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| 1 | Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs显示文摘This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in combination,on growth performance,antioxidation,inflammation and intestinal function of weaned pigs.One hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per pen.Dietary treatments included the following:1)control diet(CON),2)CON with 300 mg/kg essential oils(EO),3)CON with 500 mg/kg protease(PRO),4)CON with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for sampling.The remaining pigs were fed for an additional week and growth performance was monitored during this period.Dietary treatments had no marked effects(P>0.05)on the growth performance of pigs.However,pigs receiving EO diet had higher(P<0.05)serumglutathione peroxidase(GSH-Px)activity,and tended to decrease(P=0.063)serum concentration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(P<0.05)abundances of phylum Actinobacteria,and genera Bifidobacterium,and lower(P<0.05)phylum Bacteroidetes and genera Alloprevotella in colonic digesta.Pigs receiving PRO diet decreased(P<0.05)the serum concentration of malondialdehyde(MDA)and diamine oxidase activity,increased(P<0.05)the villus height and the ratio of villus height to crypt depth in duodenum,increased sucrase activity in jejunal mucosa,and also increased the abundance of phylum Actinobacteria in colonic digesta.Furthermore,the synergistic effects of EO and PROwas observed(P<0.05)for pigs with decreasing serum TNF-a concentration and increasing serum GSH-Px activity.Collectively,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned pigs.EO diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on reducing inflammatory parameters in weaned pigs. | Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che | 2022 | Animal Nutrition2022，，2： | 8 |
| 2 | Structural changes in the gray matter of unmedicated patients with obsessive-compulsive disorder: a voxel-based morphometric study显示文摘The aim of the current study was to use whole brain voxel-based morphometry(VBM)to assess the gray matter(GM)changes in unmedicated patients with obsessive-compulsive disorder(OCD)compared with normal controls.We compared the GM volumes in28 patients with 22 matched healthy controls using a1.5T MRI.Three-dimensional T1-weighted magnetic resonance images were obtained from all participants.VBM was performed to detect GM volume differences between the two groups.We detected increased regional GM volumes in the bilateral middle temporal gyri,bilateral middle occipital gyri,bilateral globus pallidus,right inferior parietal gyrus,left superior parietal gyrus,right parahippocampus,right supramarginal gyrus,right medial superior frontal gyrus,and left inferior frontal opercular cortex in the OCD patients relative to controls(P<0.001,uncorrected,cluster size>100 voxels).No decreased GM volume was found in the OCD group compared with normal controls.Our findings suggest that structural changes in the GM are not limited to fronto-striato-thalamic circuits in the pathogenesis of OCD.Temporo-parietal cortex may also play an important role. | Ling Tan Qing Fan Chao You Jijun Wang Zhao Dong Xuemei Wang Kemin Chen Zeping Xiao Kaida Jiang | 2013 | Neuroscience Bulletin2013，29，5： | 5 |
| 3 | Investigation of radionuclide ^(60)Co(Ⅱ) binding to TiO_2 by batch technique,surface complexation model and DFT calculations显示文摘The interaction between radionuclides and solid/water interfaces is important to understand the physicochemical processes of radionuclides in the natural environment.Herein,the interaction of 60Co(Ⅱ) with TiO 2 in aqueous solution as a function of pH and ionic strength was studied by using batch technique combined with surface complexation model and density functional theory(DFT) calculations.The batch experimental results showed that the adsorption of 60Co(Ⅱ) was dependent on pH and independent