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| 1 | Soil surface roughness change and its effect on runoff and erosion on the Loess Plateau of China显示文摘As an important parameter in the soil erosion model, soil surface roughness(SSR) is used to quantitatively describe the micro-relief on agricultural land. SSR has been extensively studied both experimentally and theoretically; however, no studies have focused on understanding SSR on the Loess Plateau of China. This study investigated changes in SSR for three different tillage practices on the Loess Plateau of China and the effects of SSR on runoff and erosion yield during simulated rainfall. The tillage practices used were zero tillage(ZT), shallow hoeing(SH) and contour ploughing(CP). Two rainfall intensities were applied, and three stages of water erosion processes(splash erosion(I), sheet erosion(II) and rill erosion(III)) were analyzed for each rainfall intensity. The chain method was used to measure changes in SSR both initially and after each stage of rainfall. A splash board was used to measure the splash erosion at stage I. Runoff and sediment data were collected continuously at 2-min intervals during rainfall erosion stages II and III. We found that SSR of the tilled surfaces ranged from 1.0% to 21.9% under the three tillage practices, and the order of the initial SSR for the three treatments was ZT0.49) for the ZT, SH and CP treatments. The runoff initiation time was longer in the SH and CP treatments than in the ZT treatment. There were no significant differences in the total runoff yields among the ZT, SH and CP treatments. Sediment loss was significantly smaller(P<0.05) in the SH and CP treatments than in the ZT treatment. | LongShan ZHAO XinLan LIANG FaQi WU | 2014 | Journal of Arid Land2014，6，4： | 30 |
| 2 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 3 | Metal-organic framework-derived phosphide nanomaterials for electrochemical applications显示文摘Because of features,such as adjustable structures,high porosity,and high crystallinity,metal-organic frameworks(MOFs)deservedly have received considerable attention.Nevertheless,there is still room for improvements in the electrical conductivity and chemical stability of some MOFs,because of which they cannot be utilized as electrode materials.Fortunately,MOF derivatives have received widespread attention in recent years,especially phosphide materials,which are widely used in practical applications because of their outstanding conductivity,excellent specific surface area,and standout charge mobility.In this review,the latest developments of MOF-derived phosphides in electrocatalysis related to energy,including the excellent performance in terms of electrochemical energy storage and ingenious strategies,and diversified synthetic approaches are emphasized and summarized.Additionally,the arduous task and feasible proposals of MOF-derived phosphides are also discussed. | Xinlan Wang Guangxun Zhang Wei Yin Shasha Zheng Qingquan Kong Jingqi Tian Huan Pang | 2022 | Carbon Energy2022，4，2： | 3 |
| 4 | A stringent dual control system overseeing transcription and activity of the Cre recombinase for the liver-specific conditional gene knock-out mouse model显示文摘Liver cancer is one of the most threatening diseases in Chinese population. Just like in other tissues, tumor initiation and development in liver involve multiple steps of genetic and epigenetic alterations with several unknown details. However, unlike in other tissues, a tis-sue specific inducible Cre recombinase system that allows temporal and spatial deletion of a target DNA fragment is still not available for in vivo functional gene annotation in hepatocytes. In our pursuit to establish such a mouse model, we designed a dual inducible Cre transgene system and tested it in cultured cells. By combining a CCAAT/enhancer binding protein β (C/EBP β) promoter derived Tet-off expression system and the estrogen receptor (ER) mediated functional control, we show a desirable profile of both hepatocyte-specificity and regulability of the Cre expression in a series of critical assessments in the cell culture system, which provides confidence in continua-tion of our ongoing pursuit in mouse. | Yu Wu Yinghua He Hongyu Zhang Xinlan Dai Xiaoyu Zhou Jun Gu Guan Wang Jingde Zhu | 2008 | Journal of Genetics and Genomics2008，35，7： | 3 |
