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| 1 | High resolution multispectral spatial light modulators based on tunable Fabry-Perot nanocavities显示文摘Spatial light modulators(SLMs)are the most relevant technology for dynamic wavefront manipulation.They find diverse applications ranging from novel displays to optical and quantum communications.Among commercial SLMs for phase modulation,Liquid Crystal on Silicon(LCoS)offers the smallest pixel size and,thus,the most precise phase mapping and largest field of view(FOV).Further pixel miniaturization,however,is not possible in these devices due to inter-pixel cross-talks,which follow from the high driving voltages needed to modulate the thick liquid crystal(LC)cells that are necessary for full phase control.Newly introduced metasurface-based SLMs provide means for pixel miniaturization by modulating the phase via resonance tuning.These devices,however,are intrinsically monochromatic,limiting their use in applications requiring multi-wavelength operation.Here,we introduce a novel design allowing small pixel and multi-spectral operation.Based on LC-tunable Fabry-Perot nanocavities engineered to support multiple resonances across the visible range(including red,green and blue wavelengths),our design provides continuous 2π phase modulation with high reflectance at each of the operating wavelengths.Experimentally,we realize a device with 96 pixels(~1 μm pitch)that can be individually addressed by electrical biases.Using it,we first demonstrate multi-spectral programmable beam steering with FOV~18° and absolute efficiencies exceeding 40%.Then,we reprogram the device to achieve multi-spectral lensing with tunable focal distance and efficiencies~27%.Our design paves the way towards a new class of SLM for future applications in displays,optical computing and beyond. | Shampy Mansha Parikshit Moitra Xuewu Xu Tobias Wwmass Rasna Maruthiyodan Veetil Xinan Liang Shi-Qiang Li Ramon Paniagua-Dominguez Arseniy I.Kuznetsov | 2022 | Light(Science & Applications)2022，11，6： | 3 |
| 2 | Lithium in-diffusion treatment of thick LiNbO 3 crystals by the vapor transport equilibration method显示文摘 | Xinan Liang Xu Xuewu Chong Tow-Chong Yuan Shaoning Yu Fengliang Tay Yong Soon | 2003 | Journal of Crystal Growth2003，，： | 2 |
| 3 | Alternative splicing of MaMYB16L regulates starch degradation in banana fruit during ripening显示文摘The alternative splicing of select genes is an important mechanism to regulate responses to endogenous and environmental signals in plants.However,the role of alternative splicing in regulating fruit ripening remains unclear.Here,we discovered that MaMYB16L,an R1-type MYB transcription factor,undergoes alternative splicing and generates two transcripts,the full-length isoform MaMYB16L and a truncated form MaMYB16S,in banana fruit.During banana fruit ripening,the alternative splicing process intensifies with downregulated MaMYB16L and upregulated MaMYB16S.Moreover,MaMYB16L is a transcriptional repressor that directly binds with the promoters of many genes associated with starch degradation and MaDREB2,a positive ripening regulator,and represses their expression.In contrast,MaMBY16S lacks a DNA-binding domain but competitively combines and forms non-functional heterodimers with functional MaMYB16L.MaMYB16L-MaMYB16S heterodimers decrease the binding capacity and transrepression activity of MaMYB16L.The downregulation of MaMYB16L and the upregulation of MaMYB16S,that is,a decreased ratio of active to non-active isoforms,facilitates the activation of ripening-related genes and thereby promotes fruit ripening.Furthermore,the transient overexpression of MaMYB16S promotes banana fruit ripening,whereas the overexpression of MaMYB16L delays this process.Therefore,the alternative splicing of MaMYB16L might generate a self-controlled regulatory loop to regulate banana fruit ripening. | Guoxiang Jiang Dandan Zhang Zhiwei Li Hanzhi Liang Rufang Deng Xinguo Su Yueming Jiang Xuewu Duan | 2021 | Journal of Integrative Plant Biology2021，63，7： | 2 |
