|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hairy Leaf 6, an AP2/ERF Transcription Factor, Interacts with OsWOX3B and Regulates Trichome Formation in Rice显示文摘毛状体形成广泛地在植物为表皮的房间区别和房间形态发生作为一个机械学的模型被学习了。然而,位于毛状体形成下面的基因、分子的机制(即,开始和延伸) 在米饭仍然保持大部分不清楚。这里,我们报导一个 AP2/ERF 抄写因素,毛乎乎的叶 6 (HL6 ) ,它在米饭控制毛状体形成。功能的分析表明 HL6 transcriptionally 在米饭调整毛状体延伸,它依赖于功能的 OsWOX3B,在毛状体充当一个关键管理者的包含 homeodomain 蛋白质开始。生物化学、分子的基因分析证明那 HL6 身体上交往与 OsWOX3B,和他们俩在毛状体形成, OsWOX3B 多半与它的直接目标基因之一在提高 HL6 的有约束力的能力期间调整一些植物生长素相关的基因的表达式, OsYUCCA5。人口基因分析显示 HL6 在米饭驯服期间在否定选择下面。一起拿,我们的调查结果提供新卓见进毛状体形成的分子的规章的网络在 ? 米饭。 | Wenqiang Sun Dawei Gao Yin Xiong Xinxin Tang Xiongfeng Xiao Chongrong Wang Sibin Yu | 2017 | Molecular Plant2017，10，11： | 20 |
| 2 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 3 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 4 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 5 | The East Asian Monsoon since the Last Glacial Maximum:Evidence from geological records in northern China显示文摘The impact of global warming on the climate of northern China has been investigated intensively, and the behavior of the East Asian monsoon during previous intervals of climatic warming may provide insight into future changes. In this study, we use paleovegetation records from loess and lake sediments in the marginal zone of the East Asian summer monsoon(EASM) to reconstruct the EASM during the interval of warming from the Last Glacial Maximum(LGM) to the Holocene. The results show that during the LGM, desert steppe or dry steppe dominated much of northern China;in addition, the southeastern margin of the deserts east of the Helan Mountains had a distribution similar to that of the present-day, or was located slightly further south, due to the cold and dry climate caused by a strengthened East Asian winter monsoon(EAWM) and weakened EASM. During the last deglaciation, with the strengthening of the EASM and concomitant weakening of the EAWM, northern China gradually became humid. However, this trend was interrupted by abrupt cooling during the Heinrich 1(H1) and Younger Dryas(YD) events. The EASM intensified substantially during the Holocene, and the monsoon rain belt migrated at least 300 km northwestwards, which led to the substantial shrinking of the desert area in the central and eastern part of northern China, and to the large expansion of plants favored by warm and humid conditions. Paleoclimatic records from the marginal zone of the EASM all show that the EASM reached its peak in the mid-Holocene, and past global climatic warming significantly strengthened the EASM, thereby greatly improving the ecological environment in northern China. Thus, northern China is expected to become wetter as global warming continues. Finally, high resolution Holocene vegetation records are sparse compared with the numerous records on the orbital timescale, and there is a need for more studies of Holocene climatic variability on the centennial-to-decadal scale. | Shiling YANG Xinxin DONG Jule XIAO | 2019 | Science China Earth Sciences2019，62，8： | 2 |
| 6 | Effects ofCaryota mitis profilin*loaded PLGA nanoparticles in a mu-rine model of allergic asthma 显示文摘 | Xiao Xiaojun Zhang Xinxin Ma Li | 2013 | Int J Nanomedicine2013，8，45： | 1 |