of ionic strength,indicating the formation of inner-sphere surface complexes on TiO 2 surfaces.The results of surface complexation models and DFT calculations indicated that the surface species of 60Co(Ⅱ) adsorbed on TiO 2 followed the trend:B structure(i.e.,60Co(Ⅱ) was linked to one bridge oxygen site) was the dominant surface species at low pH,and TT structure(i.e.,60Co(Ⅱ) was linked to two terminal oxygen sites) became the important surface complex at neutral and alkaline pH values.These results demonstrated that a multi-technique approach could lead to definitive information on the structures of adsorbed 60Co(Ⅱ) at the molecular level at the TiO 2 /water interfaces,as well as realistic models to rationalize and accurately evaluate the macroscopic manifestations of radionuclide adsorption phenomena. | REN XueMei YANG ShiTong TAN XiaoLi CHEN ChangLun WANG XiangKe | 2012 | Science China Chemistry2012，55，9： | 4 |
| 4 | Enhancing sensing capacity of terahertz metamaterial absorbers with a surface-relief design显示文摘Metamaterial absorbers(MAs)serve as important electromagnetic wave-absorbing devices that have captured the attention of researchers for a long term.Functioning as sensitive detectors to determine perturbations in an ambient environment is another significant subsidiary function.Here,we theoretically propose an optimized fabrication method to implement terahertz MAs with fewer steps and also evaluate both absorption and sensing performances of such MAs realized by the new method.Simulation findings demonstrate that such MAs can basically maintain the original absorption features perfectly,including near-complete absorption at resonance as well as strong robustness to wide incident angles.Specifically,the full width at half-maximum and quality factor of the absorption resonances attenuate less than 26%and 8%with this new method,remaining in the ranges of^0.03–0.04 THz and^20–27 for two selected example MAs.More significantly,sensing capacities of this type of MA,in terms of maximum detection range(enhancing at least 9%),observable spectral modulation(increasing at least 6.3%),and refractive index sensitivity,are improved to a large extent because of more intense coupling between resonant field and matter in the case of surface-relief MAs.This stronger coupling results from exposing more spots of the resonantly high field to direct contact with an approaching analyte,which is illustrated by field profiles of the MAs at resonance in this work.Additionally,other desirable absorber features are also explored with such MAs,like functioning as building blocks to configure multiband MAs and strong robustness against fabrication errors.Such new-style terahertz MAs shown in the paper,acting as good examples,not only prove that terahertz MAs can be fabricated by the proposed time-and cost-saving route in contrast to the traditional MA fabrication process,but also can serve as novel platforms to explore other intriguing terahertz photonic effects,such as the field enhancement effect. | WEI WANG FENGPING YAN SIYU TAN HAISU LI XUEMEI DU LUNA ZHANG ZHUOYA BAI DAN CHENG HONG ZHOU YAFEI HOU | 2020 | Photonics Research2020，8，4： | 3 |
| 5 | Properties and Structure of Microcrystal Muscovite Composite Superabsorbent显示文摘Microcrystal muscovite composite superabsorbents(MMCSA) were prepared by water solution polymerization using acrylic acid, acrylamide and itaconic acid as comonomers and microcrystal muscovite as an inorganic additive. Properties, such as water absorbency, salt absorbency, gel strength, water retention capacity and structure of MMCSA characterized by SEM and XRD, were investigated. Water absorbency, salt absorbency, gel strength, water retention capacity and thermostability were enhanced by incorporation of suitable amount of microcrystal muscovite. Water absorption of MMCSA was rapid, requiring 24.55 min to reach 63% of equilibrium absorbency(1218 g/g). Microcrystal muscovite was physically combined into the polymeric network without destroying its polycrystalline structure and microcrystal muscovite composite superabsorbent had some irregular, undulant, and small microporous holes with sheet-like microcrystal muscovite distributed in the polymeric matrix. | 万涛 XIONG Lei HUANG Runqiu SUN Mengmeng QIN Lili TAN Xuemei HU Junyan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，6： | 2 |
