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| 1 | Deep structure beneath the southwestern section of the Longmenshan fault zone and seimogenetic context of the 4.20 Lushan M_S7.0 earthquake显示文摘Magnetotelluric measurements were carried out along two profiles across the middle and southwestern sections of the Longmenshan fault zone(LMSf)from 2009 to 2011,after the 2008 Wenchuan MW7.9 earthquake.The former profile crosses the Wenchuan event epicenter and the latter one crosses 2013 Lushan MS7.0 event epicenter.The data were analyzed using advanced processing techniques,including phase tensor and two-dimensional inversion methods,in order to obtain reliable 2-D profiles of the electrical structure in the vicinity of the two earthquakes.A comparison of the two profiles indicates both similarities and differences in the deep crustal structure of the LMSf.West of the southwestern section,a crustal high conductivity layer(HCL)is present at about 10 km depth below the Songpan-Garzêblock;this is about 10 km shallower than that under the middle section of the LMSf.A high resistivity body(HRB)is observed beneath the southwestern section,extending from the near surface to the top of upper mantle.It has a smaller size than the HRB observed below the middle section.In the middle section,there is a local area of decreased resistivity within the HRB but there is absence of this area.The 2013 Lushan earthquake occurred close to the eastern boundary of HRB and the Shuangshi-Dachuan fault,of which the seismogenic context has both common and different features in comparison with the 2008 Wenchuan event.On a large scale,the 2013 Lushan earthquake is associated with the HCL and deformation in the crust including HCL of the eastern Tibetan Plateau.In order to assess seismic risk,it is important to consider both the stress state and the detailed crustal structure in different parts of the LMSf. | ZHAN Yan ZHAO GuoZe UNSWORTH Martyn WANG LiFeng CHEN XiaoBin LI Tao XIAO QiBin WANG JiJun TANG Ji CAI JunTao WANG YanZhao | 2013 | Chinese Science Bulletin2013，58，28： | 39 |
| 2 | Phosphate-Solubilizing and -Mineralizing Abilities of Bacteria Isolated from Soils显示文摘Microorganisms capable of solubilizing and mineralizing phosphorus (P) pools in soils are considered vital in promoting P bioavailability. The study was conducted to screen and isolate inorganic P-solubilizing bacteria (IPSB) and organic P-mineralizing bacteria (OPMB) in soils taken from subtropical flooded and temperate non-flooded soils, and to compare inorganic P-solubilizing and organic P-solubilizing abilities between IPSB and OPMB. Ten OPMB strains were isolated and identified as Bacillus cereus and Bacillus megaterium, and five IPSB strains as B. megaterium, Burkholderia caryophylli, Pseudomonas cichorii, and Pseudomonas syringae. P-solubilizing and -mineralizing abilities of the strains were measured using the methods taking cellular P into account. The IPSB strains exhibited inorganic P-solubilizing abilities ranging between 25.4-41.7 μg P mL-1 and organic P-mineralizing abilities between 8.2-17.8 μg P mL-1. Each of the OPMB strains also exhibited both solubilizing and mineralizing abilities varying from 4.4 to 26.5 μg P mL-1 and from 13.8 to 62.8 μg P mL-1, respectively. For both IPSB and OPMB strains, most of the P mineralized from the organic P source was incorporated into the bacterial cells as cellular P. A significantly negative linear correlation (P < 0.05) was found between culture pH and P solubilized from inorganic P by OPMB strains. The results suggested that P solubilization and mineralization could coexist in the same bacterial strain. | TAO Guang-Can TIAN Shu-Jun CAI Miao-Ying XIE Guang-Hui | 2008 | Pedosphere2008，18，4： | 33 |
