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| 1 | Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications显示文摘Objective:The programmed cell death-1 receptor/programmed cell death-1 ligand(PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity.This study was designed to evaluate the association between circulating PD-L1 expression and prognosis in patients with advanced gastric cancer.Methods:Totally 80 advanced gastric cancer patients and 40 health controls from Beijing Cancer Hospital were enrolled in the present study.Circulating PD-L1 expression was tested by enzymelinked immunosorbent assay(ELISA).The associations between the expression level of PD-L1 and clinicopathological features and prognosis were analyzed statistically.Results:Expression of PD-L1 in advanced gastric cancer patients was significantly up-regulated compared with health people(P=0.006).The expression of PD-L1 was significantly correlated with differentiation and lymph node metastasis(P=0.026 and P=0.041,respectively).Although we didn't find significant difference in all advanced gastric cancer patients with different PD-L1 expression,the adenocarcinoma patients with higher up-regulated PD-L1 expression had much better prognosis than low expression patients(65.6% vs.44.7%,P=0.028).Conclusions:PD-L1 was elevated in advance gastric cancer patients and may play an important role in tumor immune evasion and patients prognosis. | Zhixue Zheng Zhaode Bu Xijuan Liu Lianhai Zhang Ziyu Li Aiwen Wu Xiaojiang Wu Xiaojing Cheng Xiaofang Xing Hong Du Xiaohong Wang Ying Hu Jiafu Ji | 2014 | Chinese Journal of Cancer Research2014，26，1： | 37 |
| 2 | Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields. | Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai | 2018 | Journal of Environmental Sciences2018，30，2： | 12 |
| 3 | Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer显示文摘Genetically modified pigs are valuable models of human disease and donors of xenotransplanted organs.Conventional gene targeting in pig somatic cells is extremely inefficient.Zinc-finger nuclease(ZFN)technology has been shown to be a powerful tool for efficiently inducing mutations in the genome.However,ZFN-mediated targeting in pigs has rarely been achieved.Here,we used ZFNs to knock out the porcineα-1,3-galactosyl-transferase(GGTA1)gene,which generates Gal epitopes that trigger hyperacute immune rejection in pig-to-human transplantation.Primary pig fibroblasts were transfected with ZFNs targeting the coding region of GGTA1.Eighteen mono-allelic and four biallelic knockout cell clones were obtained after drug selection with efficiencies of 23.4%and 5.2%,respectively.The biallelic cells were used to produce cloned pigs via somatic cell nuclear transfer(SCNT).Three GGTA1 null piglets were born,and one knockout primary fibroblast cell line was established from a cloned fetus.Gal epitopes on GGTA1 null pig cells were completely eliminated from the cell membrane.Functionally,GGTA1 knockout cells were protected from complement-mediated immune attacks when incubated with human serum.This study demonstrated that ZFN is an efficient tool in creating gene-modified pigs.GGTA1 null pigs and GGTA1 null fetal fibroblasts would benefit research and pig-to-human transplantation. | BAO Lei CHEN HaiDe JONG UiMyong RIM CholHo LI WenLing LIN XiJuan ZHANG Dan LUO Qiong CUI Chun HUANG HeFeng ZHANG Yan XIAO Lei FU ZhiXin | 2014 | Science China(Life Sciences)2014，57，2： | 9 |
