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| 1 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 2 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 3 | Passive source range estimation with a single receiver in shallow water显示文摘An approach for long-range passive impulsive source ranging with a single receiver in shallow water is proposed,which utilizes the frequency spectrum of the warped signal autocorrelation function via warping transform.For an ideal waveguide,there are invariable frequency features both in the frequency spectrum of the warped signal corresponding to modal cut-off frequencies and the warped signal autocorrelation function due to modal interference.These intrinsic frequency features can be used to passive source ranging.So,the approximate relationship between the frequency of warped signal at an unknown source range and the intrinsic frequency extracted by the time warping transform is derived.These rules can be generalized to an actual shallow water waveguide.Employing an acoustic model to offer the invariable frequency spectrum features,the impulsive signal data collected by a single hydrophone in the North Yellow Sea in December 2011 are analyzed to verify the proposed source ranging approach.The estimated ranges are in good agreement with the ranges measured by GPS,and the mean relative error of range estimation is less than 10%. | QI Yubo ZHOU Shihong REN Yun WANG Dejun LIU Jianjun FENG Xiqiang | 2015 | Chinese Journal of Acoustics2015，34，1： | 13 |
| 4 | Incorporating DeepLabv3+and object-based image analysis for semantic segmentation of very high resolution remote sensing images显示文摘Semantic segmentation of remote sensing images is an important but unsolved problem in the remote sensing society.Advanced image semantic segmentation models,such as DeepLabv3+,have achieved astonishing performance for semantically labeling very high resolution(VHR)remote sensing images.However,it is difficult for these models to capture the precise outlines of ground objects and explore the context information that revealing relationships among image objects for optimizing segmentation results.Consequently,this study proposes a semantic segmentation method for VHR images by incorporating deep learning semantic segmentation model(DeepLabv3+)and objectbased image analysis(OBIA),wherein DSM is employed to provide geometric information to enhance the interpretation of VHR images.The proposed method first obtains two initial probabilistic labeling predictions using a DeepLabv3+network on spectral image and a random forest(RF)classifier on hand-crafted features,respectively.These two predictions are then integrated by Dempster-Shafer(D-S)evidence theory to be fed into an object-constrained higher-order conditional random field(CRF)framework to estimate the final semantic labeling results with the consideration of the spatial contextual information.The proposed method is applied to the ISPRS 2D semantic labeling benchmark,and competitive overall accuracies of 90.6%and 85.0%are achieved for Vaihingen and Potsdam datasets,respectively. | Shouji Du Shihong Du Bo Liu Xiuyuan Zhang | 2021 | International Journal of Digital Earth2021，14，3： | 9 |
| 5 | Rb-Sr and Sm-Nd Isochron Ages of the Dongmozhazhua and Mohailaheng Pb-Zn Ore Deposits in the Yushu area, southern Qinghai and Their Geological Implications显示文摘Located on the northeast margin of the Qiangtang terrane between the Jinshajiang suture zone and Bangonghu-Nujiang suture zone, the Dongmozhazhua and Mohailaheng Pb-Zn deposits in the Yushu area of Qinghai Province are representative Pb-Zn deposits of the Pb-Zn-Cu polymetallic mineralization belt in the northern part of the Nujiang-Lancangjiang-Jinshajiang area, which are in the front belt of the Yushu thrust nappe system. The formed environments of these two deposits are different from those of sediment-hosted base metal deposits elsewhere in the world. The authors hold that they were formed during the Indian-Asian continental collision and developed within the foldthrust belt combined with thrust and strike-slip-related Cenozoic basins in the interior of the collisional zone. Studying on the metallogenic epochs of these two deposits is helpful to the understanding of ore-forming regularity of the regional Pb-Zn-Cu mineralization belt and also to the search for new deposits in this region. The age of the Dongmozhazhua deposit has been determined by the Rb-Sr isochron method for sphalerite residues, whereas the age of the Mohailaheng deposit has been determined by the Rb-Sr isochron method for sphalerite residues and the Sm-Nd isochron method for fluorite. The age of the Dongmozhazhua deposit is 35.0±0.0 Ma((87Sr/86Sr)0=0.708807) for sphalerite residues. The age of the Mohailaheng deposit is 32.2±0.4 Ma((87Sr/86Sr)0=0.708514) for sphalerite residues and 31.8±0.3 Ma((143Nd/144Nd)0=0.512362) for fluorite with an average of 32.0 Ma. Together with the regional geological setting during mineralization, a possible tectonic model for metallogeny of the Dongmozhazhua and Mohailaheng Pb-Zn deposits has been established. These two ages are close to the ages of the Pb-Zn deposits in the Lanping and Tuotuohe basins, indicating that it is possible that the narrow 1000-kilometer-long belt controlled by a thrust nappe system on the eastern and northern margins of the Tibetan plateau could be a giant Pb-Zn mineralized belt. | TIAN Shihong GONG Yingli YANG Zhusen HOU Zengqian LIU Yingchao SONG Yucai XUE Wanwen LU Haifeng WANG Fuchun ZHANG Yubao ZHU Tian YU Changjie | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 8 |
