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| 1 | The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions显示文摘Transcervical resection of adhesion(TCRA)is the standard treatment for the intrauterine adhesions,but the recurrence of adhesions is a tough problem for the gynecologist.In addition,the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions(IUAs).Hence,we designed this study to explore the safety and efficacy of fresh amnion grafts for preventing the recurrence after TCRA for patients with moderate to severe IUAs.One hundred patients with moderate to severe IUAs who presented with a history of hypomenorrhea,amenorrhea and infertility were included in the study from January 2015 to December 2017.Patients were divided into amnion group(52 patients)and chitosan group(48 patients).Fresh amnion grafts or intrauterine injections of chitosan were administered after TCRA.Transvaginal ultrasonography(TVUS)and hysteroscopy were performed at the first and third month after the operation.The surgical procedures for all patients were completed successfully without relevant complications.In amnion group,8 patients exhibited relapse in the first month and 2 patients in three months after surgery;in chitosan group,23 women exhibited relapse in the first month and 18 patients in three months after surgery.Statistical analysis revealed that the recurrence rate of adhesion in amnion group was significantly lower than those of chitosan group in the first and three months after surgery(P1=0.000,P2=0.000).After TCRA,fresh amnion graft plays a significant role in preventing further adhesions than injections of chitosan. | Changjiang Li Aiqi Cai Congcong Sun Benyuan Wu Xinpei Chen Yanhua Mao Yingfeng Zhang Yating Gou Jie Yu Yuhan Wang Huanhuan Yu Jia Wang | 2020 | Genes & Diseases2020，7，2： | 11 |
| 2 | Chemical characteristics of haze particles in Xi'an during Chinese Spring Festival: Impact of fireworks burning显示文摘Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year(LNY) period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM_(2.5) samples in Xi'an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content(LWC) of the fine aerosols. PM_(2.5) during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard(75 μg/m^3). K^+(28 wt.% of the total ion mass) was the most abundant ion in the LNY period, followed by SO_4^(2-)(25 wt.%) and Cl-(18 wt.%). In contrast, NO_3^-(34 wt.%) was the most abundant species in the haze periods(hourly PM32-2.5> 75 μg/m), followed by SO_4(29.2 wt.%) and NH_4^+(16.3 wt.%), while SO_4^(2-)(35 wt.%) was the most abundant species in the clean periods(hourly PM_(2.5)< 75 μg/m^3), followed by NO_3^-(23.1 wt.%) and NH_4^+(11 wt.%). Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K_2SO_4 and KCl, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO--3/SO_4^(2-) and NH_4^+/SO_4^(2-) indicated that heterogeneous reaction of HNO_3 with NH_3 was an important formation pathway of particulate nitrate and ammonium during the LNY period. | Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 3 | Water-driven photoluminescence reversibility in CsPbBr_(3)/PDMSPUa composite显示文摘Strong ionic character endows all-inorganic perovskite nanocrystals(NCs)with particular optoelectronic features when interacting with common polar solvents,such as water.However,the interaction mechanism of water affecting perovskite NCs is still lack of in-depth understanding.This study systematically explores the roles of water on CsPbBr_(3) nanocrystals(CNCs)by finely controlling the polymer coating degree of polydimethylsiloxane-based polyurea(PDMS-PUa).Through this coating,the effect of water on CNCs is found to experience from“fluorescence quenching”owing to irreversible crystal decomposition towards“forward fluorescence reversibility”by crystal destruction and recrystallization.With gradually enhanced coating,a phenomenon of“reverse fluorescence reversibility”is further observed in that water begins to passivate the CNCs’defect states.Finally,“fluorescent balance”can be achieved with a thick enough coating,where water can hardly contact with the CNCs.Inspired by the fluorescence reversible mechanism discovered,a new wearable intelligent sensing skin is demonstrated by using the CsPbBr_(3)/PDMS-PUa composite as raw material.Both water contact and humidity change can be perceived through photoluminescence(PL)intensity,corresponding to stimuli-responsive sensory nerves of human skin.It is expected that these findings will shed some new lights on perovskite NCs. | Junhu Cai Chenhui Wang Xinpei Hu Yuanyuan Ye Lijuan Zhong Enguo Chen Yun Ye Sheng Xu Jie Sun Qun Yan Tailiang Guo | 2022 | Nano Research2022，15，7： | 4 |
