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| 1 | Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission显示文摘Dear Editor,The occurrence of concentrated pneumonia cases in Wuhan city,Hubei province of China was first reported on December 30,2019 by the Wuhan Municipal Health Commission(WHO,2020).The pneumonia cases were found to be linked to a large seafood and animal market in Wuhan,and measures for sanitation and disinfection were taken swiftly by the local government agency.The Centers for Disease Control and Prevention(CDC)and Chinese health authorities later determined and announced that a novel coronavirus(CoV),denoted as 2019-nCoV,had caused the pneumonia outbreak in Wuhan city(CDC,2020).Scientists from multiple groups had obtained the virus samples from hospitalized patients(Normile,2020).The isolated viruses were morphologically identical when observed under electron microscopy. | Xintian Xu Ping Chen Jingfang Wang Jiannan Feng Hui Zhou Xuan Li Wu Zhong Pei Hao | 2020 | Science China(Life Sciences)2020，63，3： | 737 |
| 2 | Design,modeling,and control of morphing aircraft:A review显示文摘A morphing aircraft can adapt its configuration to suit different types of tasks,which is also an important requirement of Unmanned Aerial Vehicles(UAV).The successful development of an unmanned morphing aircraft involves three steps that determine its ability and intelligent:configuration design,dynamic modeling and flight control.This study conducts a comprehensive survey of morphing aircraft.First,the methods to design the configuration of a morphing aircraft are presented and analyzed.Then,the nonlinear dynamic characteristics and aerodynamic interference caused by a morphing wing are described.Subsequently,the dynamic modeling and flight control methods for solving the flight control problems are summarized with respect to these features.Finally,the general as well as special challenges ahead of the development of intelligent morphing aircraft are discussed.The findings can provide a theoretical and technical reference for designing future morphing aircraft or morphing-wing UAVs. | Lingling CHU Qi LI Feng GU Xintian DU Yuqing HE Yangchen DENG | 2022 | Chinese Journal of Aeronautics2022，35，5： | 16 |
| 3 | PlantcircBase: A Database for Plant Circular RNAs显示文摘 | Qinjie Chu Xingchen Zhang Xintian Zhu Chen Liu Lingfeng Mao Chuyu Ye Qian-Hao Zhu Longjiang Fan | 2017 | Molecular Plant2017，10，8： | 15 |
| 4 | Numerical analysis of fuel regression rate distribution characteristics in hybrid rocket motors with different fuel types显示文摘This paper presents three-dimensional numerical simulations of the hybrid rocket motor with hydrogen peroxide (HP) and hy-droxyl terminated polybutadiene (HTPB) propellant combination and investigates the fuel regression rate distribution charac-teristics of different fuel types. The numerical models are established to couple the Navier-Stokes equations with turbulence,chemical reactions, solid fuel pyrolysis and solid-gas interfacial boundary conditions. Simulation results including the temper-ature contours and fuel regression rate distributions are presented for the tube, star and wagon wheel grains. The results demonstrate that the changing trends of the regression rate along the axis are similar for all kinds of fuel types, which decrease sharply near the leading edges of the fuels and then gradually increase with increasing axial locations. The regression rates of the star and wagon wheel grains show apparent three-dimensional characteristics, and they are higher in the regions of fuel surfaces near the central core oxidizer flow. The average regression rates increase as the oxidizer mass fluxes rise for all of the fuel types. However, under same oxidizer mass flux, the average regression rates of the star and wagon wheel grains are much larger than that of the tube grain due to their lower hydraulic diameters. | LI XinTian TIAN Hui CAI GuoBiao | 2013 | Science China(Technological Sciences)2013，56，7： | 11 |
