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| 1 | OsWRKY62 is a Negative Regulator of Basal and Xa21-Mediated Defense against Xanthomonas orvzae pv. orvzae in Rice显示文摘 | Ying Peng Laura E. Bartley Xuewei Chen Christopher Dardick Mawsheng Chern Randy Ruan Patrick E. Canlas Pamela C. Ronald | 2008 | Molecular Plant2008，1，3： | 39 |
| 2 | Component analysis of Chinese medicine and advances in fuming-washing therapy for knee osteoarthritis via unsupervised data mining methods显示文摘OBJECTIVE: To analyze the component law of Chinese medicines in fuming-washing therapy for knee osteoarthritis(KOA), and develop new fuming-washing prescriptions for KOA through unsupervised data mining methods.METHODS: Chinese medicine recipes for fuming-washing therapy for KOA were collected and recorded in a database. The correlation coefficient among herbs, core combinations of herbs, andnew prescriptions were analyzed using modified mutual information, complex system entropy cluster, and unsupervised hierarchical clustering, respectively.RESULTS: Based on analysis of 345 Chinese medicine recipes for fuming-washing therapy, 68 herbs occurred frequently, 33 herb pairs occurred frequently, and 12 core combinations were found.Five new fuming-washing recipes for KOA were developed.CONCLUSION: Chinese medicines for fuming-washing therapy of KOA mainly consist of wind-dampness-dispelling and cold-dispersing herbs, blood-activating and stasis-resolving herbs,and wind-dampness-dispelling and heat-clearing herbs. The treatment of fuming-washing therapy for KOA also includes dispelling wind-dampness and dispersing cold, activating blood and resolving stasis, and dispelling wind-dampness and clearing heat. Zhenzhutougucao(Herba Speranskiae Tuberculatae), Honghua(Flos Carthami), Niuxi(Radix Achyranthis Bidentatae), Shenjincao(Herba Lycopodii Japonici), Weilingxian(Radix et Rhizoma Clematidis Chinensis), Chuanwu(Radix Aconiti), Haitongpi(Cortex Erythrinae Variegatae), Ruxiang(Olibanum),Danggui(Radix Angelicae Sinensis), Caowu(Radix Aconiti Kusnezoffii), Moyao(Myrrha), and Aiye(Folium Artemisiae Argyi) are the main herbs used in the fuming-washing treatment for KOA. | Jun Liu Jianke Pan Yanping Wang Dingkun Lin Dan Shen Hongjun Yang Xiang Li Minghui Luo Xuewei Cao | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 32 |
| 3 | Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent显示文摘Background:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC),while the necessity of No.14 v lymph node(14v) dissection for distal GC is still controversial.Methods:A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital were enrolled in this study,of whom,243 patients also had the 14 v dissected.Other 677 patients without 14 v dissection were used for comparison.Results:Forty-five(18.5%) patients had 14 v metastasis.There was no significant difference in 3-year overall survival(OS) rate between patients with and without 14 v dissection.Following stratified analysis,in TNM stages I,II,IIIa and IV,14 v dissection did not affect 3-year OS;in contrast,patients with 14 v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc.In multivariate analysis,14 v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio(HR),1.568;95% confidence interval(CI):1.186-2.072;P=0.002].GC patients with 14 v dissection had a significant lower locoregional,especially lymph node,recurrence rate than those without 14 v dissection(11.7 % vs.21.1%,P=0.035).Conclusions:Adding 14 v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM Ⅲb/Ⅲc. | Yuexiang Liang Liangliang Wu Xiaona Wang Xuewei Ding Hongmin Liu Bin Li Baogui Wang Yuan Pan Rupeng Zhang Ning Liu Han Liang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 4 | An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors显示文摘米饭 XA21 有免疫力的受体 kinase 和在结构上联系了 XA3 受体授与免疫到 Xanthomonas oryzae pv。oryzae (Xoo ) ,细菌的叶老家的原因的代理人。这里,我们报导 OsSERK2 的隔离(米饭体的 embryogenesis receptorkinase 2 ) 并且证明 OsSERK2 断然调整免疫由 XA21 和 XA3 以及米饭免疫者 receptorFLS2 (OsFLS2 ) 调停了。为 OsSerk2 显示的瑞斯植物 silenced 改变了形态学并且把敏感归结为荷尔蒙 brassinolide。OsSERK2 在酵母与每有免疫力的受体的 intracellulardomains 交往以一种 kinase 活动依赖者方式的二混血儿的系统。OsSERK2 在 vitro 与 XA21 经历 bidirectionaltransphosphorylation 并且在 vivo 与 XA21 形成组成的建筑群。这些结果在三米饭免疫者受体的功能为 OsSERK2 表明一个必要角色并且建议和米饭免疫者受体的 thatdirect 相互作用为他们的功能是批评的。一起拿,我们的调查结果建议米饭 XA21, XA3,和 FLS2 的反省 OsSERK2 的规定的 thatthe 机制不同于 AtSERK3/BAK1-mediated regulationof Arabidopsis FLS2 和 EFR.Key 词的: | Xuewei Chena Shimin Zuo Benjamin Schwessinger Mawsheng Chern Patrick E. Canlas Deling Ruan Xiaogang Zhou Jing Wang Arsalan Daudi Christopher J. Petzold Joshua L. Heazlewood Pamela C. Ronald | 2014 | Molecular Plant2014，7，5： | 17 |
