|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progress towards understanding the pathogenesis of dengue hemorrhagic fever显示文摘Dengue virus(DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever(DHF), the latter of which can progress to dengue shock syndrome(DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future. | Xiaojing Pang Rudian Zhang Gong Cheng | 2017 | Virologica Sinica2017，32，1： | 13 |
| 2 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 3 | Synthesis of monolithic carbon aerogels with high mechanical strength via ambient pressure drying without solvent exchange显示文摘A simple,fast and cost-effective method for monolithic carbon aerogels(CAs) preparation was proposed through sol-gel polycondensation of resorcinol with fo rmaldehyde in a basic aqueous solution followed by ambient pressure drying without solvent exchange,and carbonization.The microstructure and network strength of CAs were tailored by adju sting the catalyst concentration([resorcinol]/[sodium carbonate] in the range of 300-2000),water content([deionized water]/[resorcinol] equals to 17 and 24,respectively),and gelation temperature(Tgel in the range of 30-90℃).Resultantly,the CAs with a wide range of density(0.30-1.13 g/cm3),high specific surface area(465-616 m2/g),high compressive strength(6.5-147.4 MPa)and low thermal conductivity(0.065-0.120 W·m-1 K-1) were obtained in this work.Moreover,the largesized CAs(100×100×20 mm3) can also be prepared by this method since the formed robust skeleton network can resist shrinkage/collapse of pore structure and prevent cracking during drying.The improved mechanical strength and monolithic forming abilities could be mainly attributed to the uniform arrangement of carbon particles and pores,fine particle size,abundant network structure and enhanced particle neck. | Zhi Yang Jian Li Xiaojing Xu Shengyang Pang Chenglong Hu Penglei Guo Sufang Tang Hui-Ming Cheng | 2020 | Journal of Materials Science & Technology2020，47，15： | 4 |
| 4 | An aptamer-based shear horizontal surface acoustic wave biosensor with a CVD-grown single- layered graphene film for high-sensitivity detection of a label-free endotoxin显示文摘The thickness of the sensitive layer has an important influence on the sensitivity of a shear horizontal surface acoustic wave(SH-SAW)biosensor with a delay-line structure and lower layer numbers of graphene produce better sensitivity for biological detection.Therefore,a label-free and highly sensitive SH-SAW biosensor with chemical vapor deposition(CVD-)-grown single-layered graphene(SLG)for endotoxin detection was developed in this study.With this methodology,SH-SAW biosensors were fabricated on a 36°Y-90°X quartz substrate with a base frequency of 246.2MHz,and an effective detection cell was fabricated using acrylic material.To increase the surface hydrophilicity,chitosan was applied to the surface of the SLG film.Additionally,the aptamer was immobilized on the surface of the SLG film by cross-linking with glutaraldehyde.Finally,the sensitivity was verified by endotoxin detection with a linear detection ranging from 0 to 100 ng/mL,and the detection limit(LOD)was as low as 3.53 ng/mL.In addition,the stability of this type of SH-SAW biosensor from the air phase to the liquid phase proved to be excellent and the specificity was tested and verified by detecting the endotoxin obtained from Escherichia coli(E.coli),the endotoxin obtained from Pseudomonas aeruginosa(P.aeruginosa),and aflatoxin.Therefore,this type of SH-SAW biosensor with a CVD-grown SLG film may offer a promising approach to endotoxin detection,and it may have great potential in clinical applications. | Junwang Ji Yiquan Pang Dongxiao Li Zheng Huang Zuwei Zhang Ning Xue Yi Xu Xiaojing Mu | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 5 | Graphene Oxide‐Based Fluorescent Biosensor for Protein Detection via Terminal Protection of Small‐Molecule‐Linked DNA显示文摘 | Yue He Xiaojing Xing Hongwu Tang Daiwen Pang | 2013 | Small2013，，12： | 1 |
| 6 | Immune response, clinical outcome and safety of dendritic cell vaccinein combination with cytokine?induced killer cell therapy in cancer patients显示文摘 | Yu Cui Xuejing Yang Wei Zhu Jiali Li Xiaojing Wu Yan Pang | 2013 | Oncology Letters2013，，2： | 1 |
| 7 | Face-directed Strategy for the Construction of Polyoxovanadate-based Metal-Organic Tetrahedra显示文摘Polyoxometalate-based metal-organic polyhedra(MOPs)were of particular concern because of the various exquisite building blocks and the suitable constructional characteristics.To further understand the design and particularity of polyoxovanadate-based MOPs,(NH_(2)Me)_(8){[V_(6)O_(6)(OCH_(3))_(9)(C_(6)H_(5)PO_(3))]_(4)·(BPT)_(4)}·2DMF(HNU-74)and(NH_(2)Me)12{[V_(6)O_(6)(OCH_(3))_(9)(C_(6)H_(5)PO_(3))]4·(HBCBAIP)_(4)}(SO_(4))_(2)·MeOH·DMF(HNU-75)were constructed by a face-directed synthesis strategy.Both structures were assembled with four secondary building units as vertexes and four organic ligands served as faces.Different from HNU-74,HNU-75 showed a carboxyl group free during the coordination process,resulting in the pore channels being blocked and the free carboxyl group linking outwards,paving the way for the formation of the 3D structure.Due to the pore channels of HNU-74,the adsorption of I2 was studied and the adsorption capacity was 148 mg/g. | CHEN Huiping GONG Yaru CHU Qiangqiang PANG Xiao HUANG Xiaojing TIAN Xudong YANG Weiting PAN Qinhe SU Zhongmin WANG Xinlong | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 8 | Hybrid stochastic control strategy by two-layer networks for dissipating urban traffic congestion显示文摘With the rapid development of mobile devices and geographic information systems,social network data have become part of the traffic condition dissemination system,thereby influencing traffic conditions.Current research has indicated that the dissemination of traffic congestion information can partially alleviate congestion problems and thus enhance road transportation efficiency[1]. | Xiaojing ZHONG Bin PANG Feiqi DENG Xueyan ZHAO | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员