| 5 | Numerical and experimental investigation on the effects of aft mixing chamber diaphragm in hybrid rocket motor显示文摘This paper focuses on the investigation of an aft mixing chamber diaphragm in a hybrid rocket motor.Both numerical and experimental researches are carried out to study its effects on the motor performances.The hybrid rocket motor with star fuel grain is utilized.The 90%hydrogen peroxide(HP)oxidizer and hydroxyl terminated polybutadiene(HTPB)based fuel are adopted as propellants.The diaphragm configuration settled in the aft mixing chamber includes four circular-holes with a uniform circumferential distribution.For both motors with and without the diaphragm,three-dimensional numerical simulations with gaseous combustions considered are carried out to study the flow field characteristics and motor performances.The comparison results show that the diaphragm can improve the mixing of the oxidizer and fuel.It has evident effect on increasing the motor efficiencies.Two firing experiments are conducted with full scale motors to investigate the effects of the diaphragm.The diaphragm used in the test is composed of a central steel framework and a closed thermal insulation layer.With the diaphragm employed,the combustion efficiency increases from 93.9%to 97.34%and the specific impulse efficiency increases from 80.77%to 87.28%,which verifies the positive effect of the diaphragm.Both numerical and experimental studies indicate that the scheme of the aft mixing chamber diaphragm proposed in the paper can improve the efficiencies of the hybrid rocket motor obviously. | TIAN Hui LI XinTian YU NanJia CAI GuoBiao | 2013 | Science China(Technological Sciences)2013，56，11： | 9 |
| 6 | Analysis and evaluation of electromagnetic vibration and noise in permanent magnet synchronous motor with rotor step skewing显示文摘In this paper, a multi-physics simulation model capable of electromagnetic noise prediction is established, and the effectiveness of the established simulation model in predicting and evaluating electromagnetic noise is verified. Based on the verified motor model, a rotor step skewing model which can affect electromagnetic noise is proposed, and the influence of the skewing angle on electromagnetic noise is investigated in detail. By studying the spectral characteristics of the low-order radial magnetic force which has a great influence on electromagnetic noise, the distribution of electromagnetic noise characteristics of the permanent magnet synchronous motor(PMSM) with or without the rotor step skewing is compared and analyzed. Therefore, it lays a technological foundation for predicting and suppressing the electromagnetic vibration noise of electric vehicle(EV) driving motor in the electromagnetic design. | DONG QiChao LIU XinTian QI HongZhong SUN Chao WANG YanSong | 2019 | Science China(Technological Sciences)2019，62，5： | 9 |
| 7 | How does the motor relearning program improve neurological function of brain ischemia monkeys?显示文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. | Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng | 2013 | Neural Regeneration Research2013，8，16： | 9 |
| 8 | New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity显示文摘Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A-R and lavandiolides A,B,C,H,and J.Eight compounds(1,4,10,12,13,and 19-21) were unambiguously confirmed by the single-crystal X-ray diffraction analyses,and the others were elucidated based on IR,UV,HRESIMS,1 D and 2 D NMR experiments,and comparison of the experimental and calculated ECD data.Structurally,all of them were [4+2] Diels-Alder adducts of two monomeric guaianolides.The isolates were evaluated for their cytotoxicity against three human hepatoma cell lines,and 19 compounds demonstrated cytotoxicity against HepG2,SMMC-7721,and Huh7 cell lines.Especially,compounds 1,12,14,and 15 exhibited cytotoxicity with IC50 values of 4.4,3.8,7.6,and 6.7 μmol/L(HepG2),9.6,4.6,6.6,and 6.0 μmol/L(SMMC-7721),and 7.6,4.5,6.9,and 5.6 μmol/L(Huh7),respectively.Notably,compound 12 showed the most promising activity against three human hepatoma cell lines and dose-dependently inhibited cell migration and invasion,induced G2/M cell cycle arrest and cell apoptosis in HepG2 cells,down-regulated the expression of BCL-2 and PARP-1,and activated PARP-1 to up-regulate the expression of cleaved-PARP-1. | Lihua Su Xintian Zhang Yunbao Ma Changan Geng Xiaoyan Huang Jing Hu Tianze Li Shuang Tang Cheng Shen Zhen Gao Xuemei Zhang Ji-Jun Chen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 6 |