| 5 | Quantitative description of characteristics of high-capacity channels in unconsolidated sandstone reservoirs using in situ production data显示文摘Quantitative description of the high-capacity channels in unconsolidated sandstone reservoirs,into which water was injected to improve oil recovery,is a hot topic in the fi eld of reservoir development. This paper presents a novel approach to describing quantitatively the characteristics of connected macropores in unconsolidated sandstone reservoirs using in situ production data. Based on physical simulation for formation mechanisms of high capacity channels and interwell tracer test data,a mathematical model was established to describe high-capacity channels by grey correlation theory,glow mechanism of fluid in porous media and reservoir engineering,and a program was developed to describe quantitatively the channel characteristics. The predicted results were consistent with fi eld monitoring data(80%) ,so this model could be economically and effectively used to identify high-capacity channels. | Wang Xuezhong Wang Jianyong Wang Chuanfei Zeng Liufang Liu Xuewei | 2010 | Petroleum Science2010，7，1： | 15 |
| 6 | Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo显示文摘Kaempferol 是被报导了在各种各样的恶意的肿瘤展出 antitumor 活动的 flavonoid。然而, cholangiocarcinoma (CCA ) 上的 kaempferol 的角色大部分是未知的。在这篇文章,我们发现 kaempferol 在 vitro 在 HCCC9810 和 QBC939 房间禁止了增长,减少的殖民地形成能力,和导致的 apoptosis。从 transwell 试金和愈合创伤的试金的结果证明 kaempferol 显著地在 vitro 压制了 HCCC9810 和 QBC939 房间的迁居和侵略能力。Kaempferol 被发现 Bcl-2 的表示到减少并且增加 Bax 的表情,船边交货, cleaved-caspase 3, cleaved-caspase 8, cleaved-caspase 9,并且 cleaved-PARP。另外, kaempferol 另外 downregulated phosphorylated AKT, TIMP2,和 MMP2 的层次。在 vivo,这被发现下的异种皮移植的体积(在对待 kaempferol 的组的 0.15 厘米 3) 比那小(在控制组的 0.6 厘米 3) 。Kaempferol 也在肺转移模型压制了转移 foci 的数字和卷,没有鼠标的身体重量上的显著效果。Immunohistochemistry 试金证明 Ki-67-positive 房间的数字在控制组比那在对待 kaempferol 的组是更低的。我们进一步证实在在 vivo 的 kaempferol 处理以后的 apoptosis 相关、侵略相关的蛋白质的变化类似于在 vitro 的结果。这些数据建议 kaempferol 可以是为 CCA 的处理的一个有希望的候选人代理人。 | Youyou Qin Wu Cui Xuewei Yang Baifeng Tong | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 15 |
| 7 | Laser performance of the SG-Ⅲ laser facility显示文摘SG-Ⅲ laser facility is now the largest laser driver for inertial confinement fusion research in China. The whole laser facility can deliver 180 kJ energy and 60 TW power ultraviolet laser onto target, with power balance better than 10%.We review the laser system and introduce the SG-Ⅲ laser performance here. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Jingqin Su Kuixing Zheng Xiaodong Yuan Hai Zhou Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Xuewei Deng | 2016 | High Power Laser Science and Engineering2016，4，3： | 13 |
| 8 | Laser performance upgrade for precise ICF experiment in SG-Ⅲ laser facility显示文摘The SG-Ⅲlaser facility(SG-Ⅲ)is the largest laser driver for inertial confinement fusion(ICF)researches in China,which has 48 beamlines and can deliver 180 kJ ultraviolet laser energy in 3 ns.In order to meet the requirements of precise physics experiments,some new functionalities need to be added to SG-Ⅲand some intrinsic laser performances need upgrade.So at the end of SG-Ⅲ's engineering construction,the 2-year laser performance upgrade project started.This paper will introduce the newly added functionalities and the latest laser performance of SG-Ⅲ.With these function extensions and performance upgrade,SG-Ⅲis now fully prepared for precise ICF experiments and solidly paves the way towards fusion ignition. | Wanguo Zheng Xiaofeng Wei Qihua Zhu Feng Jing Dongxia Hu Xiaodong Yuan Wanjun Dai Wei Zhou Fang Wang Dangpeng Xu Xudong Xie Bin Feng Zhitao Peng Liangfu Guo Yuanbin Chen Xiongjun Zhang Lanqin Liu Donghui Lin Zhao Dang Yong Xiang Rui Zhang Fang Wang Huaiting Jia Xuewei Deng | 2017 | Matter and Radiation at Extremes2017，2，5： | 13 |
