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| 1 | OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice显示文摘 | Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas Pamela C. Ronald | 2008 | Molecular Plant2008，1，3： | 39 |
| 2 | Laser performance of the SG-Ⅲ laser facility显示文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Xuewei Deng | 2016 | High Power Laser Science and Engineering2016，4，3： | 13 |
| 3 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 4 | Improving CLM4.5 Simulations of Land–Atmosphere Exchange during Freeze–Thaw Processes on the Tibetan Plateau显示文摘Soil is heterogeneous and has different thermal and hydraulic properties, causing varied behavior in heat and moisture transport. Therefore, soil has an important effect on land–atmosphere interactions. In this study, an improved soil parameterization scheme that considers gravel and organic matter in the soil was introduced into CLM4.5(Community Land Model). By using data from the Zoige and Madoi sites on the Tibetan Plateau, the ability of the model to simultaneously simulate the duration of freeze–thaw periods, soil temperature, soil moisture, and surface energy during freeze–thaw processes, was validated. The results indicated that:(1) the new parameterization performed better in simulating the duration of the frozen, thawing, unfrozen, and freezing periods;(2) with the new scheme, the soil thermal conductivity values were decreased;(3) the new parameterization improved soil temperature simulation and effectively decreased cold biases;(4) the new parameterization scheme effectively decreased the dry biases of soil liquid water content during the freezing, completely frozen, and thawing periods, but increased the wet biases during the completely thawed period; and(5) the net radiation, latent heat flux, and soil surface heat flux of the Zoige and Madoi sites were much improved by the new organic matter and thermal conductivity parameterization. | Siqiong LUO Xuewei FANG Shihua LYU Yu ZHANG Boli CHEN | 2017 | Journal of Meteorological Research2017，31，5： | 13 |
| 5 | Decellularized extracellular matrix scaffolds:Recent trends and emerging strategies in tissue engineering显示文摘The application of scaffolding materials is believed to hold enormous potential for tissue regeneration.Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds,they have limited repair capacity due to the difficulties in overcoming the immunogenicity,simulating in-vivo microenvironment,and performing mechanical or biochemical properties similar to native organs/tissues.Fortunately,the emergence of decellularized extracellular matrix(dECM)scaffolds provides an attractive way to overcome these hurdles,which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components.The consequent cell-seeded construct based on dECM scaffolds,especially stem cell-recellularized construct,is considered an ideal choice for regenerating functional organs/tissues.Herein,we review recent developments in dECM scaffolds and put forward perspectives accordingly,with particular focus on the concept and fabrication of decellularized scaffolds,as well as the application of decellularized scaffolds and their combinations with stem cells(recellularized scaffolds)in tissue engineering,including skin,bone,nerve,heart,along with lung,liver and kidney. | Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu | 2022 | Bioactive Materials2022，7，4： | 10 |
| 6 | Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent显示文摘Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.Methods: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. The patients were categorized into two groups based on the LVI status: a positive group(PG;presence of LVI) and a negative group(NG;absence of LVI). The clinicopathological factors corrected with LVI and prognostic variables were analyzed. Additionally, a pathological lymphovascular-node(lvN) classification system was proposed to evaluate the superiority of its prognostic prediction of GC patients compared with that of the eighth edition of the N staging system.Results: Two hundred twenty-four patients(22.2%) had LVI. The depth of invasion and lymph node metastasis were independently associated with the presence of LVI. GC patients with LVI demonstrated a significantly lower overall survival(OS) rate than those without LVI(42.8% vs. 68.9%, respectively;P<0.001). In