| 9 | Evaluation of regenerative braking based on single-pedal control for electric vehicles显示文摘More than 25%of vehicle kinetic energy can be recycled under urban driving cycles.A single-pedal control strategy for regenerative braking is proposed to further enhance energy efficiency.Acceleration and deceleration are controlled by a single pedal,which alleviates driving intensity and prompts energy recovery.Regenerative braking is theoretically analyzed based on the construction of the single-pedal system,vehicle braking dynamics,and energy conservation law.The single-pedal control strategy is developed by considering daily driving conditions,and a single-pedal simulation model is established.Typical driving cycles are simulated to verify the effectiveness of the single-pedal control strategy.A dynamometer test is conducted to confirm the validity of the simulation model.Results show that using the single-pedal control strategy for electric vehicles can effectively improve the energy recovery rate and extend the driving range under the premise of ensuring safety while braking.The study lays a technical foundation for the optimization of regenerative braking systems and development of single-pedal control systems,which are conducive to the promotion and popularization of electric vehicles. | Wei LIU Hongzhong QI Xintian LIU Yansong WANG | 2020 | Frontiers of Mechanical Engineering2020，15，1： | 5 |
| 10 | Research progress on solidification structure of alloys by synchrotron X-ray radiography: A review显示文摘The synchrotron radiation technology has recently emerged as a powerful tool to characterize the real-time microstructure evolution during solidification of alloys.Compared with other methods,the synchrotron radiation technology,along with its unique advantages of strong brightness,high energy,excellent resolution,and good monochromaticity,allows for capturing the dendrite evolution behavior of alloys in real time and can be dynamically coordinated with high-resolution CCD(Charge-coupled Device)imaging systems.This paper briefly reviews the recent advances in developing synchrotron radiation for solidification of alloys with low,medium,and high melting points,and under the external electric,magnetic,and ultrasonic fields.Furthermore,a series of microstructural features and behaviors such as dendrite morphology,growth orientation,dendrite fracture,and rotation are described in detail.Finally,the development trends and application prospects of synchrotron radiation technology in alloy solidification are forecasted. | Yongbiao Wang Sensen Jia Mingguang Wei Liming Peng Yujuan Wu Xintian Liu | 2020 | Journal of Magnesium and Alloys2020，8，2： | 5 |
| 11 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 12 | A cynomolgus monkey with naturally occurring Parkinson’s disease显示文摘Evidence for the existence of monkeys with spontaneous Parkinson’s disease(PD)has been lacking.Here,we screened macaque colonies at the Kunming Primate Research Center(Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC)accredited),Kunming Institute of Zoology,Chinese Academy of Sciences,which has a large population of monkeys(>2400),to identify naturally occurring PD monkeys. | Hao Li Ling-Yan Su Lixin Yang Min Li Qianjin Liu Zhenhui Li Yan Hu Hongwei Li Shihao Wu Wenchao Wang Yingzhou Hu Zhengbo Wang Joshua DRizak Baihui Huang Min Xu Jing Wu Long-Bao Lv Christoph W.Turck Yong Yin Yong-Gang Yao Bing Su Xintian Hu | 2021 | National Science Review2021，8，3： | 3 |
| 13 | Nearest-neighbor classifier motivated marginal discriminant projections for face recognition显示文摘边缘的菲希尔分析(MFA ) 是为脸识别的一个代表性的基于边缘的学习算法。在 MFA 的一个主要问题是怎么选择适当参数, k 1 并且 k 2,构造各自内在并且惩罚图。在这份报纸,我们建议一个新奇方法打电话近邻居(NN ) 分类器激发了边缘的判别式设计(NN-MDP ) 。由 NN 分类器激发了, NN-MDP 寻求一些设计向量阻止数据样品错误地被分类。象 MFA 一样, NN-MDP 能同时描绘样品的紧密和可分性。而且与 MFA 相对照,没有未知参数, NN-MDP 能活跃地构造内在的图和惩罚图。ORL,耶鲁,和 FERET 脸数据库上的试验性的结果显示出那 NN-MDP 不仅避免邻居参数选择的难驾驭,和高开销,而且也是更适用的比另外的方法面对识别 NN 分类器。 | Pu HUANG Zhenmin TANG Caikou CHEN Xintian CHENG | 2011 | Frontiers of Computer Science2011，5，4： | 3 |
