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| 1 | Mizoribine versus mycophenolate mofetil or intravenous cyclophosphamide for induction treatment of active lupus nephritis显示文摘 | Feng Xuebing Gu Fei Chen Weiwei Liu Yan Wei Hua Liu Lin Yin Songlou Da Zhanyun Sun Lingyun | 2014 | Chinese Medical Journal2014，，21： | 5 |
| 2 | Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China显示文摘The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still unknown.We conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read sequencing.The results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant clone.Phylogenetic analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP isolates.Additionally,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring plasmids.Importantly,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 cpKP.Intriguingly,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after 2008.We then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP infections.Thus,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations. | Cuidan Li Xiaoyuan Jiang Tingting Yang Yingjiao Ju Zhe Yin Liya Yue Guannan Ma Xuebing Wang Ying Jing Xinhua Luo Shuangshuang Li Xue Yang Fei Chen Dongsheng Zhou | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 3 | Comprehensive Analysis of Peripheral Blood Lymphocytes in 76 Women with Recurrent Miscarriage before and after Lymphocyte Immunotherapy显示文摘 | Peiyan Liang Meilan Mo Guan‐Gui Li Biao Yin Jing Cai Tonghua Wu Xuebing He Xu Zhang Yong Zeng | 2012 | Am J Reprod Immunol2012，，2： | 1 |
| 4 | Variation in Bombyx mori immune response against fungal pathogen Beauveria bassiana with variability in cell wallβ-1,3-glucan显示文摘Entomopathogenic fungi are protected by a cell wall with dynamic structure for adapting to various environmental conditions.β-1,3-Glucan recognition proteins activate the innate immune system of insects by recognizing surface molecules of fungi.However,the associations between pathogenicity and the different components of entomopathogenic fungal cell walls remain unclear.Three Beauveria bassiana strains were selected that have significantly differing virulence against Bombyx mori.The molecular mechanisms underlying the immune response in B.mori were investigated using RNA sequencing,which revealed differences in the immune response to different B.bassiana strains at 12 h post-infection.Immunofluorescence assays revealed thatβ-1,3-glucan content had an opposite trend to that of fungal virulence.β-1,3-Glucan injection upregulated BmβGRP4 expression and significantly reduced the virulence of the high-virulence strain but not that of the medium-virulence or low-virulence strains.BmβGRP4 silencing in B.mori with RNA interference resulted in the opposite virulence pattern,indicating that the virulence of B.bassiana was affected by the cell walls’content ofβ-1,3-glucan,which could be recognized by BmβGRP4.Furthermore,interference with the gene CnA(calcineurin catalytic A subunit)involved inβ-1,3-glucan synthesis eliminated differences in virulence between B.bassiana strains.These results indicate that strains of a single species of pathogenic fungi that have differing cell wall components are recognized differently by the innate immune system of B.mori. | Yulong Wang Zhen Liu Xuebing Yin Shihong Liu Kai Wang Rongjie Wan Haoran Chen Xinyang Li Bo Huang | 2024 | Insect Science2024，31，1： | 0 |
| 5 | Uniform wurtzite MnSe nanocrystals with surface-dependent magnetic behavior显示文摘锰硒化物(MnSe ) 作为一个重要磁性的半导体拥有唯一的磁性,但是 MnSe nanocrystals 的合成和性质是因为无能,与另外的半导体 nanocrystals 相比开发获得高质量的 MnSe 的更少,特别在亚稳的 wurtzite 结构。这里,我们成功地经由负担得起一致水晶尺寸的一条胶体的途径制作了 wurtzite MnSe nanocrystals 并且定制形状。胺表面活化剂的选择有约束力的力量是在形状控制和形状进化的决定因素。如果在反应解决方案的 oleylamine 的部分被 trioctylamine 代替,子弹形状能被转变成梭形状,并且四足动物形状的 nanocrystals 能在 trioctylamine 系统被形成。三维(3D ) 塑造子弹的 nanorods 的结构被先进传播电子显微镜(TEM ) 表明了 3D 断层摄影术技术。高分辨率的 TEM (HRTEM ) 和电子精力损失光谱学(鳗) 显示出那平面缺点的结构象叠差错和 twinning 沿着那样[001 ] 方向在子弹形状的生长期间产生。根据小心的 HRTEM 观察,我们为 wurtzite MnSe nanotetrapods 的形成建议 quadra 双胞胎核心生长机制。而且,由于他们的 noncompensated,表面旋转的 wurtzite MnSe nanocrystals 表演 lowtemperature 表面纺纱眼镜行为和堵住的温度与增加 nanocrystals 的表面区域 / 卷比率从 8.4 K 增加到 18.5 K。我们的结果提供 wurtzite MnSe nanocrystals 的系统的研究。 | Jie Zhang Fan Zhang Xuebing Zhao Xinran Wang Lifeng Yin Chongyun Liang Min Wang Ying Li Jiwei Liu Qingsong Wu Renchao Che | 2013 | Nano Research2013，6，4： | 0 |
