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| 1 | LHD1,an Allele of DTH8/Ghd8,Controls Late Heading Date in Common Wild Rice (Oryza rufipogon)显示文摘Flowering at suitable time is very important for plants to adapt to complicated environments and produce their seeds successfully for reproduction.In rice (Oryza rufipogon Griff.) photoperiod regulation is one of the important factors for controlling heading date.Common wild rice,the ancestor of cultivated rice,exhibits a late heading date and a more sensitive photoperiodic response than cultivated rice.Here,through map-based cloning,we identified a major quantitative trait loci (QTL) LHD1 (Late Heading Date 1),an allele of DTH8/Ghd8,which controls the late heading date of wild rice and encodes a putative HAP3/NF-YB/CBF-A subunit of the CCAAT-box-binding transcription factor.Sequence analysis revealed that several variants in the coding region of LHD1 were correlated with a late heading date,and a further complementary study successfully rescued the phenotype.These results suggest that a functional site for LHD1 could be among those variants present in the coding region.We also found that LHD1 could down-regulate the expression of several floral transition activators such as Ehd1,Hd3a and RFT1 under long-day conditions,but not under short-day conditions.This indicates that LHD1 may delay flowering by repressing the expression of Ehd1,Hd3a and RFT1 under long-day conditions. | Xiaodong Dai Younian Ding Lubin Tan Yongcai Fu Fengxia Liu Zuofeng Zhu Xianyou Sun Xuewen Sun Ping Gu Hongwei Cai Chuanqing Sun | 2012 | Journal of Integrative Plant Biology2012，54，10： | 23 |
| 2 | Construction of a recombinant lentivirus containing human microRNA-7-3 and its inhibitory effects on glioma proliferation显示文摘In the present study, we constructed a lentivirus, FIV-CMV-GFP-miR-7-3, containing the microRNA-7-3 gene and the green fluorescent protein gene, and used it to transfect human glioma U251 cells. Fluorescence microscopy showed that 80% of U251 cells expressed green fluorescence. Real-time reverse transcription PCR showed that microRNA-7-3 RNA expression in U251 cells was significantly increased. Proliferation was slowed in transfected U251 cells, and most cells were in the G 1 phase of the cell cycle. In addition, the expression of the serine/threonine protein kinase 2 was decreased. Results suggested that transfection with a lentivirus carrying microRNA-7-3 can effectively suppress epidermal growth factor receptor pathway activity in U251 cells, arrest cell cycle transition from G 1 phase to S phase and inhibit glioma cell growth. | Lun Dong Chongxu Han Hengzhu Zhang Xuewen Gu Jian Li Yongkang Wu Xiaodong Wang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 3 | Research on controllable alkaline soil degradation of 5-substituted chlorsulfuron显示文摘Sulfonylurea(SU) has become one class of the most important herbicides worldwide due to their ultralow application rate and mammalian toxicity. Recently application licenses of 3 classical SU herbicides chlorsulfuron, metsulfuron-methyl and ethametsulfuron were suspended due to their undesirable long persistence which is incompatible with the particular rotation planting system in China. Our previous study has discovered that electron-donating groups, especially dimethylamino and diethylamino substituents, on the 5 th position of the benzene ring in chlorsulfuron, greatly accelerated its degradation rate in an acidic soil(p H 5.41). Owing to the natural slower degradation of SUs in alkaline soil,dimethylamino and diethylamino substituted chlorsulfuron Ia and Ib were further studied in an alkaline soil(p H 8.46) with chlorsulfuron as a control. The experimental data indicated that the half-life of degradation(DT_(50)) of Ia was 3.36 days while Ib was 6.25 days which amounted to 30 and 15 folds faster than chlorsulfuron(DT_(50)84.53 days), respectively. The research confirmed that our newly-designed structures Ia and Ib can hasten their degradation rate in alkaline soil as well as in acidic soil. This structural modification of the classical SU provided an opportunity to control the degradation rate to reduce their impact on relevant environment and ecology. | Shaa Zhou Xuewen Hua Wei Wei Minggui Chen Yucheng Gu Sha Zhou Haibin Song Zhengming Li | 2018 | Chinese Chemical Letters2018，29，6： | 2 |