| 3 | Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma显示文摘AIM:To study the HER-2/neu protein expression and gene amplification in gastric carcinoma and their relation.METHODS:One hundred and forty-five formalin-fixed and paraffin-embedded tumor tissue samples from Chinese gastric carcinoma patients were studied with immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH)methods.Clinicopathologic data about all patients were collected.RESULTS:The levels of HER-2 3+,HER-2 2+and HER21+were measurable in 6.9%,8.3%and 17.2%of the samples,respectively.No HER-2 was stained in 67.6% of the samples.FISH showed that HER-2 gene was amplified in 18 samples,10 HER-2 3+samples,5 HER-2 2+samples,and 3 HER-2 1+samples with IHC staining.HER-2 status was not correlated with the sex and age of patients,and tumor size,location or differentiation,but with the depth of invasion,TNM stage,lymph node and distant metastasis as well as histopathological classification of gastric cancer(P<0.05).CONCLUSION:All samples with IHC as HER-2 expression should be analyzed with FISH.Detection of HER-2 gene amplification can assess the malignant biological behaviors and prognosis of gastric cancer. | Shi-Yan Yan Ying Hu Jian-Gao Fan Guo-Quan Tao Yong-Ming Lu Xu Cai Bao-Hua Yu Yi-Qun Du | 2011 | World Journal of Gastroenterology2011，17，11： | 34 |
| 4 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 5 | Hepatic resection: an analysis of the impact of operative and perioperative factors on morbidity and mortality rates in 2008 consecutive hepatectomy cases显示文摘背景 Hepatectomy 是一种标准肝的外科的技术。hepatectomy 的安全在外科的技术与改进一致被改进了。分析的这研究起作用并且与 hepatectomy.Methods 联系的 pedoperative 因素经历了在 1986 年 1 月和 2005 年 12 月之间的连续 hepatectomies 的 2008 个病人的一个总数回顾地被调查。诊断基于病理学的调查结果被做。分别地,恶意的结果和良性的肝疾病要求切除术的条件占了 58.5% 和 41.2% 。主要的肝癌症说明了 76.1% 恶意的肿瘤,当 hilar cholangiocarcinomas 占了 6.7% 时。Hemangiomas (41.7%) 和 hepatolithiasis (29.6%) 良性的条件是最普通的。微波同轴的凝结在 236 个我们的肝切除术案例中被使用。全面手术后的复杂并发症率是 14.44% ,哪个 12.54% 切除术为主要的肝癌症被执行, 16.40% 为第二等的肝癌症,并且 16.32% 为 hepatolithiasis。全面医院死亡是 0.55% ,并且那为恶意的肝疾病是 0.51% 。高死亡(2.53%) 为 hilar cholangiocarcinomas (在 79 种情况中的二死亡) 与广泛的肝切除术被联系。微波同轴的凝结前切除术,分级的孩子呸,操作时间,停留的手术后的长度,和外科手术前的浆液白朊铺平是病态的独立预言者。血损失,分级的孩子呸,操作时间和外科手术前的浆液白朊水平是死亡的独立预言者。结论 Hepatectomy 能与低病态和死亡安全地被执行,如果它与最佳的 perioperative 管理和创新外科的技术被执行。 | HUANG Zhi-qiang XU Li-ning YANG Tao ZHANG Wen-zhi HUANG Xiao-qiang CAI Shou-wang ZHANG Ai-qun FENG Yu-quan ZHOU Ning-xin DONG Jia-hong | 2009 | Chinese Medical Journal2009，，19： | 23 |
| 6 | A Simple and Rapid Colloidal Gold-based Immunochromatogarpic Strip Test for Detection of FMDV Serotype A显示文摘A sandwich format immunochromatographic assay for detecting foot-and-mouth disease virus (FMDV) serotypes was developed. In this rapid test,affinity purified polyclonal antibodies from Guinea pigs which were immunized with sucking-mouse adapted FMD virus (A/AV88(L) strain) were conjugated to colloidal gold beads and used as the capture antibody,and affinity purified polyclonal antibodies from rabbits which were immunized with cell-culture adapted FMD virus (A/CHA/09 strain) were used as detector antibody. On the nitrocellulose membrane of the immunochromatographic strip,the capture antibody was laid on a sample pad,the detector antibody was printed at the test line(T) and goat anti-guinea pigs IgG antibodies were immobilized to the control line(C). The lower detection limit of the test for a FMDV 146S antigen