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| 1 | Pathogenic effects of biofilm with chronic pseudomonas aeruginosa lung infection in rats显示文摘Objective:To establish an animal model of P.aeruginosa biofilm associated with chronic pulmonary infection and investigate the pathogenic effects of biofilm.Methods:Experiments in vitro,measuring the MICS,MBCS of levofloxacin(LFX),ceftazidime(CAZ)in PAO579 in alginate beads and planktonic PAO579.Rats were challenged with 0.1 ml of PAO579(109CFU/ml)in alginate beads or 0.1 ml of planktonic PAO579(109 CFU/ml),3,7,14 days after challenging,bacteriological,pathological features were observed.Results:The MICS,MBCS of LFX,CAZ in PAO579 in alginate beads were higher than those in planktonic PAO579 in vitro.CFU/lung in alginate beads group was significantly higher than that in planktonic bacteria group(P = 0.002,P = 0.004,P = 0.002,respectively);macroscopic lung pathology and the inflammation in alginate beads group were significantly more severe compared to those in planktonic bacteria group in vivo.Conclusion:P.aeruginosa biofilm protected bacterium from killing of antibiotics and might mediate the host immune damage in the lung tissue and made bacterium evade the host immune defense. | Ping Yan Yiqiang Chen Zhijun Song Hong Wu Jinliang Kong Xuejun Qin | 2008 | Journal of Nanjing Medical University2008，22，1： | 7 |
| 2 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 3 | Palynological evidence sheds new light on the age of the Liuqu Conglomerates in Tibet and its geological significance显示文摘The Liuqu Conglomerates consist of a suit of terrestrial molasse deposits formed in a foreland basin of the Himalaya-Tibet orogenic belt before the collision of India and Eurasia.These deposits record considerable geological information regarding the late tectonic evolution of the Neotethyan ocean.The palynological study of interlayers of mudstone and mud-sandstones indicates an Oligocene age.The palynological assemblage consists mainly of deciduous broad-leaved angiosperms,with some coniferous gymnosperms and evergreen broad-leaved angiosperms.The deposits reflect a broad-leaved deciduous forest or mixed with conifer-broad-leaved forest ecotypes,showing a warm-temperate or temperate zone climatic environment.This work provides significant new information about the tectonic evolution,paleogeography,and paleoenvironment of southern Tibet during the Cenozoic. | WEI LiJie LIU XiaoHan YAN FuHua MAI XueShun LI GuangWei LIU XiaoBing ZHOU XueJun | 2011 | Science China Earth Sciences2011，54，6： | 5 |
| 4 | Improved EMD Based on Piecewise Cubic Hermite Interpolation and Mirror Extension显示文摘This paper proposes an improved Empirical mode decomposition(EMD)method piecewise cubic hermite interpolation and mirror extension.Firstly,mirror expansion method is used to expand preliminary signal endpoint;then the piecewise cubic Hermite interpolation algorithm is applied to obtain the envelopes.Finally Intrinsic mode functions(IMFs)are obtained through improved EMD(MPC-HEMD).Through the analysis on Simulation signals and Electroencephalogram(EEG)signals,we found that the new method was better than the traditional method. | ZHANG Xuejun HUO Yan WAN Dongsheng | 2020 | Chinese Journal of Electronics2020，29，5： | 4 |
| 5 | A novel one-step reaction sodium-sulfur battery with high areal sulfur loading on hierarchical porous carbon fiber显示文摘Room temperature sodium-sulfur(RT Na-S)batteries are gaining extensive attention as attractive alternatives for large-scale energy storage,due to low cost and high abundancy of sodium and sulfur in nature.However,the dilemmas regarding soluble polysulfides(Na_(2)Sn,4 | Qiubo Guo Shuo Sun Keun-il Kim Hongshen Zhang Xuejun Liu Chenglin Yan Hui Xia | 2021 | Carbon Energy2021，3，3： | 3 |