| 7 | Paclitaxel-induced stress granules increase LINE-1 mRNA stability to promote drug resistance in breast cancer cells显示文摘Abnormal expression of long interspersed element-1(LINE-1)has been implicated in drug resistance,while our previous study showed that chemotherapy drug paclitaxel(PTX)increased LINE-1 level with unknown mechanism.Bioinformatics analysis suggested the regulation of LINE-1 mRNA by drug-induced stress granules(SGs).This study aimed to explore whether and how SGs are involved in drug-induced LINE-1 increase and thereby promotes drug resistance of triple negative breast cancer(TNBC)cells.We demonstrated that SGs increased LINE-1 expression by recruiting and stabilizing LINE-1 mRNA under drug stress,thereby adapting TNBC cells to chemotherapy drugs.Moreover,LINE-1 inhibitor efavirenz(EFV)could inhibit drug-induced SG to destabilize LINE-1.Our study provides the first evidence of the regulation of LINE-1 by SGs that could be an important survival mechanism for cancer cells exposed to chemotherapy drugs.The findings provide a useful clue for developing new chemotherapeutic strategies against TNBCs. | Xiao Shi Xinxin Si Ershao Zhang Ruochen Zang Nan Yang He Cheng Zhihong Zhang Beijing Pan Yujie Sun | 2021 | The Journal of Biomedical Research2021，35，6： | 1 |
| 8 | Information metasurfaces and intelligent metasurfaces显示文摘Metamaterials and metasurfaces have inspired worldwide interest in the recent two decades due to their extraordinary performance in controlling material parameters and electromagnetic properties.However,most studies on metamaterials and metasurfaces are focused on manipulations of electromagnetic fields and waves,because of their analog natures.The concepts of digital coding and programmable metasurfaces proposed in 2014 have opened a new perspective to characterize and design metasurfaces in a digital way,and made it possible to control electromagnetic fields/waves and process digital information simultaneously,yielding the birth of a new direction of information metasurfaces.On the other hand,artificial intelligence(AI)has become more important in automatic designs of metasurfaces.In this review paper,we first show the intrinsic natures and advantages of information metasurfaces,including information operations,programmable and real-time control capabilities,and space–time-coding strategies.Then we introduce the recent advances in designing metasurfaces using AI technologies,and particularly discuss the close combinations of information metasurfaces and AI to generate intelligent metasurfaces.We present self-adaptively smart metasurfaces,AI-based intelligent imagers,microwave cameras,and programmable AI machines based on optical neural networks.Finally,we indicate the challenges,applications,and future directions of information and intelligent metasurfaces. | Qian Ma Che Liu Qiang Xiao Ze Gu Xinxin Gao Lianlin Li Tie Jun Cui | 2022 | Photonics Insights2022，1，1： | 1 |
| 9 | Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a mu- fine model of allergic asthma 显示文摘 | Xiao Xiaojun Zhang Xinxin Ma Li | 2013 | Int J Nanomedicine2013，8，： | 1 |
| 10 | Circulating exosome-like vesicles of humans with nondiabetic obesity impaired isletβ-cell proliferation,which was associated with decreased Omentin-1 protein cargo显示文摘The regulation ofβ-cell mass in the status of nondiabetic obesity remains not well understood.We aimed to investigate the role of circulating exosome-like vesicles(ELVs)isolated from humans with simple obesity in the regulation of isletβ-cell mass.Between June 2017 and July 2019,81 subjects with simple obesity and 102 healthy volunteers with normal weight were recruited.ELVs were isolated by ultra-centrifugation.The proliferations ofβ-cells and islets were measured by 5-ethynl-2′-deoxyuridine(EdU).Protein components in ELVs were identified by Quantitative Proteomic Analysis and verified by Western blot and ELISA.The