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| 1 | Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis显示文摘Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to DR.In this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were identified.Systematic searches of PUBMED,Springer Link and the Cochrane Clinical Trials Database were conducted using the keywords 'diabetic retinopathy' and 'calcium dobesilate'.The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent angiography.The summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels. | ZHANG XinYuan LIU Wei WU ShanShan JIN JingLong LI WeiHong Wang NingLi | 2015 | Science China(Life Sciences)2015，58，1： | 54 |
| 2 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 3 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 4 | Environmental changes during early-middle Holocene from the sediment record of the Chaohu Lake,Anhui Province显示文摘A typical lake sediment core is obtained from the Chaohu Lake in the lower reaches of the Yangtze River,Anhui Province,China.The timing scale is constrained by AMS 14 C dating method.Climate proxies such as pollen and grain size in the core are analyzed to reconstruct the environment changes at this site approximately between 9870 and 2170 cal.a BP.The results indicate that at the research area, the climate in the early-middle Holocene had evolved through 3 stages.From 9870 to 6040 cal.a BP, proxy records show a warm and dry climate with low water levels after the late-glacial period.During this stage,cool and dry events occurred at about 8910 and 6060-6030 cal.a BP.Then,between 6040 and 4860 cal.a BP,the climate was humid and vegetation was more flourishing in the Chaohu Lake Valley.The Holocene Optimum occurred at 5840-5500 cal.a BP in the Chaohu Lake,showing the best condition of water and heat.Elm Decline occurred at the period of 5380-4930 cal.a BP.Since 4860 cal.a BP,the climate was warm and dry through 2170 cal.a BP as shown in both pollen spectrum and grain-size histories.Two obvious dry events occurred in 3760 and 2170 cal.a BP,respectively.At 2170 cal.a BP,the water level of the Chaohu Lake reached the lowest as the lakebed possibly exposed. Such lake sediment observations are consistent with the historical records in this area. | XinYuan Wang GuangSheng Zhang Li Wu XiHui Zhang EnLou Zhang XiaYun Xiao QingFeng Jiang | 2008 | Chinese Science Bulletin2008，53，S1： | 15 |
| 5 | A coherence-based phase aberration correction method in medical ultrasound显示文摘A coherence-based correction method was proposed in order to improve the lateral resolution and enhance the contrast of medical ultrasound imaging in the presence of phase aberration.The averaged coherence factor was proposed at first and used as a metric to evaluate phase aberration correction.By maximizing the averaged coherence factor,the time delay parameter of each channel was adjusted.A new set of coherence factors was calculated and the corrected data was optimized to form the final B-mode image.The simulations on point targets and a cyst phantom showed that the proposed method outperformed the nearest neighboring cross correlation method and conventional coherence-weighting method,and the lateral resolution and contrast ratio was improved by approximately 0.24mm and 18dB respectively.The proposed method combined the advantages of phase error correction and coherence-weighting,which could improve imaging qualities effectively in medical ultrasound. | XIA Xinyuan LI Ping WU Wentao MENG Xiaohui | 2015 | Chinese Journal of Acoustics2015，34，3： | 7 |
