zones and at the Qinghai-Tibet Plateau due to high β_(sne).The optimized SAR_(err) model explainsβ_(sor) andβ_(sne) well,but notβ_(sim).Current mean annual temperature determinesβ_(sor) and β_(sne) of Lauraceae more than anomalies and velocities of temperature or precipitation since the Last Glacial Maximum.Conclusions:Current low temperatures and high climatic heterogeneity are the main factors explaining the high multi-siteβ-diversity of Lauraceae.In contrast to analyses of the β-diversity of entire species assemblages,studies of single plant families can provide complementary insights into the drivers of β-diversity of evolutionarily more narrowly defined entities. | Ziyan Liao Youhua Chen Kaiwen Pan Mohammed A.Dakhil Kexin Lin Xianglin Tian Fengying Zhang Xiaogang Wu Bikram Pandey Bin Wang Niklaus E.Zimmermann Lin Zhang Michael P.Nobis | 2022 | Forest Ecosystems2022，9，2： | 1 |
| 15 | Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results显示文摘The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four decades.The lack of precipitation observations is a bottleneck for the study of land surface processes in this region.Over the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 stations.The observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air interactions.The observation dataset has been released in the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu ZHOU Yaozhi JIANG Xiangnan YAO Hui LU Xiaogang MA Lin OUYANG Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO Jianhong ZHOU Mijun ZOU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 16 | Quick estimation of parameters for the land surface data assimilation system and its influence based on the extended Kalman filter and automatic differentiation显示文摘Soil moisture plays a crucial role in drought monitoring,flood forecasting,and water resource management.Data assimilation methods can integrate the strengths of land surface models(LSM)and remote sensing data to generate highprecision and spatio-temporally continuous soil moisture products.However,one of the challenges of the land data assimilation system(LDAS)is how to accurately estimate model and observation errors.To address this,we had previously proposed a dualcycle assimilation algorithm that can simultaneously estimate the model and observation errors,LSM parameters,and observation operator parameters.However,this algorithm requires a large ensemble size to guarantee stable parameter estimates,resulting in low efficiency and limiting its large-scale applications.To address this limitation,the authors employed the following approaches:(1)using automatic differentiation to compute the Jacobian matrix of LSM instead of constructing a tangent linear model of LSM,and(2)replacing the ensemble Kalman filter framework with the extended Kalman filter(EKF)framework to improve the efficiency of parameter optimization for the dual-cycle algorithm.The EKF-based dual-cycle algorithm accelerated the parameter estimation efficiency near 60 times during a 90-day time period with a model integration time step of 1 h.To evaluate the dual-cycle LDAS at the regional-scale,it was applied to assimilate the SMAP soil moisture over the Tibetan Plateau,and soil moisture estimates were validated using in situ observations from four different climatic areas.The results showed that the EKF-based dual-cycle LDAS corrected biases in both the model and observations and produced more accurate estimates of soil moisture,land surface temperature,and evapotranspiration than did the open loop with default parameters.Furthermore,the spatial distribution of soil parameters(sand content,clay content,and porosity)obtained from the LDAS was more reasonable than those of default values.The EKF-based dual-cycle algorithm developed in this study is expected to improve the assimilation skills of land surface,ecological,and hydrological studies. | Jiaxin TIAN Hui LU Kun YANG Jun QIN Long ZHAO Jianhong ZHOU Yaozhi JIANG Xiaogang MA | 2023 | Science China Earth Sciences2023，66，11： | 0 |