| 4 | 慢性疾病与体力活动(英文)显示文摘Chronic diseases have become a focal point of public health worldwide with estimates of trillions of dollars in annual health care cost and causing more than 36 million deaths a year.Lifestyle factors such as physical inactivity are heavily correlated with the development of many chronic diseases.New strategies for primary and secondary disease prevention are desperately needed to aid in blunting the negative economic and social impact of these diseases.Physical activity(PA) and exercise are now considered principal interventions for use in primary and secondary prevention of chronic diseases.Currently,more emphasis in primary prevention of disease is necessary to reduce disease risk in youth and adults;however with chronic disease prevalence so high,similar emphasis is also necessary for secondary prevention in those children and adults already inflicted with chronic diseases.Conditions such as cardiovascular disease,type 2 diabetes,obesity,and cancer are drastically improved when PA and exercise are part of a medical management plan.In addition,the national PA guidelines in conjunction with PA promotion tools like Exercise is Medicine? are needed to promote increased PA and exercise levels worldwide. | J. Larry Durstine Benjamin Gordon ZhengzhenWang Xijuan Luo | 2013 | Journal of Sport and Health Science2013，2，1： | 9 |
| 5 | Polybrominated diphenyl ethers in chicken tissues and eggs from an electronic waste recycling area in southeast China显示文摘The levels and distributions of polybrominated diphenyl ethers(PBDEs) in chicken tissues from an electronic waste(e-waste) recycling area in southeast China were investigated.Human dietary intake by local residents via chicken muscle and eggs was estimated.The mean PBDEs concentrations in tissues ranged from 15.2 to 3138.1 ng/g lipid weight(lw) and in egg the concentration was 563.5 ng/g lw.The results showed that the level of total PBDEs(ΣPBDEs) in the chicken tissue was 2-3 orders of magnitude higher than those reported in the literature.The large difference of ΣPBDEs concentrations between tissues confirmed that the distribution of PBDEs in tissues depend on tissue-specificity rather than the 'lipid-compartment'.BDE-209 was the predominant congener(82.5%-94.7% of ΣPBDEs) in all chicken tissues except in brain(34.7% of ΣPBDEs),which indicated that deca-BDE(the major commercial PBDE formulation comprising 65%-70% of total production) was major pollution source in this area and could be bioaccumulated in terrestrial animals.The dietary PBDEs intake of the local residents from chicken muscle and egg,assuming only local bred chickens and eggs were consumed,ranged from 2.2 to 22.5 ng/(day·kg body weight(bw)) with a mean value of 13.5 ng/(day·kg bw),which was one order of magnitude higher than the value reported in previous studies for consumption of all foodstuffs. | Xiaofei Qin Zhanfen Qin Yan Li Yaxian Zhao Xijuan Xia Shishuai Yan Mi Tian Xingru Zhao Xiaobai Xu Yongjian Yang | 2011 | Journal of Environmental Sciences2011，23，1： | 8 |
| 6 | Ecotoxicological effects of mixed pollutants resulted from e-wastes recycling and bioaccumulation of polybrominated diphenyl ethers in Chinese loach(Misgurnus anguillicaudatus)显示文摘To understand potential ecotoxicological effects of electrical and electronic equipment waste (e-waste) recycling and polybrominated diphenyl ethers (PBDEs) bioaccumulation in loaches, a semi-field experiment using Chinese loach (Misgurnus anguillicaudatus) as experimental fish was performed. Larval loaches were kept in net-cage for three months in an e-wastes recycling site and a reference site in Southeastern China. There was significant difference of the survival rate between the loaches from the e-wastes recycling site (27%, 19/70) and from reference site (70%, 49/70). Histopathological responses were also found in all the livers examined in loaches from the e-wastes recycling site. These results showed that mixed pollutants resulted from e-wastes recycling led to ecotoxicological effects on loaches. The bioaccumulation of polybrominated diphenyl ethers (PBDEs), the main pollutants in e-waste, in loaches was also studied, the mean concentration of total PBDEs in sediment was 6726.17 ng/g wet weight and in water samples was 4.08 ng/L (dissolved phase). BDE 209 was the dominant congener in sediment and with relatively high concentration in water. Relatively low concentration of BDE 209 (less than 0.01% of total PBDEs) and high concentration of BDE47 (up to 39.34% of total PBDEs) were detected in loaches. | QIN Xiaofei XIA Xijuan LI Yan ZHAO Yaxian YANG Zhongzhi FU Shan TI-AN Mi ZHAO Xingru QIN Zhanfen XU Xiaobai YANG Yongjian | 2009 | Journal of Environmental Sciences2009，21，12： | 6 |