| 4 | Flexible electronic eardrum显示文摘有高敏感和快反应速度的灵活 mechanosensors 可以推进保健设备的便携、可植入的应用,例如即时心率,脉搏,并且呼吸监视。在这份报纸,我们与 micro-structured 金字塔数组基于围单人赛的碳 nanotubes,聚乙烯,和 poly-dimethylsiloxane 介绍新奇灵活电子鼓膜(EE ) 。EE 设备在在 20-13,000 Hz 的一个频率领域以内检测并且记录声音显示出高敏感,高 signal-to-noise 比率(约 55 dB ) ,和快反应时间(76.9 s ) 。为健全察觉的机制被调查,敏感用微观结构,厚度,和紧张状态是坚定的。我们也证明设备能区分人的声音。灵活电子鼓膜的这崭新的表演为象可植入的听觉的生物电子和个人语音识别那样的许多应用程序有含意。 | Yang Gu Xuewen Wang Wen Gu Yongjin Wu Tie Li Ting Zhang | 2017 | Nano Research2017，10，8： | 2 |
| 5 | Decreased miRNA-148a is associated with lymph node metastasis and poorclinical outcomes and functions as a suppressor of tumor metastasis in non-smallcell lung cancer显示文摘 | Yong Chen Lingfeng Min Xizhi Zhang Suwei Hu Buhai Wang Wei Liu Rui Wang Xuewen Gu Weigan Shen Houning Lv Jing Zou Yuexiang Chen Xingxiang Xu Longbang Chen | 2013 | Oncology Reports2013，，4： | 1 |
| 6 | Promoting osteogenic differentiation in pre-osteoblasts and reducing tibial fracture healing time using functional nanofibers显示文摘当人工的织物代替,各种各样的合成材料现在被使用,并且在织物工程正在定义新边疆。在现在的学习,合成的膜基于丝绸丝心蛋白(SF ) 被制作形成合成骨膜。制作的膜被他们的形态学,孔, biocompatibility, biodegradability,化学结构,和机械性质物理化学地描绘。跟随 polycaprolactone (打印机控制语言) 的增加到丝绸纤维,与真丝膜,和表面 wettability 相比在裂缝的延伸有 3-5-fold 增加被保留。在膜以内的 SF 的降级时间被增加打印机控制语言也延长。与纯打印机控制语言膜或塑料文化盘子相比,基于 SF 的膜显著地提高了细胞的生存能力和 MC3T3-E1 房间的 osteogenic 区别能力。osteogenic 区别标记的更高的表示层次(老牛相关的抄写因素 2 (RUNX2 ) ,碱的磷酸酶(高山) ,和 osteopontin (OP )) 进一步在骨头相关的应用支持了 SF 部件的使用。经由 endochondral 骨头形成愈合了的一个非刚性的内部固定(non-RIF ) 骨折模型被创造,并且骨折胼胝样品是镇定的在外科以后在 8 个星期执行微计算断层摄影术,组织学,和 immunohistochemistry 分析。使矿物化的多骨的胼胝伴随的更小的骨头体积在 SF/PCL 对待膜的老鼠被观察。Immunohistochemistry 也显示展出的 SF/PCL 对待膜的老鼠增加了 osteocalcin 表示,但是减少了骨胶原类型 X 表示。这些调查结果能为与提高的 intramembranous 骨化对待弄碎的破裂导致其他的策略并且减少 endochondral 骨化。 | Gu Cheng Jiajia Chen Qun Wang Xuewen Yang Yuet Cheng Zhi Li Hu Tu Hongbing Deng Zubing Li | 2018 | Nano Research2018，11，7： | 1 |
| 7 | Design, Synthesis, Structure-Activity Relationship and Insecticidal Activities of Trifluoromethyl-Containing Sulfiliminyl and Sulfoximinyl Phthalic Acid Diamide Structure显示文摘Due to a novel mode action,low toxicity to mammals and low residue characteristics,phthalic acid diamides have aroused considerable interests in agricultural chemistry.With introduction of N-cyano,N-trifluoroacetyl,N-carbamoylsulfiliminyl and sulfoximinyl substituents into phthalamides,12 novel derivatives containing trifluoromethyl moiety were designed and synthesized.All title compounds were characterized by ^(1)H NMR and high-resolution mass spectrometry.The preliminary results of biological activity assessment indicated that some title compounds exhibited moderate to good insecticidal activities against oriental armyworm(Pseudaletia separata Walker).In particular,Va gave higher activity against oriental armyworm and diamondback moth.The present work reported that the new trifluoromethylated diamides incorporating N-trifluoroacetylsulfoximinyl moieties are potential lead compounds for further structure optimization,providing some insight into the relating structure-activity relationship. | Sha Zhou Tao Yan Sha Zhou Xuewen Hua Baolei Wang Yucheng Gu Lixia Xiong Yongqiang Li Zhengming Li | 2014 | Chinese Journal of Chemistry2014，32，7： | 1 |
| 8 | Correlation between X-ray cross-complementing group 1 polymorphisms and the onset risk of glioma A meta-analysis显示文摘OBJECTIVE:To evaluate the association of X-ray cross-complementing group 1(XRCC1)Arg399Gln,Arg194Trp and Arg280His polymorphisms with the risk of glioma.DATA SOURCES:A systematic literature search of papers published from January 2000 to August2012 in PubMed,Embase,China National Knowledge Infrastructure database,and Wanfang database was performed.The key words used were'glioma','polymorphism',and'XRCC1 or X-ray repair cross-complementing group 1'.References cited in the retrieved articles were screened manually to identify additional eligible studies.STUDY SELECTION:Studies were identified according to the following inclusion criteria:case-control design was based on unrelated individuals;and genotype frequency was available to estimate an odds ratio(OR)and 95%confidence interval(CI).Meta-analysis was performed for the selected studies after strict screening.Dominant and