| 14 | Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discover显示文摘Technology advances in genomics,proteomics,and metabolomics largely expanded the pool of potential therapeutic targets.Compared with the in vitro setting,cell-based screening assays have been playing a key role in the processes of drug discovery and development.Besides the commonly used strategies based on colorimetric and cell viability,we reason that methods that capture the dynamic cellular events will facilitate optimal hit identification with high sensitivity and specificity.Herein,we propose a live-cell screening strategy using structured illumination microscopy (SIM) combined with an automated cell colocalization analysis software,CellprofilerTM,to screen and discover drugs for mitochondria and lysosomes interaction at a nanoscale resolution in living cells.This strategy quantitatively benchmarks the mitochondria-lysosome interactions such as mitochondria and lysosomes contact (MLC) and mitophagy.The automatic quantitative analysis also resolves fine changes of the mitochondria-lysosome interaction in response to genetic and pharmacological interventions.Super-resolution live-cell imaging on the basis of quantitative analysis opens up new avenues for drug screening and development by targeting dynamic organelle interactions at the nanoscale resolution,which could facilitate optimal hit identification and potentially shorten the cycle of drug discovery. | Qixin Chen Xintian Shao Zhiqi Tian Yang Chen Payel Mondal Fei Liu Fengshan Wang Peixue Ling Weijiang He Kai Zhang Zijian Guo Jiajie Diao | 2019 | Nano Research2019，12，5： | 2 |
| 15 | Yolk-Shell Cu_(2)O@CuO-decorated RGO for High-Performance Lithium-Ion Battery Anode显示文摘Based on the great advantages of an inner hollow structure and excellent solid counterpart capacity,complex hierarchical structures have been widely used as electrodes for lithium-ion batteries.Herein,hierarchical yolk-shell Cu_(2)O@Cu O-decorated RGO(YSRs)was designed and synthesized via a multistep approach.Octahedron-like Cu_(2)O-decorated RGO was firstly produced,in which GO was reduced slightly while cuprous oxide was synthesized.Subsequently,the controlled oxidation of Cu_(2)O@RGO led to the synthesis of special YSRs,which were composed of a solid Cu_(2)O core,spur-CuO,CuO shell,and RGO covered.As anode materials,YSRs could provide considerable capacity density.Meanwhile,the void existed between shells and solid active materials retaining the advantages of inner hollow structure.As a result,the unique architecture of the materials renders the composites with enhanced electronic and ionic diffusion kinetics,high specific capacity(~894 m Ah g^(-1),0.1 C),and an excellent rate capability. | Fangzhao Pu Yilu Bai Jian Lv Xintian Zhao Guanchen Wu Chuncai Kong Bosen Lei Xiaojing Zhang Hong Jin Zhimao Yang | 2022 | Energy & Environmental Materials2022，5，1： | 2 |
| 16 | Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype显示文摘Whether direct manipulation of Parkinson’s disease(PD)risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved issue.Here,we used an adeno-associated virus serotype 9(AAV9)-delivered CRISPR/Cas9 system to directly co-edit PINK1 and DJ-1 genes in the substantia nigras(SNs)of two monkey groups:an old group and a middle-aged group.After the operation,the old group exhibited all the classic PD symptoms,including bradykinesia,tremor,and postural instability,accompanied by key pathological hallmarks of PD,such as severe nigral dopaminergic neuron loss(>64%)and evidentα-synuclein pathology in the gene-edited SN.In contrast,the phenotype of their middle-aged counterparts,which also showed clear PD symptoms and pathological hallmarks,were less severe.In addition to the higher final total PD scores and more severe pathological changes,the old group were also more susceptible to gene editing by showing a faster process of PD progression.These results suggested that both genetic and aging factors played important roles in the development of PD in the monkeys.Taken together,this system can effectively develop a large number of genetically-edited PD monkeys in a short time(6–10 months),and thus provides a practical transgenic monkey model for future PD studies. | Hao Li Shihao Wu Xia Ma Xiao Li Tianlin Cheng Zhifang Chen Jing Wu Longbao Lv Ling Li Liqi Xu Wenchao Wang Yingzhou Hu Haisong Jiang Yong Yin Zilong Qiu Xintian Hu | 2021 | Neuroscience Bulletin2021，37，9： | 2 |