| 7 | Preparation of La2O3 by ion-exchange membrane electrolysis of LaCl3 aqueous solution显示文摘The ion-exchange membrane electrolysis technology was applied inventively in the preparation of lanthanum hydroxide,after calcination,lanthanum oxide was obtained eventually.The effect of the concentration of lanthanum chlo ride solution on electrolytic product was mainly investigated.The phase composition,micro morphology,particle size and chlorine content of the product were characterized,respectively.Under the conditions of this work,the product that forms by electrolysis of LaCl3 aqueous solution directly is La(OH)3.When the initial concentration of LaCl3 changes from 0.1 to 0.5 mol/L,the current efficiency of La(OH)3 increases from 60%to 85%,the product roasted at 800℃for 1.5 h is La2O3,whose median particle size(D50)is 10-20μm,the mass fraction of chloride ion is less than 0.02 wt%.Additio nally,the prepared La2O3 particles are porous and non-spherical particle s,which are composed of small crystals with sheet structure. | Deliang Meng Qiuyue Zhao Xijuan Pan Ting’an Zhang | 2019 | Journal of Rare Earths2019，37，9： | 3 |
| 8 | UWB Channel Modeling and Simulation with Continuous Frequency Response显示文摘Ultra-wideband(UWB)technology is a prospective technology for high-rate transmission and accurate localization in the future communication systems.State-of-art channel modeling approaches usually divide the UWB channel into several sub-band channels and model them independently.By considering frequency-dependent channel parameters,a novel analytical UWB channel model with continuous frequency response is proposed.The composite effect of all frequency components within the UWB channel on the channel impulse response(CIR)of delay domain is derived based on the continuous channel transfer function(CTF)of frequency domain.On this basis,a closed-form simulation model for UWB channels and geometry-based parameter calculation method are developed,which can guarantee the continuity of channel characteristics on the frequency domain and greatly reduce the simulation complexity.Finally,the proposed method is applied to generate UWB channel with 2 GHz bandwidth at sub-6GHz and millimeter wave(mmWave)bands,respectively.The channel measurements are also carried out to validate the proposed method.The simulated CIR and power gain are shown to be in good agreement with the measurement data.Moreover,the comparison results of power gain and Doppler power spectral density(DPSD)show that the proposed UWB channel model Received:Apr.23,2022 Revised:Jun.09,2022 Editor:Wei Fan achieves a good balance between the simulation accuracy and efficiency. | Kai Mao Qiuming Zhu Xijuan Ye Ruirui Feng Fuqiao Duan Yang Miao Maozhong Song | 2022 | China Communications2022，19，11： | 3 |
| 9 | A general altitude-dependent path loss model for UAV-to-ground millimeter-wave communications显示文摘A general empirical path loss(PL) model for air-to-ground(A2 G) millimeter-wave(mm Wave) channels is proposed in this paper. Different from existing PL models, the new model takes the height factor of unmanned aerial vehicles(UAVs) into account, and divides the propagation conditions into three cases(i.e., line-of-sight, reflection,and diffraction). A map-based deterministic PL prediction algorithm based on the ray-tracing(RT) technique is developed, and is used to generate numerous PL data for different cases. By fitting and analyzing the PL data under different scenarios and UAV heights, altitude-dependent model parameters are provided. Simulation results show that the proposed model can be effectively used to predict PL values for both low-and high-altitude cases.The prediction results of the proposed model better match the RT-based calculation results than those of the Third Generation Partnership Project(3 GPP) model and the close-in model. The standard deviation of the PL is also much smaller. Moreover, the new model is flexible and can be extended to other A2 G scenarios(not included in this paper) by adjusting the parameters according to the simulation or measurement data. | Qiuming ZHU Mengtian YAO Fei BAI Xiaomin CHEN Weizhi ZHONG Boyu HUA Xijuan YE | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，6： | 2 |