| 6 | Color spaces of safflower (Carthamus tinctorius L.) for quality assessment显示文摘Objective:In this study,safflower(Carthamus tinctorius L.)was taken as a representative example to examine the application of color characteristics to evaluate quality.Methods:A computer vision system was established for the objective and nondestructive assessment of color using image processing algorithms.Color parameters were investigated based on the RGB,L*a*b and HSV color spaces.The content of hydroxysafflor yellow A(HSYA),a major bioactive constituent of safflower,was determined by high-performance liquid chromatography.The relationship between HSYA content and color values was investigated by Pearson correlation analysis.A multiple linear regression model was established to predict the HSYA content from color values.Results:The red color and lightness of safflower were found to be significantly related to HSYA content.The prediction equation obtained by multiple regression was reliable with an R2 value of 0.805(P<.01).Conclusion:The results suggest that the computer vision technique could be used as a promising and non-destructive technology for color measurement and quality evaluation of CHM. | Manfei Xu Chenzhao Du Na Zhang Xinyuan Shi Zhisheng Wu Yanjiang Qiao | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 5 |
| 7 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 8 | Extraction of palaeochannel information from remote sensing imagery in the east of Chaohu Lake, China显示文摘Palaeochannels 是 unconsolidated 沉积或在古老的、当前不活跃的河和流隧道系统里扔的巩固半的沉积岩石的存款。它从当前活跃的河隧道的 overbank 存款是不同的,包括定期不流动的短暂的水功课。我们介绍了一光谱从有特殊时间阶段的 SPOT-5 形象的基于特征的 palaeochannel 信息抽取模型,它被遥感机制的分析的优点造了并且光谱 palaeochannel 的特征,从空间分发与它的区别结合了并且光谱当前活跃的河隧道的特征,另外,随遥感判定的建立,在遥感的 palaeochannel 的特征想象。这个模型跟随监督分类的进程[箭头权利] 掩盖的农田和主要部件分析[箭头权利] 地下的 palaeochannel 信息抽取[箭头权利] 信息联合[箭头权利] palaeochannel 系统图象。在乔胡·莱克的东方的 Zhegao 河山谷作为一个学习区域被选择,并且 SPOT-5 形象被用作数据的来源。当这个方法成功地被使用了提取 palaeochannel 信息时,结果是令人满意的,它能为地区性的遥感考古学和 neotectonic 研究提供好参考。然而,这个方法的适用性需要作为空间特征在另外的区域进一步被测试并且光谱 palaeochannel 的反应可能是不同的[出版摘要] | Xinyuan WANG Zhenya GUO Li WU Cheng ZHU Hui HE | 2012 | Frontiers of Earth Science2012，6，1： | 4 |
| 9 | Increasing prevalence of antibiotic resistance genes in manured agricultural soils in northern China显示文摘Land application of manure tends to result in the dissemination of antibiotic resistance in the environment.In this study,the influence of long-term manure application on the enrichment of antibiotic resistance genes(ARGs)and mobile genetic elements(MGEs)in agricultural soils was investigated.All the analyzed eight ARGs(tetA,tetW,tetX,sull,sulll,ermF,aac(6')-Ib-cr and blaTEM)and two MGEs(intJJ and Tn916/1545)were detected in both the manured and control soils,with relative abundances ranging from 10^-6 to 10^-2 Compared with the control soil,the relative abundances of ARGs and MGEs in manured soils were enriched 1.0-18.1 fold and 0.6-69.1 fold,respectively.High-throughput sequencing analysis suggested that at the phylum level,the bacteria carrying intll and ermF might be mainly affiliated with Proteobacteria and Bacteroides,respectively.The dominant genera carrying intll and ermF cow\d be Pseudomonas and Bacteroides,independent of manure application.Correlation analysis revealed that ARGs had strong links with soil physicochemical properties(TC,TN,and OM),heavy metals(Cu,Zn and Pb)and MGEs,indicating that the profile and spread of ARGs might be driven by the combined impacts of multiple factors.In contrast,soil pH and C/N exhibited no significant relationships with ARGs.Our findings provide evidence that long-term manure application could enhance the prevalence and stimulate the propagation of antibiotic resistance in agricultural soils. | Nan Wu Weiyu Zhang Shiyu Xie Ming Zeng Haixue Liu Jinghui Yang Xinyuan Liu Fan Yang | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 3 |
| 10 | Rapid analysis of dyed safflowers by color objectification and pattern recognition methods显示文摘Objective:Rapid discrimination of three classes of safflowers,dyed safflower,adulterated safflower,and pure safflower using computer vision and image processing algorithms.Methods:A low cost computer vision system(CVS)was designed to measure the color of safflowers in the RGB(red,green,blue),L^*a^*b^*,and HSV(hue,saturation,vale)color spaces.The color moments in these three color spaces were extracted from the acquired images as color features of safflower.In addition,five kinds of pigments that are commonly used to dye safflowers were identified by high-performance liquid chromatography as a reference.Pattern recognition methods were investigated for rapid discrimination,including an unsupervised principal component analysis(PCA)algorithm and a supervised partial least squares discriminant