multivariate analysis,LVI was identified as an independent prognostic factor for GC patients(hazard ratio: 1.370;95% confidence interval: 1.094-1.717;P=0.006). Using strata analysis, significant prognostic differences between the groups were only observed in patients at stage I-IIIa or N0-2. The lvN classification was found to be more appropriate to predict the OS of GC patients after curative surgery than the pN staging system. The-2 log-likelihood of lvN classification(4,746.922) was smaller than the value of pN(4,765.196), and the difference was statistically significant(χ^2=18.434, P<0.001).Conclusions: The presence of LVI influences the OS of GC patients at stage Ⅰ-Ⅲ a or N0-2. LVI should be incorporated into the pN staging system to enhance the accuracy of the prognostic prediction of GC patients. | Liangliang Wu Yuexiang Liang Chen Zhang Xiaona Wang Xuewei Ding Chongbiao Huang Han Liang | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 7 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
| 8 | Deciphering Rice Lesion Mimic Mutants to Understand Molecular Network Governing Plant Immunity and Growth显示文摘Plant lesion mimic mutants(lmms)generally possess autoimmunity and hypersensitive response(HR)-like cell death in the absence of biotic or abiotic stress.They have attracted much attention because they are useful tools for deciphering the interaction between defense signaling and growth.Recent studies have identified more than 30 lmms involved in the plant immune response and cell death in rice.Genes underlying these lmms,coding for diverse types of proteins,mainly regulate transcription,protein translation and modification,vesicular trafficking and catalyzation of metabolism.Here,we presented an overview of the most recent advances on the study of lmms in rice and proposed a perspective on potential utilization of LMM genes in agriculture. | ZHU Xiaobo ZE Mu CHERN Mawsheng CHEN Xuewei WANG Jing | 2020 | Rice science2020，27，4： | 7 |
| 9 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 10 | Fighting the enemy: How rice survives the blast pathogen's attack显示文摘Global food security is threatened by rice blast disease caused by the filamentous fungus Magnaporthe oryzae.An understanding of rice resistance mechanisms is fundamental to developing strategies for disease control.In this review,we summarize recent advances in pathogen-associated molecular pattern-triggered immunity,effector-triggered immunity,defense regulator-mediated immunity,and effects of nutrient elements on rice blast resistance.We outline strategies used for breeding rice cultivars with improved disease resistance.We also present the major research challenges for rice blast disease resistance and propose approaches for future investigation. | Junjie Yin Lijuan Zou Xiaobo Zhu Yuyan Cao Min He Xuewei Chen | 2021 | The Crop Journal2021，9，3： | 6 |
| 11 | Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration显示文摘Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue engineering.Designing and fabricating hydrogels with high adhesive strength,stability and regeneration potential are major challenges to be overcome.This study fabricated injectable adhesive hyaluronic acid(HA)hydrogel modified by aldehyde groups and methacrylate(AHAMA)on the polysaccharide backbone with multiple anchoring mechanisms(amide bond through the dynamic Schiff base reaction,hydrogen bond and physical interpenetration).AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment(at least 7 days),together with higher adhesive strength(43 KPa to skin and 52 KPa to glass),as compared to commercial fibrin glue(nearly 10 KPa)and HAMA hydrogel(nearly 20 KPa).The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared in situ.In vitro cell culture experiments showed that AHAMA hydrogel could enhance proliferation(1.2-folds after 3 days)and migration(1.5-folds after 12 h)of bone marrow stem cells(BMSCs),as compared to cells cultured in a culture dish.Furthermore,in a rat osteochondral defect model,implanted AHAMA hydrogel significantly promoted integration between neo-cartilage and host tissues,and significantly improved cartilage regeneration(modified O’Driscoll histological scores of 16.0±4.1 and 18.3±4.6 after 4 and 12-weeks of post-implantation in AHAMA groups respectively,12.0±2.7 and 12.2±2.8 respectively in HAMA groups,9.8±2.4 and 11.5±2.1 respectively in untreated groups).Hence,AHAMA hydrogel is a promising adhesive biomaterial for clinical cartilage regeneration and other biomedical applications. | Jiaqing Chen Jiabei Yang Li Wang Xuewei Zhang Boon Chin Heng Dong-An Wang Zigang Ge | 2021 | Bioactive Materials2021，6，6： | 6 |
