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| 1 | Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application显示文摘Erythrocytes(red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems(DDS) because of their features of biocompatibility,biodegradability, and long circulating half-life. Accordingly, a 'camouflage' comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed,providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems. | Qing Xia Yongtai Zhang Zhe Li Xuefeng Hou Nianping Feng | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 26 |
| 2 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 3 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 4 | Preliminary assessing no-surgical treatment response in bronchogenic carcinoma with double-phase contrast material-enhanced computed tomography显示文摘评估双阶段的功效的目的在 preliminarily 在 bronchogenic 癌估计没有外科的治疗反应对比提高材料的计算断层摄影术(CT ) 。有在没有外科的治疗以后的 bronchogenic 癌的 52 个病人经历了双阶段的方法对比提高材料的计算断层摄影术。在非离子的对比材料经由赌注被管理以后,二螺线 CT 扫描分别地在 25 和 90 秒点被获得以由使用一个汽车注射者的 4 mL/s 的率的肘的静脉。每扫描上的 Precontrast 和柱子对比变细被记录,山峰高度是计算的。改进模式在在对比媒介的注射以后在 25 和 90 秒点获得的图象上被评估。结果 Precontrast 变细,在 25 和 90 秒点的柱子对比变细是 42.20 ± 7.43 胡, 57.35 ± 10.09 胡和 71.85 ± 12.45 胡分别地。在 precontrast 变细的统计上重要的差别都没在我们在治疗前在情况中被获得的旧学习(吝啬的 precontrast 变细 40.70 胡) 在学习和结果在我们的结果之间被发现(t = 1.455, P = 0.152 >
0.05 ) 。在没有外科的治疗以后的 bronchogenic 癌的山峰高度(29.46 ± 10.85 胡) 是比在在我们的旧学习获得的治疗前的 bronchogenic 癌的显著地低的(吝啬的山峰高度 35.79 胡;t = 4.206, P = 0.001 <
0.05 ) 。52 个盒子中的 32 个在 90 秒点显示出同类的改进。32 个盒子,与不同类的改进有 21, 7 与不同类的改进, 2 与中央改进并且 2 与在 25 秒点的外部改进。在没有外科的处理以后的结论 Bronchogenic 癌在对比材料的管理以后显示出渐渐的增加到山峰高度。山峰高度能反映 bronchogenic 癌的血供应并且可能是为在 bronchogenic 癌的没有外科的治疗反应的评估的索引。 | Shenjiang Li Yong Zhao Yan Zhu Feng Zhu Debin Liu Wenjie Liang Xuefeng Cui Wenjie Bi | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 9 |
| 5 | Solidification microstructure of M2 high speed steel by different casting technologies显示文摘The present work investigated the solidification microstructure of AISI M2 high speed steel manufactured by different casting technologies, namely iron mould casting and continuous casting. The results revealed that the as-cast structure of the steel was composed of the iron matrix and the M2C eutectic carbide networks, which were greatly refined in the ingot made by continuous casting process, compared with that by the iron mould casting process. M2C eutectic carbides presented variation in their morphologies and growth characteristics in the ingots by both casting methods. In the ingot by iron mould casting, they have a plate-like morphology and grow anisotropically. However, in the ingot made by continuous casting, the carbides evolved into the fiber-like shape that exhibited little characteristics of anisotropic growth. It was noticed that the fiber-like M2C was much easier to decompose and spheroidize after heated, as a result, the carbides refined remarkably, compared with the case of plate-like carbides in the iron mould casting ingot. | Zhou Xuefeng Fang Feng Jiang Jianjing | 2011 | China Foundry2011，8，3： | 9 |
| 6 | Towards single-molecule optoelectronic devices显示文摘Benefiting from the development of molecular electronics and molecular plasmonics, the interplay of light and electronic transport in molecular junctions has attracted growing interest among researchers in both fields, leading to a new research direction of 'single-molecule optoelectronics'. Here, we review the latest developments of photo-modulated charge transport,electroluminescence and Raman spectroscopy from single-molecule junctions, and suggest future directions for single-molecule optoelectronics. | Lijue Chen Anni Feng Maoning Wang Junyang Liu Wenjing Hong Xuefeng Guo Dong Xiang | 2018 | Science China Chemistry2018，61，11： | 7 |
| 7 | Flotation behavior of four dodecyl tertiary amines as collectors of diaspore and kaolinite显示文摘由一系列第三级的胺(DRN,兽穴, DPN 和 DBN ) 之一的水铝石和 kaolinite 的筹款被调查。第三级的胺与水铝石相比为 kaolinite 显示出更好漂浮的恢复。最大的恢复 D 值在从 3 ~ 8 的一个 pH 范围上是 45% 。英尺红外系列在 kaolinite 和水铝石的表面上证实氢氧根组的存在。希腊语的第六个字母潜在的大小证明矿物质表面否定地在一个宽 pH 范围上被控告。氢氧根组的电离主要说明控告机制的表面。第三级的胺的吸附在在一个收集者之间的静电的效果对静电的效果和差别主要到矿物质表面上到期,二种矿物质能解释筹款分离。从取代者组的引入的电子、位的效果为四第三级的胺导致不同收集的力量。 | Changmiao Liu Feng Ansheng Guo Zhenxu Cao Xuefeng Hu Yuehu | 2011 | Mining Science and Technology2011，21，2： | 5 |
