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| 1 | Traditional Chinese medicine integrated with chemotherapy for stage Ⅳ non-surgical gastric cancer: a retrospective clinical analysis显示文摘OBJECTIVE: Traditional Chinese medicine(TCM) is regarded as an important treatment for gastric cancer patients, especially for those in advanced stage. To evaluate the effects of TCM treatment on gastric cancer patients, the authors performed a retrospective study to report the result of the integrated treatment of TCM with chemotherapy for stage IV non-surgical gastric cancer.METHODS: In this study, 182 patients with stage IV and non-surgical gastric cancer were retrospectively analyzed to evaluate the effects of TCM integrated with chemotherapy. Among the 182 cases, 88 cases received integrated therapy consisting of TCM and chemotherapy, while 94 cases received chemotherapy alone. The overall survival and Karnofsky performance status(KPS) score were measured as the main outcome.RESULTS: The median overall survival of the integrated therapy group and chemotherapy group were 16.9 and 10.5 months, respectively. The 1-, 3-and 5-year survival rates of integrated therapy group vs. chemotherapy group were 70% vs. 32%, 18% vs. 4%, and 11% vs. 0%, respectively. There was a significant difference between the two groups(χ2 = 42.244, P < 0.001). After six-month treatment, KPS scores of the integrated therapy group and the chemotherapy group were 75.00 ± 14.78 and 60.64 ± 21.39, respectively(P < 0.001). The Cox regression analysis showed that TCM treatment is a protective factor for patients' overall survival. CONCLUSION: This study demonstrated that TCM integrated with chemotherapy may prolong overall survival and improve survival rate and life quality of patients with stage IV non-surgical gastric cancer. | xuan liu li-juan xiu jian-peng jiao jing zhao ying zhao ye lu jun shi yong-jin li min ye yu-fang gu xiao-wei wang jing-yu xu ci-an zhang yong-ying liu yun luo xiao-qiang yue | 2017 | Journal of Integrative Medicine2017，15，6： | 18 |
| 2 | Salt-responsive genes in rice revealed by cDNA microarray analysis显示文摘We used cDNA microarrays containing ~9,000 unigenes to identify 486 salt responsive expressed sequence tags (ESTs) (representing ~450 unigenes) in shoots of the highly salt-tolerant rice variety, Nona Bokra (Oryza sativa L. Ssp.Indica pv. Nona). Some of the genes identified in this study had previously been associated with salt stress. Howeverthe majority were novel, indicating that there is a great number of genes that are induced by salt exposure. Analysis of the salt stress expression profile data of Nona provided clues regarding some putative cellular and molecular processes that are undertaken by this tolerant rice variety in response to salt stress. Namely, we found that multiple transcription factors were induced during the initial salt response of shoots. Many genes whose encoded proteins are implicated in detoxification, protectant and transport were rapidly induced. Genes supporting photosynthesis were repressed and those supporting carbohydrate metabolism were altered. Commonality among the genes induced by salt exposure with those induced during senescence and biotic stress responses suggests that there are shared signaling pathways among these processes. We further compared the transcriptome changes of the salt-sensitive cultivar, IR28, with that of Nona rice. Many genes that are salt responsive in Nona were found to be differentially regulated in IR28. This study identified a large number of candidate functional genes that appear to be involved in salt tolerance and further examination of these genes may enable the molecular basis of salt tolerance to be elucidated. | Dai Yin CHAO Yong Hai LUO Min SHI Da LUO Hong Xuan LIN | 2005 | Cell Research2005，15，10： | 17 |
| 3 | Research advances in traditional Chinese medicine syndromes in cancer patients显示文摘Traditional Chinese medicine(TCM)syndrome,also known as TCM ZHENG or TCM pattern,is an integral and essential part of TCM theory that helps to guide the design of individualized treatments.A TCM syndrome,in essence,is a characteristic profi le of all clinical manifestations in one patient that can be readily identifi ed by a TCM practitioner.In this article,the authors reviewed the presentations of TCM syndromes in seven common malignancies(liver,lung,gastric,breast,colorectal,pancreatic and esophageal cancers),the objectivity and the standardization of TCM syndrome differentiation,the evaluation of TCM syndrome modeling in cancer research,and syndrome differentiation-guided TCM treatment of cancers.A better understanding of TCM syndrome theory,as well as its potential biological basis,may contribute greatly to the clinical TCM diagnosis and the treatment of cancer. | Qing Ji Yun-quan Luo Wen-hai Wang Xuan Liu Qi Li Shi-bing Su | 2016 | Journal of Integrative Medicine2016，14，1： | 17 |