| 6 | Advances in Urban Meteorological Research in China显示文摘Over the past decades,a large number of studies have been carried out in the field of urban meteorology in China.This paper summarizes the main progress in urban meteorology research from four aspects:urban meteorological observation network and field campaign,multi-scale model of urban meteorology,interaction between urban meteorology and atmospheric environment,and the impacts of urbanization on weather and climate.Major advances are as follows.China’s major cities have established or are improving comprehensive urban meteorological observation networks characterized by multi-platform,multi-variable,multi-scale,multi-link,and multi-function.Beijing,Nanjing,Shanghai,and other cities carried out urban meteorological field campaigns,which were included in the WMO research demonstration project.Wind tunnel experiments and scale-model outdoor experiments were successfully conducted.Multi-scale urban meteorological and air quality prediction numerical model systems have been developed and put into operational use.The urban heat island effect;urban impacts on precipitation,regional climate,and air quality;urban planning;and interaction between urban meteorology and atmospheric environment are extensively investigated.Finally,efforts to improve observational technology,data assimilation,and urban system modeling,to explore the impacts of urbanization on environment and human health,and to provide integrated urban hydro-meteorological climate and environmental services are planned ahead. | Shiguang MIAO Weimei JIANG Ping LIANG Hongnian LIU Xuemei WANG Jianguo TAN Ning ZHANG Ju LI Wupeng DU Lin PEI | 2020 | Journal of Meteorological Research2020，34，2： | 2 |
| 7 | Quantitative determination of free phytosterols in tobacco leaves by UPLC-MS/ MS显示文摘 | TAN Jianlin NIU Xuemei YANG Guangyu | 2013 | Journal of Liquid Chromatography and Related Technologies2013，36，5： | 1 |
| 8 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 9 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 10 | Identification of Functional Genetic Variants in Cyclooxygenase-2 and Their Association With Risk of Esophageal Cancer显示文摘 | Xuemei Zhang Xiaoping Miao Wen Tan Baitang Ning Zhihua Liu Yuan Hong Wenguang Song Yongli Guo Xinyu Zhang Yan Shen Boqin Qiang Fred F. Kadlubar Dongxin Lin | 2005 | Gastroenterology2005，，2： | 1 |
| 11 | Crystal structures of GI.8 Boxer virus P dimers in complex with HBGAs, a novel evolutionary path selected by the Lewis epitope显示文摘人的 noroviruses (huNoVs ) 作为附件因素,在 genogroup (G) ,我和 GII huNoVs 使用不同有约束力的接口认出 histo 血组抗原(HBGA ) 。在由主人 HBGA 的选择下面的 GII huNoVs 的基因、进化的关系很好经由很多结构的研究被阐明了;然而,在官方补给的 11 月之中的如此的关系由于仅仅有类似的有约束力的侧面的三个官方补给的 11 月的 HBGA 有约束力的接口的结构被知道的事实仍然保持不太清楚。在水晶吊楔绑定紧张的 P dimers 组织的这研究,不绑 A 和 H 抗原的 GI.8 拳击手病毒( BV ),在有吊楔 b 的建筑群( Le <啜class=“ a-plus-plus ”> b )和 Le <啜class=“ a-plus-plus ”>分别地, y 抗原被决定并且与那些相比三以前已知的官方补给的 huNoVs ,即 GI.1 Norwalk 病毒( NV ), GI.2 FUV258 ( FUV )和绑 A/H/Le 抗原的 GI.7 TCH060 ( TCH )。 BV 的 HBGA 有约束力的接口由与先锋的半乳糖交往的一个保存中央有约束力的衣袋( CBP )组成,并且一个开发得好的 Le epitope有约束力的地点由五氨基酸形成了,包括从长P环的三连续残余和从 P1 子域的海岸炮舰的残余,没在另一方面在另外的官方补给的11月被看见的一个特征,在另外的官方补给的11月观察的 H epitope/acetamido 绑定地点极大地在 BV 被堕落。这些数据解释多态的人的 HBGA 选择的官方补给的 11 月的进化路径。当 CBP 被保存时,包围 CBP 的区域是灵活的,提供为变化的自由。H epitope/acetamido 绑定地点的损失和 GI.8 BV 的 Le 有约束力的地点的加强是主机路易斯 epitope 选择的如此的变化的一个典型例子。 | Ning Hao Yutao Chen Ming Xia Ming Tan Wu Liu Xiaotao Guan Xi Jiang Xuemei Li | 2015 | Protein & Cell2015，6，2： | 1 |
