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| 1 | A Multicentre Prospective Evaluation of the Impact of Renal Insufficiency on In-hospital and Long-term Mortality of Patients with Acute ST-elevation Myocardial Infarction显示文摘 | Chao Li Dayi Hu Xubo Shi Li Li Jingang Yang Li Song Changsheng Ma | 2015 | Chinese Medical Journal2015，，1： | 18 |
| 2 | A universal coherent source for quantum key distribution显示文摘We propose a concept of universal coherent source for quantum key distribution. The weak coherent pulse (WCP) and heralded single photon source (HSPS) are the most common photon sources for state-of-art quantum key distribution (QKD). However, there exists a prominent crossover between the maximal secure distance and the secure key generating rate in short and middle distance if one applies these two sources in a practical decoy state quantum key distribution. It is shown that by combining the heralded pair coherent state (HPCS) photon source and the practical decoy state method together, one can not only strengthen the maximal secure transmission distance, but also improve key generat-ing rate at short and medium distance. Moreover, the advancement in key generating is not confined in the particular protocol utilized and can be easily checked for both BB84 and SARG protocol. Finally, we clearly demonstrate how the HPCS-based decoy method works effectively and feasibly by proposing an efficient HPCS-based '1 signal+2 decoy' state method. | ZHANG ShengLi ZOU XuBo LI ChuanFeng JIN ChenHui GUO GuangCan | 2009 | Chinese Science Bulletin2009，54，11： | 15 |
| 3 | Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins显示文摘蛋白质治疗,治疗学的蛋白质在那里被交付对待混乱,为治疗疾病被认为最安全、很直接的途径。然而,它的应用被有效策略的少量高度为在他们的管理以后在 vivo 交付蛋白质和治疗学的蛋白质的快速的清理限制。这里,我们表明能显著地延长治疗学的蛋白质的发行量时间以及最小化他们的 immunogenicity 的新奇策略。这被与抵抗蛋白质吸附的 crosslinked phosphorylcholine 聚合物的薄层包含单个蛋白质分子完成。通过广泛的细胞的研究,我们证明 crosslinked phosphorylcholine 聚合物壳有效地阻止包含的蛋白质是由巨噬细胞的 phagocytosed,它在 vivo 在 nanoparticles 的清理起一个必要作用。而且,聚合物壳阻止包含的蛋白质被有免疫力的房间识别。作为结果,对治疗学的蛋白质的有免疫力的回答有效地被压制。这个工作描述一个可行方法延长循环时间并且减少治疗学的蛋白质的 immunogenicity,它可以在多样的疾病的治疗支持新奇蛋白质治疗的发展和申请。 | Sheng Liang Yang Liu Xin Jin Gan Liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu | 2016 | Nano Research2016，9，4： | 11 |
| 4 | Modeling and simulation of urea-water-solution droplet evaporation and thermolysis processes for SCR systems显示文摘A reliable mathematical model of urea-water-solution(UWS) droplet evaporation and thermolysis is developed.The well known Abramzon–Sirignano evaporation model is corrected by introducing an adjustment coefficient considering the different evaporation behaviors of UWS droplet at different ambient temperatures. A semidetailed kinetic scheme of urea thermolysis is developed based on Ebrahimian's work. Sequentially, the evaporation characteristics, decomposition efficiency of a single UWS droplet and deposit formation are simulated. As a result, the relation of evaporation time, relative velocity, exhaust temperature and droplet initial diameter is presented. Synchronously, it indicates that temperature is the decisive factor for urea thermolysis. Different temperatures result in different deposit components, and deposit yield is significantly influenced by temperature and decomposition time. The current work can provide guidance for designing urea injection strategy of SCR systems. | Xubo Gan Dongwei Yao Feng Wu Jiawei Dai Lai Wei Xingwen Li | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 7 |
