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| 1 | Long-Term Androgen-Induced Nonalcoholic Fatty Liver Disease in a Polycystic Ovary Syndrome Mouse Model is Related to Mitochondrial Dysfunction显示文摘Objective:Metabolic disorders are markedly common in women with polycystic ovary syndrome(PCOS),and nonalcoholic fatty liver disease(NAFLD)is observed in 30%-55%of all PCOS patients.Many studies have reported that autophagy and apoptosis,which are closely related to mitochondrial function,play important roles in the development of NAFLD.Therefore,in this study,we aimed to explore the role of mitochondrial dysfunction caused by liver apoptosis and autophagy imbalance in the development of NAFLD in a PCOS mouse model.Methods:We used a dihydrotestosterone(DHT)-induced PCOS model to mimic the pathological process of hyperandrogenism.Hematoxylin and eosin and Oil Red O staining assays were used to observe the pathological changes in the liver.Western blotting and quantitative real-time polymerase chain reaction were used to perform mitochondrion-related assays.Results:Hepatic steatosis and different degrees of inflammation were observed in the DHT-treated mice.The expression of molecules involved in the respiratory chain and aerobic respiration process was altered.The levels of the key molecules associated with apoptosis and autophagy were abnormal.Conclusions:Androgens may play a role in the process of hepatic steatosis development by affecting mitochondrial function and subsequently inducing apoptosis and autophagy.Such phenomena might be involved in the pathogenesis of NAFLD in women with PCOS. | Peng Cui Jie-Mei Shi Tong Ma Lin Rao Xiao-Yu Tong Wei Hu Xiao-Qing Xu Fei-Fei Zhang Xin Li Hakan Billig Linus R.Shao Yi Feng | 2021 | Reproductive and Developmental Medicine2021，5，2： | 0 |
| 2 | Effect of spatial spectrum overlap on Fourier ptychographic microscopy显示文摘Fourier ptychographic microscopy(FPM)is a newly developed imaging technique which stands out by virtue of its high-resolution and wide FOV.It improves a microscope's imaging perfor-mance beyond the diffraction limit of the employed optical components by illuminating the sample with oblique waves of different incident angles,similar to the concept of synthetic aperture.We propose to use an objective lens with high-NA to generate oblique illuminating waves in FPM.We demonstrate utilizing an objective lens with higher NA to iluminate the sample leads to better resolution by simulations,in which a resolution of 0.28 pum is achieved by using a high-NA illuminating objective lens(NA=1.49)and a low-NA collecting objective lens(NA=0.2)in coherent imaging(λ=488 nm).We then deeply study FPM's exact relevance of convergence speed to spatial spectrum overlap in frequency domain.The simulation results show that an overlap of about 60%is the optimal choice to acquire a high-quality recovery(520*520 pixels)with about 2 min's computing time.In addition,we testify the robustness of the algorithm of FPM to additive noises and its suitability for phase objects,which further proves FPM's potential application in biomedical imaging. | Qiulan Liu Cuifang Kuang Yue Fang Peng Xiu Yicheng Li Ruixin Wen Xu Linu | 2017 | Journal of Innovative Optical Health Sciences2017，，2： | 0 |
| 3 | Aliphatic Phosphenium Canon Featuring A P-S Bond显示文摘ThefirstStablephOSphenlU门nCatlonWaSfoUndlfl1972.TheirCXteflslVeCheffilstTyWererespectivelyreviewedbyCowley-In1985andbySanchez三In1990.RecentInteresthasfocusedontheroleoffunctlonalllzatlonofthephosphoruscenterInthestabllltvandreactlvlty‘-”.yur... | Tian Bac HUANG Linu Fei LIU Xuang Long XU Wen Fang HUANG Ke WANG (Institute of Pesticides and Pharmaceuticals,East China University of Seience and Technology,Institute of Organi Synthesis,Central China Normal University ,Wuhan 430079) | 1999 | Chinese Chemical Letters1999，10，3： | 0 |
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