| 4 | Staged carotid artery angioplasty and stenting for patients with high-grade carotid stenosis with high risk of developing hyperperfusion injury:a retrospective analysis of 44 cases显示文摘Background:Hyperperfusion syndrome(HPS)is a rare but potentially a life-threatening complication after carotid artery angioplasty and stenting(CAS).Staged CAS has been an alternative to prevent HPS.Materials and methods:44 of 908 patients with high-grade internal carotid artery stenosis or near occlusion were at risk of HPS because of poor collateral flow and impaired cerebral blood flow(CBF).They were treated with first(stage 1),followed by a full CAS(stage 2)1 month later.Their 30-day outcomes were tabulated and analysed.Results:During follow-up,1 of the 44(2.2%)patients developed HPS immediately,3(7%)had postprocedural HPS(ie,transcranial Doppler(TCD)>120%)without clinical symptoms and 3(7%)required stenting at stage 1 for carotid dissections.After stage 1,there were significant improvement between the preprocedural and postprocedural CBF(0.98±0.06 vs 0.85±0.05,p<0.05),mean transit time(MTT;1.05±0.05 vs 1.15±0.05,p<0.05),time to peak(TTP;1.04±0.06 vs 1.20±0.06,p<0.05)on CT perfusion(CTP),and CBF(66.41±7.41 vs 44.44±6.43,p<0.05)on TCD.After stage 2,improvement was seen in CBF(1.01±0.07 vs 0.98±0.06,p<0.05),MTT(1.01±0.05 vs 1.05±0.05,p<0.05),TTP(0.99±0.06 vs 1.04±0.06,p<0.05)on CTP and CBF(66.41±7.41 vs 93.78±18.81,p<0.05)on TCD.2 had postoperative increase of middle cerebral artery mean flow velocity of 120%after stage 2 without clinical symptoms.Conclusion:Staged carotid artery stenting probably decreased the chance of developing HPS in this group of selected patients.Although requiring a 2-step intervention,staged CAS may be a safe and effective alternative. | Dapeng Mo Gang Luo Bo Wang Ning Ma Feng Gao Xuan Sun Xiaotong Xu Zhongrong Miao | 2016 | Stroke & Vascular Neurology2016，1，4： | 14 |
| 5 | SYNTHESIS AND PROPERTIES OF NOVEL POLY(IMINO KETONE)S AS HIGH-PERFORMANCE POLYMERS显示文摘Di(4-bromophenyl)ketone and various aromatic diamines as the monomers,a series of novel poly(imino ketone)s (PIKs)have been synthesized via palladium-catalyzed aryl amination,which is Hartwig-Buchwald polycondensation reaction.The structures of PIKs are characterized by means of elemental analysis,FT-IR,~1H-NMR and UV-Vis spectroscopy. The results show a good agreement with the proposed structure.The general properties of PIKs are studied by DSC,TG and wide-angle X-ray diffraction,the solubility behavior... | Chang, Guan-jun Luo, Xuan Zhang, Lin Lin, Run-xiong | 2008 | Chinese Journal of Polymer Science2008，26，1： | 11 |
| 6 | 3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways显示文摘3-Acetyl-oleanolic 酸(3Ac-OA ) 是 oleanolic 酸(OA ) 的衍生物,它在糖尿病和新陈代谢的症候群上显示出治疗学的有益的效果。在这研究,我们调查了 3Ac-OA 是否在老鼠和它的潜在的位于非酒精的脂肪肝疾病(NAFLD ) 下面机制在有益的效果上施加了。有 3Ac-OA (1-100 mol/L ) 的处理 dose-dependently 减少了全部的胆固醇(TC ) 和在对待船边交货的主要老鼠 hepatocytes 的 triglyceride (TG ) 和在 vitro 的人的 HepG2 房间线的细胞内部的层次。而且,染色研究的油红证明 3Ac-OA 在对待船边交货的主要老鼠 hepatocytes 在类脂化合物微滴的数字引起了剂量依赖者减少。SD 老鼠被喂为 6 个星期并且随后的一本高胖的食谱(HFD ) 与 3Ac-OA 对待(60, 30, 15 mg 愠摮漠捣灩瑩污挠牯楴散 ? 湡 ? 湩琠敨 ??栠灩潰慣灭污猠'T | Qiong OU-YANG Chun-xiao XUAN Xue WANG Han-qiong LUO Jin-e LIU Lan-lan WANG Ting-ting LI Yu-peng CHEN Jun LIU | 2018 | Acta Pharmacologica Sinica2018，39，8： | 8 |
| 7 | Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital,China显示文摘Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of“Guidance for maternal and fctal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital'.This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection diagnostic criteria,inspection precautions,drug treatment options,indications and methods of termination of pregnancy,postpartum fever,breastfeeding considerations,mode of mother-to-child transmission,neonatal isolation and advice on nconatal nursing,to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. | Shao-shuai WANG Xuan ZHOU Xing-guang LIN Yan-yan LIU Jian-li WU Lali Mwamaka Shariful Xiao-lin HU Zhi-bui RONG Wei LIU Xiao-ping LUO Zhuo CHEN Wan-jiang ZENG Su-hua CHEN Ding MA Ling CHEN Ling FENG | 2020 | Current Medical Science2020，40，2： | 8 |
