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| 1 | Liquid biopsy for esophageal cancer: Is detection of circulating cell-free DNA as a biomarker feasible?显示文摘Esophageal cancer(EC)is a common cancer and is histopathologically classified into esophageal squamous cell carcinoma and esophageal adenocarcinoma.EC is a worldwide public health issue because of late diagnosis and lack of effective therapy.In contrast to standard tumor biopsies,liquid biopsies are emerging as a tool which is minimally invasive that can complement or even substitute more classical approaches.Specifically,cell-free DNA(cfDNA)has shown promise in cancer-related clinical applications.Indeed,cfDNA has been shown to be an effective circulating biomarker for non-invasive cancer diagnosis and monitoring of cancer patients.Although the clinical application of cfDNA has been reported on other cancers,few studies have evaluated its use in EC.Here,we review this relevant literature and discuss limitations and advantages of its application in the diagnosis and monitoring of EC. | Zuyang Yuan Xinfeng Wang Xiao Geng Yin Li Juwei Mu Fengwei Tan Qi Xue Shugeng Gao Jie He | 2021 | Cancer Communications2021，41，1： | 4 |
| 2 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 3 | L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma显示文摘Objective:L1 cell adhesion molecule(L1 CAM)exhibits oncogenic activity in tumors.However,the link between L1 CAM and the tumor microenvironment remains poorly understood in patients with esophageal squamous cell carcinoma(ESCC).In this study,we investigated how L1 CAM expression in ESCC affects the oncogenic characteristics of tumor cells and the tumor microenvironment.Methods:Human ESCC samples were collected,and the m RNA and protein levels of L1 CAM were examined by real-time PCR and immunohistochemistry.Overexpression and knockdown gene expression assays were used for mechanistic studies.The cell proliferation and cell cycle were measured with CCK-8 assays and flow cytometry.Cell migration and invasion ability were measured with Transwell assays.Multiplex bead-based assays were performed to identity the factors downstream of L1 CAM.Xenograft studies were performed in nude mice to evaluate the effects of L1 CAM on tumor growth and regulatory T cell(Treg)recruitment.Results:L1 CAM expression was significantly elevated in ESCC tissues(P<0.001)and correlated with poorer prognosis(P<0.05).Ablation of L1 CAM in ESCC cells inhibited tumor growth and migration,and increased tumor cell apoptosis(P<0.05).In the tumor microenvironment,L1 CAM expression correlated with Treg infiltration in ESCC by affecting CCL22 secretion.Mechanistically,L1 CAM facilitated CCL22 expression by activating the PI3 K/Akt/NF-κB signaling pathway.Furthermore,CCL22 promoted Treg recruitment to the tumor site;the Tregs then secreted TGF-β,which in turn promoted L1 CAM expression via Smad2/3 in a positive feedback loop.Conclusions:Our findings provide new insight into the mechanism of immune evasion mediated by L1 CAM,suggesting that targeting L1 CAM-CCL22-TGF-βcrosstalk between tumor cells and Tregs may offer a unique means to improve treatment of patients with ESCC. | Xuan Zhao Shasha Liu Xinfeng Chen Jianyi Zhao Feng Li Qitai Zhao Tan Xie Lan Huang Zhen Zhang Yu Qi Yang Yang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 4 | Dynamic friction energy dissipation and enhanced contrast in high frequency bimodal atomic force microscopy显示文摘Dynamic friction occurs not only between two contact objects sliding against each other,but also between two relative sliding surfaces several nanometres apart.Many emerging micro-and nano-mechanical systems that promise new applications in sensors or information technology may suffer or benefit from noncontact friction.Herein we demonstrate the distance-dependent friction energy dissipation between the tip and the heterogeneous polymers by the bimodal atomic force microscopy(AFM)method driving the second order flexural and the first order torsional vibration simultaneously.The pull-in problem caused by the attractive force is avoided,and the friction dissipation can be imaged near the surface.The friction dissipation coefficient concept is proposed and three different contact states are determined from phase and energy dissipation curves.Image contrast is enhanced in the intermediate setpoint region.The work offers an effective method for directly detecting the friction dissipation and high resolution images,which overcomes the disadvantages of existing methods such as contact mode AFM or other contact friction and wear measuring instruments. | Xinfeng TAN Dan GUO Jianbin LUO | 2022 | Friction2022，10，5： | 1 |
| 5 | Active control of friction realized by vibrational excitation:Numerical simulation based on the Prandtl-Tomlinson model and molecular dynamics显示文摘Superlubricity and active friction control have been extensively researched in order to reduce the consumption of fossil energy,the failure of moving parts,and the waste of materials.The vibration-induced superlubricity(VIS)presents a promising solution for friction reduction since it does not require high-standard environment.However,the mechanism underlying the VIS remains unclear since the atomic-scale information in a buried interface is unavailable to experimental methods.In this paper,the mechanism of VIS was examined via numerical calculation based on the Prandtl-Tomlinson(PT)model and molecular dynamics(MD)simulations.The results revealed that the pushing effect of stick-slip is one of the direct sources of friction reduction ability under vibrational excitation,which was affected by the response amplitude,frequency,and the trace of the tip.Moreover,the proportion of this pushing effect could be modulated by changing the phase difference when applying coupled vibrational excitation in x-and z-axis.This results in a significant change in friction reduction ability with phase.By this way,active friction control from the stick-slip to superlubricity can be achieved conveniently. | Xiao MA Xinfeng TAN Dan GUO Shizhu WEN | 2023 | Friction2023，11，7： | 0 |
