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| 1 | 慢性疾病与体力活动(英文)显示文摘Chronic diseases have become a focal point of public health worldwide with estimates of trillions of dollars in annual health care cost and causing more than 36 million deaths a year.Lifestyle factors such as physical inactivity are heavily correlated with the development of many chronic diseases.New strategies for primary and secondary disease prevention are desperately needed to aid in blunting the negative economic and social impact of these diseases.Physical activity(PA) and exercise are now considered principal interventions for use in primary and secondary prevention of chronic diseases.Currently,more emphasis in primary prevention of disease is necessary to reduce disease risk in youth and adults;however with chronic disease prevalence so high,similar emphasis is also necessary for secondary prevention in those children and adults already inflicted with chronic diseases.Conditions such as cardiovascular disease,type 2 diabetes,obesity,and cancer are drastically improved when PA and exercise are part of a medical management plan.In addition,the national PA guidelines in conjunction with PA promotion tools like Exercise is Medicine? are needed to promote increased PA and exercise levels worldwide. | J. Larry Durstine Benjamin Gordon ZhengzhenWang Xijuan Luo | 2013 | Journal of Sport and Health Science2013，2，1： | 9 |
| 2 | XIAP regulates akt activity and caspase-3-dependent cleavage during eisplatin-induced apoptosis in human ovarian epithelial cancer eells显示文摘 | Eric A Gordon B M Benjamin K T | 2001 | Cancer Res2001，61，5： | 1 |
| 3 | Techniques and Training with GreenLight HPS 120-W Laser Therapy of the Prostate: Position Paper显示文摘 | Gordon Muir Fernando Gómez Sancha Alexander Bachmann Benjamin Choi Edward Collins Jean de la Rosette Oliver Reich Shahin Tabatabaei Henry Woo | 2007 | European Urology Supplements2007，，： | 1 |
| 4 | The role of antidepressants in the management of inflammatory bowel disease (IBD): A short report on a clinical case-note audit显示文摘 | Antonina A. Mikocka-Walus Andrea L. Gordon Benjamin J. Stewart Jane M. Andrews | 2011 | Journal of Psychosomatic Research2011，，2： | 1 |
| 5 | The tyrosine phosphatase Shp2 (PTPN11) in cancer显示文摘 | Gordon Chan Demetrios Kalaitzidis Benjamin G. Neel | 2008 | Cancer and Metastasis Reviews2008，，2： | 1 |
| 6 | Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel显示文摘 | Giuseppe Gagliardi Olcay Kandemir Michelle Guida Serena Benvestito Gordon W. H. Stamp Massimo Pignatelli Theo G. M. Ruers Irving S. Benjamin John M. A Northover Ian C. Talbot | 1995 | Virchows Archiv1995，，2： | 1 |
| 7 | Exercise Training as Therapy for Heart Failure: Current Status and Future Directions显示文摘 | Jerome L. Fleg Lawton S. Cooper Barry A. Borlaug Mark J. Haykowsky William E. Kraus Benjamin D. Levine Marc A. Pfeffer Ileana L. Pi?a David C. Poole Gordon R. Reeves David J. Whellan Dalane W. Kitzman | 2015 | Circulation: Heart Failure2015，，： | 1 |
| 8 | NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network显示文摘 | Jean-Claude Platel Kathleen A. Dave Valerie Gordon Benjamin Lacar Maria E. Rubio Angélique Bordey | 2010 | Neuron2010，，6： | 1 |
| 9 | Stability of trapped fermionic gases with attractive interactions显示文摘 | Fregoso Benjamin M Baym Gordon | 2006 | Physical Review A2006，73，04： | 1 |
| 10 | Causes and consequences of aneuploidy in cancer Nature Reviews显示文摘 | David J Gordon Benjamin Resio David Pellman | 2012 | Genetics2012，13，： | 1 |
| 11 | Exercise Training Versus Propranolol in the Treatment of the Postural Orthostatic Tachycardia Syndrome显示文摘 | Qi Fu Tiffany B. VanGundy Shigeki Shibata Richard J. Auchus Gordon H. Williams Benjamin D. Levine | 2011 | Hypertension2011，，2： | 1 |