| 12 | Differential expression analysis and regulatory network reconstruction for genes associated with muscle growth and adipose deposition in obese and lean pigs显示文摘During the growth and development of skeletal muscle cells and adipose cells, the regulatory mechanism of micro-effect polygenes determines porcine meat quality, carcass characteristics and other relative quantitative traits. Obese and lean type pig breeds show obvi- ous differences in muscle growth and adipose deposition; however, the molecular mechanism underlying this phenotypic variation remains unknown. We used pathway-focused oligo microarray studies to examine the expression changes of 140 genes associated with muscle growth and adipose deposition in longissimus dorsi muscle at six growth stages (birth, 1, 2, 3, 4 and 5 months) of Landrace (a leaner, Western breed) and Taihu pigs (a fatty, indigenous, Chinese breed). Variance analysis (ANOVA) revealed that differences in the expression of 18 genes in Landrace pigs and three genes in Taihu pigs were very significant (FDR-adjusted permutation, P < 0.01) and di?erences for 22 genes in Landrace pigs and seven genes in Taihu pigs were significant (FDR-adjusted permutation, P < 0.05) among six growth stages. Clustering analysis revealed a high level of signi?cance (FDR-adjusted, P < 0.01) for four gene expression patterns, in which genes that strongly up-regulated were mainly associated with the positive regulation of myofiber formation and fatty acid biogenesis and genes that strongly down-regulated were mainly associated with the inhibition of cell proliferation and positive regulation of fatty acid b-oxidation. Based on a dynamic Bayesian network (DBN) model, gene regulatory networks (GRNs) were reconstructed from time-series data for each pig breed. These two GRNs initially revealed the distinct differences in physiological and biochemical aspects of muscle growth and adipose deposition between the two pig breeds; from these results, some potential key genes could be identified. Quantitative real-time RT-PCR (QRT-PCR) was used to verify the microarray data for five modulated genes, and a good correlation between the two measures of expression was observed for both two pig breeds at different growth stages (r = 0.876 ± 0.095). These results highlight some possible candidate genes for porcine meat quality and carcass traits and provide some data on which gene(s) should be further studied for elucidating the molecular mechanism of muscle growth and fat deposition. | Mingzhou Li Xuewei Li Li Zhu Xiaokun Teng Huasheng Xiao Surong Shuai Lei Chen Qiang Li Yujiao Guo | 2008 | Progress in Natural Science:Materials International2008，18，4： | 5 |
| 13 | Theories,technologies and practices of lacustrine shale oil exploration and development:A case study of Paleogene Kongdian Formation in Cangdong sag,Bohai Bay Basin,China显示文摘As the main factors affecting stable and high production and the production regularity of lacustrine shale oil are unclear,the theoretical understandings,key exploration and development technologies,development effect and production regularity of lacustrine shale oil have been analyzed and summarized based on 700 m cores taken systematically from Paleogene Kong 2 Member of 4 wells in Cangdong sag,over 100000 analysis data and formation testing data.Three theoretical understandings on shale oil enrichment and high production have been reached:(1)High-quality shale with“three highs and one low”is the material base for shale oil enrichment.(2)Medium-slightly high thermal evolution degree is the favorable condition for shale oil enrichment.