| 6 | An active damping vibration control system for wind tunnel models显示文摘In wind tunnels, long cantilever sting support systems with low structural damping encounter flow separation and turbulence during wind tunnel tests, which results in destructive low-frequency and big-amplitude resonance, leading to data quality degradation and test envelope limitation. To ensure planed test envelope and obtain high-quality data, an active damping vibration control system independent of balance signal based on stackable piezoelectric actuators and velocity feedback using accelerometer, is proposed to improve the support stability and wind tunnel testing safety in transonic wind tunnel. Meanwhile, a design of powerful sting-root embedded active damping device is given and an active vibration control method is presented based on the mechanism analysis of aircraft model vibration. Furthermore, a self-adaptive fuzzy Proportion Differentiation(PD) control model is proposed to realize control parameters adjustment automatically for various testing conditions. Besides, verification tests are performed in laboratory and a continuous transonic wind tunnel. Experimental results indicate that the aircraft model does not vibrate obviously from -4° to 11° at Ma = 0.6, the number of useable angle-of-attack has increased by 7° at Ma = 0.6 and 5° at Ma = 0.7 respectively, satisfying the requirements of practical wind tunnel tests. | Wei LIU Mengde ZHOU Zhengquan WEN Zhuang YAO Yu LIU Shihong WANG Xiaochun CUI Xiao LI Bing LIANG Zhenyuan JIA | 2019 | Chinese Journal of Aeronautics2019，32，9： | 8 |
| 7 | Fundamental and Technical Challenges for a Compatible Design Scheme of Oxyfuel Combustion Technology显示文摘Oxyfuel combustion with carbon capture and sequestration(CCS) is a carbon-reduction technology for use in large-scale coal-fired power plants. Significant progress has been achieved in the research and development of this technology during its scaling up from 0.4 MWth to 3 MWth and 35 MWth by the combined efforts of universities and industries in China. A prefeasibility study on a 200 MWe large-scale demonstration has progressed well, and is ready for implementation. The overall research development and demonstration(RD&D) roadmap for oxyfuel combustion in China has become a critical component of the global RD&D roadmap for oxyfuel combustion. An air combustion/oxyfuel combustion compatible design philosophy was developed during the RD&D process. In this paper, we briefly address fundamental research and technology innovation efforts regarding several technical challenges, including combustion stability, heat transfer, system operation, mineral impurities, and corrosion. To further reduce the cost of carbon capture, in addition to the large-scale deployment of oxyfuel technology, increasing interest is anticipated in the novel and nextgeneration oxyfuel combustion technologies that are briefly introduced here, including a new oxygen-production concept and flameless oxyfuel combustion. | Chuguang Zheng Zhaohui Liu Jun Xiang Liqi Zhang Shihong Zhang Cong Luo Yongchun Zhao | 2015 | Engineering2015，1，1： | 7 |
| 8 | Rhizosphere and bulk soil enzyme activities in a Nothotsuga longibracteata forest in the Tianbaoyan National Nature Reserve,Fujian Province,China显示文摘The rhizosphere, distinct from bulk soil, is defined as the volume of soil around living roots and influenced by root activities. We investigated protease,invertase, cellulase, urease, and acid phosphatase activities in rhizosphere and bulk soils of six Nothotsuga longibracteata forest communities within Tianbaoyan National Nature Reserve, including N. longibracteata + either Phyllostachys pubescens, Schima superba, Rhododendron simiarum, Cunninghamia lanceolata, or Cyclobalanopsis glauca, and N. longibracteata pure forest. Rhizosphere soils possessed higher protease, invertase, cellulase, urease,and acid phosphatase activities than bulk soils. The highest invertase, urease, and acid phosphatase activities were observed in rhizosphere samples of N. longibracteata+ S.superba. Protease was highest in the N. longibracteata + R. simiarum rhizosphere, while cellulase was highest in the pure N. longibracteata