| 9 | Improving CLM4.5 Simulations of Land–Atmosphere Exchange during Freeze–Thaw Processes on the Tibetan Plateau显示文摘Soil is heterogeneous and has different thermal and hydraulic properties, causing varied behavior in heat and moisture transport. Therefore, soil has an important effect on land–atmosphere interactions. In this study, an improved soil parameterization scheme that considers gravel and organic matter in the soil was introduced into CLM4.5(Community Land Model). By using data from the Zoige and Madoi sites on the Tibetan Plateau, the ability of the model to simultaneously simulate the duration of freeze–thaw periods, soil temperature, soil moisture, and surface energy during freeze–thaw processes, was validated. The results indicated that:(1) the new parameterization performed better in simulating the duration of the frozen, thawing, unfrozen, and freezing periods;(2) with the new scheme, the soil thermal conductivity values were decreased;(3) the new parameterization improved soil temperature simulation and effectively decreased cold biases;(4) the new parameterization scheme effectively decreased the dry biases of soil liquid water content during the freezing, completely frozen, and thawing periods, but increased the wet biases during the completely thawed period; and(5) the net radiation, latent heat flux, and soil surface heat flux of the Zoige and Madoi sites were much improved by the new organic matter and thermal conductivity parameterization. | Siqiong LUO Xuewei FANG Shihua LYU Yu ZHANG Boli CHEN | 2017 | Journal of Meteorological Research2017，31，5： | 13 |
| 10 | Orderly Porous Covalent Organic Frameworks-based Materials:Superior Adsorbents for Pollutants Removal from Aqueous Solutions显示文摘Covalent organic frameworks(COFs)are a new type of crystalline porous polymers known for chemical stability,excellent structural regularity,robust framework,and inherent porosity,making them promising materials for capturing various types of pollutants from aqueous solutions.This review thoroughly presents the recent progress and advances of COFs and COF-based materials as superior adsorbents for the efficient removal of toxic heavy metal ions,radionuclides,and organic pollutants.Information about the interaction mechanisms between various pollutants and COF-based materials are summarized from the macroscopic and microscopic standpoints,including batch experiments,theoretical calculations,and advanced spectroscopy analysis.The adsorption properties of various COF-based materials are assessed and compared with other widely used adsorbents.Several commonly used strategies to enhance COF-based materials’adsorption performance and the relationship between structural property and sorption ability are also discussed.Finally,a summary and perspective on the opportunities and challenges of COFs and COF-based materials are proposed to provide some inspiring information on designing and fabricating COFs and COF-based materials for environmental pollution management. | Xiaolu Liu Hongwei Pang Xuewei Liu Qian Li Ning Zhang Liang Mao Muqing Qiu Baowei Hu Hui Yang Xiangke Wang | 2021 | The Innovation2021，2，1： | 12 |
| 11 | Fractal model of lightning channel for simulating lightning strikes to transmission lines显示文摘How to accurately evaluate the direct-strike lightning protection is one of the key issues in the design of transmission lines. In this paper, three important issues in applying the fractal simulation to the lightning protection of transmission lines were discussed, including the criteria and implementation of upward leader inception, the connection with the magnitude of lightning current, and the calculation and control of fractal dimensions. Then we conducted the simulation iterately, leading to statistical results, which indicate that even if the transmission line satisfies the perfect shielding condition, shielding failure fault remains possible. Furthermore, we calculated the shielding failure fault rates of an EHV line with different ground obliquities and distribution of strike points over the interval between two neighboring towers along a UHV-DC line to find out the weak point of transmission-line lightning protection. This work provides a promising approach for improving the lightning protection property of transmission lines by optimizing the configuration of shielding wires and phase or pole conductors. | HE JinLiang ZHANG XueWei DONG Lin ZENG Rong LIU ZeHong | 2009 | Science China(Technological Sciences)2009，52，11： | 12 |