| 5 | Distribution and assessment of hydrogeochemical processes of F-rich groundwater using PCA model:a case study in the Yuncheng Basin,China显示文摘Hydrogeochemistry and factor analysis were conducted together to assess the distribution and the major geochemical processes in fluoride-contaminated shallow groundwater in the Yuncheng Basin.Spatially,fluoride concentration was low(<1.5 mg/L)in the southern piedmont plain,medium(<4 mg/L)in the central basin,and high(up to 14.1 mg/L)in Kaolao lowland areas in shallow aquifers.A three-factor principal component analysis model explained over 75.1%of the total variance.Sediment weathering leaching and evapotranspiration were recognized as the first primary hydrochemical processes response for the groundwater chemistry and explained the largest portion(42.1%)of the total variance.Factor two reflects the negative influence of human activities,with a positive loading of NO3^-and HCO3^-,and negative loading of well depth.Fluoride-bearing mineral dissolution and alkaline condition was ranked as the third factors responding for groundwater chemistry and explained 11.2%of the total variance. | Tao Liu Xubo Gao Xiaobo Zhang Chengcheng Li | 2020 | Acta Geochimica2020，39，2： | 2 |
| 6 | Potentially harmful metals,and health risk evaluation in groundwater of Mardan,Pakistan:Application of geostatistical approach and geographic information system显示文摘This study investigates the values of pH,total dissolved solids(TDS),elevation,oxidative reduction potential(ORP),temperature,and depth,while the concentrations of Br,and potentially harmful metals(PHMs)such as Cr,Ni,Cd,Mn,Cu,Pb,Co,Zn,and Fe in the groundwater samples.Moreover,geographic information system(GIS),XLSTAT,and IBM SPSS Statistics 20 software were used for spatial distribution modeling,principal component analysis(PCA),cluster analysis(CA),and Quantile-Quantile(Q-Q)plotting to determine groundwater pollution sources,similarity index,and normal distribution reference line for the selected parameters.The mean values of pH,TDS,elevation,ORP,temperature,depth,and Br were 7.2,322 mg/L,364 m,188 mV,29.6℃,70 m,0.20 mg/L,and PHMs like Cr,Ni,Cd,Mn,Cu,Pb,Co,Zn,and Fe were 0.38,0.26,0.08,0.27,0.36,0.22,0.04,0.43 and 0.86 mg/L,respectively.PHMs including Cr(89%),Cd(43%),Mn(23%),Pb(79%),Co(20%),and Fe(91%)exceeded the guideline values set by the world health organization(WHO).The significant R^(2)values of PCA for selected parameters were also determined(0.62,0.67,0.78,0.73,0.60,0.87,-0.50,0.69,0.70,0.74,-0.50,0.70,0.67,0.79,0.59,and-0.55,respectively).PCA revealed three geochemical processes such as geogenic,anthropogenic,and reducing conditions.The mineral phases of Cd(OH)_(2),Fe(OH)_(3),FeOOH,Mn_(3)O_(4),Fe_(2)O_(3),MnOOH,Pb(OH)_(2),Mn(OH)_(2),MnO_(2),and Zn(OH)_(2)(-3.7,3.75,9.7,-5.8,8.9,-3.6,2.2,-4.6,-7.7,-0.9,and 0.003,respectively)showed super-saturation and under-saturation conditions.Health risk assessment(HRA)values for PHMs were also calculated and the values of hazard quotient(HQ),and hazard indices(HI)for the entire study area were increased in the following order:Cd>Ni>Cu>Pb>Mn>Zn>Cr.Relatively higher HQ and HI values of Ni,Cd,Pb,and Cu were greater than one showing unsuitability of groundwater for domestic,agriculture,and drinking purposes.The long-term ingestion of groundwater could also cause severe health concerns such as kidney,brain dysfunction,liver,stomach problems,and even cancer. | Abdur Rashid Muhammad Ayub Asif Javed Sardar Khan Xubo Gao Chengcheng Li Zahid Ullah Tariq Sardar Juma Muhammad Shahla Nazneen | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 7 | Paclitaxel formulation with stable sustained-release behavior and its biological safety evaluation显示文摘Biological safety and stable sustained-release of the drug are two crucial issues involved in the formulation of paclitaxel.Focusing on these issues, by using the FDA approved polylactide as carrier material, soybean lecithin as surfactant and maltodextrin as thickener, paclitaxel loaded PLA microspheres were simply prepared by solvent evaporation, thus guaranteeing the biological safety. The introduction of maltodextrin as a thickener aided to a stable sustained-release of paclitaxel. Surface morphology, particle size, drug loading rate, encapsulation efficiency and in vitro drug release behavior were