| 4 | Coupled electrophysiological recording and single cell transcriptome analyses revealed molecular mechanisms underlying neuronal maturation显示文摘哺乳动物的大脑是异构的,包含形成各种各样的神经电路,感觉,运动,思维,和情感通过产生的触处的十亿个神经原和万亿。大脑的细胞的异质使学习神经电路配线的分子的逻辑困难,修剪,直到最近, transcriptome 与分辨率使基因译码规章的单个房间分析的激活,和粘性联网可能的内在的上述的电路性质。这里,我们在在文化在单个人的神经原上执行 electrophysiological 和整个染色体的 transcriptome 分析报导成功。用加权的基因 Coexpression 网络分析(WGCNA ) ,我们鉴别基因簇高度相关, neuronal 成熟由 electrophysiological 特征判定了。在涉及 ubiquitination 和 mitochondrial 功能的 neuronal 成熟和基因之间的一个紧密的连接被揭示。而且,我们识别了候选人基因的一张表,它能潜在地为 neuronal 成熟用作 biomarkers。联合 electrophysiological 记录和单个房间 transcriptome 分析将在未来用作强大的工具为神经电路功能揭开分子的逻辑。 | Xiaoying Chen Kunshan Zhang Liqiang Zhou Xinpei Gao Junbang Wang Yinan Yao Fei He Yuping Luo Yongchun Yu Siguang Li Liming Cheng Yi E. Sun | 2016 | Protein & Cell2016，7，3： | 2 |
| 5 | Optical Brain Imaging: A Powerful Tool for Neuroscience显示文摘As the control center of organisms,the brain remains little understood due to its complexity. Taking advantage of imaging methods,scientists have found an accessible approach to unraveling the mystery of neuroscience. Among these methods,optical imaging techniques are widely used due to their high molecular specificity and single-molecule sensitivity. Here,we overview several optical imaging techniques in neuroscience of recent years,including brain clearing,the micro-optical sectioning tomography system,and deep tissue imaging. | Xinpei Zhu Yanfang Xia Xuecen Wang Ke Si Wei Gong | 2017 | Neuroscience Bulletin2017，33，1： | 2 |
| 6 | Rabies Virus Pseudotyped with CVS-N2C Glycoprotein as a Powerful Tool for Retrograde Neuronal Network Tracing显示文摘Efficient viral vectors for mapping and manipulating long-projection neuronal circuits are crucial in structural and functional studies of the brain. The SAD strain rabies virus with the glycoprotein gene deleted pseudotyped with the N2 C glycoprotein(SAD-RV(DG)-N2 C(G)) shows strong neuro-tropism in cell culture, but its in vivo efficiency for retrograde gene transduction and neuro-tropism have not been systematically characterized.We compared these features in different mouse brain regions for SAD-RV-N2 C(G) and two other widely-used retrograde tracers, SAD-RV(DG)-B19(G) and r AAV2-retro. We found that SAD-RV(DG)-N2 C(G) enhanced the infection efficiency of long-projecting neurons by^10 times but with very similar neuro-tropism, compared with SAD-RV(DG)-B19(G). On the other hand, SAD-RV(DG)-N2 C(G) had an infection efficiency comparable with r AAV2-retro, but a more restricted diffusion range, and broader tropism to different types and regions of longprojecting neuronal populations. These results demonstrate that SAD-RV(DG)-N2 C(G) can serve as an effective retrograde vector for studying neuronal circuits. | Xutao Zhu Kunzhang Lin Qing Liu Xinpei Yue Huijie Mi Xiaoping Huang Xiaobin He Ruiqi Wu Danhao Zheng Dong Wei Liangliang Jia Weilin Wang Anne Manyande Jie Wang Zhijian Zhang Fuqiang Xu | 2020 | Neuroscience Bulletin2020，36，3： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Syn- thesis of Mn203/poly (styrene-co-butyl methacrylate ) resin composites and their oil-absorbing properties 显示文摘 | Zhang Tao Zhang Qian Wang Xinpei | 2015 | RSCAdv2015，5，10： | 1 |
| 9 | Immune phenotypes of prostate cancer cells: Evidence of epithelial immune cell-like transition?显示文摘Prostate cancers(PCa)have been reported to actively suppress antitumor immune responses by creating an immune-suppressive microenvironment.There is mounting evidence that PCas may undergo an‘‘Epithelial Immune Cell-like Transition’’(EIT)by expressing molecules conventionally associated with immune cells(e.g.,a variety of cytokines/receptors,immune transcription factors,Ig motifs,and immune checkpoint molecules),which subsequently results in the suppression of anti-cancer immune activity within the tumor microenvironment.Recent progress within the field of immune therapy has underscored the importance of immune checkpoint molecules in cancer development,thus leading to the development of novel immunotherapeutic approaches.Here,we review the expression of select immune checkpoint molecules in PCa epithelial and associated immune cells,with particular emphasis on clinical data supporting the concept of an EIT-mediated phenotype in PCa.Furthermore,we summarize current advances in anti-immune checkpoint therapies,and provide perspectives on their potential applicability. | Dong Lin Xinya Wang Stephen Yiu Chuen Choi Xinpei Ci Xin Dong Yuzhuo Wang | 2016 | Asian Journal of Urology2016，3，4： | 1 |