| 5 | ACID ELECTROLYTIC TREATMENT PROCESS OF SCRAP BATTERY SLUDGE显示文摘ACIDELECTROLYTICTREATMENTPROCESSOFSCRAPBATTERYSLUDGE①ChenWeiping,ZengYue,YangXia,ChenXinlan,JingYanboInstituteofEnvironmental... | Chen Weiping, Zeng Yue, Yang Xia, Chen Xinlan, Jing Yanbo Institute of Environmental Protection, Hunan University, Changsha 410082 | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 2 |
| 6 | Soil surface roughness effects on infiltration process of a cultivated slopes on the Loess Plateau of China显示文摘 | Zhao Longshan Wang Linhua Liang Xinlan | 2013 | Water Resources Management2013，27，14： | 1 |
| 7 | Synthesis, characterisation and flame retardance behaviour of poly (ethylene terephthalate) copolymer containing triaryl phosphine oxide显示文摘 | Wang Lisheng Wang Xinlan Yan Guilin | 2000 | Polym Degr2000，69，1： | 1 |
| 8 | Effect of bacterial intra-species community interactions on the production and activity of volatile organic compounds显示文摘Microorganisms experience intra-and inter-species interactions in the soil,and how these interactions affect the production of microbial volatile organic compounds(VOCs)is still not well-known.Here we evaluated the production and activity of microbial VOCs as driven by bacterial intra-species community interactions.We set up bacterial communities of increasing biodiversity out of 1–4 strains each of the Gram-positive Bacillus and Gram-negative Pseudomonas genera.We evaluated the ability of each community to provide two VOCmediated services,pathogen suppression and plant-growth promotion and then correlated these services to the production of VOCs by each community.The results showed that an increase in community richness from 1 to 4 strains of both genera increased VOC-mediated pathogen suppression and plant-growth promotion on agar medium and in the soil,which was positively correlated with the production of pathogen suppressing and plant growth-promoting VOCs.Pseudomonas strains maintained while Bacillus strains reduced community productivity with an increase in community richness and produced eight novel VOCs compared with the monocultures.These results revealed that intra-species interactions may vary between Gram-negative and Gram-positive species but improved VOC-mediated functioning with respect to pathogen suppression and plant-growth promotion by affecting the amount and diversity of produced VOCs potentially affecting plant disease outcomes. | Jianing Wang Xinlan Mei Zhong Wei Waseem Raza Qirong Shen | 2021 | Soil Ecology Letters2021，3，1： | 1 |
| 9 | Saikosaponin?d suppresses the expression of cyclooxygenase?2 throughthe phospho?signal transducer and activator of transcription 3/hypoxia?induciblefactor?1α pathway in hepatocellular carcinoma cells显示文摘 | Shuixiang He Guifang Lu Helei Hou Zhenjun Zhao Zhanfang Zhu Xinlan Lu Jinghong Chen Zhilun Wang | 2014 | Molecular Medicine Reports2014，，5： | 1 |
| 10 | Synthesis characterization and flame retardance behaviour of poly (ethylene terephthalate) copolymer containing triaryl phosphine oxide显示文摘 | Wang Lisheng Wang Xinlan Yan Guilin | 2000 | Polymer Degradation and Stability2000，69，1： | 1 |
| 11 | Hypoglycernic effects and con- stituents of the barks of Cyclocarya paliurus and their inhibiting activi- ties to glucosidase and glycogen phosphorylase显示文摘 | LI Shan LI Jian GUAN Xinlan | 2011 | Fitoterapia2011，82，7： | 1 |
| 12 | Isolation of mesophyll protoplasts from tea(Camellia sinensis)and localization analysis of enzymes involved in the biosynthesis of specialized metabolites显示文摘Specialized metabolites in tea(Camellia sinensis)are fundamental quality factors.It is important to characterize gene function in vivo to identify key enzymes and reactions involved in the biosynthesis of such metabolites.Here we report a transient expression method to analyze gene function in isolated tea mesophyll protoplasts.This method is an alternative approach to traditional genetic transformation for studies on gene function in vivo.We screened several tea cultivars and different digestion conditions to optimize protoplast isolation.Digestion of newly emerged leaves of C.sinensis‘Zhongbai 4’with 3%cellulase R-10 and 0.3%macerozyme R-10 for about 12 h yielded approximately 107 mesophyll protoplasts.Genes encoding enzymes involved in secondary metabolite synthesis were transiently expressed in the protoplasts,and their subcellular locations were determined.With further improvements in the transfection efficiency,this transient expression system will contribute greatly to the analyses of in vivo gene function in tea. | Ying Zhou Rufang Deng Xinlan Xu Ziyin Yang | 2021 | Beverage Plant Research2021，1，1： | 1 |