investigated.Biological safety evaluations such as acute toxicity, allergies, hemolysis, skin stimulation and genotoxicity test were also carried out. Results showed that the obtained microspheres were biocompatible and could release paclitaxel at a desirable constant rate.Therefore, the simply prepared paclitaxel formulation with good biological safety and desirable release behavior exhibited great potential of local injection of paclitaxel for the clinical use in the future. | LI XuePing ZHAN Qi QI HongZhao HAN DongLin QIN YaoYao CHEN Ning LONG LiXia ZHAO Jin HOU Xin YUAN XuBo YANG XianJin | 2019 | Science China(Technological Sciences)2019，62，7： | 2 |
| 8 | Genetic Variation Assessed with Microsatellites in Mass Selection Lines of the Pacific Oyster (Crassostrea gigas) in China显示文摘Four successive mass selection lines of the Pacific oyster, Crassostrea gigas, selected for faster growth in breeding programs in China were examined at ten polymorphic microsatellite loci to assess the level of allelic diversity and estimate the effective population size. These data were compared with those of their base population. The results showed that the genetic variation of the four generations were maintained at high levels with an average allelic richness of 18.8–20.6, and a mean expected heterozygosity of 0.902–0.921. They were not reduced compared with those of their base population. Estimated effective population sizes based on temporal variances in microsatellite frequencies were smaller to that of sex ratio-corrected broodstock count estimates. Using a relatively large number of broodstock and keeping an equal sex ratio in the broodstock each generation may have contributed to retaining the original genetic diversity and maintaining relatively large effective population size. The results obtained in this study showed that the genetic variation was not affected greatly by mass selection progress and high genetic variation still existed in the mass selection lines, suggesting that there is still potential for increasing the gains in future generations of C. gigas. The present study provided important information for future genetic improvement by selective breeding, and for the design of suitable management guidelines for genetic breeding of C. gigas. | WANG Xubo LI Qi YU Hong KONG Lingfeng | 2016 | Journal of Ocean University of China2016，15，6： | 2 |
| 9 | Divergence in homoeolog expression of the grain length-associated gene GASR7 during wheat allohexaploidization显示文摘Hexaploid wheat has triplicated homoeologs for most of the genes that are located in subgenomes A, B, and D. GASR7, a member of the Snakin/GASA gene family, has been associated with grain length development in wheat. However, little is known about divergence of its homoeolog expression in wheat polyploids. We studied the expression patterns of the GASR7 homoeologs in immature seeds in a synthetic hexaploid wheat line whose kernels are slender like those of its maternal parent(Triticum turgidum, AABB, PI 94655) in contrast to the round seed shape of its paternal progenitor(Aegilops tauschii, DD, AS2404). We found that the B homoeolog of GASR7 was the main contributor to the total expression level of this gene in both the maternal tetraploid progenitor and the hexaploid progeny, whereas the expression levels of the A and D homoeologs were much lower. To understand possible mechanisms regulating different GASR7 homoeologs, we firstly analyzed the promoter sequences of three homoeologous genes and found that all of them contained gibberellic acid(GA) response elements, with the TaG ASR7 B promoter(pT aG ASR7B) uniquely characterized by an additional predicted transcriptional enhancer. This was confirmed by the GA treatment of spikes where all three homoeologs were induced, with a much stronger response for TaG ASR7 B. McrB C enzyme assays showed that the methylation status at pT