| 12 | Numerical simulation of bubble plumes in overlying water of gas hydrate in the cold seepage active region显示文摘To study the seismic responses produced by gas hydrate bubble plumes in the cold seepage active region, we constructed a plume water body model based on random medium theory and acoustic velocity model of bubble medium. The plume water body model was forward simulated by finite difference. Seismic records of single shot show the scattered waves produced by the plume. The scattered wave energy is strong where the plume exists. Where the scattered wave energy is stronger, the minimum of travel time is always above the plume, which has no relationship with the shot's position. Seismic records of shot gathers were processed by prestack time migration. The migration section shows that the scattered waves produced by plumes can be imaged distinctly with higher accuracy. These researches laid a foundation for further study on the seismic responses produced by plumes and provided a new approach for the identification of gas hydrate. | LI CanPing LIU XueWei GOU LiMin WANG XiangChun YIN JunJie XIE ChengLiang | 2013 | Science China Earth Sciences2013，56，4： | 11 |
| 13 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 14 | Characteristics analysis on high density spatial sampling seismic data显示文摘中国的大陆人免职盆被复杂地质的结构和各种各样的水库岩性学描绘。因此,高精确探索方法被需要。高密度空间采样是一种新技术增加地震探索的精确性。我们简短讨论点来源和接收装置技术,分析高密度在 situ 方法的空间采样,介绍吉季斯· J · O 介绍的对称的采样原则。Vermeer,并且讨论高密度从波浪地连续性的观点的空间采样技术。我们强调高密度的分析空间采样特征,包括高密度,首先,裂缝为近的表面结构的调查有利,改善静态的修正精确,在到增加的短偏移量的稠密的接收装置间距的使用在浅深度的有效范围,和思考成像的精确性。协调噪音不是 aliased 和噪音分析精确,抑制作为结果增加。空间采样提高的高密度各种各样的数学变换的波浪地连续性和精确性,它受益飘动地分离。最后,我们指出空间采样技术是的高密度的困难的部分处理的数据。更多的研究需要在分析并且处理地震数据的巨大的数量的方法上被做。 | Cai Xiling Liu Xuewei Deng Chunyan Lv Yingme | 2006 | Applied Geophysics2006，3，1： | 11 |
| 15 | Decellularized extracellular matrix scaffolds:Recent trends and emerging strategies in tissue engineering显示文摘The application of scaffolding materials is believed to hold enormous potential for tissue regeneration.Despite the widespread application and rapid advance of several tissue-engineered scaffolds such as natural and synthetic polymer-based scaffolds,they have limited repair capacity due to the difficulties in overcoming the immunogenicity,simulating in-vivo microenvironment,and performing mechanical or biochemical properties similar to native organs/tissues.Fortunately,the emergence of decellularized extracellular matrix(dECM)scaffolds provides an attractive way to overcome these hurdles,which mimic an optimal non-immune environment with native three-dimensional structures and various bioactive components.The consequent cell-seeded construct based on dECM scaffolds,especially stem cell-recellularized construct,is considered an ideal choice for regenerating functional organs/tissues.Herein,we review recent developments in dECM scaffolds and put forward perspectives accordingly,with particular focus on the concept and fabrication of decellularized scaffolds,as well as the application of decellularized scaffolds and their combinations with stem cells(recellularized scaffolds)in tissue engineering,including skin,bone,nerve,heart,along with lung,liver and kidney. | Xuewei Zhang Xi Chen Hua Hong Rubei Hu Jiashang Liu Changsheng Liu | 2022 | Bioactive Materials2022，7，4： | 10 |