is 11.7ng/ml as determined in serial tests after the strip device was assembled and the assay condition optimization. No cross reactions were found with FMDV serotype C,Swine vesicular disease (SVD),Vesicular stomatiti svirus (VSV) and vesicular exanthema of swine virus (VES) viral antigens with this rapid test. Clinically,the diagnostic sensitivity of this test for FMDV serotypes A was 88.7% which is as same as an indirect-sandwich ELISA. The specificity of this strip test was 98.2% and is comparable to the 98.7% obtained with indirect-sandwich ELISA. This rapid strip test is simple,easy and fast for clinical testing on field sites; no special instruments and skills are required,and the result can be obtained within 15 min. To our knowledge,this is the first rapid immunochromatogarpic assay for serotype A of FMDV. | Tao Jiang Zhong Liang Wei-wei Ren Juan Chen Xiao-ying Zhi Guang-yu Qi Xiang-tao Liu Xue-peng Cai | 2011 | Virologica Sinica2011，26，1： | 22 |
| 7 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 8 | Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients显示文摘AIM: To investigate the relationship between H pylori infection, blood ammonia concentration and hepatic encephalopathy (HE), and the effect of H pylori eradication in cirrhotic patients. METHODS: From July 2003 to January 2005, 457 cirrhotic patients in five regions of Zhejiang Province were enrolled. Patients were evaluated for demographics, number connection test, H pylori infection, liver impairment, blood ammonia concentration and HE. Patients with H pylori infection were given 1 wk therapy with omeprazole plus clarithromycin and tinidazole. 14C urea breath test was performed and mental symptoms and blood ammonia level were reassessed after bacterium eradication. RESULTS: Overall H pylori infection rate was 60.6%, and HE occurred in 47.5% of cirrhotic patients. Subclinical HE (SHE) was detected in 55 of 117 cirrhotic patients. Blood ammonia concentration in H pylori negative (n = 180) and positive (n = 277) cirrhotic patients was 53.8 ± 51.4 and 78.4 ± 63.6 μmol/L, respectively (P < 0.01), which was significantly reduced to 53.5 ± 37.7 μmol/L after bacterium eradication (n = 126) (P < 0.01). Blood ammonia was 97.5 ± 81.0 μmol/L in H pylori -positive cirrhotic patients, and this did not significantly change in those with persistent infection after H pylori eradication (n = 11). HE was more frequently observed in patients with H pylori infection than in those without (58.5% vs 30.6%, P < 0.01). HE rate significantly dropped to 34.1% after H pylori eradiation (P < 0.01). H pylori prevalence significantly differed among cirrhotic patients with HE (74.4%), SHE(69.1%), and those without HE (53.2%) (P < 0.05). Blood ammonia level was significantly different among cirrhotic patients with HE (94.5 ± 75.6 μmol/L), SHE (59.9 ± 49.2 μmol/L), and without HE (47.3 ± 33.5 μmol/L) (P < 0.05). Logistic regression analysis showed that blood ammonia concentration, Child-Pugh stage, upper gastrointestinal bleeding, electrolyte disturbance, and urea nitrogen were risk factors for HE. CONCLUSION: H pylori infection is an important factor for inducing high blood ammonia concentration and HE in cirrhotic patients. H pylori eradication may be helpful for treatment and prevention of HE. | Shu-Jie Chen Liang-Jing Wang Qin Zhu Jian-Ting Cai Tao Chen Jian-Min Si | 2008 | World Journal of Gastroenterology2008，14，12： | 19 |