aG ASR7 D was increased during allohexaploidization, consistent with the repressed expression of TaG ASR7 D. For pT aG ASR7 A, the distribution of repetitive sequence-derived 24-nucleotide(nt) small interfering RNAs(siR NAs) were found which suggests possible epigenetic regulation because 24-nt siR NAs are known to mediate RNA-dependent DNA methylation. Our results thus indicate that both genetic and epigenetic mechanisms may be involved in the divergence of GASR7 homoeolog expression in polyploid wheat. | Dongdong Zhang Bingnan Wang Junmin Zhao Xubo Zhao Lianquan Zhang Dengcai Liu Lingli Dong Daowen Wang Long Mao Aili Li | 2015 | The Crop Journal2015，3，1： | 2 |
| 10 | Finite groups with few non-cyclic subgroups显示文摘 | LI Shirong ZHAO Xubo | 2007 | J Group Theory2007，10，： | 1 |
| 11 | Enrichment of fluoride in groundwater under the impact of saline water intrusion at the salt lake area of Yuncheng basin,northern China显示文摘 | Xubo Gao Yanxin Wang Yilian Li | | 0，，04： | 1 |
| 12 | Enrichment of fluoride in groundwater under the impact of saline water intrusion at the salt lake area of Yuncheng basin, northern China显示文摘 | Xubo Gao Yanxin Wang Yilian Li Qinghai Guo | 2007 | Environmental Geology2007，，4： | 1 |
| 13 | Surface photodynamic ion sterilization of ITO-Cu_(2)O/ZnO preventing touch infection显示文摘Pathogenic microbial infections are threatening the people’s health and even life.The most common channel of infections can be caused by skin contact,especially hand touching facilities such as touching screen.In this work,Cu_(2)O covered with ZnO nanofilm was prepared on the surface of indium tin oxide conductive glass by electrodeposition and the followed atomic layer deposition process.This composite coating had a light transmittance of 71.5%,which met the light transmission needs of touch screen device.Electron spin resonance spectra showed that composite materials can generate more reactive oxygen species(ROS)than a single component under solar light irradiation.This was because a p-n junction with a built-in electric field was formed at the interface after Cu_(2)O contacting with ZnO.In the process of photocatalysis,photogenerated electrons and holes migrated at the interface driven by the built-in electric field,which promoted the separation of carriers.The antibacterial rate against Staphylococcus aureus reached 92.5%after 3 min of light irradiation with simulated sunlight due to the synergy of ROS and Cu ions,Zn ions.Therefore,this work may provide a potential method for antibacterial application of preventing hand touch infections. | Zexin Liu Xiangmei Liu Zhenduo Cui Yufeng Zheng Zhaoyang Li Yanqin Liang Xubo Yuan Shengli Zhu Shuilin Wu | 2022 | Journal of Materials Science & Technology2022，，27： | 1 |
| 14 | Enrichment of fluoride in groundwater under the impact of saline water intrusion at the salt lake area of Yuncheng basin, northern China显示文摘 | Xubo Gao Yanxin Wang Yilian Li Qinghai Guo | 2007 | Environmental Geology2007，，4： | 1 |
| 15 | Growth of large scale PtTe,PtTe_(2) and PtSe_(2) films on a wide range of substrates显示文摘1T phase of transition metal dichalcogenides(TMDCs)formed by group 10 transition metals(e.g.Pt,Pd)have attracted increasing interests due to their novel properties and potential device applications.Synthesis of large scale thin films with controlled phase is critical especially considering that these materials have relatively strong interlayer interaction and are difficult to exfoliate.Here we report the growth of centimeter-scale PtTe,1T-PtTe2 and 1T-PtSe2 films via direct deposition of Pt metals followed by tellurization or selenization.We find that by controlling the Te flux,a hitherto-unexplored PtTe phase can also be obtained,which can be further tuned into PtTe2 by high temperature annealing under Te flux.These films with different thickness can be grown on a wide range of substrates,including NaCl