forest rhizosphere.All samples exhibited obvious rhizosphere effects on enzyme activities with a significant linear correlation between acid phosphatase and cellulase activities(p \ 0.05) in rhizosphere soils and between protease and acid phosphatase activities(p \ 0.05) in bulk soils. A principal component analysis, correlating 13 soil chemical properties indices relevant to enzyme activities, showed that protease, invertase, acid phosphatase, total N, and cellulase were the most important variables impacting rhizosphere soil quality. | Shihong Xiao Huiming You Weibin You Jinshan Liu Changtang Cai Jianqin Wu Zhirong Ji Shihua Zhan Zhesen Hu Zhongrui Zhang Dongjin He | 2017 | Journal of Forestry Research2017，28，3： | 7 |
| 9 | Ailanthone:a new potential drug for castration-resistant prostate cancer显示文摘Prostate cancer (PCa) is the most common male cancer [1, 2]. PCa initially depends on androgen receptor (AR) signaling for growth and survival. Androgen deprivation therapy causes a temporary reduction in PCa tumor burden, but the tumor eventually develops into castrationresistant prostate cancer (CRPC) with the ability to grow again in the absence of androgens [3]. Mechanisms of CRPC progression include AR amplification and overexpression [4], AR gene rearrangement promoting synthesis of constitutively-active truncated AR splice variants (ARVs) [4], and induction of intracrine androgen metabolic enzymes [3]. Current anti-androgen therapies including MDV3100 (Enzalutamide) and abiraterone have focused on the androgen-dependent activation of AR through its ligand-binding domain (LBD), but do not provide a continuing clinical benefit for patients with CRPC and presumably fail due to multiple mechanisms including the expression of AR-Vs lacking the LBD [5]. These AR-Vs signal in the absence of ligand and are therefore resistant to LBD-targeting AR antagonists or agents that repress androgen biosynthesis [6]. | Shihong Peng Zhengfang Yi Mingyao Liu | 2017 | Chinese Journal of Cancer2017，36，5： | 6 |
| 10 | Early diagenetic growth of carbonate concretions in the upper Doushantuo Formation in South China and their significance for the assessment of hydrocarbon source rock显示文摘Mineralogical and textural characteristics and organic carbon composition of the carbonate concretions from the upper Doushantuo Formation (ca. 551 Ma) in the eastern Yangtze Gorge area reveal their early diagenetic (shallow) growth in organic-rich shale. High organic carbon content (up to 10%) and abundance of framboidal pyrites in the hosting shale suggest an anoxic or euxinic depositional environment. Well-preserved cardhouse clay fabrics in the concretions suggest their formation at 0-3 m burial depth, likely associated with microbial decomposition of organic matter and anaerobic oxidation of methane. Gases through decomposition of organic matter and/or from methanogenesis created bubbles and cavities, and anaerobic methane oxidation at the sulfate reduction zone resulted in carbonate precipitation, filling in bubbles and cavities to form spherical structures of the concretions. Rock pyrolysis analyses show that the carbonate concretions have lower total organic carbon (TOC) content but higher effective carbon than those in the host rocks. This may be caused by enclosed organic matter in pores of the concretions so that organic matter was protected from further modification during deep burial and maintained high hydrocarbon generating potential even in over-matured source rock. As a microbialite sensu latu, concretions have special growth conditions and may provide important information on the microbial activities in depositional and early burial environments. | DONG Jin ZHANG ShiHong JIANG GanQing ZHAO QingLe LI HaiYan SHI XiaoYing LIU JunLai | 2008 | Science China Earth Sciences2008，51，9： | 4 |
| 11 | Graphene oxide as a photocatalytic nuclease mimicking nanozyme for DNA cleavage显示文摘Developing nanomaterial-based enzyme mimics for DNA cleavage is an interesting challenge and it has many potential applications.Single-layered graphene oxide(GO)is an excellent platform for DNA adsorption.In addition,GO has been employed for photosensitized generation of reactive oxygen species(ROS).Herein,we demonstrate that GO sheets could cleave DNA as anuclease mimicking nanozyme in the presence of UV or blue light.For various DNA sequences and lengths,well-defined product bands were observed along with photobleaching of the fluorophore label on the DNA.Different from previously reported GO cleavage of DNA,our method did not require metal ions such as Cu^2+.Fluorescence spectroscopy suggested a high adsorption affinity between GO and DNA.For comparison,although zero-dimensional fluorescent carbon dots(C-dots)had higher photosensitivity ir terms of producing ROS,their cleavage activity was much lower and only smeared cleavage products were observed,indicatingthat the ROS acted on the DNA in solution.Based on the results,GO behaved like a classic heterogeneous catalyst following substrate adsorption,reaction,and product desorption steps.This simple strategy may help in the design of new nanozymes by introducing light. | Jinyi Zhang Shihong Wu Lingzi Ma Peng Wu Juewen Liu | 2020 | Nano Research2020，13，2： | 4 |