recessive genetic models were used and the relationship between homozygous mutant genotype frequencies and mutant gene frequency and glioma incidence was investigated.We chose the fixed or random effect model according to the heterogeneity to calculate OR and 95%CI,and sensitivity analyses were conducted.Publication bias was examined using the inverted funnel plot and the Egger’s test using Stata 12.0 software.MAIN OUTCOME MEASURES:Association of XRCC1 Arg399Gln,Arg194Trp,and Arg280His polymorphisms with the risk of glioma,and subgroup analyses were performed according to different ethnicities of the subjects.RESULTS:Twelve articles were included in the meta-analysis.Eleven of the articles were concerned with the Arg399Gln polymorphism and glioma onset risk.Significantly increased glioma risks were found only in the dominant model(Gln/Gln+Gln/Arg versus Arg/Arg:OR=1.26,95%CI=1.03-1.54,P=0.02).In the subgroup analysis by ethnicity,significantly increased risk was found in Asian subjects in the recessive(OR=1.46,95%CI=1.04-2.45,P=0.03)and dominant models(OR=1.40,95%CI=1.10-1.78,P=0.007),and homozygote contrast(OR=1.69,95%CI=1.17-2.45,P=0.005),but not in Caucasian subjects.For association of the Arg194Trp(eight studies)and Arg280His(four studies)polymorphisms with glioma risk,the meta-analysis did not reveal a significant effect in the allele contrast,the recessive genetic model,the dominant genetic model,or homozygote contrast.CONCLUSION:The XRCC1 Arg399Gln polymorphism may be a biomarker of glioma susceptibility,especially in Asian populations.The Arg194Trp and Arg280His polymorphisms were not associated with overall glioma risk. | Xinquan Gu Hongyan Sun Liping Chang Ran Sun Hongfeng Yang Xuewen Zhang Xianling Cong | 2013 | Neural Regeneration Research2013，8，26： | 1 |
| 9 | Laser-ablated violet phosphorus/graphene heterojunction as ultrasensitive ppb-level room-temperature NO sensor显示文摘Two dimensional(2D)materials are promising gas sensing materials,but the most of them need to be heated to show promising sensing performance.Sensing structures with high sensing performance at room-temperature are urgent.Here,another 2D material,violet phosphorus(VP)nanoflake is investigated as gas sensing material.The VP nanoflakes have been effectively ablated to have layers of 1–5 layers by laser ablation in glycol.The VP nanoflakes are combined with graphene to form VP/G heterostructuresbased NO sensor.An ultra-high gauge factor of 3×10^(7)for ppb-level sensing and high resistance response of 59.21%with ultra-short recovery time of 6s for ppm-level sensing have been obtained.The sensing mechanism is also analysed by density functional theory(DFT)calculations.The adsorption energy of VP/G is calculated to be-0.788 e V,resulting in electrons migration from P to N to form a P-N bond in the gap between VP and graphene sheet.This work provides a facile approach to ablate VP for mass production.The as-produced structures have also provided potential gas sensors with ultrasensitive performance as ppb-level room-temperature sensors. | Xiaohui Ye Ming Qi Hao Qiang Mengzhen Chen Xi Zheng Mengyue Gu Xuewen Zhao Yanling Yang Chaozheng He Jinying Zhang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 10 | Control of crystal growth to obtain needle-shaped violet phosphorus with excellent photocatalytic degradation performance显示文摘The control of crystal growth is important but challenging for multi-disciplinary research.Violet phosphorus,the most stable phosphorus allotrope,has recently been produced as a unique semiconducting layered structure.The crystal orientation and morphology bring extra performance due to its unique structure and anisotropy.Herein,the layered violet phosphorus has been controlled to grow along the c-axis to give tunable length up to centimeters with the assistance of tin,while the reported flat bulk ones with thickness are limited to micrometers.The as-produced needle-shaped violet phosphorus has also been demonstrated to significantly enhance the photocatalytic degradation of methyl orange pollutants due to its special crystallographic orientation.About 98.6%of methyl orange pollutants with a concentration of 50 ppm were degraded within 80 min under visible light conditions by needle-shaped violet phosphorus,which is much more effective than that of amorphous red phosphorus with only 14.1%degradation. | Mengting Jin Yanhao Wang Mengyue Gu Xuewen Zhao Rongzheng Zhao Yuhao Zhang Yonghong Cheng Jinying Zhang | 2023 | Nano Research2023，16，2： | 0 |