| 6 | Crystallization Behavior of High Purity Fused Magnesia显示文摘The chemical composition and microstructure of Tibetan microcrystalline magnesite were studied by means of XRF,XRD and FESEM. It is found that the microcrystalline magnesite has uniformly distributed grains,mostly in the range of 2-4 μm,and the MgO content is47. 80%. In fused magnesia,the druses are colorless transparent periclase megacrysts without impurity,while the crust sand is white,with a high MgO content up to97%-99%. The periclase crystals are big,appearing as faced and step-growth morphology. Massive secondary long columnar periclase is crystallized. | LI Xuejun GAO Zhenxin YAN Guanghui ZHANG Wei FU Qiuhua | 2017 | China's Refractories2017，26，2： | 2 |
| 7 | A comparison of lightwand and laryngoscopic intubation techniques in patients undergoing laparoscopic cholecystectomy显示文摘Objective:To assess the effects of lightwand and laryngoscopic intubation techniques in patients undergoing laparoscopic cholecystectomy (LC). Methods:300 ASA physical status I and II patients,undergoing LC,were randomly assigned to two groups,with 150 cases in each group. Patients in the LS group underwent endotracheal intubation using a standard direct-suspension laryngoscopic technique. Patients in the LW group were intubated by using transillumination with a lightwand. Mean arterial pressure and heart rate were recorded before induction,and at 1,3 and 5 min after intubation. The incidence and of sore throat,hoarseness,and dysphagia was assessed twenty-four hours after surgery. Results:This study demonstrated no clinically significant difference in cardiovascular variables between the two techniques. Patients had a significantly lower incidence of sore throat,hoarseness,and dysphagia when the lightwand was used for intubation. Conclusion:This study suggests that lightwand intubation may decrease the incidence of postoperative sore throat,hoarseness,and dysphagia,thereby potentially increasing satisfaction in surgical patients. Therefore,more frequent use of the lightwand is recom-mended for endotracheal intubation. | Chenglan Xie Congjin Ju Jiawen Cheng Xuejun Yan Dengquan Guo | 2009 | Journal of Nanjing Medical University2009，23，3： | 2 |
| 8 | A NEW APPROACH TO HOLISTIC NITROGEN MANAGEMENT IN CHINA显示文摘Since the 1980s,the widespread use of N fertilizer has not only resulted in a strong increase in agricultural productivity but also caused a number of environmental problems,induced by excess reactive N emissions.A range of approaches to improve N management for increased agricultural production together with reduced environmental impacts has been proposed.The 4R principles(right product,right amount,right time and right place)for N fertilizer application have been essential for improving crop productivity and N use efficiency while reducing N losses.For example,site-specific N management(as part of 4R practice)reduced N fertilizer use by 32%and increased yield by 5%in China.However,it has not been enough to overcome the challenge of producing more food with reduced impact on the environment and health.This paper proposes a new framework of food-chainnitrogen-management(FCNM).This involves good N management including the recycling of organic manures,optimized crop and animal production and improved human diets,with the aim of maximizing resource use efficiency and minimizing environmental emissions.FCNM could meet future challenges for food demand,resource sustainability and environmental safety,key issues for green agricultural transformation in China and other countries. | Xuejun LIU Zhenling CUI Tianxiang HAO Lixing YUAN Ying ZHANG Baojing GU Wen XU Hao YING Weifeng ZHANG Tingyu LI Xiaoyuan YAN Keith GOULDING David KANTER Robert HOWARTH Carly STEVENS Jagdish LADHA Qianqian LI Lei LIU Wim DE VRIES Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 2 |
| 9 | Substrate-bound structure of the E. coil multidrug resistance transporter MdfA显示文摘 | Jie Heng Yan Zhao Ming Liu Yue Liu Junping Fan Xianping Wang Yongfang Zhao Xuejun C Zhang | 2015 | Cell Research2015，25，9： | 2 |
| 10 | Thermodynamics of ABC transporters显示文摘ABSTRACTABC transporters 形式所有 transporter 家庭的最大,和他们的结构的学习在最近的年取得了巨大的进步。然而尽管有如此的进展,决定的精确机制在 ATP 水解作用和 conformational 变化追随者之间联合精力要阐明的底层绑定遗体。这里,我们在场我们为 ABC 进口商和出口商的热力学的分析,并且介绍微分绑定的精力和有弹性的 conformational 精力的二个新概念进讨论。我们希望 ABC transporters 的结构的分析将从今以后也考虑运输机制的热力学的方面。 | Xuejun C. Zhang Lei Han Yan Zhao | 2016 | Protein & Cell2016，7，1： | 2 |