| 6 | Transformation of Undesired Li_(2)CO_(3)into Lithiophilic Layer Via Double Replacement Reaction for Garnet Electrolyte Engineering显示文摘Garnet-type solid-state electrolytes(SSEs)are a remarkable Li-ion electrolyte for the realization of next-generation all-solid-state lithium batteries due to their excellent stability against Li metal as well as high ionic conductivities at room temperature.However,garnet electrolytes always contain undesired and hardly removable Li_(2)CO_(3) contaminations that have persistently large resistance and unstable interface contact with Li metal.This is a critical bottleneck for the practical application of garnet electrolytes.Here,we design a novel strategy to completely root out Li_(2)CO_(3) both inside and on the surface of garnet.This is achieved by a so-called double replacement reaction between Li_(2)CO_(3) and SiO_(2) during one-step hot press process for garnet electrolyte densification.It leads to in-situ transformation of LixSiOy(LSO)mostly locating around the grain boundaries of garnet.Due to the higher ion conductivity and better electrochemistry stability of LSO than Li_(2)CO_(3),the modified garnet electrolyte shows much improved electrochemical performance.Moreover,the wettability between modified garnet electrolyte and lithium metals was significantly enhanced in the absence of surface Li_(2)CO_(3).As a proof of concept,an assembled Li symmetric cell with modified garnet electrolyte displays a high critical current density(CCD)of 0.7 mA cm^(-2)and a low interfacial impedance(5Ωcm^(2))at 25℃.These results indicate that the upcycling of Li_(2)CO_(3)is a promising strategy to well-address the degradation and interfacial issue associated with garnet electrolytes. | Jiaxu Zhang Ruohan Yu Jun Li Huiyu Zhai Gangjian Tan Xinfeng Tang | 2022 | Energy & Environmental Materials2022，5，3： | 0 |
| 7 | Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures显示文摘Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have layered structures with excellent tribological properties.Since the energy difference between hexagonal-molybdenum ditelluride(2H-MoTe_(2))and distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2))is very small among the transition metal dichalcogenides(TMDCs),MoTe_(2) becomes one of the most promising candidates for phase engineering.In our experiment,we found that the friction force and friction coefficient(COF)of 2H-MoTe_(2) were an order of magnitude smaller than those of 1T′-MoTe_(2) by the atomic force microscope(AFM)experiments.The friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) was further verified in molecular dynamics(MD)simulations.The density functional theory(DFT)calculations suggest that the friction contrast is related to the difference in sliding energy barrier of the potential energy surface(PES)for a tip sliding across the surface.The PES obtained from the DFT calculation indicates that the maximum energy barrier and the minimum energy path(MEP)energy barrier of 2H-MoTe_(2) are both smaller than those of 1T′-MoTe_(2),which means that less energy needs to be dissipated during the sliding process.The difference in energy barrier of the PES could be ascribed to its larger interlayer spacing and weaker Mo–Te interatomic interactions within the layers of 2H-MoTe_(2) than those of 1T′-MoTe_(2).The obvious friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) not only provides a new non-destructive means to detect the phase transition by the AFM,but also provides a possibility to tune friction by controlling the phase transition,which has the potential to be applied in extreme environments such as space lubrication. | Lina ZHANG Xinfeng TAN Jianguo JIAO Dan GUO Jianbin LUO | 2024 | Friction2024，12，1： | 0 |
| 8 | Interlayer friction behavior of molybdenum ditelluride with different structures显示文摘The interlayer friction behavior of two-dimensional transition metal dichalcogenides(TMDCs)as crucial solid lubricants has attracted extensive attention in the field of tribology.In this study,the interlayer friction is measured by laterally pushing the MoTe_(2)powder on the MoTe_(2)substrate with the atomic force microscope(AFM)tip,and density functional theory(DFT)simulations are used to rationalize the experimental results.The experimental results indicate that the friction coefficient of the 1T'-MoTe_(2)/1T'-MoTe_(2)interface is 2.025×10^(−4),which is lower than that of the 2H-MoTe_(2)/2H-MoTe_(2)interface(3.086×10^(−4)),while the friction coefficient of the 1T'-MoTe_(2)/2H-MoTe_(2)interface is the lowest at 6.875×10^(−5).The lower interfacial friction of 1T'-MoTe_(2)/1T'-MoTe_(2)compared to 2H-MoTe_(2)/2H-MoTe_(2)interface can be explained by considering the relative magnitudes of the ideal average shear strengths and maximum shear strengths based on the interlayer potential energy.Additionally,the smallest interlayer friction observed at the 1T'-MoTe_(2)/2H-MoTe_(2)heterojunction is attributed to the weak interlayer electrostatic interaction and reduction in potential energy corrugation caused by the incommensurate contact.This work suggests that MoTe_(2)has comparable interlayer friction properties to MoS_(2)and is expected to reduce interlayer friction in the future by inducing the 2H-1T'phase transition. | Lina Zhang Xinfeng Tan Jianguo Jiao Dan Guo Jianbin Luo | 2023 | Nano Research2023，16，8： | 0 |
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