role of specific exosomal protein was analyzed by gain-of-function approach in ELVs released by 3T3-L1 preadipocytes.Circulating ELVs from subjects with simple obesity inhibitedβ-cell proliferation in vitro without affecting its apoptosis,secretion,and inflammation.The protein levels of Rictor and Omentin-1 were downregulated in circulating ELVs from subjects with simple obesity and associated with the obesity-linked pathologic conditions.The ELV-carried Omentin-1 and Omentin-1 protein per se were validated to increaseβ-cell proliferation and activate Akt signaling pathway.Moreover,Omentin-1 in ELVs was downregulated by insulin.The circulating ELVs may act as a negative regulator forβ-cell mass in nondiabetic obesity through inhibitingβ-cell proliferation.This effect was associated with downregulated Omentin-1 protein in ELVs.This newly identified ELV-carried protein could be a mediator linking insulin resistance to impairedβ-cell proliferation and a new potential target for increasingβ-cell mass in obesity and T2DM. | Qian Ge Xinxin Xie Xiangjun Chen Rongfeng Huang Cheng-Xue Rui Qianna Zhen Renzhi Hu Min Wu Xiaoqiu Xiao Xi Li | 2022 | Genes & Diseases2022，9，4： | 1 |
| 11 | Short-term roxithromycin treatment attenuates airway inflammation via MAPK/NF-κB activation in a mouse model of allergic asthma显示文摘 | Xinxin Ci Xiao Chu Xue Xu Hongyu Li Xuming Deng | 2012 | Inflammation Research2012，，7： | 1 |
| 12 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 13 | Dry-etched ultrahigh-Q silica microdisk resonators on a silicon chip显示文摘We demonstrate the fabrication of ultrahigh quality(Q) factor silica microdisk resonators on a silicon chip by inductively coupled plasma(ICP) etching. We achieve a dry-etched optical microresonator with an intrinsic Q factor as high as 1.94×10^(8) from a 1-mm-diameter silica microdisk with a thickness of 4 μm. Our work provides a chip-based microresonator platform operating in the ultrahigh-Q region that will be useful in nonlinear photonics such as Brillouin lasers and Kerr microcombs. | JIAXIN GU JIE LIU ZIQI BAI HAN WANG XINYU CHENG GUANYU LI MENGHUA ZHANG XINXIN LI QI SHI MIN XIAO XIAOSHUN JIANG | 2021 | Photonics Research2021，9，5： | 1 |
| 14 | Hesperidin Suppresses Ovalbumin-Induced Airway Inflammation in a Mouse Allergic Asthma Model显示文摘 | Dajun Wei Xinxin Ci Xiao Chu Miaomiao Wei Shucheng Hua Xuming Deng | 2012 | Inflammation2012，，1： | 1 |
| 15 | Oxytetracycline attenuates all-ergic airway inflammation in mice via inhibition of the NF-κB pathway显示文摘 | Xinxin Ci Chu Xiao Chen Chi | 2011 | J Clin Immunol2011，31，2： | 1 |
| 16 | Directly wireless communication of human minds via non-invasive brain-computer-metasurface platform显示文摘Brain-computer interfaces(BCIs),invasive or non-invasive,have projected unparalleled vision and promise for assisting patients in need to better their interaction with the surroundings.Inspired by the BCI-based rehabilitation technologies for nerve-system impairments and amputation,we propose an electromagnetic brain-computer-metasurface(EBCM)paradigm,regulated by human’s cognition by brain signals directly and non-invasively.We experimentally show that our EBCM platform can translate human’s mind from evoked potentials of P300-based electroencephalography to digital coding information in the electromagnetic domain non-invasively,which can be further processed and transported by an information metasurface in automated and wireless fashions.Directly wireless communications of the human minds are performed between two EBCM operators with accurate text transmissions.Moreover,several other proof-of-concept mind-control schemes are presented using the same EBCM platform,exhibiting flexibly-customized capabilities of information processing and synthesis like visual-beam scanning,wave modulations,and pattern encoding. | Qian Ma Wei Gao Qiang Xiao Lingsong Ding Tianyi Gao Yajun Zhou Xinxin Gao Tao Yan Che Liu Ze Gu Xianghong Kong Qammer HAbbasi Lianlin Li Cheng‑Wei Qiu Yuanqing Li Tie Jun Cui | 2022 | eLight2022，2，1： | 1 |