| 6 | CASCIRE surveillance network and work on avian influenza viruses显示文摘Studies on influenza virus by Chinese Academy of Sciences(CAS)could be traced back as early as 2005 by the CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI),who discovered that Qinghai-like Clade 2.2H5N1 subtype highly pathogenic avian influenza virus(HPAIV)first caused severe outbreak in wild birds in Qinghai Lake(Liu et al.,2005). | Yuhai Bi Weifeng Shi Jianjun Chen Quanjiao Chen Zhenghai Ma Gary Wong Wenxia Tian Renfu Yin Guanghua Fu Yongchun Yang William J.Liu Chuansong Quan Qianli Wang Shenghu He Xiangdong Li Qianfeng Xia Lixin Wang Zhaohui Pan Laixing Li Hong Li Wen Xu Ying Luo Hui Zeng Lianpan Dai Haixia Xiao Kirill Sharshov Alexander Shestopalov Yi Shi Jinghua Yan Xuebing Li Yingxia Liu Fumin Lei Wenjun Liu George F.Gao | 2017 | Science China(Life Sciences)2017，60，12： | 0 |
| 7 | pH-responsive aldehyde-bearing cyclometalated iridium(Ⅲ) complex for tracking intracellular pH fluctuations under external stimulation显示文摘Intracellular p H undertakes critical functions in various biological and pathological processes. It is important to monitor intracellular p H fluctuations for understanding physiological and pathological processes.Here, one aldehyde-bearing cyclometalated iridium(Ⅲ) complex([(4-pba)_(2)Ir(dcphen)]PF_(6), 4-pba = 4-(2-pyridyl) benzaldehyde, dcphen = 4,7-dichloro-1,10-phenanthroline, probe 1) was synthesized and used to track intracellular p H fluctuations. Probe 1 displayed p H-dependent luminescence property in p H range of 1.81–6.81 with an evaluated p Kavalue of 4.30 in BR buffer-DMSO(v:v = 99:1). An intramolecular hydrogen bonds assisted p H-responsive mechanism was proposed for the p H-responsive behavior of probe1. Probe 1 was successfully applied for imaging and tracking p H fluctuations in He La cells under external stimulation with fast response time, good photostability as well as low cytotoxicity and high cell permeability. This work demonstrates that aldehyde-bearing cyclometalated iridium(Ⅲ) complex can be used as alternative p H-responsive probe for real-time tracking intracellular p H fluctuations, which provides a strategy for the design of p H-responsive probe in versatile applications. | Manping Qian Danyang Zhang Hetong Qi Xuebing Yang Guanjun Yin Chengxiao Zhang Jianzhong Guo Honglan Qi | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 8 | Construction of charge transfer chain in Bi_(12)TiO_(20)-Bi_(4)Ti_(3)O_(12)/α-Bi_(2)O_(3)composites to accelerate photogenerated charge separation显示文摘Photogenerated charge separation and transfer is one of the bottleneck steps in photocatalysis,and efficient charge separation strategies are strongly desired.Here,mimicking the electron transport chain in natural photosynthesis,we report the design and fabrication of a charge transfer chain using bismuth-based semiconductor as a proof-of-concept.In view of the thermodynamic energy band positions and structural similarity based on the density functional theory(DFT)analysis,heterostructured combination ofα-Bi_(2)O_(3),perovskite-like Bi_(4)Ti_(3)O_(12),and sillenite Bi12TiO20 was designed for fabrication of charge transfer chain.By tuning the molar ratio of Bi and Ti precursors,the Bi_(4)Ti_(3)O_(12)and Bi12TiO20 particles were formed on the surface ofα-Bi_(2)O_(3)by an insitu transformation process,giving rise to Bi_(12)TiO_(20)-Bi_(4)Ti_(3)O_(12)/α-Bi_(2)O_(3)composites with charge transfer chain.We propose that the effective charge transfer is accomplished amongα-Bi_(2)O_(3),Bi12TiO20,and Bi_(4)Ti_(3)O_(12),which significantly improves the photogenerated charge separation and transfer,as indicated by photoluminescene,time-resolved photoluminescene,and electrochemical impedance spectra results.As expected,the Bi_(12)TiO_(20)-Bi_(4)Ti_(3)O_(12)/α-Bi_(2)O_(3)shows the superior photocatalytic activity for the degradation of environmental pollutants with high concentration.Even for the refractory pollutants like 4-chlorophenol,the optimal Bi_(12)TiO_(20)-Bi_(4)Ti_(3)O_(12)/α-Bi_(2)O_(3)composite shows 28 times higher than that ofα-Bi_(2)O_(3)for photocatalytic degradation,verifying the superiority of photogenerated charge transfer chain in photocatalysis.This work demonstrates the feasibility of the charge transfer chain strategy to boost the photogenerated charge separation,which is of great significance for designing energy and environmental-related materials in heterogonous photocatalysis. | Jincheng Yin Xuebing Chen Guanna Li Dongxu Liu Chun Li Rengui Li Bingxing Xie Johannes H.Bitter Jing Zhang | 2023 | Nano Research2023，16，3： | 0 |
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