| 8 | Challenges and strategies in high-accuracy manufacturing of the world’s largest SiC aspheric mirror显示文摘In the process of manufacturing the world’s largest silicon carbide(SiC)aspheric mirror,the primary difficulties are mirror blank preparation,asphere fabrication,and testing,as well as cladding and coating.Specifically,the challenges include the homogeneity of the complicated structure casting,accuracy and efficiency of the fabrication process,print-through effect,fidelity and precision of test procedure,stress and denseness of cladding process,the dynamic range of interferometric measurement,and air turbulence error due to the long optical path.To break through such a barrier of difficulties,we proposed the water-soluble room temperature vanishing mold and gel casting technology,homogeneous microstructure reaction-formed joint technology,nano-accuracy efficient compound fabrication,gravity unloading technology,high-denseness low-defect physical vapor deposition(PVD)Si-cladding technology,test data fusion method,and time-domain averaging method,etc.Based on the proposed technologies and methods,we have accomplished the world’s largest SiC aspheric mirror with a size of φ4.03 m.The impressive performance of the SiC aspheric mirror is validated by the characteristics of the fabricated SiC aspheric mirror.The aerial density of the SiC blank is less than 120 kg/m^(2),surface shape test accuracy is better than 6 nm RMS,thickness inhomogeneity of the cladding layer is less than 5%,and the final surface figure error and roughness are 15.2 nm RMS and 0.8 nm RMS,respectively. | Xuejun Zhang Haixiang Hu Xiaokun Wang Xiao Luo Ge Zhang Wenxing Zhao Xiaoyi Wang Zhenyu Liu Ling Xiong Erhui Qi Congcong Cui Yanchao Wang Yingjie Li Xu Wang Longxiang Li Yang Bai Qiang Cheng Zhiyu Zhang Ruigang Li Wa Tang Xuefeng Zeng Weijie Deng Feng Zhang | 2022 | Light(Science & Applications)2022，11，12： | 3 |
| 9 | Natural variations of ZmSRO1d modulate the trade-off between drought resistance and yield by affecting ZmRBOHC-mediated stomatal ROS production in maize显示文摘While crop yields have historically increased,drought resistance has become a major concern in the context of global climate change.The trade-off between crop yield and drought resistance is a common phenomenon;however,the underlying molecular modulators remain undetermined.Through genome-wide association study,we revealed that three non-synonymous variants in a drought-resistant allele of ZmSRO1d-R resulted in plasma membrane localization and enhanced mono-ADP-ribosyltransferase activity of ZmSRO1d toward ZmRBOHC,which increased reactive oxygen species(ROS)levels in guard cells and promoted stomatal closure.ZmSRO1d-R enhanced plant drought resilience and protected grain yields under drought conditions,but it led to yield drag under favorable conditions.In contrast,loss-of-function mutants of ZmRBOHC showed remarkably increased yields under well-watered conditions,whereas they showed compromised drought resistance.Interestingly,by analyzing 189 teosinte accessions,we found that the ZmSRO1d-R allele was present in teosinte but was selected against during maize domestication and modern breeding.Collectively,our work suggests that the allele frequency reduction of ZmSRO1d-R in breeding programs may have compromised maize drought resistance while increased yields.Therefore,introduction of the ZmSRO1d-R allele into modern maize cultivars would contribute to food security under drought stress caused by global climate change. | Huajian Gao Junjun Cui Shengxue Liu Shuhui Wang Yongyan Lian Yunting Bai Tengfei Zhu Haohao Wu Yijie Wang Shiping Yang Xuefeng Li Junhong Zhuang Limei Chen Zhizhong Gong Feng Qin | 2022 | Molecular Plant2022，15，10： | 2 |