| 17 | A Neural Regression Model for Predicting Thermal Conductivity of CNT Nanofluids with Multiple Base Fluids显示文摘High thermal conductivity of carbon nanotube nanofluids(k_(nf))has received great attention.However,the current researches are limited by experimental conditions and lack a comprehensive understanding of k_(nf) variation law.In view of proposition of data-driven methods in recent years,using experimental data to drive prediction is an effective way to obtain k_(nf),which could clarify variation law of k_(nf) and thus greatly save experimental and time costs.This work proposed a neural regression model for predicting k_(nf).It took into account four influencing factors,including carbon nanotube diameter,volume fraction,temperature and base fluid thermal conductivity(k_(f)).Where,four conventional fluids with k_(f),including R113,water,ethylene glycol and ethylene glycol-water mixed liquid were considered as base fluid considers.By training this model,it can predict k_(nf) with different factors.Also,change law of four influencing factors considered on the k_(nf) enhancement has discussed and the correlation between different influencing factors and k_(nf) enhancement is presented.Finally,compared with nine common machine learning methods,the proposed neural regression model shown the highest accuracy among these. | ZOU Hanying CHEN Cheng ZHA Muxi ZHOU Kangneng XIAO Ruoxiu FENG Yanhui QIU Lin ZHANG Xinxin WANG Zhiliang | 2021 | Journal of Thermal Science2021，30，6： | 1 |
| 18 | Florfenicol inhibits al- lergic airway inflammation in mice by p38 MAPK- mediated phosphorylation of GATA 3 显示文摘 | Xinxin C Chi C Xiao C | 2011 | Clin Im- munol2011，138，： | 1 |
| 19 | iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker of colorectal cancer显示文摘Colorectal 癌症(CRC ) 是世界范围的癌症相关的死亡的一个领先的原因。我们试图为 CRC 的早诊断作为潜在的 biomarkers 发现新奇分子。没有浆液的调节媒介成功地从三 CRC 纸巾和邻近的正常织物被收集。基于 iTRAQ 的量的 proteomic 分析被使用在在主要 CRC mucosa 和邻近的正常 mucosa 之间的 secretome 比较差别。145 种蛋白质的一个总数被识别。这些蛋白质, 29 在 CRC 和正常织物之间是显著地不同的。Tropomyosin 2 (TPM2 ) 展出了最重要的差别;因此,这蛋白质为进一步的确认被选择。量的即时 PCR 显示 TPM2 的 mRNA 表示显著地与配对的邻近的正常织物相比在 CRC 织物减少了。Immunohistochemical 分析也证实 TPM2 恰好在 CRC 织物在蛋白质层次被检测。在摘要,这研究为未来 biomarker 应用揭示了潜在的分子并且为联系癌症的 secretome 的微分分析提供了一条有效途径。TPM2 可能为 CRC 的早诊断是珍贵的。 | Yiming Ma Ting Xiao Quan Xu Xinxin Shao Hongying Wang | 2016 | Frontiers of Medicine2016，10，3： | 1 |
| 20 | A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection显示文摘Dear Editor,Identifying the host factors that are utilized for virus infection and mapping their cell-type expression profile can help to understand the viral tissue/organ tropism and pathogenesis.Much effort has been devoted to the identification of SARS-CoV-2 infection-dependent host factors.CRISPR-based activation(Konermann et al.,2015). | Fei Feng Yunkai Zhu Yanlong Ma Yuyan Wang Yin Yu Xinran Sun Yuanlin Song Zhugui Shao Xinxin Huang Ying Liao Jingyun Ma Yuping He Mingyuan Wang Longhai Tang Yaowei Huang Jincun Zhao Qiang Ding Youhua Xie Qiliang Cai Hui Xiao Chun Li Zhenghong Yuan Rong Zhang | 2023 | Protein & Cell2023，14，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员