| 10 | The coupled method Fuzzy AHP applies to solve multi criteria decision making problems显示文摘 | JIANG Xinpei ZHENG Bao WANG Liying | 2009 | WSEAS Transactions on Mathematics2009，8，11： | 1 |
| 11 | The coupled method fuxzy-AHP applys to solve multi-criteria decision making problems显示文摘 | Jiang Xinpei Zheng Bao Wang Liying | 2009 | WSEAS Transactions on Mathematics2009，11，8： | 1 |
| 12 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 13 | The coupled method fuzzy-ahp applys to solve multi-criteria decision making problems, wseas transactions on mathematics显示文摘 | Jiang Xinpei Zheng Bao Wang Liying | 2009 | 11(8): 657-6662009，11，8： | 1 |
| 14 | Gelatin encapsulation of chloropicrin and 1,3-dichloropropene as fumigants for soilborne diseases in the greenhouse cultivation of cucumber and tomato显示文摘Combined use of chloropicrin(Pic) and 1,3-dicloropropene(1,3-D) is as effective as methyl bromide(MB) at controlling soilborne diseases in many trials and commercial uses. However, Pic and 1,3-D are both highly volatile and may pose strong exposure risks to humans and the environment. A gelatin capsule formulation containing Pic and 1,3-D has been developed to reduce exposure risks to workers and bystanders and improved application safety. We conducted two experiments in tomato and cucumber greenhouses located in Beijing and Qingdao, China, to study the efficacy of Pic plus 1,3-D gelatin capsules applied at different dosages and soil depths. Results indicated that both injection and gelatin capsules of Pic plus 1,3-D provided good control of soil nematodes and reduced disease index of Fusarium wilt and root-knot nematode. Plant yield of tomato and cucumber treated with gelatin capsules was similar to MB treatment. Based on our results, gelatin capsules applied at a soil depth of 15 cm provided better control of soilborne diseases and led to higher fruit yield compared to an application depth of 5 cm. In conclusion, a gelatin capsule of Pic plus 1,3-D is a promising and novel formulation, which not only shows good efficacy in controlling soilborne diseases, but also reduces potential exposure risks of fumigants. | YAN Dong-dong WANG Qiu-xia LI Yuan OUYANG Can-bin GUO Mei-xia Jim Xinpei Huang John Busacca Jong Neng Shieh Alisa Ye Yu Phil Howard Don Williams CAO Ao-cheng | 2017 | Journal of Integrative Agriculture2017，16，8： | 0 |
| 15 | Current researches on design and manufacture of biopolymer-based osteochondral biomimetic scaffolds显示文摘Currently,osteochondral(OC)tissue engineering has become a potential treatment strategy in repairing chondral lesions and early osteoarthritis due to the limited self-healing ability of cartilage.However,it is still challenging to ensure the integrity,physiological function and regeneration ability of stratified OC scaffolds in clinical application.Biomimetic OC scaffolds are attractive to overcome the above problems because of their similar biological and mechanical properties with native OC tissue.As a consequence,the researches on biomimetic design to achieve the tissue function of each layer,and additive manufacture(AM)to accomplish composition switch and ultrastructure of personalized OC scaffolds have made a remarkable progress.In this review,the design methods of biomaterial and structure as well as computer-aided design,and performance prediction of biopolymer-based OC scaffolds are presented;then,the characteristics and limitations of AM technologies and the integrated manufacture schemes in OC tissue engineering are summarized;finally,the novel biomaterials and techniques and the inevitable trends of multifunctional bio-manufacturing system are discussed for further optimizing production of tissue engineering OC scaffolds. | Yanen Wang Ying Guo Qinghua Wei Xinpei Li Kang Ji Kun Zhang | 2021 | Bio-Design and Manufacturing2021，4，3： | 0 |