| 11 | Comparison of severe pneumonia caused by Human metapneumovirus and respiratory syncytial virus in hospitalized children显示文摘 | Yuqing Wang Wei Ji Zhengrong Chen Yong Yan Xuejun Shao Jun Xu | 2014 | Indian Journal of Pathology and Microbiology2014，，： | 1 |
| 12 | Damage evolution of yttria-stabilized zirconia induced by He irradiation显示文摘 | Tengfei Yang Xuejun Huang Yuan Gao Chenxu Wang Yanwen Zhang Jianming Xue Sha Yan Yugang Wang | 2011 | Journal of Nuclear Materials2011，，1： | 1 |
| 13 | Image restoration of an off-axis three-mirror anastigmatic optical system with wavefront coding technology显示文摘 | Yan Feng Zheng Ligong Zhang Xuejun | 2008 | Optics Express2008，17，16： | 1 |
| 14 | Ultrasonicpretreated waste activated sludge hydrolysis and volatile fatty acid accumulation under alkaline conditions:effect of temperature显示文摘 | ZHUO Guihua YAN Yuanyuan TAN Xuejun | | 0，，01： | 1 |
| 15 | Effect of pretreatment with different concertrations of morphine, fentanyl and tramadol on the differentiation of human helper T cells in vitro显示文摘Objective: To investigate and compare the effects of different concentrations of morphine, fentanyl and tramadol on the differentiation of human adult helper T cells in vitro. Methods: Twenty out-patients without immune disease were selected and their peripheral blood was collected. Then the whole blood of peripheral blood mononuclear cells (PBMCs) were pretreated with different concentration of morphine, fentanyl and tramadol for 24 h. The level of CD4+IFN-γ+IL-2+/CD4+IL-4+IL-10+ was analyzed by three-color flow cytometry, and the CD4+CCR5+ and CD4+CCR3+ cells were counted to observe the imbalance of Th2/Th2. Results: The number of Th2 increased significantly and the ratio of Th2/Th2 decreased dramatically compared with the control group, and there was a dose-dependent fashion in all drugs. Conclusion: Morphine, fentanyl and tramadol can direct Th0 cells toward Th2 differentiation, especially morphine and fentanyl. | Yanning Qian Wenjie Jin Ping Chen Ling Wang Huijuan Wang Yuke Tian Xuejun Zhou | 2005 | Journal of Nanjing Medical University2005，19，6： | 1 |
| 16 | Synthesis and surface properties of semi-interpenetrating fluorine-containing polyacrylate and epoxy resin networks显示文摘 | Xuejun Cui Yan Gao Shuangling Zhong Zaihang Zheng Yuxia Cheng Hongyan Wang | 2012 | Journal of Polymer Research2012，，3： | 1 |
| 17 | Spatial learning and memory defi- cit of low level polybrominated diphenyl ethers-47 in male adult rat is modulated by intracellular glutamate receptors显示文摘 | Yan T Xiang L Xuejun J | 2012 | J Toxicol Sci2012，37，： | 1 |
| 18 | Ultrasonic pretreated waste activated sludge hydrolysis and volatile fatty acid accumulation under alkaline conditions: effect of temperature 显示文摘 | ZHUO Guihua YAN Yuanyuan TAN Xuejun | 2012 | Journal of Biotechnology2012，159，1： | 1 |
| 19 | A novel virus-like particle based on hepatitis B core antigen and substrate-binding domain of bacterial molecular chaper- one DnaK显示文摘 | XueJun Wang Kai Gu Qi Yan Xiong | 2009 | Vaccine2009，，： | 1 |
| 20 | Metalens in harmony with refractive optics显示文摘Optical dispersion is an inherent property of all materials in nature. Due to the dispersion of the optical material and the phase accumulation of the light field at different wavelengths, chromatic aberration is inevitable in commercial optical lens. When taking pictures by lenses with severe chromatic aberration, the images will look blurred or noticeably colored edges (red, green, blue) around the objects, especially in high-contrast situations. Thus, achromatism, correction of the chromatic aberration, is extremely important in broadband optical applications. There are mainly two approaches in the correction of the chromatic aberration in existing optical systems: combining the refractive lenses with different dispersions or introducing the diffractive optical elements. However, it is still a technical challenge to achieve that goal in the entire visible light band. | Xueyi Zhu Shuming Wang Xuejun Yan Minghui Lu | 2019 | Science Bulletin2019，64，12： | 1 |
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