which can be further dissolved to obtain free-standing PtTe2 or PtSe2 films.Moreover,a systematic thickness dependent resistivity and Hall conductivity measurements show that distinguished from the semiconducting PtSe2 with hole carriers,PtTe2 and PtTe films are metallic.Our work opens new opportunities for investigating the physical properties and potential applications of group 10 TMDC films and the new monochalcogenide PtTe film. | Kenan Zhang Meng Wang Xue Zhou Yuan Wang Shengchun Shen Ke Deng Huining Peng Jiaheng Li Xubo Lai Liuwan Zhang Yang Wu Wenhui Duan Pu Yu Shuyun Zhou | 2021 | Nano Research2021，14，6： | 1 |
| 16 | Withdrawal Weighting Image-Impedance Connected SAW Filters with Al-Mo Alloy Electrodes显示文摘To obtain high reliability of surface acoustic wave(SAW)devices,Mo was added to Al electrodes on 128°Y-X LiNbO_3 substrates by a d.c.magnetron sputtering deposition.Influence of Mo additive on the mechanical properties of Al films was investigated.It was found that the Al-Mo alloy films displayed a superior adhesion to substrates.With the Al-Mo alloy films,a 1.65 GHz-range image-impedance connected SAW filter was designed and fabricated.In this structure of SAW filter, for satisfying stopband requirements a dual-track structure was applied.Withdrawal weighting of interdigital transducers(IDT) was used to adjust the bandwidth of SAW filter. | Dongmei Li Xubo Wang Feng Pan | 2006 | 稀有金属材料与工程2006，35，A03： | 1 |
| 17 | Tumor necrosis factor-alpha(TNF-α) in spotted halibut Verasper variegatus at the embryonic and metamorphic stages显示文摘As an aquatic fish,the spotted halibut Verasper variegatus is highly susceptible to bacterial and virus infections.Tumor necrosis factor-alpha(TNF-α)as a cytokine could control the inflammatory responses.The functions of TNF-αin many species have been widely studied,particularly in mammals.However,little is known about the TNF-αfunctions in V.variegatus.We first cloned and sequenced the TNF-αgene in V.variegatus(VvTNF-α).The two conserved cysteine residues,transmembrane sequence,Thr-Leu motif,and TNF family signature,as well as the TA-rich motifs of its proteins related to inflammatory responses had high similarity to those of the other teleost and mammalian TNF-α.The phylogenetic analysis showed that VvTNF-αwas consistent with TNF-αgenes of other vertebrates.The VvTNF-αtranscripts were extensively distributed in the peripheral blood leukocytes(PBLs),spleen,and gill,indicating that the VvTNF-αhad a role in immune function.Furthermore,treatment with pathogen-associated molecular patterns(PAMPs)could induce a rapid and significant increase of VvTNF-αin the PBLs,which reveals that VvTNF-αdoes participate in the host immune responses against bacterial and viral pathogens.We found that VvTNF-αhad an interesting expression pattern during metamorphosis,showing that the flatfish TNF-αmay have some novel functions during specific developmental stages.In addition,the 3 D structure prediction of VvTNF-αprovided an indication of how it is likely to interact with other proteins.Therefore,VvTNF-αhas multiple functions,and provides valuable information to explore novel functions of TNF-α. | LI Zan LIU Xiumei DU Xinxin ZHANG Kai CHEN Yan WANG Xubo WANG Zhigang YU Haiyang ZHANG Quanqi | 2020 | Journal of Oceanology and Limnology2020，38，2： | 1 |