(3)Laminar felsic shale is the optimal shale layer for oil enrichment in semi-deep lake facies.Key exploration and development technologies such as shale oil enrichment layer and area evaluation and prediction,horizontal well pattern layout,shale oil reservoir fracturing,optimization of shale oil production regime have been established to support high and stable shale oil production.Under the guidance of these theoretical understandings and technologies,shale oil in Cangdong sag has achieved high and stable production,and 4 of them had the highest production of over 100 tons a day during formation testing.In particular,Well GY5-1-1 L had a daily oil production of 208 m^(3).By April,2022,the 28 wells combined have a stable oil production of 300–350 tons a day,and have produced 17.8×10^(4) t of oil cumulatively.It is found that the shale oil production of horizontal well declines exponentially in natural flow stage,and declines in step pattern and then tends stable in the artificial lift stage.Proportion of light hydrocarbons in produced shale oil is in positive correlation with daily oil production and decreases regularly during production test. | ZHAO Xianzheng ZHOU Lihong PU Xiugang JIN Fengming HAN Wenzhong SHI Zhannan CHEN Changwei JIANG Wenya GUAN Quansheng XU Jing LIU Xuewei ZHANG Wei MA Jianying | 2022 | Petroleum Exploration and Development2022，49，3： | 4 |
| 14 | Apple SERRATE negatively mediates drought resistance by regulating MdMYB88 and MdMYB124 and microRNA biogenesis显示文摘The function of serrate(SE)in miRNA biogenesis in Arabidopsis is well elucidated,whereas its role in plant drought resistance is largely unknown.In this study,we report that MdSE acts as a negative regulator of apple(Malus×domestica)drought resistance by regulating the expression levels of MdMYB88 and MdMYB124 and miRNAs,including mdm-miR156,mdm-miR166,mdm-miR172,mdm-miR319,and mdm-miR399.MdSE interacts with MdMYB88 and MdMYB124,two positive regulators of apple drought resistance.MdSE decreases the transcript and protein levels of MdMYB88 and MdMYB124,which directly regulate the expression of MdNCED3,a key enzyme in abscisic acid(ABA)biosynthesis.Furthermore,MdSE is enriched in the same region of the MdNECD3 promoter where MdMYB88/MdMYB124 binds.Consistently,MdSE RNAi transgenic plants are more sensitive to ABA-induced stomatal closure,whereas MdSE OE plants are less sensitive.In addition,under drought stress,MdSE is responsible for the biogenesis of mdm-miR399,a negative regulator of drought resistance,and negatively regulates miRNAs,including mdm-miR156,mdm-miR166,mdm-miR172,and mdm-miR319,which are positive regulators of drought resistance.Taken together,by revealing the negative role of MdSE,our results broaden our understanding of the apple drought response and provide a candidate gene for apple drought improvement through molecular breeding. | Xuewei Li Pengxiang Chen Yinpeng Xie Yan Yan Liping Wang Huan Dang Jing Zhang Lingfei Xu Fengwang Ma Qingmei Guan | 2020 | Horticulture Research2020，7，1： | 4 |
| 15 | Characterization and Fine Mapping of GLABROUS RICE 2 in Rice显示文摘Glabrous rice exhibits glabrous leaves and hulls because neither of these structures have trichomes on their surfaces.Glabrous rice varieties have become an important germplasm resource in the rice industry because they have considerable packaging efficiency and can reduce skin itching and dust during harvesting,drying,and packing(Shim et al.,2012;Zhang et al.,2012).Trichomes are ubiquitous in land plants and they originate from the expansion of the epidermal cell and then develop through growth,differentiation,or cell division to produce hair-like tissues that extend from epidermal | Yuping Wang Weilan Chen Peng Qin Yanyan Huang Bingtian Ma Xinhao Ouyang Xuewei Chen Shigui Li | 2013 | Journal of Genetics and Genomics2013，40，11： | 4 |
| 16 | OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae显示文摘Somatic embryogenesis receptor kinase(SERK)proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae(Xoo) and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid(BR) signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, respectively.OsSERK1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae. | Shimin Zuo Xiaogang Zhou Mawsheng Chen Shilu Zhang Benjamin Schwessinger Deling Ruan Can Yuan Jing Wang Xuewei Chen Pamela C.Ronald | 2014 | Journal of Integrative Plant Biology2014，56，12： | 4 |
| 17 | Understanding the molecular mechanisms of trade-offs between plant growth and immunity显示文摘Trade-offs between plant growth and immunity are a well-known phenomenon in plants that are meant to ensure the best use of limited resources.Recently,many advances have been achieved on molecular regulations of the trade-offs between plant growth and immunity.Here,we provide an overview on molecular understanding of these trade-offs including those regulated at the transcriptional level or post-transcriptional level by transcriptional factors,microRNAs,and post-translational modifications of proteins,respectively.The understanding on the molecular regulation of these trade-offs will provide new strategies to breed crops with high yield and enhanced resistance to disease. | Jing Wang Xiaoyu Long Mawsheng Chem Xuewei Chen | 2021 | Science China(Life Sciences)2021，64，2： | 4 |
