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| 1 | Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo显示文摘Kaempferol 是被报导了在各种各样的恶意的肿瘤展出 antitumor 活动的 flavonoid。然而, cholangiocarcinoma (CCA ) 上的 kaempferol 的角色大部分是未知的。在这篇文章,我们发现 kaempferol 在 vitro 在 HCCC9810 和 QBC939 房间禁止了增长,减少的殖民地形成能力,和导致的 apoptosis。从 transwell 试金和愈合创伤的试金的结果证明 kaempferol 显著地在 vitro 压制了 HCCC9810 和 QBC939 房间的迁居和侵略能力。Kaempferol 被发现 Bcl-2 的表示到减少并且增加 Bax 的表情,船边交货, cleaved-caspase 3, cleaved-caspase 8, cleaved-caspase 9,并且 cleaved-PARP。另外, kaempferol 另外 downregulated phosphorylated AKT, TIMP2,和 MMP2 的层次。在 vivo,这被发现下的异种皮移植的体积(在对待 kaempferol 的组的 0.15 厘米 3) 比那小(在控制组的 0.6 厘米 3) 。Kaempferol 也在肺转移模型压制了转移 foci 的数字和卷,没有鼠标的身体重量上的显著效果。Immunohistochemistry 试金证明 Ki-67-positive 房间的数字在控制组比那在对待 kaempferol 的组是更低的。我们进一步证实在在 vivo 的 kaempferol 处理以后的 apoptosis 相关、侵略相关的蛋白质的变化类似于在 vitro 的结果。这些数据建议 kaempferol 可以是为 CCA 的处理的一个有希望的候选人代理人。 | Youyou Qin Wu Cui Xuewei Yang Baifeng Tong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 15 |
| 2 | MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells显示文摘MicroRNA-132(miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain.Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells(NSCs)and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration(MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, speci?c overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus(DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These ?ndings indicate that miR-132 is involved in opioid addiction,probably by promoting the differentiation of NSCs in the adult DG. | Meng Jia Xuewei Wang Haolin Zhang Can Ye Hui Ma Mingda Yang Yijing Li Cailian Cui | 2019 | Neuroscience Bulletin2019，35，3： | 6 |
| 3 | Overexpression of S100A4 is closely associated with the progressionand prognosis of gastric cancer in young patients显示文摘 | Hua Li Ziquan Liu Chuanxiang Xu Yunyun Chen Jianwei Zhang Bo Cui Xuewei Chen Gaihong An Xiaojun She Hongtao Liu Zifeng Jiang Tianhui Wang | 2013 | Oncology Letters2013，，5： | 1 |
| 4 | The physical and chemical properties of synthetic and natural jadeite for jewellery 显示文摘 | Zhao Tinghe Yan Xuewei Cui Shuojing Niu Wei | 1994 | Journal of Material Science1994，293，3： | 1 |
| 5 | Synthesis of the clinopyroxenes join CaMgSi2O6- NaAlSi2O6 for jewellery 显示文摘 | Zhao Tinghe Yan Xuewei Cui Shuojing Zhu Yibing | 1995 | Journal of Material Science1995，30，4： | 1 |
| 6 | UNCONDITIONALLY OPTIMAL ERROR ANALYSIS OF THE SECOND-ORDER BDF FINITE ELEMENT METHOD FOR THE KURAMOTO-TSUZUKI EQUATION显示文摘This paper aims to study a second-order semi-implicit BDF finite element scheme for the Kuramoto-Tsuzuki equations in two dimensional and three dimensional spaces.The proposed scheme is stable and the nonlinear term is linearized by the extrapolation technique.Moreover,we prove that the error estimate in L^(2)-norm is unconditionally optimal which means that there has not any restriction on the time step and the mesh size.Finally,numerical results are displayed to illustrate our theoretical analysis. | Yuan Li Xuewei Cui | 2023 | Journal of Computational Mathematics2023，41，2： | 0 |
| 7 | Measurement and Correlation of Electrical Conductivity of β-Cyclodextrin in Water Solution显示文摘The electrical conductivity of 4% β-cyclodextrin in water solution had been measured by electrode method from(323.65~353.65) K at atmospheric pressure. The experimental data were correlated with the modified Arrhenius equation, and themodel estimations showed good agreement with the experimental data. | Shanshan Jin Xuewei Cui Yingping Qi Yongfeng Shen Hua Li | 2018 | 材料科学与工程(中英文B版)2018，8，4： | 0 |
| 8 | Individual blastomeres of 4-and 8-cell embryos have ability to develop into a full organism in mouse显示文摘Following fertilization in mammals,the zygote initiates the developmental program,which has a transient capacity to generate cell types of both embryonic and extraembryonic lineages,which is defined as totipotency (Condic,2014),In mice, only zygotes and blastomeres of 2-cell stage embryos are considered totipotent,since they have the ability to develop into a full organism without the requirement of carrier cells (Tarkowski, 1959;Ishiuchi and Torres-Padilla,2013).However,the blastomeres of the 4-cell or later stage embryos quickly lose this ability (Rossant,1976). | Xinxin Zhang Tianda Li Linlin Zhang Liyuan Jiang Tongtong Cui Xuewei Yuan Chenxin Wang Zhonghua Liu Ying Zhang Wei Li Qi Zhou | 2018 | Journal of Genetics and Genomics2018，45，12： | 0 |
| 9 | Sulfation of the extracellular polysaccharide from the edible fungus Stropharia rugosoannulata with its antioxidant activity显示文摘An acidic extracellular polysaccharide(EPS)was gained from Stropharia rugosoannulata fermentation broth by the alcohol precipitate method.Sulfated derivative of EPS(S-EPS)was gained by chlorosulfonic acid-pyridine method and the conditions were as follows:pyridine as the reaction solvent,temperature 80°C,and reaction time 90 min.The chemical structure and chain conformation of EPS and S-EPS were characterized by FT-IR,NMR and size exclusion chromatography(SEC)coupled with multi-angle laser light scattering(MALLS)detection.FT-IR spectra indicated the sulfated group was linked to the polymer.The EPS mainly consists of mannose,glucose and glucuronic acid,and the glycosidic bond type is mainly(1→4)-linked and(1→6)-linked.C6 and C2 were substituted by sulfate groups.The EPS was degraded into smaller molecular weight(Mw)polysaccharides with the larger molecular size(Rg)after sulfation and S-EPS has better hydrophilicity.Moreover,the sulfated derivative S-EPS was found to have a better scavenging ability on hydroxyl radicals than EPS.It proved that the chemical modification of S.rugosoannulata polysaccharides by sulfation effectively enhanced their antioxidant activity. | Hui Hao Chun Cui Yuqing Xing Xuewei Jia Bingjie Ma Wenyi Kang Tianxiao Li Mingqi Gao Chunping Xu | 2023 | Journal of Future Foods2023，3，1： | 0 |
| 10 | Overexpression of Stella improves the efficiency of nuclear transfer reprogramming显示文摘In mammalians,the state of a somatic cell can be reversed from the terminal state to the totipotent state by means of somatic cell nuclear transfer(SCNT)(Gurdon,1962)or induced pluripotent stem cells(iPSCs)(Takahashi and Yamanaka,2006).The DNA methylation and transcriptome profiles of embryonic stem cells(ESCs)derived from SCNT embryos(NT-ESCs)correspond | Leyun Wang Fei Teng Xuewei Yuan Chao Liu qiang Wang Yufei Li Tongtong Cui Tianda Li Zhonghua Liu Qi Zhou | 2017 | Journal of Genetics and Genomics2017，44，7： | 0 |
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