| 9 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 10 | Rhododendron Molle(Ericaceae):phytochemistry,pharmacology,and toxicology显示文摘Rhododendron molle G. Don, belonging to the Ericaceae family, is a traditional Chinese medicinal plant with a wide spectrum of pharmacological effects. This paper aimed to review the phytochemistry, pharmacology and toxicology of R. molle, and to discuss the tendency of future investigations on this plant. A systematic review of literature about R. molle was carried out using resources including classic books about Chinese herbal medicine, and scientific data bases including CNKI, Pubmed, Sci Finder, Scopus, and Web of Science. Over 67 compounds, including diterpenes, triterpenes, flavonoids, and lignans, had been extracted and identified from R. molle. The extracts/monomers isolated from the root, flower and fruits of this plant were used as effective agents for treating pains, inflammatory diseases, hypertension, and pest, etc. In addition, diterpenes, such as rhodojaponin III, were considered as the toxic agents associated with the toxicities of this plant. These findings will be significant for the discovery of new drugs from this plant and full utilization of R. molle. | CAI Yong-Qing HU Jian-Hui QIN Jie SUN Tao LI Xiao-Li | 2018 | Chinese Journal of Natural Medicines2018，16，6： | 16 |
| 11 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 12 | Influence factors of serum fibrosis markers in liver fibrosis显示文摘AIM: To analyze the factors which influence the serum levels of hyaluronic acid (HA), type Ⅲ pro-collagen (PCIII), laminin (LN) and type Ⅳ collagen (C-Ⅳ) in liver fibrosis.METHODS: The serum specimens from 141 chronic hepatitis patients were assayed for fibrosis indexes including HA, PCIIT,LN and C-Ⅳ with radioimmunoassay (RIA) and liver function indexes by an automatic biochemistry analyzer. The patients were then divided into consistent group and inconsistent group. The patients'clinical manifestations were recorded,routine blood pictures were done by a blood counter and analyzer (AC-900). Liver biopsy specimens were examined path-morphologically. The inner diameters of portal vein,splenic vein and thickness of spleen were all measured by ultrasonography.RESULTS: Sixteen patients (14.16 %) had serum fibrosis indexes inconsistent with histological stage of their hepatic fibrosis. Their serum fibrosis indexes did not correlate with the stage of hepatic fibrosis (P>0.05), but were positively correlated with the grade of inflammation (X2=12.07, P<0.05).At the same time, serum albumin (ALB) and the ratio of albumin and globulin (A/G) were significantly increased (t=3.06, P<0.01), (t=3.70, P<0.01). Serum levels of glutamicpyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST), γ-glutamyl transferase (GGT) and globulin (GLB) were all significantly decreased (t=2.45, P<0.05), (t=2.33,P<0.05), (t=2.08, P<0.05), (t=3.03, P<0.01). Weary degree also decreased more obviously (X2=7.52, P<0.05), but other clinical manifestations, routine blood indexes, serum levels of alkaline phosphatase (AKP), total bilirubin (TBTL), total protein (TP), width of main portal vein, width of splenic vein and thickness of spleen had no significant change (P>0.05).CONCLUSION: Serum fibrosis indexes can be influenced by the grade of inflammation, some liver function indexes and clinical manifestations. Comprehensive analysis is necessary for its proper interpretation. | Jun Tao Hui-Qin Peng Wei-Min Cai Feng-Qin Dong Hong-Lei Weng Rong-Hua Liu, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003 Zhejiang Province, China | 2003 | World Journal of Gastroenterology2003，9，11： | 15 |