| 12 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 13 | A Method of Eliminating Information Disclosure in View Publishing显示文摘Although it is convenient to exchange data by publishing view, but it may disclose sensitive information. The problem of how to eliminate information disclosure becomes a core problem in the view publishing process. In order to eliminate information disclosure, deciding view security algorithm and eliminating information disclosure algorithm are proposed, and the validity of the algorithms are proved by experiment. The experimental results showing, deciding view security algorithm can decide the safety of a set of views under prior knowledge, and eliminating information disclosure algorithm can eliminate disclosure efficiently. | LIU Guohua GAO Shihong | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 4 |
| 14 | Rayleigh backscattering: a method to highly compress laser linewidth显示文摘Ultra-narrow linewidth laser with several hundred hertz at room temperature has attracted a great deal of attention in recent years and played a critical role in both optical sensing and communication fields. In this paper, a new method based on Rayleigh backscattering to highly compress the laser linewidth was proposed and demonstrated theoretically and experimentally. By theoretical analysis and simulation, Rayleigh backscattering can be collected in any waveguide structure and all wave bands,which could have a revolutionary impact on the field of laser. A single-longitudinal mode fiber ring laser with130-Hz linewidth was achieved with self-injection feedback structure at normal atmospheric temperature. The linewidth compression based on Rayleigh backscattering lies in the fact that laser linewidth after scattering is narrower than that of incident light in high Rayleigh scattering structure. The self-rejection feedback method expanding free spectra range of laser cavity simultaneously was used to further suppress the mode-hopping and stabilizing output. Experimental results showed that the laser linewidth can be easily narrowed to hundreds of hertz with side-mode suppression up to 75 dB. This agrees with the theoretical analysis and simulation results qualitatively. | Tao Zhu Shihong Huang Leilei Shi Wei Huang Min Liu Kinseng Chiang | 2014 | Chinese Science Bulletin2014，59，33： | 3 |
| 15 | Effect of Lactobacillus salivarius H strain isolated from Chinese dry-cured ham on the color stability of fresh pork显示文摘The aim of this research is to investigate the effect of lactic acid bacteria(LAB)on color stability of fresh pork.Of the seven LAB strains isolated from the Chinese dry-cured hams,H strain was identified as Lactobacillus salivarius(CCTCC M2010374)by serial biochemical tests and 16S rRNA analysis.The fresh pork samples were immersed in the H strain and Lactobacillus fermentum extracts for 1 min after ultrasonic cells disruption and samples immersed in sterile 0.9%(m/V)saline was served as a control group,then samples were vacuum packaged and stored at 4◦C.Nitrate oxide synthase(NOS)and metmyoglobin(MetMb)reductase were found in the cells extracts of H strain.After 6 days of storage,H strain group was found to be associated with the highest CIE a*values(P<0.05)and the lowest MetMb(41%).L.salivarius H strain has thus shown a beneficial effect on the color stability of fresh pork.Further research is necessary to elucidate its mechanism.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Zhen Luo Vincent Gasasira Yuhui Huang Dengyong Liu Xihong Yang Shihong Jiang Wenfeng Hu | 2013 | Food Science and Human Wellness2013，2，3： | 3 |
| 16 | Filling Rules of Bevel Gears in the Closed-die Cold Forging显示文摘The closed-died cold forging technology of the bevel gears used in Jada car was investigated. With the analysis of the strain field and velocity field of the plastic deformation and the endured forces of the dies, the filling rules for the metal were analyzed by the elastic-plastic finite element method (FEM). The results show that there is a great difference among closed-die cold forging, extrusion and forging, as far as the metal flowing is concerned. The outer addendum cannot be filled completely in the closed-die cold forging of the bevel gears, and the round angle will be formed. But it does not influence the application of the bevel gears. At the beginning, the rigid area is formed in the cavity of the lower die. And then it will move upwards to supply the metal for the gear filling. For the closed-die cold forging of the bevel gears, the force acting on the upper die and the lower die is significantly different. | Huamin LIU Liangju HUANG Shenhua YANG Shihong ZHANG | 2005 | Journal of Materials Science & Technology2005，21，6： | 3 |