| 16 | Modifying regeneration strategies classification to enhance the understanding of dominant species growth in fire-prone forest in Southwest China显示文摘Background:In fire-prone ecosystems,plant species having different post-fire regeneration strategies(PFRS)coexist at the local scale while showing different growth dynamics.To evaluate the effect of PFRS on species regeneration,we investigated the plant communities burned in different years in the central Yunnan Province,Southwest China.Several indicators describing plant growth and population importance were measured to compare the regeneration of four dominant tree species,including one facultative seeders(FS)and three obligate resprouters(OR).Partial correlation and mixed linear effect modeling were applied to disentangle the contribution of intrinsic and environmental factors to the interspecific variation in post-fire regeneration.Results:We identified two subtypes of plant growth strategy in the early post-fire stage for OR species;i.e.,number growth(ORþN)priority and height growth(ORþH)priority for sprouting stems.Generally,the FS and OR species varied in height growth rate with different temporal dynamics.The ORþN species occupied post-fire space horizontally with more resprouts and larger coverage than ORþH and FS species at the earlier stage.In contrast,the ORþH species generally had far less resprouts per clump,more variations in stem height and basal diameter.Factor analysis showed that the variation of post-fire plant regeneration was not effectively explained by environmental factors(R2<20%);however,the linear mixed models with the modified PFRS as a random effect substantially increased the explanation.Conclusions:The differentiated regeneration dynamics and growth priorities in the four dominant tree species indicated a critical dichotomy of habitat occupation strategy for the resprouter species during the early stage of post-fire forest restoration.Our study uncovered a trade-off between height versus number growth priority in the post-fire tree growth strategy and provides a novel perspective in understanding the living space occupying(niche partitioning)process and species coexistence in post-fire forest community assembly. | Caifang Luo Yueqiang Liu Zehao Shen Kang Yang Xinpei Wang Youxu Jiang | 2022 | Forest Ecosystems2022，9，1： | 0 |
| 17 | Arsenic removal from acidic industrial wastewater by ultrasonic activated phosphorus pentasulfide显示文摘Arsenic is one of the main harmful elements in industrial wastewater.How to remove arsenic has always been one of the research hotspots in academic circles.In the process of arsenic removal by traditional sulfuration,the use of traditional sulfurizing agent will introduce new metal cations,which will affect the recycling of acid.In this study,phosphorus pentasulfide (P_(2)S_(5)) was used as sulfurizing agent,which hydrolyzed to produce H_(3)PO_(4) and H_(2)S without introducing new metal cations.The effect of ultrasound on arsenic removal by P_(2)S_(5) was studied.Under the action of ultrasound,the utilization of P_(2)S_(5) was improved and the reaction time was shortened.The effects of S/As molar ratio and reaction time on arsenic removal rate were investigated under ultrasonic conditions.Ultrasonic enhanced heat and mass transfer so that the arsenic removal rate of 94.5%could be achieved under the conditions of S/As molar ratio of 2.1:1 and reaction time of 20 min.In the first 60 min,under the same S/As molar ratio and reaction time,the ultrasonic hydrolysis efficiency of P_(2)S_(5) was higher.This is because P_(2)S_(5) forms ([(P_(2)S_(4))])^(2+)under the ultrasonic action,and the structure is damaged,which is easier to be hydrolyzed.In addition,the precipitation after arsenic removal was characterized and analyzed by X-ray diffraction,scanning electron microscope-energy dispersive spectrometer,X-ray fluorescence spectrometer and X-ray photoelectron spectroscopy.Our research avoids the introduction of metal cations in the arsenic removal process,and shortens the reaction time. | Bo Yu Guang Fu Xinpei Li Libo Zhang Jing Li Hongtao Qu Dongbin Wang Qingfeng Dong Mengmeng Zhang | 2023 | Chinese Journal of Chemical Engineering2023，60，8： | 0 |