| 12 | Tuning the crystallite size of monoclinic ZrO_(2) to reveal critical roles of surface defects on m–ZrO_(2) catalyst for direct synthesis of isobutene from syngas显示文摘The effects of crystallite size on the physicochemical properties and surface defects of pure monoclinic ZrO_(2) catalysts for isobutene synthesis were studied.We prepared a series of monoclinic ZrO_(2) catalysts with different crystallite size by changing calcination temperature and evaluated their catalytic performance for isobutene synthesis from syngas.ZrO_(2) with small crystalline size showed higher CO conversion and isobutene selectivity,while samples with large crystalline size preferred to form dimethyl ether(DME)instead of hydrocarbons,much less to isobutene.Oxygen defects(ODefects)analyzed by X-ray photoelectron spectroscopy(XPS)provided evidence that more ODefectsoccupied on the surface of ZrO_(2) catalysts with smaller crystalline size.Electron paramagnetic resonance(EPR)and ultraviolet–visible diffuse reflectance(UV–vis DRS)confirmed the presence of high concentration of surface defects and Zr3+on mZrO_(2)-5.9 sample,respectively.In situ diffuse reflectance infrared Fourier transform spectroscopy(in situ DRIFTS)analysis indicated that the adsorption strength of formed formate species on catalyst reduced as the crystalline size decreased.These results suggested that surface defects were responsible for CO activation and further influenced the adsorption strength of surface species,and thus the products distribution changed.This study provides an in-depth insight for active sites regulation of ZrO_(2) catalyst in CO hydrogenation reaction. | Xuemei Wu Minghui Tan Bing Xu Shengying Zhao Qingxiang Ma Yingluo He Chunyang Zeng Guohui Yang Noritatsu Tsubaki Yisheng Tan | 2021 | Chinese Journal of Chemical Engineering2021，34，7： | 1 |
| 13 | 3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing显示文摘The three-dimensional(3D)conformation of chromatin is integral to the precise regulation of gene expression.The 3D genome and genomic variations in non-alcoholic fatty liver disease(NAFLD)are largely unknown,despite their key roles in cellular function and physiological processes.Highthroughput chromosome conformation capture(Hi-C),Nanopore sequencing,and RNA-sequencing(RNA-seq)assays were performed on the liver of normal and NAFLD mice.A high-resolution 3D chromatin interaction map was generated to examine different 3D genome hierarchies including A/B compartments,topologically associated domains(TADs),and chromatin loops by Hi-C,and whole genome sequencing identifying structural variations(SVs)and copy number variations(CNVs)by Nanopore sequencing.We identified variations in thousands of regions across the genome with respect to 3D chromatin organization and genomic rearrangements,between normal and NAFLD mice,and revealed gene dysregulation frequently accompanied by these variations.Candidate target genes were identified in NAFLD,impacted by genetic rearrangements and spatial organization disruption.Our data provide a high-resolution 3D genome interaction resource for NAFLD investigations,revealed the relationship among genetic rearrangements,spatial organization disruption,and gene regulation,and identified candidate genes associated with these variations implicated in the pathogenesis of NAFLD.The newly findings offer insights into novel mechanisms of NAFLD pathogenesis and can provide a new conceptual framework for NAFLD therapy. | Lina Xu Lianhong Yin Yan Qi Xuemei Tan Meng Gao Jinyong Peng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 14 | Hypervalent iodine-mediated gem-difluorination of vinyl halides enabled by exclusive 1,2-halo migration显示文摘β-Difluorinated alkyl halides are of significant value in the modular synthesis of gem-difluorinated molecules.An exclusive 1,2-halo migratory gem-difluorination of vinyl halides with in situ-generated PhIF_(2)·HF is described.This