analysis(PLS-DA)algorithm.Results:The mean error(e)between color values measured with the colorimeter and calculated with the CVS was 2.4%,with a high correlation coefficient(r)of 0.9905.This result indicated that the established CVS was reliable for color estimation of safflowers.The PLS-DA model,which had a total accuracy of 91.89%,outperformed the PCA model in classifying pure,adulterated,and dyed safflowers.Conclusion:The color objectification is a promising tool for rapid identification of dyed and adulterated safflowers. | Manfei Xu Shengyun Dai Zhisheng Wu Xinyuan Shi Yanjiang Qiao | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 11 | Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction显示文摘 | Chongming Wu Yan Li Yan Chen Xinyuan Lao Linghui Sheng Rongji Dai Weiwei Meng Yulin Deng | 2010 | Phytomedicine2010，，4： | 1 |
| 12 | Effect of Transgenic Corn Cultivation and Sampling Location on Feeding Habits of Collembola显示文摘 | Baifeng Wang Liang Chang Donghui Wu Xinyuan Song | 2014 | Journal of Agricultural Science and Technology(A)2014，4，3： | 1 |
| 13 | The response of carbon black filled high-density polyethylene to microwave processing显示文摘 | Fanghui Liu Xinyuan Qian Xian Wu Chao Guo Yanwei Lei Jie Zhang | 2010 | Journal of Materials Processing Tech2010，，14： | 1 |
| 14 | herative Improvement of a solution for an Ill-Conditioned System of Linear Equations Based on a Linear Dynamic System显示文摘 | WU Xinyuan SHAO Rong ZHU Yaran | 2002 | Computers and Mathematics with Applications2002，44，： | 1 |
| 15 | Wilkinson' s iterative refinement of solution with automatic step-size control for linear system of e- quations 显示文摘 | WU Xinyuan FANG Yonglie | 2007 | Applied Mathematics and Computation2007，193，： | 1 |
| 16 | On a class of quadratic convergence iteration formulae without derivatives显示文摘 | Wu Xinyuan Wu Hongwei | 2000 | Applied Mathematics and Computation2000，107，23： | 1 |
| 17 | Note on the improvement of Newton's method for system of nonlinear equations显示文摘 | Wu Xinyuan | 2007 | Applied Mathematics and Computation2007，189，2： | 1 |
| 18 | Controllable synthesis of a hollow Cr2O3 electrocatalyst for enhanced nitrogen reduction toward ammonia synthesis显示文摘As a fascinating alternative to the energy-intensive Haber-Bosch process,the electrochemically-driven N_(2) reduction reaction(NRR)utilizing the N_(2) and H_(2)O for the production of NH3 has received enormous attention.The development and preparation of promising electrocatalysts are requisite to realize an efficient N_(2) conversion for NH3 production.In this research,we propose a template-assisted strategy to construct the hollow electrocatalyst with controllable morphology.As a paradigm,the hollow Cr_(2)O_(3) nanocatalyst with a uniform size(~170 nm),small cavity and ultrathin shell(~15 nm)is successfully fabricated with this strategy.This promising hollow structure is favourable to trap N_(2) into the cavity,provides abundant active sites to accelerate the three-phase interactions,and facilitates the reactant transfer across the shell.Attributed to these synergetic effects,the designed catalyst displays an outstanding behaviour in N_(2) fixation for NH3 production in ambient condition.In the neutral electrolyte of 0.1 mol·L^(-1) Na_(2)SO_(4),an impressive electrocatalytic performance with the NH3 generation rate of 2.72μg·h^(-1)·cm^(-2) and a high FE of 5.31%is acquired respectively at-0.85 V with the hollow Cr_(2)O_(3) catalyst.Inspired by this work,it is highly expected that this approach could be applied as a universal strategy and extended to fabricating other promising electrocatalysts for realizing highly efficient nitrogen reduction reaction(NRR). | Lei Shi Yu Yin Hong Wu Rajan Arjan Kalyan Hirani Xinyuan Xu Jinqiang Zhang Nasir Rafique Abdul Hannan Asif Shu Zhang Hongqi Sun | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 19 | On a class of quadratic convergence iteration formulae without derivatives 显示文摘 | WU Xinyuan WU Hongwei | 2000 | Appl Math Comp2000，107，： | 1 |
| 20 | A new continuation Newton-like method and its deformation 显示文摘 | WU Xinyuan | 2000 | Appl Math Comp2000，112，： | 1 |
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