| 18 | Fine mapping of the rice bacterial blight resistance gene Xa-4 and its co-segregation marker显示文摘An F2 population developed from the Xa-4 near isogenic lines, IR24 and IRBB4, was used for fine mapping of the rice bacterial blight resistance gene, Xa-4. Some restriction fragment length polymorphism (RFLP) markers on the high-density map constructed by Harushima et al. and the amplified DMA fragments homologous to the conserved domains of plant disease resistance (R) genes were used to construct the genetic linkage map around the gene Xa-4 by scoring susceptible individuals in the population. Xa-4 was mapped between the RFLP marker G181 and the polymerase chain reaction (PCR) marker M55. The R gene homologous fragment marker RS13 was found co-segregating with Xa-4 by analyzing all the plants in the population. This result opened an approach to map-based cloning of this gene, and marker RS13 can be applied to molecular marker-assisted selection of Xa-4 in rice breeding programs. | WANG Wenming ZHOU Yongli JIANG Guanhuai MA Bojun CHEN Xuewei ZHANG Qi ZHU Lihuang ZHAI Wenxue | 2000 | Chinese Science Bulletin2000，45，19： | 4 |
| 19 | Alterations in cecal microbiota of Jinhua piglets fostered by a Yorkshire sow显示文摘Gut microbiota play important roles in host health and diseases.Several factors,in particular antibiotics,affect the gut microbiota of pigs.Cross-fostering has been applied as a regular practice to equalize litter size,reduce pre-weaning mortality and increase body weight.However,the effect of cross-fostering on cecal microbiota is unclear.In this study,we fostered three Jinhua pigs to a Yorkshire sow.The fostered Jinhua piglets grew significantly faster than their biological siblings.To explore whether the cecal microbiota of piglets will alter during fostering,we characterized the cecal microbiota of allpiglets by examining the V3 hypervariable region of 16S rDNA.We observed altered cecal microbiota in these piglets using the Illumina HiSeq 2000 platform,and this was accompanied with an increase in growth rate after fostering.The relative abundance of Bacteroidetes in the fostered Jinhua piglets was decreased compared with their biological siblings,although still higher in comparison with their new littermates.Beta-diversity analysis also showed that the cecal microbiota of the adopted Jinhua piglets differed from their biological siblings with a shift toward their step-siblings.Our data show that cecal microbiota of piglets were altered after cross-fostering while the growth rate increased. | Lingjin Xian Ying Li Zhi Jiang Jideng Ma Long Jin Lei Chen Chaowei Zhou Jie Zhang Yingkai Liu Li Zhu An-an Jiang Guoqing Tang Jian Xiao Jinyong Wang Bo Zeng Mingzhou Li Xuewei Li | 2014 | Chinese Science Bulletin2014，59，32： | 4 |
| 20 | Fabrication of superstable gold nanorod-carbon nanocapsule as a molecule loading material显示文摘In this work, we fabricated a monodisperse nanocomposite by coating gold nanorods(Au NRs) with a layer of biocompatible, stable carbon, obtaining Au NR@Carbon core–shell nanocapsules, which without any functionalization could be used as a molecule loading material due to its high surface areas. In this system, the Au NR core had a high-absorption cross section for conversion of near-infrared light to heat, which could be explored for local hyperthermia. The carbon shell, which was biocompatible and stable even under concentrated acidic and alkaline conditions, was able to adsorb molecules with p–p interactions or electrostatic interactions. In comparison with Au NR@Si O2, Au NR@Carbon nanocapsules demonstrate the following merits:(1) simple and green synthesis method,(2) far more stable with respect to high-temperature stability and(3) larger molecule loading capacity,which indicate great potential in the biomedical applications. | Wei Gao Xuewei Wang Huanhuan Fan Zhiling Song Xiaofang Lai Zhuo Chen Weihong Tan | 2015 | Science Bulletin2015，60，12： | 3 |
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