| 4 | Synthesis of ultralarge-pore FDU-12 silica with face-centered cubic structure显示文摘 | HUANG Liang YAN Xuewu KRUK M | 2010 | Langrnuir2010，26，14： | 1 |
| 5 | Membrane Fouling Alleviation by Chemically Enhanced Backwashing in Treating Algae-Containing Surface Water: From Bench-Scale to Full-Scale Application显示文摘Ultrafiltration(UF)has been increasingly implemented in drinking water treatment plants;however,algae and their secretions can cause severe membrane fouling and pose great challenges to UF in practice.In this study,a simple and practical chemically enhanced backwashing(CEB)process was developed to address such issues using various cleaning reagents,including sodium hypochlorite(NaClO),sodium chloride(NaCl),sodium hydroxide(NaOH),sodium citrate,and their combinations.The results indicate that the type of chemical played a fundamental role in alleviating the hydraulically irreversible membrane fouling(HIMF),with NaClO as the best-performing reagent,followed by NaCl.Furthermore,a CEB process using a combination of NaClO with NaCl,NaOH,or sodium citrate delivered little improvement in the alleviation of membrane fouling compared with NaClO alone.The optimized dosage and dosing frequency of NaClO were 10 mg·L^(-1) two times per day.Long-term pilot-scale and full-scale experiments further verified the feasibility of the CEB process in relieving algae-derived membrane fouling.Compared with the conventional hydraulic backwashing without chemical involvement,the CEB process can effectively remove the organic foulants including biopolymers,humic substances,and proteinlike substances by means of oxidization,thereby weakening the cohesive forces between the organic foulants and the membrane surface.Therefore,the CEB process can efficiently alleviate the algae-related membrane fouling with lower chemical consumption,and is proposed as an alternative to control membrane fouling in treating the algae-containing surface water. | Xiaobin Tang Tiecheng Guo Haiqing Chang Xiao Yue Jinlong Wang Haikuan Yu Binghan Xie Xuewu Zhu Guibai Li Heng Liang | 2022 | Engineering2022，，12： | 0 |
| 6 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 7 | Structure-based drug discovery of novel fusedpyrazolone carboxamide derivatives as potent and selective AXL inhibitors显示文摘a novel and promising antitumor target,AXL plays an important role in tumor growth,metastasis,immunosuppression and drug resistance of various malignancies,which has attracted extensive research interest in recent years.In this study,by employing the structure-based drug design and bioisosterism strategies,we designed and synthesized in total 54 novel AXL inhibitors featuring a fusedpyrazolone carboxamide scaffold,of which up to 20 compounds exhibited excellent AXL kinase and BaF3/TEL-AXL cell viability inhibitions.Notably,compound 59 showed a desirable AXL kinase inhibitory activity(IC_(50):3.5 nmol/L)as well as good kinase selectivity,and it effectively blocked the cellular AXL signaling.In turn,compound 59 could potently inhibit BaF3/TEL-AXL cell viability(IC_(50):1.5 nmol/L)and significantly suppress GAS6/AXL-mediated cancer cell invasion,migration and wound healing at the nanomolar level.More importantly,compound 59 oral administration showed good pharmacokinetic profile and in vivo antitumor efficiency,in which we observed significant AXL phosphorylation suppression,and its antitumor efficacy at 20 mg/kg(qd)was comparable to that of BGB324 at 50 mg/kg(bid),the most advanced AXL inhibitor.Taken together,this work provided a valuable lead compound as a potential AXL inhibitor for the further antitumor drug development. | Feifei Fang Yang Dai Hao Wang Yinchun Ji Xuewu Liang Xia Peng Jiyuan Li Yangrong Zhao Chunpu Li Danyi Wangh Yazhou Li Dong Zhang Dan Zhang Meiyu Geng Hong Liu Jing Ai Yu Zhou | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
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