| 17 | Effects of stocking density on the growth and immunity of Atlantic salmon salmo salar reared in recirculating aquaculture system(RAS)显示文摘Atlantic salmon reared in recirculating aquaculture system(RAS) may lead to inappropriately high stocking density, because ?sh live in a limited space. Finding the suitable stocking density of Atlantic salmon reared in RAS is very important for RAS industry. In this paper, the in?uence of stocking density on growth and some stress related physiological factors were investigated to evaluate the ef fects of stocking density. The ?sh were reared for 220 days at ?ve densities(A: 24 kg/m^3; B: 21 kg/m^3; C: 15 kg/m^3; D: 9 kg/m^3 and E: 6 kg/m^3). The results show that 30 kg/m^3 might be the maximum density which RAS can af ford in China. The stocking densities under 30 kg/m^3 have no ef fect on mortality of Atlantic salmon reared in RAS. However, the speci?c growth rate(SGR), ?nal weight and weight gain in the high density group were signi?cantly lower than the lower density groups and middle density groups. Moreover, feed conversion rate(FCR) had a negative correlation with density. Plasma hormone T_3 and GH showed signi?cant decrease with the increase of the stocking density of the experiment. Furthermore, thyroid hormone(T 3), GH(growth hormone) activities were decreased with stocking density increase. However, plasma cortisol, GOT(glutamic oxalacetic transaminase) and GPT(glutamic pyruvic transaminase) activities were increase with stocking density increase. And the stocking density has no ef fects on plasma lysozyme of Atlantic salmon reared in RAS. These investigations would also help devise effcient ways to rear adult Atlantic salmon in China and may, in a way, help spread salmon mariculture in China. | WANG Yanfeng CHI Liang LIU Qinghua XIAO Yongshuang MA Daoyuan XIAO Zhizhong XU Shihong LI Jun | 2019 | Journal of Oceanology and Limnology2019，37，1： | 2 |
| 18 | Effect of sound waveguide on near-field in shallow water显示文摘Wavenumber integration and eigenray techniques for near-filed computation within range of 100 m and frequency from 20 Hz to 15 kHz in shallow water are used in this paper.In different hydrological conditions, locations of measurement system, central frequencies and 1/3 octave frequency band, the calculated transmission loss of near-field is compared with that calculated according to the spherical attenuation law. Numerical simulation shows that the muliple-path interference effect in sound wavegulde should be considered to evaluate the sound level of underwater radiating | ZHOU Shihong LIU Mingke CHEN Zongqi (Institute of Dalian Scientific Test and Control Technology Dalian 116013) | 1999 | Chinese Journal of Acoustics1999，18，3： | 2 |
| 19 | Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats显示文摘In this study, rat models of Parkinson's disease induced by substantia nigra injection of 6-hydroxy-dopamine were intragastrically administered Zhichan powder daily for 50 days. Reverse transcription PCR results showed that tyrosine hydroxylase mRNA expression in the rat substantia nigra was significantly increased, while monoamine oxidase B mRNA expression was significantly decreased in the Zhichan powder group, compared with the model group. In addition, the levels of striatal dopamine and homovanillic acid, the ratio of dopamine to homovanillic acid, and the activity of blood superoxide dismutase were all higher in the Zhichan powder group than in the model group, but the content of malondialdehyde in blood was lower. Our experimental findings indicate that Zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase B and tyrosine hydroxylase in the substantia nigra of Parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. | Qingwei Zhou Jiajun Chen Shihong Yi Yongwei Lou Weimin Tang Yongmao Liu Pengguo Zhang | 2012 | Neural Regeneration Research2012，7，27： | 2 |
| 20 | Characterization of viromes within mosquito species in China显示文摘Mosquitoes are vectors of multiple disease-causing agents that cause worldwide outbreaks of serious infectious diseases in both humans and animals. These arboviral agents include Dengue virus (DENV), Zika virus (ZIKV), chikungunya virus, yellow fever virus, Japanese encephalitis virus (JEV),and Rift Valley fever virus. Thus, mosquitoes are key to the study of viral origin, spread, and the epidemic tendency of these infectious diseases (Hall and Macdonald, 2016). | Jiang Du Fan Li Yelin Han Shihong Fu Bo Liu Nan Shao Haoxiang Su Weijia Zhang Dandan Zheng Wenwen Lei Jie Dong Lilian Sun Ying He Jianmin Wang Fan Yang Huanyu Wang Guodong Liang Zhiqiang Wu Qi Jin | 2020 | Science China(Life Sciences)2020，63，7： | 2 |
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