| 13 | Changes in China’s lakes: climate and human impacts显示文摘Lakes have played a critical role in providing water and ecosystem services for people and other organisms in China for millennia.However,accelerating climate change and economic boom have resulted in unprecedented changes in these valuable lakes.Using Landsat images covering the entity of the country,we explored the changes in China’s lakes and the associated driving forces over the last 30 years(i.e.mid-1980 s to 2015).We discovered that China’s lakes have changed with divergent regional trends:in the sparsely populated Tibetan Plateau,lakes are abundant and the lake area has increased dramatically from 38596 to46831 km^2(i.e.increased by 8235 km^2,or 21.3%),whereas,in the densely populated northern and eastern regions,lakes are relatively scarce and the lake area has decreased from 36659 to 33657 km^2(i.e.decreased by 3002 km^2,or 8.2%).In particular,severe lake decreases occurred in the Mongolia-Xinjiang Plateau and the Eastern Plain(-2151 km^2).Statistical analyses indicated that climate was the most important factor controlling lake changes in the Tibetan Plateau,the Yun-Gui Plateau and the Northeast Plain.However,the strength of climatic control on lake changes was low in the Eastern Plain and the Mongolia-Xinjiang Plateau,where human activities,e.g.impoldering,irrigation and mining,have caused serious impacts on lakes.Further lake changes will exacerbate regional imbalances between lake resources and population distribution,and thus may increase the risk of water-resource crises in China. | Shengli Tao Jingyun Fang Suhui Ma Qiong Cai Xinyu Xiong Di Tian Xia Zhao Leqi Fang Heng Zhang Jiangling Zhu Shuqing Zhao | 2020 | National Science Review2020，7，1： | 14 |
| 14 | Modification of larch wood by intensive microwave irradiation显示文摘落叶松木头被微波照耀在不同绚烂的紧张和对待的持续时间下面对待。和 un-treatedfor 比较的对待微波的木头标本在压力容器走水路被使妊娠然后由 SEM 为渗透,机械性能和微观结构变化测试了在落叶松木头上学习微波处理的修正表演。结果证明没有破裂(粗腐殖质) 的模量和弹性(MOE ) 的模量的显著减少,在微波处理的合适的条件下面,落叶松木头的渗透被改进。光线的实质和某坑膜被破裂,并且微小的裂缝在细胞壁被形成。在细胞壁的微小的裂缝的形成是服务人造气体和液体和这的隧道贡献改进木头的渗透。 | LIU Hong-Hai WANG Qing-Wen YANG Lin JIANG Tao CAI Ying-Chun | 2005 | Journal of Forestry Research2005，16，3： | 14 |
| 15 | Spatial distribution and focal mechanism solutions of the Wenchuan earthquake series:Results and implications显示文摘We relocate the spatial distribution of the devastating 12 May 2008 Wenchuan earthquake and its aftershocks.The relocation database is obtained from 89 stations deployed by the China Earthquake Administration,including 54 525 seismograms from 1 376 local earthquakes over MS3.5 between 12 May 2008 and 3 August 2008.The cross-correlation technique used in this paper has greatly improved the relocation precision by giving much more accurate P-wave differential travel-time measurements than those obtained from routinely picked phase onsets.At the same time,we pick P-wave polarity observations of the Wenchuan earthquake series (hereafter referred to as WES) from 1 023 stations in China and 59 IRIS (Incorporated Research Institutions of Seismology) stations.Then,employing a newly developed program CHNYTX,we obtain 83 well-determined focal mechanism solutions (hereafter referred to as FMSs).Based on spatial distribution and FMSs of the WES,we draw following conclusions:(1) The region near the main shock exhibits a buried low-angle northwest-dipping seismic zone with the main shock at its upper end and two conjugated seismic zones dipping southeast with roughly equal dip-angle;(2) The compressional directions of all kinds of FMSs of the WES are subhorizontal,which reflects the dominant stress in this area is compressional;(3) The