| 18 | Super-resolution microscopy and its applications in neuroscience显示文摘Optical microscopy promises researchers to soe most tiny substances directly.However,the resolution of conventional microscopy is resticted by the diffraction limit.This makes it a challenge to observe subcellular processes happened in nanoscale.The development of super-resolution microscopy provides a solution to this challenge.Here,we briefly review several commonly used super-resolution techniques,explicating their basic principles and applications in biological science,especially in neuroscience.In addition,characteristics and limitations of each techrique are compared to provide a guidance for biologists to choose the most suitable tool. | Xuecen Wang Jiahao Wang Xinpei Zhu Yao Zheng Ke Si Wei Gong | 2017 | Journal of Innovative Optical Health Sciences2017，，5： | 0 |
| 19 | Fast tracking alien gene discovery by molecular markers in a late flowering Chinese cabbage-cabbage translocation line‘AT7–4'显示文摘Flowering time is an important agronomic trait of Chinese cabbage with late flowering being a primary breeding objective.In our previous work,we obtained Chinese cabbage-cabbage translocation lines that contained several beneficial cabbage genes.Cabbage-specific molecular markers show that these genes were coming from chromosome C01 of cabbage.In this study,we investigated the inheritance of flowering time in a couple of translocation lines and analyzed the transmission rate of molecular markers in the offspring.Consequently,we obtained the late flowering Chinese cabbage-cabbage translocation line‘AT7–4’in which the flowering time was later than that of‘85–1’by about 7 days under 4-week vernalization.Based on previous studies of the genomes of Chinese cabbage and cabbage,we located the cabbage-specific molecular markers that were closely linked at the top of the chromosome A01 in the F2mapping population generated by self-crossing F1s derived from a cross between the translocation line‘AT7–4’and Chinese cabbage‘14–36’.Five flowering-related genes in the alien fragment were found by functional annotation and their molecular markers were developed.This study lays the foundation for the future improvement of Chinese cabbage varieties using A-C translocation lines. | Hui Li Aixia Gu Daling Feng Na Li Rui Yang Xinpei Zhang Shuangxia Luo Umer Karamat Qianyun Wang Shuxin Xuan Xueping Chen Yin Lu Yanhua Wang Shuxing Shen Jianjun Zhao | 2023 | Horticultural Plant Journal2023，9，1： | 0 |
| 20 | Novel spontaneous myelodysplastic syndrome mouse model显示文摘Background:Myelodysplastic syndrome(MDS)is a group of disorders involving he-mopoietic dysfunction leading to leukemia.Although recently progress has been made in identifying underlying genetic mutations,many questions still remain.Animal models of MDS have been produced by introduction of specific mutations.However,there is no spontaneous mouse model of MDS,and an animal model to simulate natu-ral MDS pathogenesis is urgently needed.Methods:In characterizing the genetically diverse mouse strains of the Collaborative Cross(CC)we observed that one,designated JUN,had abnormal hematological traits.This strain was thus further analyzed for phenotypic and pathological iden-tification,comparing the changes in each cell population in peripheral blood and in bone marrow.Results:In a specific-pathogen free environment,mice of the JUN strain are rela-tively thin,with healthy appearance.However,in a conventional environment,they become lethargic,develop wrinkled yellow hair,have loose and light stools,and are prone to infections.We found that the mice were cytopenic,which was due to abnor-mal differentiation of multipotent bone marrow progenitor cells.These are common characteristics of MDS.Conclusions:A mouse strain,JUN,was found displaying spontaneous myelodysplas-tic syndrome.This strain has the advantage over existing models in that it develops MDS spontaneously and is more similar to human MDS than genetically modified mouse models.JUN mice will be an important tool for pathogenesis research of MDS and for evaluation of new drugs and treatments. | Weisha Li Lin Cao Mengyuan Li Xingjiu Yang Wenlong Zhang Zhiqi Song Xinpei Wang Lingyan Zhang Grant Morahan Chuan Qin Ran Gao | 2021 | Animal Models and Experimental Medicine2021，4，2： | 0 |
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