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| 1 | Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells显示文摘Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe_3O_4 nanoparticles into chitosan/polyethylene glycol(PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field(AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells(MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications. | Zheng Cao Dan Wang Yongsan Li Wensheng Xie Xing Wang Lei Wao Yen Wei Xiumei Wang Lingyun Zhao | 2018 | Science China(Life Sciences)2018，61，4： | 5 |
| 2 | Effect of PEG conformation and particle size on the cellular uptake efficiency of nanoparticles with the HepG2 cells显示文摘 | Yong Hu Jingwei Xie Yen Wah Tong Chi-Hwa Wang | 2006 | Journal of Controlled Release2006，，1： | 1 |
| 3 | Rapid hot embossing of polymer microstructures using carbide-bonded graphene coating on silicon stampers显示文摘 | Xie P He P Yen Y C | 2014 | Surface and Coatings Technology2014，258，： | 1 |
| 4 | Mechanical-robust and recyclable polyimide substrates coordinated with cyclic Ti-oxo cluster for flexible organic solar cells显示文摘With the rapid development of flexible optoelectronic devices,recyclability is highly desirable for alleviating resource waste and environmental pollution,but remains challenging.Here,a fully closed-loop recyclable crosslinked polyimide(RCPI)was fabricated via carboxyl ligand exchange between the CPI with pendent carboxyl groups and the cyclic Ti-oxo cluster(CTOC)with labile carboxyl ligands,which could be reconverted into reprocessable CPI and CTOC solution by pivalic acid.The RCPI-based embedded AgNWs@RCPI electrode shows comparable high conductivity,transparency and low roughness with ITO(indium tin oxide)/glass electrode,and meanwhile outstanding mechanical robustness.The related flexible organic solar cells(FOSCs)provided a high efficiency of 14.78% and maintained~97% of the initial efficiency after 5000 bending cycles at a small bending radius of 1 mm.Moreover,the recyclability of the RCPI still retains after being manufactured into the FOSCs.This work provides a promising strategy for recyclable flexible optoelectronic devices. | Guangcong Zhang Qiaomei Chen Chengcheng Xie Yongmei Wang Chaowei Zhao Chengyi Xiao Yen Wei Weiwei Li | 2022 | npj Flexible Electronics2022，6，1： | 1 |
| 5 | Relationship between students' moti- vation and their participation in asynchronous online discussions 显示文摘 | XIE K Durrington V Yen L L | 2011 | MERLOT Journal of Online Learning and Teaching2011，7，1： | 1 |
| 6 | Invasice spe- cies in China: An overview显示文摘 | Xie Yen Li Zhen-yu Gregg W P | 2000 | Biodiversity and Con- servation2000，10，： | 1 |
| 7 | Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa显示文摘Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor loss.Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival.This study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal degeneration.Additionally,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem humans.In this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in C57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp waveforms.To investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with age.Human retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in vitro.Photoreceptor density was evaluated by rhodopsin immunolabeling.In vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp waveforms.Retinal function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),respectively.Immunolabeling was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse retinas.Oscilloscope recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest voltage.Evaluation of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human eyes.The temperature recordings during and after electrical stimulation indicated no significant temperature change in vivo and only a subtle temperature increase in vitro(~0.5-1.5°C).Electrical stimulation increased photoreceptor survival in human retinal explant cultures,particularly at the ramp waveform.Transcorneal electrical stimulation(rectangular+ramp)waveforms significantly improved the survival and function of S and M-cones and enhanced visual acuity based on the optomotor response results.Histology and immunolabeling demonstrated increased photoreceptor survival,improved outer nuclear layer thickness,and increased bipolar cell sprouting in Rho^(-/-)mice.These results indicate that transcorneal electrical stimulation effectively delivers the electrical field to the retina,improves photoreceptor survival in both human and mouse retinas,and increases visual function in Rho^(-/-)mice.Combined rectangular and ramp waveform stimulation can promote photoreceptor survival in a minimally invasive fashion. | Sam Enayati Karen Chang Anton Lennikov Menglu Yang Cherin Lee Ajay Ashok Farris Elzaridi Christina Yen Kasim Gunes Jia Xie Kin-Sang Cho Tor Paaske Utheim Dong Feng Chen | 2024 | Neural Regeneration Research2024，19，11： | 0 |
| 8 | Necroptosis-elicited host immunity:GOx-loaded MoS_(2) nanocatalysts for self-amplified chemodynamic immunotherapy显示文摘Nanoparticles induced potent antitumor immunotherapy plays a significant role for enhancing conventional therapeutic effectiveness.However,revealing the pathway of how nanoagents themselves trigger the host immunity or how to maximize the immunotherapy efficacy still needs further exploration.Herein,rose-like MoS2 nanoflowers modified with 2-deoxy-D-glucose(2-DG)and glucose oxidase(GOx)(MPGGFs)have been successfully fabricated via a one-pot hydrothermal reaction and following one-by-one surface modification as a multifunctional nanocatalyst for photothermal therapy enhanced self-amplified chemodynamic immunotherapy(PTT-co-CDT).By introducing GOx,the obtained MPGGFs exhibited self-amplified chemodynamic therapeutic efficacy under hypoxia tumor microenvironment(TME)because of the raised intracellular H2O2 level via enzyme-catalysis of oxygen.Furthermore,combined with the intrinsic excellent photothermal conversion efficiency of MoS2 nanoflowers,PTT-co-CDT performances by MPGGFs could effectively induce the necroptosis of tumor cells both in vitro and in vivo.Then the induced necroptosis via PTT-co-CDT by MPGGFs could directly trigger host immunity by activating the antigen-specific T-cells(CD4^(+) and CD8^(+)).Finally,the excellent in vivo safety of MPGGFs makes us believe that the successful construction of rose-like multifunctional nanocatalyst not only has great potentials for self-amplified chemodynamic immunotherapy,but also provides a paradigm for exploring necroptosis triggered host immunity for cancer treatment. | Wensheng Xie Jingsong Lu Zhenhu Guo Xiaoxiao Guo Yongjiu Chi Jieling Ye Junxin Zhang Wanling Xu Lingyun Zhao Yen Wei | 2022 | Nano Research2022，15，3： | 0 |
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