| 13 | Treatment‐related adverse events of antibody‐drug conjugates in clinical trials:A systematic review and meta‐analysis显示文摘Background:The wide use of antibody‐drug conjugates(ADCs)is transforming the cancer‐treatment landscape.Understanding the treatment‐related adverse events(AEs)of ADCs is crucial for their clinical application.We conducted a meta‐analysis to analyze the profile and incidence of AEs related to ADC use in the treatment of solid tumors and hematological malignancies.Methods:We searched the PubMed,Embase,and Cochrane Library databases for articles published from January 2001 to October 2022.The overall profile and incidence of all‐grade and grade≥3 treatment‐related AEs were the primary outcomes of the analysis.Results:A total of 138 trials involving 15,473 patients were included in this study.The overall incidence of any‐grade treatment‐related AEs was 100.0%(95%confidence interval[CI]:99.9%–100.0%;I2=89%)and the incidence of grade≥3 treatment‐related AEs was 6.2%(95%CI:3.0%–12.4%;I2=99%).Conclusions:This study provides a comprehensive overview of AEs related to ADCs used for cancer treatment.ADC use resulted in a high incidence of any‐grade AEs but a low incidence of grade≥3 AEs.The AE profiles and incidence differed according to cancer type,ADC type,and ADC components. | Jinming Li Guoshuang Shen Zhen Liu Yaobang Liu Miaozhou Wang Fuxing Zhao Dengfeng Ren Qiqi Xie Zitao Li Zhilin Liu Yi Zhao Fei Ma Xinlan Liu Zhengbo Xu Jiuda Zhao | 2023 | Cancer Innovation2023，2，5： | 1 |
| 14 | Synthesis of hyperbranched polymers via a facile self-condensing vinyl polymerization system glycidyl methacrylate/Cp2TiClz/Zn 显示文摘 | Liua Xiaohui Youmei Baoa Tang Xinlan | 2010 | Polymer2010，，51： | 1 |
| 15 | Intratumoral injection with 188 Re sulfide suspension for treatment of transplanted human liver carcinomain nudemice显示文摘 | Junfeng Y Ruping Z Xinlan D | 2000 | Nucl Med Biol2000，27，4： | 1 |
| 16 | Biocontrol of Fusarium wilt disease for Cucumis melo melon using bio-organic fertilizer显示文摘 | Qingyun Zhao Caixia Dong Xingming Yang Xinlan Mei Wei Ran Qirong Shen Yangchun Xu | 2010 | Applied Soil Ecology2010，，1： | 1 |
| 17 | Hytx~glycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase 显示文摘 | LI Shan LI Jian GUAN Xinlan | 2011 | Fitoterapia2011，82，7： | 1 |
| 18 | Knockout of ISCA 1 causes early embryonic death in rats显示文摘Background : Iron-sulfur cluster assembly 1( ISCA 1) is an iron-sulfur(Fe/S) carrier protein that accepts Fe/S from a scaffold protein and transfers it to target proteins including the mitochondrial Fe/S containing proteins. ISCA 1 is also the newly identified causal gene for multiple mitochondrial dysfunctions syndrome( MMDS). However, our knowledge about the physiological function of ISCA 1 in vivo is currently limited. In this study, we generated an ISCA 1 knockout rat line and analyzed the embryo development. Methods : ISCA 1 knockout rats were generated by replacing the exon1 of ISCA 1 gene with the mC herry-Cre fusion gene using CRISPR-Cas9 technology. The ISCA 1 expression pattern was analyzed by fluorescence imaging using ISCA 1 promotor driven Cre and mC herry expression. The embryonic morphology was examinated by microscope and mitochondrial proteins were tested by Western blot. Results : An ISCA 1 knockout rat line was obtained, which expressed mC herry-Cre fusion protein. Both of the fluorescence images from mC herry and Cre induced mC herry in a reporter rat strain, showing that ISCA 1 expressed in most of the tissues in rats. The ISCA 1 knockout resulted in abnormal development at 8.5 days, with a significant decrease of NDUFA 9 protein and an increase of aconitase 2( ACO 2) in rat embryos. Conclusion : Deletion of ISCA 1 induced early death in rats. ISCA 1 affected the expression of key proteins in the mitochondrial respiratory chain complex, suggesting that ISCA 1 has an important influence on the respiratory complex and energy metabolism. | Xinlan Yang Dan Lu Xu Zhang Wei Chen Shan Gao Wei Dong Yuanwu Ma Lianfeng Zhang | 2019 | Animal Models and Experimental Medicine2019，2，1： | 1 |
| 19 | Biocontrol of Fusarium wilt disease for Cucumis melo melon using bio-organic fertilizer显示文摘 | Qingyun Zhao Caixia Dong Xingming Yang Xinlan Mei Wei Ran Qirong Shen Yangchun Xu | 2010 | Applied Soil Ecology2010，，1： | 1 |
| 20 | Single Nueleotide polymorphisms in the regulatory region of HLA-DRB expressed genes显示文摘 | XINLAN F DONGMING L BIN L | 2005 | Hum Immunol2005，66，： | 1 |
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