| 10 | 显示恶性孤立肺结节分叶征的理想CT层厚(英文)显示文摘Objective: The aim of this study was to determine an optimal slice thickness that was efficient in revealing lobulation of malignant solitary pulmonary nodules (SPNs) on multi-slice spiral computed tomography (MSCT) images preliminarily. Methods: Fifty patients with malignant SPNs (diameter ≤ 3 cm) underwent multidetector-row computed tomography of the chest in a single-breath-hold technique. The raw data were acquired with a collimation of 0.625 mm. Three sets of contiguous images were reconstructed with 1-, 2-, and 5-mm slice thickness, respectively. The lobulation sign of SPNs on the computed tomography (CT) images presented in 1-, 2-, and 5-mm slice thickness was compared. Using the 1-mm sections as the gold standard, an optimal slice thickness in revealing lobulation sign of SPNs was determined. Results: The 1-mm-thick images CT revealed 98 lobulations (25 with chord distance < 1 mm; 30 with chord distance 1-2 mm; 43 with chord distance > 2 mm) of 45 malignant SPNs. 18 lobulations with chord distance < 1 mm presented in 2-mm-thick sections were as same as those in 1-mm-thick sections. Statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.023 < 0.05). 16 lobulations with chord distance < 1 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.004 < 0.05). The 24 lobulations with chord distance 1-2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number were found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.261 > 0.05). 13 lobulations with chord distance 1-2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.003 < 0.05). 40 lobulations with chord distance ﹥2 mm presented in 2-mm-thick sections were as same as that in 1-mm-thick sections. No statistically significant difference in lobulations number was found between that revealed in 2-mm-thick images and that in 1-mm-thick images (P = 0.631 > 0.05). 36 lobulations with chord distance ﹥2 mm presented in 5-mm-thick sections were as same as that in 1-mm-thick sections. There was no statistically significant difference in lobulations number between that revealed in 5-mm-thick images and that in 1-mm-thick images (P = 0.264 > 0.05). Conclusion: It is suggested that the use of 1-mm slice thickness is suitable in revealing lobulations with chord distance < 1 mm. A 2-mm slice thickness is suggested to be used in revealing lobulations with chord distance 1-2 mm and 5-mm slice thickness to be used in revealing lobulations with chord distance > 2 mm. | Shenjiang Li Changcheng Li Xin Wang Debin Liu Wenjie Liang Feng Zhu Yan Zhu Xuefeng Cui Wenjie Bi | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 2 |
| 11 | Impact of switching frequencies on the TID response of SiC power MOSFETs显示文摘Different switching frequencies are required when SiC metal-oxide-semiconductor field-effect transistors(MOSFETs)are switching in a space environment.In this study,the total ionizing dose(TID)responses of SiC power MOSFETs are investigated under different switching frequencies from 1 kHz to 10 MHz.A significant shift was observed in the threshold voltage as the frequency increased,which resulted in premature failure of the drain-source breakdown voltage and drain-source leakage current.The degradation is attributed to the high activation and low recovery rates of traps at high frequencies.The results of this study suggest that a targeted TID irradiation test evaluation method can be developed according to the actual switching frequency of SiC power MOSFETs. | Sheng Yang Xiaowen Liang Jiangwei Cui Qiwen Zheng Jing Sun Mohan Liu Dang Zhang Haonan Feng Xuefeng Yu Chuanfeng Xiang Yudong Li Qi Guo | 2021 | Journal of Semiconductors2021，42，8： | 2 |