principal compressional direction of the regional stress around Wenchuan is roughly perpendicular to the strike of Beichuan-Yingxiu fault,while around Qingchuan it is roughly parallel to the strike of Qingchuan fault.In intermediate part of the Longmenshan area,the principal compressional direction of the stress should be in-between;(4) The possibly existed molten materials in the lower crust of Songpan-Garze terrain have small contribution to the local stress state in Longmenshan area.The listric geometries of the Longmenshan faults most probably resulted from subhorizontal compression along NW-SE direction in history. | Chen Cai Chunquan Yu Kai Tao Xingping Hu Yuan Tian Hao Zhang Xiaofeng Cui Jieyuan Ning | 2011 | Earthquake Science2011，24，1： | 13 |
| 16 | Comparative biomechanical study of reversed less invasive stabilization system and proximal femoral nail antirotation for unstable intertrochanteric fractures显示文摘 | Chen Ying Liu Shouyao Lin Peng Wang Yunting Wang Jinhui Tao Jianfeng Cai Rongrong | 2014 | Chinese Medical Journal2014，，23： | 13 |
| 17 | Roasting Properties of Pellets With Iron Concentrate of Complex Mineral Composition显示文摘Investigation was conducted on roasting properties of pellets with an iron concentrate of complex mineral composition.The results indicated that the pellets of complex mineral composition concentrate required higher preheating temperature and longer preheating time than that of single magnetite concentrate.Therefore,it is difficult for preheated pellets to withstand the mechanical collision in the roasting process in rotary kiln.It was found that after the iron concentrate being subjected to high pressure roll grinding,the specific surface area reached 2029.1 cm2/g.Consequently,the preheating and roasting temperature of pellets were decreased by 70 and 50 ℃ and preheating and roasting time were decreased by 2 and 4 min,respectively.Meanwhile,the compression strength of preheated and roasted pellets were increased by 200 N for a pellet and 220 N for a pellet,respectively.The mechanism lied in that the increase of specific surface area activated thermal reaction and promoted formation of inter-grain bridge. | FAN Jian-jun QIU Guan-zhou JIANG Tao GUO Yu-feng CAI Mei-xia | 2011 | Journal of Iron and Steel Research(International)2011，18，7： | 12 |
| 18 | Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease显示文摘Genistein is effective against amyloid-β toxicity,but the underlying mechanisms are unclear.We hypothesized that genistein may protect neurons by inhibiting the mitochondrial apoptotic pathway,and thereby play a role in the prevention of Alzheimer's disease.A rat model of Alzheimer's disease was established by intraperitoneal injection of D-galactose and intracerebral injection of amyloid-β peptide(25–35).In the genistein treatment groups,a 7-day pretreatment with genistein(10,30,90 mg/kg) was given prior to establishing Alzheimer's disease model,for 49 consecutive days.Terminal deoxyribonucleotidyl transferase-mediated d UTP nick end labeling assay demonstrated a reduction in apoptosis in the hippocampus of rats treated with genistein.Western blot analysis showed that expression levels of capase-3,Bax and cytochrome c were decreased compared with the model group.Furthermore,immunohistochemical staining revealed reductions in cytochrome c and Bax immunoreactivity in these rats.Morris water maze revealed a substantial shortening of escape latency by genistein in Alzheimer's disease rats.These findings suggest that genistein decreases neuronal loss in the hippocampus,and improves learning and memory ability.The neuroprotective effects of genistein are associated with the inhibition of the mitochondrial apoptotic pathway,as shown by its ability to reduce levels of caspase-3,Bax and cytochrome c. | Yan Wang Biao Cai Jing Sha Ting-ting Wang Run-ze Cai Chang-ju Ma Tao Han Jun Du | 2016 | Neural Regeneration Research2016，11，7： | 12 |