| 16 | Clopidogrel with aspirin in High- risk patients with Acute Non- disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial显示文摘Background In patients with a minor ischaemic stroke or transient ischaemic attack(TIA),separate trials have shown that dual antiplatelet therapy with clopidogrel plus aspirin(clopidogrel-aspirin)or ticagrelor plus aspirin(ticagrelor-aspirin)are more effective than aspirin alone in stroke secondary prevention.However,these two sets of combination have not been directly compared.Since clopidogrel was less effective in stroke patients who were CYP2C19 loss-of function(LOF)allele carriers,whether ticagrelor-aspirin is clinically superior to clopidogrel-aspirin in this subgroup of patients with stroke is unclear.Aim To describe the rationale and design considerations of the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events(CHANCE-2)trial.Design CHANCE-2 is a randomised,double-blind,double-dummy,placebo-controlled,multicentre trial that compares two dual antiplatelet strategies for minor stroke or TIA patients who are CYP2C19 LOF allele carriers:ticagrelor(180 mg loading dose on day 1 followed by 90 mg twice daily on days 2-90)or clopidogrel(300 mg loading dose on day 1 followed by 75 mg daily on days 2-90),plus open-label aspirin with a dose of 75-300 mg on day 1 followed by 75 mg daily on day 2-21.All will be followed for 1 year.Study outcomes The primary efficacy outcome is any stroke(ischaemic or haemorrhagic)within 3 months and the primary safety outcome is any severe or moderate bleeding event within 3 months.Discussion The CHANCE-2 trial will evaluate whether ticagrelor-aspirin is superior to clopidogrel-aspirin for minor stroke or TIA patients who are CYP2C19 LOF allele carriers. | Yongjun Wang Claiborne Johnston Philip M Bath Xia Meng Jing Jing Xuewei Xie Anxin Wang Yuesong Pan Anding Xu Qiang Dong Yilong Wang Xingquan Zhao Zixiao Li Hao Li | 2021 | Stroke & Vascular Neurology2021，6，2： | 10 |
| 17 | Further studies on the numerical simulation of bubble plumes in the cold seepage active region显示文摘Using the occurrence characteristics of bubble plumes in the South China Sea as a reference, this paper continues to study the seismic responses produced by bubble plumes in the cold seepage active region. To make the plume modelling scheme more reasonable, we modified the original modelling scheme and reconstructed a plume water body model based on the variation of its radius as bubbles rise in seawater. The plume seismic records of shot gathers were obtained by forward simulation. The seismic records of single shot show obvious characteristics of a scattering wave field and the periodic characteristics of the model. Seismic records of shot gathers were processed using prestack depth migration. The boundary of its imaging section has a good convergence effect.The migration sections can be imaged distinctly with higher accuracy. The aforementioned studies once again laid a foundation for the further study of the seismic responses produced by plumes. They also gradually probed a more suitable seismic data processing method for plumes and provided a theoretical guidance for the identification of plumes. | LI Canping GOU Limin YOU Jiachun LIU Xuewei OU Chuling | 2016 | Acta Oceanologica Sinica2016，35，1： | 8 |
| 18 | Multi-scale simulation of single crystal hollow turbine blade manufactured by liquid metal cooling process显示文摘Liquid metal cooling(LMC) process as a powerful directional solidification(DS) technique is prospectively used to manufacture single crystal(SC) turbine blades. An understanding of the temperature distribution and microstructure evolution in LMC process is required in order to improve the properties of the blades. For this reason, a multi-scale model coupling with the temperature field, grain growth and solute diffusion was established. The temperature distribution and mushy zone evolution of the hollow blade was simulated and discussed.According to the simulation results, the mushy zone might be convex and ahead of the ceramic beads at a lower withdrawal rate, while it will be concave and laggard at a higher withdrawal rate, and a uniform and horizontal mushy zone will be formed at a medium withdrawal rate. Grain growth of the blade at different withdrawal rates was also investigated. Single crystal structures were all selected out at three different withdrawal rates.Moreover, mis-orientation of the grains at 8 mm/min reached ~30°, while it was ~5° and ~15° at 10 mm/min and 12 mm/min, respectively. The model for predicting dendritic morphology was verified by corresponding experiment. Large scale for 2D dendritic distribution in the whole sections was investigated by experiment and simulation, and they presented a well agreement with each other. | Xuewei Yan Hang Zhang Ning Tang Changbo Sun Qingyan Xu Baicheng Liu | 2018 | Progress in Natural Science:Materials International2018，28，1： | 8 |