| 18 | Virulence changes in Vibrio parahaemolyticus during the freezing of Penaeus chinensis显示文摘Although Vibrio parahaemolyticus has become the most common pathogen in fresh and frozen seafood,its virulence changes have often been ignored during the processing of seafood.To investigate these potential risks,we used frozen Penaeus chinensis as examples,and the most virulent factors of V.parahaemolyticus,including amounts,viable but nonculturable(VBNC)status,toxins TDH and TRH,and virulence genes tdh and trh,were determined.Bacterial quantities were signifi cantly reduced during drain and sprinkling phases,but caused by different factors.By SYTO9 and PI staining showed that washing was the main reason for the bacterial reduction at the drain phase,while the strain entering VBNC state was another reason at sprinkling phase.Their hemolysis toxicity,produced by TDH and TRH,became stronger after inoculation on shrimp,and could be detected throughout the process.Moreover,tdh and trh also exhibited trends similar to that of the hemolysis toxicity test.tdh was almost to a two-fold expression level during ice-glazing phase,while trh only express at a low level,less than half of the expression level before inoculation.These results demonstrated that the strains were not dead during freezing process,but became VBNC cells,which still produced and accumulated toxins,especially TDH,the most virulent factor. | Zenghui Gao Heer Ding Ke Li Qiang Zhang Xubo Zhao Bin Liu Tianli Yue | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 19 | Functionalization of PEG-PM PC-based polymers for potential theranostic applications显示文摘The synergistic effect of polyethylene glycol(PEG)and poly(2-methacry-loyloxyethyl phosphorytcholine)(PMPC)can effectively reduce the protein absorption,which is beneficial to theranostics.However,PEG-PMPC-based polymers have rarely been used as nanocarriers in the theranostic field due to their limited modifiability and weak interaction with other materials.Herein,a plain method was proposed to endow them with the probable ability of loading small active agents,and the relationship between the structure and the ability of loading hydrophobic agents was explored,thus expanding their applications.Firstly,mPEG-PMPC or 4-arm-PEG-PMPC polymer was synthesized by atom transfer radical polymerization(ATRP)using mPEG-Br or 4-arm-PEG-Br as the macroinitiator.Then a strong hydrophobic segment,poly(butyl methacrylate)(PBMA),was introduced and the ability to load small hydrophobic agents was further explored.The results showed that linear mPEG-PMPC-PBMA could form micelles 50-80 nm in size and load the hydrophobic agent such as Nile red efficiently.In contrast,star-like 4-arm-PEG-PMPC-PBiyiA,a monomolecular micelle(10-20 nm),could hardly load any hydrophobic agent.This work highlights effective strategies for engineering PEG-PMPC-based polymers and may facilitate the further application in numerous fields. | Ning CHEN Sidi LI Xueping LI Lixia LONG Xubo YUAN Xin HOU Jin ZHAO | 2021 | Frontiers of Materials Science2021，15，2： | 0 |
| 20 | The effect of umbrella-type branching on the blood circulation and tumor targeting of star-branched PLA-PMPC copolymer micelles显示文摘The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study. For the purpose, star-branched poly(lactic acid) and poly(2-methacryloyloxyethyl phosphorylcholine)(PLA-PMPC)copolymers with umbrella-type AB3,(AB3)_(2), and(AB3)_(3) architecture were synthesized by branching at the PLA core. Micelles self-assembled from these copolymers were used to evaluate the effect of core branching on blood circulation and tumor targeting. The results showed that branching changed the behavior of polymeric self-assembly in solution, thereby changing the size and surface anti-fouling performance of the polymeric micelles. Moreover, star-branched copolymer micelles with a higher branching degree allowed their payload to persist better in blood(half-time prolonged from 7.1, 8.6 to 13.8 h) and for a 1.72-fold higher content at the tumor site. These studies suggest that raising the branching degree of amphiphilic copolymer potentially offers a promising strategy for the design of carriers capable of enhanced circulation and targeting in vivo. | LONG LiXia CHENG LinJie HOU JingJing WANG LiMei WANG Xu HE LiGang LI SiDi ZHAO Jin HOU Xin KANG ChunSheng YUAN XuBo | 2021 | Science China(Technological Sciences)2021，64，1： | 0 |
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