| 19 | A matched-pair comparison between bilateral intrafascial and interfascial nerve-sparing techniques in extraperitoneal laparoscopic radical prostatectomy显示文摘这研究的目的是在 extraperitoneal laparoscopic 激进分子前列腺切除术与 interfascial 神经圆材技术相比验证 intrafascial 神经圆材技术的优点。从 2010 年 3 月到 2011 年 8 月,有局部性的前列腺癌症(PCa ) 的 65 个病人经历了双边的 intrafascial 神经圆材 extraperitoneal laparoscopic 激进分子前列腺切除术。这些病人与局部性的 PCa 在 12 比率被匹配到 130 个病人经历了在 2008 年 1 月和 2011 年 8 月之间的双边的 interfascial 神经圆材 extraperitoneal laparoscopic 激进分子前列腺切除术。起作用的数据和 oncological 和两个组的功能的结果被比较。在起作用的数据,病理学的阶段和在这些组之间的积极外科的边缘的全面的率没有差别。有 9 和 13 个病人,分别地在 intrafascial 组和 interfascial 组失去到后续。intrafascial 技术比 interfascial 技术在 3 和 6 个月提供了克制的更早的恢复。相等的结果在 12 个月在两个组以克制被发现。在 6 个月和 12 个月的力量的更好的率在更年轻的病人被发现(年龄 ≤ 65 年) 并且经历了 intrafascial 神经圆材 extraperitoneal laparoscopic 激进分子前列腺切除术的全面病人。生物化学的没有前进的幸存率 1 年手术后地在两个组是类似的。用严格的指示,与 interfascial 神经圆材技术相比, intrafascial 技术提供了类似的起作用的结果和短期的 oncological 结果,克制的更快的恢复和更好的力量。intrafascial 神经圆材技术为是到 cT2a 的临床的阶段 cT1 并且有正常外科手术前的力量的年轻 PCa 病人被推荐为一条比较喜欢的途径。 | Tao Zheng Xu Zhang Xin Ma Hong-Zhao Li jiang-Pin Gao Wei Cai Jun Dong Guang-Fu Chen Bao-Jun Wang Tao-Ping Shi Er-Lin Song Wei-Hao Chen Qing-Bo Huang | 2013 | Asian Journal of Andrology2013，15，4： | 12 |
| 20 | Breviscapine attenuates acute pancreatitis by inhibiting expression of PKCα and NF-κB in pancreas显示文摘AIM:To study the effect of breviscapine (Bre) on activity of protein kinase Cα (PKCα) and nuclear factor (NF)-κB in pancreas,and the mechanism of Bre attenuating acute pancreatitis (AP). METHODS:One hundred and eight rats were randomly divided into acute necrotizing pancreatitis (ANP) group,Bre group (ANP + Bre group) and sham operation (SO) group,36 rats in each group. ANP model was induced by a retrograde injection of 4% sodium deoxycholate into the bilio-pancreatic duct. Fifteen minutes after the ANP model was induced,the rats in Bre group were intraperitoneally injected with Bre (0.4 mg/100 g body weight or 0.1 mL/100 g body weight). Survival time and mortality of rats were calculated. Serum amylase and malondialdehyde levels were measured,volume of ascites was recorded and morphology of pancreas and lung was evaluated at 1,5 and 10 h,after the ANP model was induced,respectively. Expressions of PKCα and subunit p65 of NF-κB in pancreas were detected by immunohistochemistry and Western blotting. RESULTS:The life span of rats was longer and the mortality was lower in Bre group than in ANP group 13.51 ± 5.46 vs 25.36 ± 8.11 (P < 0.05). The amylase and MDA levels as well as the volume of ascites were lower and the pathological changes in pancreas and lung were less in Bre group than ANP group (P < 0.05),indicating that the pancreatitis is less severe in Bre group than ANP group. The activation of PKCα and NF-κB p65 in pancreas was induced rapidly and reached their peak at 1 h or 5 h after ANP,but their activity in Bre group was significantly inhibited. CONCLUSION:Bre exerts its therapeutic effect on AP by inhibiting the activation of PKCα and NF-κB p65 in pancreas. | Hong Zhang Cui-Zhu Cai Xiao-Qin Zhang Tao Li Xiao- Yun Jia Bao-Lan Li Liang Song Xiao-Jun Ma | 2011 | World Journal of Gastroenterology2011，17，14： | 11 |
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