| 10 | Thyroid disruption by technical decabromodiphenyl ether (DE-83R) at low concentrations in Xenopus laevis显示文摘Decabromodiphenyl ether (decaBDE),as a flame retardant,is widely produced and used.To study the thyroid disruption by technical decaBDE at low concentrations,Xenopus laevis tadpoles were exposed to technical decaBDE mixture DE-83R (1-1000 ng/L) in water from stage 46/47 (free swimming larvae,system of Nieuwkoop and Faber) to stage 62.DE-83R at concentration of 1000 ng/L significantly delayed the time to metamorphosis (presented by forelimb emergence,FLE).Histological examination showed that DE83R at all tested concentrations caused histological alterations-multilayer follicular epithelial cell and markedly increased follicle size accompanied by partial colloid depletion and increase in the peripheral colloid vacuolation,in thyroid glands.All tested concentrations of DE-83R also induced a down-regulation of thyroid receptor mRNA expression.These results demonstrated that technical decaBDE disrupted the thyroid system in X.laevis tadpoles.Analysis of polybrominated diphenyl ethers (PBDEs) (sum of 39 congeners) in X.laevis indicated that mean concentrations of total PBDEs in X.laevis exposed to 1,10,100,1000 ng/L were 11.0,128.1,412.1,1400.2 ng/g wet weight,respectively.Considering that PBDEs burden of X.laevis tadpoles was close to PBDEs levels in amphibians as reported in previous studies,our study has raised new concerns for thyroid disruption in amphibians of technical decaBDE at environmentally relevant concentrations. | Xiaofei Qin Xijuan Xia Zhongzhi Yang Shishuai Yan Yaxian Zhao Rongguo Wei Yan Li Mi Tian Xingru Zhao Zhanfen Qin Xiaobai Xu | 2010 | Journal of Environmental Sciences2010，22，5： | 2 |
| 11 | Size-dependent optical prop erties of nanocrystalline CeO2 : Er obtained by combustion syn thesis显示文摘 | Yu Xijuan Xie Pingbo Su Qingde | 2001 | Physical Chemistry Chemical Physics2001，3，23： | 1 |
| 12 | Optimization algorithm for computing exact Minkowski sum of 3D convex polyhe- dra 显示文摘 | Guo Xijuan Gao Ying Liu Yong | 2008 | IJICIC2008，6，4： | 1 |
| 13 | A new al- gorithm for computing exact Minkowski sum of convex pol- yhedral 显示文摘 | Zhang Buying Guo Xijuan Geng Qing~ia ct al | 2013 | Advances in Information Sciences and Serv- ice Sciences2013，6，： | 1 |
| 14 | Analysis for dy- namics performance indices of 4 - RR (RR) R parallel mechanism显示文摘 | Guo Xijuan Liu Shuang Wang Zhenchun | 2006 | International Journal of Innovative Compu- ting Information and control2006，2，4： | 1 |
| 15 | Metabolic Conversion of N′-(2,4-dimethylphenyl)-N-methylformamidine Pesticide and the Analysis of the Metabolites显示文摘 | Zhu Naikai Du Xiuying Xia Xijuan Wang Shuqin An Fengchun | 2000 | Bulletin of Environmental Contamination and Toxicology2000，，1： | 1 |
| 16 | Anlysis for Dynamics Performance Indices of 4--RR(RR)R Parallel Mechanism显示文摘 | Guo Xijuan Liu Shuang Wang Zhenchun | 2006 | International Journal of In- novative Computing Information and Control2006，2，4： | 1 |
| 17 | DEM generation and error analysis using the first Chinese airborne dual-antenna interferometric SAR data显示文摘 | Zhongchang Sun Huadong Guo Xinwu Li Xijuan Yue Qingni Huang | 2011 | International Journal of Remote Sensing2011，，23： | 1 |
| 18 | Impacts of Mining Activity on Algae in Le An River 显示文摘 | Zhu Naikai Xiao Xijuan Wang Yuehua | 1992 | Journal of Environmental Sciences(China)1992，4，3： | 1 |
| 19 | Analysis for dynamics performance indices of 4-RR(RR)R parallel mechanism 显示文摘 | GUO Xijuan LIU Shuang | 2006 | International Journal of Innovative Computing Information and Control2006，2，4： | 1 |
| 20 | Bringing a family practice model of health to the people′s republic of China显示文摘 | Linda Z.Nieman James Kvake Xijuan Fu | | 0，，09： | 1 |
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