| 12 | Microstructures and Phase Transition Points of As-Cast Mg-Zn-Y System Alloys显示文摘As-cast microstructures and their distribution of Mg-Zn-Y ternary alloy with high magnesium, low zinc and yttrium were examined using Nikon Epiphot optical microscopy(OM), RigakuD/max-3C X-ray diffraction(XRD), and JEOL JSM-6700F scanning electron microscopy (SEM) equipped with an energy-dispersive X-ray spectroscopy (EDS). In the as-cast microstructures, Yttrium and zinc tend to segregate at grain boundaries, therefore meets the compositional condition to form Mg-Zn-Y compounds at grain boundaries even with relatively low content of Y. The principal ternary phase in Mg-Zn-Y alloys can be consisted of W-phase (Mg3Y2Zn3), Z-phase (Mg3YZn6) and X-phase (Mg 12YZn). Combining differential thermal analyzer (DTA) the phase transformation temperature of alloys were discussed. The eutectic melting temperature of W-phase at 520 ℃, the phase transformation temperature of Z-phase at 445 ℃ and the melting temperature of X-phase at 540 ℃ are shown. | Feng Juanni Guo Xuefeng Xu Chunjie Zhang Zhongming | 2006 | Journal of Rare Earths2006，24，1： | 2 |
| 13 | The behavior of N, N - dipropyl dodecyl amine as a collector in the flotation of kaolinite and diaspore 显示文摘 | Changmiao Liu Yuehua Hu Ansheng Feng Zhenxu Guo Xuefeng Cao | 2011 | Minerals Engineer- ing2011，24，8： | 1 |
| 14 | A single parameter dynamic searching algorithm for multi-layer neural networks (Part I) 显示文摘 | WANG Xuefeng FENG Yingjun ZHAO Xin | 2008 | International Journal of Innovative Computing Information and Control2008，4，9： | 1 |
| 15 | Development of akinetic model for industrial oxidation of p-xylene by RBF-PLSand CCA显示文摘 | YAN Xuefeng DU Wenli QIAN Feng | 2004 | AIChE Journal:Process Systems Engineering2004，50，6： | 1 |
| 16 | A single parameter dynamic searching algorithm for muhi-layer neural networks (Part II) 显示文摘 | WANG Xuefeng ZHAO Xin FENG Yingjun | 2008 | International Journal of Innovative Computing Information and Control2008，4，11： | 1 |
| 17 | Development of a Kinetic Model for Industrial Oxidation of p-Xylene by RBF-PLS and CGA显示文摘 | Yan Xuefeng Du Wenli Qian Feng | 2004 | AIChE Journal2004，50，6： | 1 |
| 18 | 显示文摘 | Sun Taolei Feng Lin Gao Xuefeng | 2005 | Accounts of Chemical Research2005，38，8： | 1 |
| 19 | Optimization of mechanized soil covering path based on the agronomic mode of full-film double-ditch with double-width filming显示文摘In order to further improve the working performance and efficiency of mechanized tillage operation of a full-film double-ditch seedbed,under the working conditions of different parameters of the spiral push-type soil covering device with double-width filming,the dynamic soil covering characteristics and soil covering uniformity of the device were analyzed,the collaborative and interactive coupling mechanism of the horizontal pushing process of the mulching soil and horizontally two-way spiral soil transmission device were revealed,and the main reasons for the influence of different soil covering belts on the change of soil particle number distribution were analyzed.Based on the full-film double-ditch mode with double-width filming,the mechanized soil covering path was optimized.In order to further reduce the disturbance on mulching soil by two-way spiral pushing,a kind of parallel shunt type soil covering device with double-width filming was designed,then a discrete element method was adopted to make simulation analysis and optimize the parallel shunt type soil covering device with double-width filming.Field verification tests showed that after the operation of the full-film double-ditch combined machine with double-width filming and soil covering installed with the parallel shunt type soil covering device,the qualified rate of the film edge soil covering width was 96.1%,an increase of 1.6%compared to that before optimization;the qualified rate of soil covering width at the center of the big ridge was 93.5%,an increase of 1.9%compared to that before optimization;the qualified rate of the soil covering thickness was 97.7%,an increase of 0.2%compared to that before optimization.The test indicators reached the requirements of relevant national and industrial standards,showing that the test results met the design requirements,and the working conditions of verification tests were consistent with the simulation results. | Fei Dai Wenjuan Guo Xuefeng Song Yang Zhang Ruijie Shi Feng Wang Wuyun Zhao | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 1 |
| 20 | 显示文摘 | Feng Xiqiao Gao Xuefeng Wu Ziniu | 2007 | Langmuir2007，23，9： | 1 |
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