| 17 | Generation of knockout rabbits using transcription activator-like effector nucleases显示文摘Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platformscontributing to redefine the boundaries of modern biological research. They are composed of a non-specificcleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications byinducing efficient DNA double-strand breaks at desired loci. Among other remarkable uses, these nucleases havebeen employed to produce gene knockouts in mid-size and large animals, such as rabbits and pigs, respectively.This approach is cost effective, relatively quick, and can produce invaluable models for human disease studies,biotechnology or agricultural purposes. Here we describe a protocol for the efficient generation of knockout rabbitsusing transcription activator-like effector nucleases, and a perspective of the field. | Yu Wang Nana Fan Jun Song Juan Zhong Xiaogang Guo Weihua Tian Quanjun Zhang Fenggong Cui Li Li Philip N Newsome Jon Frampton Miguel A Esteban Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 0 |
| 18 | Electric-driven flexible-roller nanoimprint lithography on the stress-sensitive warped wafer显示文摘Surface nanopatterning of semiconductor optoelectronic devices is a powerful way to improve their quality and performance.However,photoelectric devices’inherent stress sensitivity and inevitable warpage pose a huge challenge on fabricating nanostructures large-scale.Electric-driven flexible-roller nanoimprint lithography for nanopatterning the optoelectronic wafer is proposed in this study.The flexible nanoimprint template twining around a roller is continuously released and recovered,controlled by the roller’s simple motion.The electric field applied to the template and substrate provides the driving force.The contact line of the template and the substrate gradually moves with the roller to enable scanning and adapting to the entire warped substrate,under the electric field.In addition,the driving force generated from electric field is applied to the surface of substrate,so that the substrate is free from external pressure.Furthermore,liquid resist completely fills in microcavities on the template by powerful electric field force,to ensure the fidelity of the nanostructures.The proposed nanoimprint technology is validated on the prototype.Finally,nano-grating structures are fabricated on a gallium nitride light-emitting diode chip adopting the solution,achieving polarization of the light source. | Yu Fan Chunhui Wang Jiaxing Sun Xiaogang Peng Hongmiao Tian Xiangming Li Xiaoliang Chen Xiaoming Chen Jinyou Shao | 2023 | International Journal of Extreme Manufacturing2023，5，3： | 0 |
| 19 | Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway显示文摘为人的自发的上升大动脉的动脉瘤(IAAA ) 负责的细胞、分子的机制仍然保持未知。矩阵 metalloproteinase-2 (MMP-2 ) 是为在动脉瘤的墙中的细胞外的矩阵的降级的关键酶。这研究的目的是阐明血管收缩素 II (Ang II ) 的角色在在 IAAA 大动脉的墙中感应的 MMP-2 的小径。量的聚合酶链反应和西方的污点分析被用来在在 IAAA 病人与那些登上大动脉的标本比较 MMP-2 mRNA 和蛋白质层次(n = 10 ) 并且心移植施主(n = 5 ) 没有任何 aortopathy。MMP-2 表示显著地被增加,这被发现,它在 IAAA 墙中与有弹性的 lamellae 混乱被联系。另外,表示在上升 angiotensinogen (AGT ) 和 Ang II 铺平从有或没有 IAAA 的个人的大动脉的纸巾被西方的污点分析和放射性免疫测定分别地检测。结果证明 AGT 和 Ang II 蛋白质的表情显著地在上升被增加 IAAA 病人的大动脉的纸巾。而且, Ang II 是否导致 MMP-2 表示,用人的 IAAA 墙前 vivo 文化被调查。外长的 Ang II 以一种剂量依赖者方式增加了 MMP-2 表示,这被发现,它被 Ang II 类型完全禁止 1 受体(AT1R ) 禁止者 candesartan 并且被 c6 月 N 终端 kinase (JNK ) 调停激活。一起拿,这些结果显示 Ang II 能在前 vivo 经由 AT1R 和 JNK 导致 MMP-2 表示的增加有教养的 IAAA 大动脉的墙,并且建议血管收缩素受体 blocker (ARB ) 药和 JNK 禁止者在 IAAA 的预防或治疗有潜力。 | Chunmao Wang Qian Chang Xiangyang Qian Chuan Tian Xiaogang Sun | 2015 | Acta Biochimica et Biophysica Sinica2015，47，7： | 0 |
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