| 8 | Association betweenITGA2 C807T polymorphism and gastric cancer risk显示文摘AIM:To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.METHODS:A hospital-based case-control study was conducted,including 307 gastric cancer patients and 307 ageand gender-matched control subjects.The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.RESULTS:The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P=0.019).Compared with individuals with the wild genotype CC,subjects with the variant genotypes (CT+ TT) had a significantly higher risk of gastric cancer (adjusted odds ratio=1.57,95% CI=1.13-2.17,P=0.007).In stratified analyses,the elevated gastric cancer risk was especially evident in older individuals aged>58 years,nonsmokers and rural subjects.Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.CONCLUSION:The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer,differentiation and invasion of gastric cancer. | Jie Chen Nan-Nan Liu Jia-Qi Li Li Yang Ying Zeng Xiao-Mei Zhao Lin-Lin Xu Xuan Luo Bin Wang Xue-Rong Wang | 2011 | World Journal of Gastroenterology2011，17，23： | 7 |
| 9 | Preparation of (2E)-3-(4'-Halophenyl)prop-2-enoyl Sulfachlorpyridazine Sodium Salts and Their Interaction with Bovine Serum Albumin by Fluorescence Spectroscopy显示文摘 | DU Chuan-rong LUO Xuan WEI Jin-rui HE Ting-ting ZHENG Xiao-yu LIN Cui-wu | 2013 | Chemical Research in Chinese Universities2013，29，5： | 7 |
| 10 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 11 | Impaired tumor angiogenesis and VEGF- induced pathway in endothelial CD146 knockout mice显示文摘 | Qiqun Zeng Zhenzhen Wu Hongxia Duan Xuan Jiang Tao Tu Di Lu Yongting Luo Ping Wang Lina Song Jing Feng Dongling Yang Xiyun Yan | 2014 | Protein & Cell2014，5，6： | 6 |
| 12 | Bi-, Y-Codoped TiO2 for Carbon Dioxide Photocatalytic Reduction to Formic Acid under Visible Light Irradiation显示文摘 | Pengju Du Tongming Su Xuan Luo Xiantai Zhou Zuzeng Qin Hongbing Ji Jianhua Chen | 2018 | Chinese Journal of Chemistry2018，36，6： | 5 |
| 13 | Multi-objective Dynamic Optimal Power Flow of Wind Integrated Power Systems Considering Demand Response显示文摘This paper studies the economic environmental energy-saving day-ahead scheduling problem of power systems considering wind generation(WG)and demand response(DR)by means of multi-objective dynamic optimal power flow(MDOPF).Within the model,fuel cost,carbon emission and active power losses are taken as objectives,and an integrated dispatch modeof conventional coal-fired generation,WG and DRis utilized.The corresponding solution process to the MDOPF is based on ahybrid of a non-dominated sorting genetic algorithm-II(NSGA-II)and fuwzy satisfaction-maximizing method,where NSGA-II obtains the Pareto frontier and the fuzzy satisfaction-maximizing method is the chosen strategy.Illustrative cases of different scenarios are performed based on an IEEE 6-units\,30-nodes system,to verify the proposed model and the solution process,as well as the benefits obtained by the DR into power system. | Rui Ma Xuan Li Yang Luo Xia Wu Fei Jiang | 2019 | CSEE Journal of Power and Energy Systems2019，5，4： | 5 |
| 14 | The effects of oleanolic acid on atherosclerosis in different animal models显示文摘 | Hanqiong Luo Jine Liu Qiong Ouyang Chunxiao Xuan Lanlan Wang Tingting Li Jun Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，4： | 4 |
| 15 | Expression of miR-1304 in patients with esophageal carcinoma and risk factors for recurrence显示文摘BACKGROUND Esophageal carcinoma is a malignant gastrointestinal tumor with a very poor prognosis.MicroRNA(miR)-1304 is a newly discovered non-coding RNA,which shows differential expression in other cancers,and its clinical value in esophageal carcinoma remains unclear.AIM To explore the expression of miR-1304 in patients with esophageal carcinoma and its clinical value.METHODS The expression of miR-1304 in patients with esophageal carcinoma was analyzed based on the data on miR in esophageal carcinoma downloaded from The Cancer Genome Atlas database.Quantitative real-time polymerase chain reaction was adopted to determine the expression of miR-1304 in the tissues and serum of patients.The clinical diagnostic value of miR-1304 and independent factors for recurrence and prognosis of esophageal carcinoma were then analyzed.The potential target genes of miR-1304 were predicted,and then analyzed based on gene ontology,Kyoto Encyclopedia of Genes,and