| 11 | Optimizing water-saving irrigation schemes for rice(Oryza sativa L.)using DSSAT-CERES-Rice model显示文摘Rice is one of the major crops in China,and enhancing the rice yield and water use efficiency is critical to ensuring food security in China.Determining how to optimize a scientific and efficient irrigation and drainage scheme by combining existing technology is currently a hot topic.Crop growth models can be used to assess actual or proposed water management regimes intended to increase water use efficiency and mitigate water shortages.In this study,a CERES-Rice model was calibrated and validated using a two-year field experiment.Four irrigation and drainage treatments were designed for the experiment:alternate wetting and drying(AWD),controlled drainage(CD),controlled irrigation and drainage for a low water level(CID1),and controlled irrigation and drainage for a high water level(CID2).According to the indicators normalized root mean square error(NRMSE)and index of agreement(d),the calibrated CERES-Rice model accurately predicted grain yield(NRMSE=6.67%,d=0.77),,shoot biomass(NRMSE=3.37%,d=0.77),actual evapotranspiration(ETa)(NRMSE=3.83%,d=0.74),irrigation volume(NRMSE=15.56%,d=0.94),and leaf area index(NRMSE=9.69%,d=0.98)over 2 a.The calibrated model was subsequently used to evaluate rice production in response to the four treatments(AWD,CD,CID1,and CID2)under 60 meteorological scenarios which were divided into wet years(22 a),normal years(16 a),and dry years(22 a).Results showed that the yield of AWD was the largest among four treatments in different hydrological years.Relative to that of AWD,the yield of CD,CID1,and CID2 were respectively reduced by 5.7%,2.6%,8.7%in wet years,9.2%,2.3%,8.6% in normal years,and 9.2%,3.8%,3.9% in dry years.However,rainwater use efficiency and irrigation water use efficiency were the greatest for CID2 in different hydrological years.The entropy-weighting TOPSIS model was used to optimize the four water-saving irrigation schemes in terms of water-saving,labor-saving and high-yield,based on the simulation results of the CERES-Rice model in the past 60 a.These results showed that CID1 and AWD were optimal in the wet years,CID1 and CID2 were optimal in the normal and dry years.These results may provide a strong scientific basis for the optimization of water-saving irrigation technology for rice. | Shikai Gao Qiongqiong Gu Xuewen Gong Yanbin Li Shaofeng Yan Yuanyuan Li | 2023 | International Journal of Agricultural and Biological Engineering2023，16，2： | 0 |
| 12 | Horizontal Push Plate Test and Simulation of CRTS II Slab Ballastless Track显示文摘Good interlayer interface performance is the key to maintaining the stability of CRTSⅡslab ballastless track structure.In a project,the tangential cohesion parameters of CRTSⅡslab ballastless track structure are generally measured by horizontal push plate test,so as to measure the interlayer interface performance.Horizontal push plate contraction scale and full scale tests of CRTSⅡslab ballastless track structure are carried out to obtain the tangential force-displacement relation curve of the interlayer interface,thus obtaining the parameters of cohesion model.A threedimensional progressive damage analysis model for CRTSⅡslab ballastless track structure is established,the whole process inversion of the horizontal push plate test is carried out,and the reliability of the contraction scale test results is verified by means of simulation and comparative analysis of test results.The results show that the greater the tangential stiffness of the interlayer interface of the track structure,the weaker the interlayer deformation coordination capability;the more significant the non-uniformity of the interface damage,the more likely the stress concentration;the greater the fracture toughness,the less likely the disjoint in the interlayer interface of the track structure. | LIU Xuewen GU Yonglei LIU Yu | 2022 | Chinese Railways2022，，2： | 0 |
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