| 19 | Prognostic significance of lymphovascular infiltration in overall survival of gastric cancer patients after surgery with curative intent显示文摘Objective: Lymphovascular infiltration(LVI) is frequently detected in gastric cancer(GC) specimens. Studies have revealed that GC patients with LVI have a poorer prognosis than those without LVI.Methods: In total, 1,007 patients with curatively resected GC at Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital were retrospectively enrolled. The patients were categorized into two groups based on the LVI status: a positive group(PG;presence of LVI) and a negative group(NG;absence of LVI). The clinicopathological factors corrected with LVI and prognostic variables were analyzed. Additionally, a pathological lymphovascular-node(lvN) classification system was proposed to evaluate the superiority of its prognostic prediction of GC patients compared with that of the eighth edition of the N staging system.Results: Two hundred twenty-four patients(22.2%) had LVI. The depth of invasion and lymph node metastasis were independently associated with the presence of LVI. GC patients with LVI demonstrated a significantly lower overall survival(OS) rate than those without LVI(42.8% vs. 68.9%, respectively;P<0.001). In multivariate analysis,LVI was identified as an independent prognostic factor for GC patients(hazard ratio: 1.370;95% confidence interval: 1.094-1.717;P=0.006). Using strata analysis, significant prognostic differences between the groups were only observed in patients at stage I-IIIa or N0-2. The lvN classification was found to be more appropriate to predict the OS of GC patients after curative surgery than the pN staging system. The-2 log-likelihood of lvN classification(4,746.922) was smaller than the value of pN(4,765.196), and the difference was statistically significant(χ^2=18.434, P<0.001).Conclusions: The presence of LVI influences the OS of GC patients at stage Ⅰ-Ⅲ a or N0-2. LVI should be incorporated into the pN staging system to enhance the accuracy of the prognostic prediction of GC patients. | Liangliang Wu Yuexiang Liang Chen Zhang Xiaona Wang Xuewei Ding Chongbiao Huang Han Liang | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 20 | Identification and characterization of rice blast resistance gene Pid4 by a combination of transcriptomic profiling and genome analysis显示文摘Map-based cloning of plant disease resistance (R) genes is time-consuming. Here, we reported the isolation of blast R gene Pid4 using comparative transcriptomic profiling and genome-wide sequence analysis. Pid4 encodes a coiled-coil nucleotide-binding site leucine-rich repeat(CC-NBS-LRR) protein and is constitutively expressed at diverse developmental stages in the rice variety Digu. The Pid4 protein is localized in both the nucleus and cytoplasm. Introduction of Pid4 into susceptible rice cultivars confers race-specific resistance to leaf and neck blast. Amino acid sequence comparison and blast resistance spectrum tests showed that Pid4 is a novel R gene, different from the previously reported R genes located in the same gene cluster. A Pid4 Indel marker was developed to facilitate the identification of Pid4 in different rice varieties. We demonstrated that a plant R gene can be quickly isolated using transcriptomic profiling coupled with genome-wide sequence analysis. | Zhixiong Chen Wen Zhao Xiaobo Zhu Chengdong Zou Junjie Yin Mawsheng Chern Xiaogang Zhou Heng Ying Xin Jiang Yongzhen Li Haicheng Liao Mengping Cheng Weitao Li Min He Jing Wang Jichun Wang Bingtian Ma Jirui Wang Shigui Li Lihuang Zhu Xuewei Chen | 2018 | Journal of Genetics and Genomics2018，45，12： | 7 |
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