| 12 | The tyrosine phosphatase Shp2 in cancer 显示文摘 | GORDON C DMETRIOS K BENJAMIN N | 2008 | Cancer Metastasis Rev2008，27，2： | 1 |
| 13 | Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance显示文摘 | Patricia C. Underwood Bindu Chamarthi Jonathan S. Williams Bei Sun Anand Vaidya Benjamin A. Raby Jessica Lasky-Su Paul N. Hopkins Gail K. Adler Gordon H. Williams | 2012 | Metabolism2012，，5： | 1 |
| 14 | A novel fiber-optic sensor array based on the sagnac interferometer显示文摘 | Benjamin J V Michel J F D Gordon S K | 1999 | Lightwave Tecnology1999，17，11： | 1 |
| 15 | Prism adaptation and unilateral neglect:Review and analysis显示文摘 | Gordon M Redding Benjamin Wallace | | 0，，01： | 1 |
| 16 | Development of Inhibitory Control Across the Life Span显示文摘 | Benjamin R Williams Gordon D Logan | 1999 | Developmental Psychology1999，，： | 1 |
| 17 | The tyrosine phosphatase Shp2 in cancer显示文摘 | Gordon C Dmetrios K Benjamin N ct al | 2008 | Cancer Metastasis Rev2008，27，2： | 1 |
| 18 | 共识指南和循证指南中基于低质量证据的强推荐及其合理性的经验性分析显示文摘目的探讨共识指南及循证指南的证据质量与推荐强度是否一致。研究设计经验性分析。数据来源美国心脏病学会/美国心脏协会(ACC/AHA)和美国临床肿瘤学会(ASCO)于2021年3月27日前制订的指南。指南选择纳入推荐意见符合以下标准的指南:明确报告循证或共识意见、推荐意见独立于指南全文、报告证据质量和推荐强度。数据提取由2名研究人员独立提取资料,提取内容包括:推荐意见类型(共识意见或循证意见)、制订推荐意见的分级系统、推荐强度和证据质量。研究团队统计了低质量证据强推荐和不合理的低质量证据强推荐(不符合GRADE标准)的数量。结果本研究共纳入12部ACC/AHA指南中的1434条推荐意见以及69部ASCO指南中的1094条推荐意见。ACC/AHA指南共有504条基于低质量证据的推荐意见,其中200条(40%)是共识意见,304条(60%)是循证意见;ASCO指南中包含404条基于低质量证据的推荐意见,其中292条(72%)是共识意见,112条(28%)是循证意见。ACC/AHA和ASCO制订的指南中,共识指南比循证指南出现了更多基于低质量证据的强推荐,ACC/AHA[比值比(0R)=2.1,95%可信区间(CI)(1.5-3.1)],ASCO[OR=2.9,95%CI(1.1-7.8)],以及更多不合理的低质量证据强推荐,ACC/AHA[OR=2.6,95%CI(1.7-3.7)],ASCO[OR=5.1,95%CI(1.6-16.0)]。结论与循证指南相比,共识指南更容易形成不符合循证医学基本原则的推荐意见。确保证据质量与推荐强度的一致性和合理性是制订可信赖指南的关键。 | 姚亮 Muhammad Muneeb Ahmed Gordon H Guyatt 闫沛静 惠旭 王琪 杨克虎 田金徽 Benjamin Djulbegovic 李紫珺(译) 郭珂(译) 姚亮(校) 王琪(校) 田金徽(校) 杨克虎(校) | 2022 | 英国医学杂志中文版2022，25，3： | 0 |
| 19 | Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease显示文摘BACKGROUND Patients with inflammatory bowel disease(IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin C deficiency in Crohn’s disease(CD) and ulcerative colitis(UC) patients, as well as the impact of clinical, biomarker and endoscopic disease severity on the development of vitamin C deficiency.AIM To determine proportions and factors associated with vitamin C deficiency in CD and UC patients.METHODS In this retrospective study, we obtained clinical, laboratory and endoscopic data from CD and UC patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin C level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301ultimately met criteria for inclusion in the study. The primary aim described vitamin C deficiency(≤ 11.4 μmol/L) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with deficiency.RESULTS Of 301 IBD patients, 21.6% had deficiency, including 24.4% of CD patients and 16.0% of UC patients. Patients with elevated C-reactive protein(CRP)(39.1% vs 16.9%, P < 0.001) and fecal calprotectin(50.0% vs 20.0%, P = 0.009) had significantly higher proportions of deficiency compared to those without. Penetrating disease(P = 0.03),obesity(P = 0.02) and current biologic use(P = 0.006) were also associated with deficiency on univariate analysis. On multivariate analysis, the objective inflammatory marker utilized for analysis(elevated CRP) was the only factor associated with deficiency(odds ratio = 3.1, 95%confidence interval: 1.5-6.6, P = 0.003). There was no difference in the presence of clinical symptoms of scurvy in those with vitamin C deficiency and those without.CONCLUSION Vitamin C deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin C deficiency. | Benjamin Langan Gordon Jonathan S Galati Stevie Yang Randy S Longman Dana Lukin Ellen J Scherl Robert Battat | 2022 | World Journal of Gastroenterology2022，28，33： | 0 |
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