Genomes,and protein-protein interaction.RESULTS The expression of miR-1304 in the tissues and serum of patients with esophageal carcinoma increased,and was also increased according to the database.Patients with high expression of miR-1304 suffered increased rates of tumor≥3 cm,low differentiation and stage II+III.miR-1304 had a diagnostic value in identifying esophageal carcinoma,tumor size,differentiation and TNM stage.Tumor size,differentiation,TNM stage,and miR-1304 were independent risk factors for recurrence of esophageal carcinoma,and they had certain predictive and diagnostic value for the recurrence of esophageal carcinoma.Seventy-eight patients showed a 3-year survival rate of 38.46%,and patients with high expression of miR-1304 had a relatively lower survival rate.Multivariate analysis revealed that tumor size,differentiation,recurrence and miR-1304 were independent factors for the prognosis of patients.MiRTarBase,miRDB,and Targetscan predicted 20 target genes in total.Gene ontology enrichment analysis found 18 functions with aP<0.05,and Kyoto Encyclopedia of Genes,and Genomes analysis found 11 signal pathways with aP<0.05.String analysis of protein co-expression found 269 relationship pairs,of which co-expression with epidermal growth factor was the most common.CONCLUSION miR-1304 can be used as a potential indicator for the diagnosis and recurrence of esophageal carcinoma and for survival of patients with this disease. | Yun-Gang Luo Li-Wei Duan Xuan Ji Wen-Yuan Jia Yun Liu Mao-Lei Sun Guo-Min Liu | 2020 | World Journal of Gastroenterology2020，26，6： | 4 |
| 16 | Statistical analysis of fracture properties based on particle swarm optimization and Pearson correlation coefficient method显示文摘Prediction of reservoir fracture is the key to explore fracture-type reservoir. When a shear-wave propagates in anisotropic media containing fracture,it splits into two polarized shear waves: fast shear wave and slow shear wave. The polarization and time delay of the fast and slow shear wave can be used to predict the azimuth and density of fracture. The current identification method of fracture azimuth and fracture density is cross-correlation method. It is assumed that fast and slow shear waves were symmetrical wavelets after completely separating,and use the most similar characteristics of wavelets to identify fracture azimuth and density,but in the experiment the identification is poor in accuracy. Pearson correlation coefficient method is one of the methods for separating the fast wave and slow wave. This method is faster in calculating speed and better in noise immunity and resolution compared with the traditional cross-correlation method. Pearson correlation coefficient method is a non-linear problem,particle swarm optimization( PSO) is a good nonlinear global optimization method which converges fast and is easy to implement. In this study,PSO is combined with the Pearson correlation coefficient method to achieve identifying fracture property and improve the computational efficiency. | ZHOU Yin FENG Xuan Enhedelihai LUO Teng YANG Xueting HE Mei | 2015 | Global Geology2015，18，1： | 4 |
| 17 | Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells显示文摘Background:Tooth is vital not only for a good smile,but also good health.Yet,we lose tooth regularly due to accidents or diseases.An ideal solution to this problem is to regenerate tooth with patients’own cells.Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells(ifhU-iPSCs).Results:We first differentiated ifhU-iPSCs to epithelial sheets,which were then recombined with E14.5 mouse dental mesenchymes.Tooth-like structures were recovered from these recombinants in 3 weeks with success rate up to 30%for 8 different iPSC lines,comparable to H1 hESC.We further detected that ifhU-iPSC derived epithelial sheets differentiated into enamel-secreting ameloblasts in the tooth-like structures,possessing physical properties such as elastic modulus and hardness found in the regular human tooth.Conclusion:Our results demonstrate that ifhU-iPSCs can be used to regenerate patient specific dental tissues or even tooth for further drug screening or regenerative therapies. | Jinglei Cai Yanmei Zhang Pengfei Liu Shubin Chen Xuan Wu Yuhua Sun Ang Li Ke Huang Rongping Luo Lihui Wang Ying Liu Ting Zhou Shicheng Wei Guangjin Pan Duanqing Pei | 2013 | Cell Regeneration2013，2，1： | 4 |