protocol provides a general and practical approach towards a wide variety ofβ-difluorinated alkyl bromides.Bothα-andβ-bromoalkyl alkenes are suitable substrates,leading to two distinct types of products.The extension of this protocol to vinyl chloride and iodide are also feasible.The synthetic versatility of this method has been highlighted by the late-stage modification of complex small molecules and further transformations of theβ-difluorinated alkyl halides to valuable CF_(2)-containing compounds. | Chenglong Li Yangzhen Liao Xuemei Tan Xiaozu Liu Peijun Liu Wen-Xin Lv Honggen Wang | 2021 | Science China Chemistry2021，64，6： | 1 |
| 15 | Assessment of urban air quality in China using air pollution indices (APIs)显示文摘 | Litao Wang Pu Zhang Shaobo Tan Xiujuan Zhao Dandan Cheng Wei Wei Jie Su Xuemei Pan | 2013 | Journal of the Air & Waste Management Association2013，，2： | 1 |
| 16 | Resistin and insulin resistance in hepatocytes: Resistin disturbs glycogen metabolism at the protein level显示文摘 | Yang Yang Meifang Xiao Yiqing Mao Hui Li Shuyong Zhao Yi Gu Rong Wang Jianqiang Yu Xuemei Zhang David M. Irwin Gang Niu Huanran Tan | 2008 | Biomedicine & Pharmacotherapy2008，，5： | 1 |
| 17 | Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer显示文摘 | Wen Tan Jianxiong Wu Xuemei Zhang | 2007 | Carcinogenesis2007，28，6： | 1 |
| 18 | Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer显示文摘 | Zhang Xuemei Miao Xiaoping Tan Wen | 2005 | Gastroenterology2005，129，： | 1 |
| 19 | The type IX secretion system: Insights into its function and connection to glycosylation in Cytophaga hutchinsonii显示文摘The recently discovered type IX secretion system(T9SS)is limited to the Bacteroidetes phylum.Cytophaga hutchin-sonii,a member of the Bacteroidetes phylum widely spread in soil,has complete orthologs of T9SS components and many T9SS substrates.C.hutchinsonii can efficiently degrade crystalline cellulose using a novel strategy,in which bacterial cells must be in direct contact with cellulose.It can rapidly glide over surfaces via unclear mech-anisms.Studies have shown that T9SS plays an important role in cellulose degradation,gliding motility,and ion assimilation in C.hutchinsonii.As reported recently,T9SS substrates are N-or O-glycosylated at their C-terminal domains(CTDs),with N-glycosylation being related to the translocation and outer membrane anchoring of these proteins.These findings have deepened our understanding of T9SS in C.hutchinsonii.In this review,we focused on the research progress on diverse substrates and functions of T9SS in C.hutchinsonii and the glycosylation of its substrates.A model of T9SS functions and the glycosylation of its substrates was proposed. | Wenxia Song Xueke Zhuang Yahong Tan Qingsheng Qi Xuemei Lu | 2022 | Engineering Microbiology2022，2，3： | 0 |
| 20 | An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation显示文摘An aerosol formulation containing 7.5 mg of R-salbutamol sulfate was developed.The aerosol was nebulized with an air-jet nebulizer,and further assessed according to the new European Medicines Agency(EMA)guidelines.A breath simulator was used for studies of delivery rate and total amount of the active ingredient at volume of 3 mL.A next generation impactor(NGI)with a cooler was used for analysis of the particle size and in vitro lung deposition rate of the active ingredient at 51C.The anti-asthmatic efficacy of the aerosol formulation was assessed in guinea pigs with asthma evoked by intravenous injection of histamine compared with racemic salbutamol.Our results show that this aerosol formulation of R-salbutamol sulfate met all the requirements of the new EMA guidelines for nebulizer.The efficacy of a half-dose of R-salbutamol equaled that of a normal dose of racemic salbutamol. | Xuemei Zhang Qing Liu Junhua Hu Ling Xu Wen Tan | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 0 |
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