| 17 | Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling显示文摘To prepare a stable complex of doxycycline(Doxy)and hydroxypropy-β-cyclodextrin(HP-β-CD)for ophthalmic delivery,the optimum formulation and preparation conditions were investigated using response surface methodology(RSM),artificial neural network(ANN)and support vector machine(SVM)modeling.The molar ratios of HP-β-CD/Doxy and Mg^(2+)/Doxy,inclusion time and temperature were selected as independent variables (X_(1)-X_(4)) and inclusion efficiency and stability of the Doxy-HP-β-CD complex were selected as dependent(response)variables(Y_(1) and Y_(2)).The optimal formulation predicted by genetic algorithm(GA)combined with the models was characterized by microscopy and nuclear magnetic resonance spectrometry,and the stability of Doxy in the complex was evaluated.The highest values of Y_(1) and Y_(2) were obtained using an ANN model combined with GA which predicted the values of X_(1)-X_(4) to be 4,10.8,12 h and 25℃,respectively.The modeling and optimization results indicated that a feed-forward back-propagation ANN with one hidden layer and 10 hidden units showed better fitting to both responses compared to the RSM and SVM models.GA proved to be an efficient tool in multiobjective optimization of a pharmaceutical formulation. | Zhouhua Wang Zixin He Lei Zhang Haohao Zhang Meimei Zhang Xinguo Wen Guilan Quan Xintian Huang Xin Pan Chuanbin Wu | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 2 |
| 18 | Impact of sesame lignan on physical and oxidative stability of flaxseed oil-in-water emulsion显示文摘Recent studies have shown that the highly susceptibility to oxidation ofα-linolenic acid(ALA)enriched emulsion delivery system was harmful for human health which limited their incorporation into functional food.Impacts of natural sesamol(SOH)and sesamin(SES)on stability of flaxseed oil-in-water emulsion were investigated.Results showed that SOH indicated higher antioxidant activity and significantly prolonged the time of emulsion oil-off by retarding oil droplet aggregation in a dose dependent manner throughout storage.Moreover,SOH showed substantial extended lag phase of lipid oxidation products,especially for secondary oxidation products(thiobarbituric acid-reactive substances,TBARS),with a maximum reduction of 70%with 800 M dosage.The antioxidative efficiency of SOH might relate to its strong ability of scavenging free radical and chelate transition metal.Furthermore,SOH significantly enhanced interfacial barrier property and reduced permeation rate of peroxyl radical across emulsion interface by hydrogen bonds between sugar groups of saponin molecules and SOH.However,no obvious change in barrier property of emulsion was observed in SES.SOH improved physicochemical property of flaxseed oil-in-water emulsion with higher antioxidant activity and stronger interfacial barrier property,so that it could be serve as plant-based antioxidant in oil-in-water emulsion delivery system. | Xintian Wang Kun Yu Chen Cheng Xiao Yu David Julian McClements Wenwen Huang Jia Yang Fenghong Huang Qianchun Deng | 2019 | Oil Crop Science2019，4，4： | 1 |
| 19 | Research on the Relationships of the Domestic Mutual Investment of China Based on the Cross-shareholding Networks of the Listed Companies显示文摘 | Ma Yuanyuan Zhuang Xintian Li Lingxuan | 2011 | Physica A2011，，390： | 1 |
| 20 | A variant of estrogen receptor-alpha, hER-alpha36: transduction of estrogen-and antiestrogen-dependent membrane-initiated mitogenic signaling显示文摘 | Wang Zhaoyi Zhang Xintian Shen Peng | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
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