| 18 | Eu(Ⅲ) complex-doped PMMA having fast radiation rate and high emission quantum efficiency显示文摘Three Eu(Ⅲ) ternary complexes,Eu(hfa-H) 3(Phen),Eu(hfa-H) 3(Bipy) and Eu(hfa-H) 3(Bath)(hfa = hexafluoroacetylacetonate,Phen = 1,10-phenanthroline,Bipy = 2,2 0-bipyridine,Bath = bathophenanthroline),were synthesized.Their luminescent properties were studied by incorporating deuterated Eu(Ⅲ) complexes in a poly(methylmethacrylate)(PMMA) matrix,and the results indicated that luminescent PMMA including Eu(hfa-D) 3(Bath) showed promising results for applications to novel organic Eu(Ⅲ) devices,such as the high-power laser materials.Additionally,all the three Eu(Ⅲ) complexes exhibited good thermostabilization. | Jin Li Zhang Bo Wei Chen Xuan Luo Kai Du | 2012 | Chinese Chemical Letters2012，23，8： | 4 |
| 19 | Prefrontal cortical α_(2A)-adrenoceptors and a possible primate model of attention deficit and hyperactivity disorder显示文摘Attention deficit and hyperactivity disorder(ADHD), a prevalent syndrome in children worldwide, is characterized by impulsivity, inappropriate inattention, and/or hyperactivity. It seriously afflicts cognitive development in childhood, and may lead to chronic under-achievement, academic failure, problematic peer relationships, and low self-esteem. There are at least three challenges for the treatment of ADHD. First, the neurobiological bases of its symptoms are still not clear. Second, the commonly prescribed medications, most showing short-term therapeutic efficacy but with a high risk of serious side-effects, are mainly based on a dopamine mechanism. Third, more novel and efficient animal models, especially in nonhuman primates, are required to accelerate the development of new medications. In this article, we review research progress in the related fields, focusing on our previous studies showing that blockade of prefrontal cortical α2A-adrenoceptors in monkeys produces almost all the typical behavioral symptoms of ADHD. | Chao-Lin Ma Xuan Sun Fei Luo Bao-Ming Li | 2015 | Neuroscience Bulletin2015，31，2： | 3 |
| 20 | Comprehensive multi-omics analysis identified core molecular processes in esophageal cancer and revealed GNGT2 as a potential prognostic marker显示文摘BACKGROUND Esophageal cancer is one of the most poorly diagnosed and fatal cancers in the world.Although a series of studies on esophageal cancer have been reported,the molecular pathogenesis of the disease remains elusive.AIM To investigate comprehensively the molecular process of esophageal cancer.METHODS Differential expression analysis was performed to identify differentially expressed genes(DEGs)in different stages of esophageal cancer from The Cancer Genome Atlas data.Exacting gene interaction modules were generated,and hub genes in the module interaction network were found.Further,through survival analysis,methylation analysis,pivot analysis,and enrichment analysis,some important molecules and related functions/pathways were identified to elucidate potential mechanisms in esophageal cancer.RESULTS A total of 7457 DEGs and 14 gene interaction modules were identified.These module genes were significantly involved in the positive regulation of protein transport,gastric acid secretion,insulin-like growth factor receptor binding,and other biological processes as well as p53 signaling pathway,epidermal growth factor signaling pathway,and epidermal growth factor receptor signaling pathway.Transcription factors(including hypoxia inducible factor 1A)and noncoding RNAs(including colorectal differentially expressed and hsa-miR-330-3p)that significantly regulate dysfunction modules were identified.Survival analysis showed that G protein subunit gamma transducin 2(GNGT2)was closely related to survival of esophageal cancer.DEGs with strong methylation regulation ability were identified,including SST and SH3GL2.Furthermore,the expression of GNGT2 was evaluated by quantitative real time polymerase chain reaction,and the results showed that GNGT2 expression was significantly upregulated in esophageal cancer patient samples and cell lines.Moreover,cell counting kit-8 assay revealed that GNGT2 could promote the proliferation of esophageal cancer cell lines.CONCLUSION This study not only revealed the potential regulatory factors involved in the development of esophageal cancer but also deepens our understanding of its underlying mechanism. | Guo-Min Liu Xuan Ji Tian-Cheng Lu Li-Wei Duan Wen-Yuan Jia Yun Liu Mao-Lei Sun Yun-Gang Luo | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
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