|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of Y on the Microstructure, Mechanical and Bio-corrosion Properties of Mg-Zn-Ca Bulk Metallic Glass显示文摘The micro-alloying effects of Y on the microstructure, mechanical properties, and bio-corrosion behavior of Mg69-xZn27Ca4Yx(x= 0, 1, 2 at.%) alloys were investigated through X-ray diffraction, compressive tests,electrochemical treatments, and immersion tests. The Mg69Zn27Ca4 alloy was found to be absolutely amorphous, and its glass-forming ability decreased with the addition of Y. The Mg68Zn27Ca4Y1 alloy exhibited an ultrahigh compressive strength above 1010 MPa as well as high capacity for plastic strain above 3.1%.Electrochemical and immersion tests revealed that these Y-doped MgeZ neC a alloys had good bio-corrosion resistance in simulated body fluid(SBF) at 37℃. The results of the cytotoxicity test showed high cell viabilities for these alloys, which means good bio-compatibility. | Jingfeng Wang Yang Li Song Huang Yiyun Wei Xingfeng Xi Kaiyong Cai Fusheng Pan | 2014 | Journal of Materials Science & Technology2014，30，12： | 8 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Paleomagnetic results from Late Carboniferous to Early Permian rocks in the northern Qiangtang terrane, Tibet, China, and their tectonic implications显示文摘Results of a systematic paleomagnetic study are reported based on Late Carboniferous to Early Permian sedimentary rocks on the north slope of the Tanggula Mountains,in the northern Qiangtang terrane(NQT),Tibet,China.Data revealed that magnetic minerals in limestone samples from the Zarigen Formation(CP^z)are primarily composed of magnetite,while those in sandstone samples from the Nuoribagaribao Formation(Pnr)are dominated by hematite alone,or hematite and magnetite in combination.Progressive thermal,or alternating field,demagnetization allowed us to isolate a stable high temperature component(HTC)in 127 specimens from 16 sites which successfully passed the conglomerate test,consistent with primary remnance.The tilt-corrected mean direction for Late Carboniferous to Early Permian rocks in the northern Qiangtang terrane is D_s=30.2°,I_s=-40.9°,k_s=269.0,a_(95)=2.3°,N=16,which yields a corresponding paleomagnetic pole at 25.7°N,241.5°E(dp/dm=2.8°/1.7°),and a paleolatitude of 23.4°S.Our results,together with previously reported paleomagnetic data,indicate that:(1)the NQT in Tibet,China,was located at a low latitude in the southern hemisphere,and may have belonged to the northern margin of Gondwana during the Late Carboniferous to Early Permian;(2)the Paleo-Tethys Ocean was large during the Late Carboniferous to Early Permian,and(3)the NQT subsequently moved rapidly northwards,perhaps related to the fact that the Paleo-Tethys Ocean was rapidly contracting from the Late Permian to Late Triassic while the Bangong Lake-Nujiang Ocean,the northern branch of the Neo-Tethys Ocean,expanded rapidly during this time. | YANG XingFeng CHENG Xin ZHOU YaNan MA Lun ZHANG XiaoDong YAN ZhaoSheng PENG XiMing SU HaiLun WU HanNing | 2017 | Science China Earth Sciences2017，60，1： | 5 |
| 4 | Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner显示文摘As one of the hallmarks of cancer,metabolic reprogramming leads to cancer progression,and targeting glycolytic enzymes could be useful strategies for cancer therapy.By screening a small molecule library consisting of 1320 FDA-approved drugs,we found that penfluridol,an antipsychotic drug used to treat schizophrenia,could inhibit glycolysis and induce apoptosis in esophageal squamous cell carcinoma(ESCC).Gene profiling and Ingenuity Pathway Analysis suggested the important role of AMPK in action mechanism of penfluridol.By using drug affinity responsive target stability(DARTS)technology and proteomics,we identified phosphofructokinase,liver type(PFKL),a key enzyme in glycolysis,as a direct target of penfluridol.Penfluridol could not exhibit its anticancer property in PFKL-deficient cancer cells,illustrating that PFKL is essential for the bioactivity of penfluridol.High PFKL expression is correlated with advanced stages and poor survival of ESCC patients,and silencing of PFKL significantly suppressed tumor growth.Mechanistically,direct binding of penfluridol and PFKL inhibits glucose consumption,lactate and ATP production,leads to nuclear translocation of FOXO3a and subsequent transcriptional activation of BIM in an AMPK-dependent manner.Taken together,PFKL is a potential prognostic biomarker and therapeutic target in ESCC,and penfluridol may be a new therapeutic option for management of this lethal disease. | Cancan Zheng Xiaomei Yu Yiyao Liang Yidong Zhu Yan He Long Liao Dingkang Wang Yanming Yang Xingfeng Yin Ang Li Qingyu He Bin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 5 | Spatial variation in egg polymorphism among cuckoo hosts across 4 continents显示文摘Although egg color polymorphism has evolved as an effective defensive adaptation to brood parasitism,spatial variations in egg color polymorphism remain poorly characterized.Here,we investigated egg polymorphism in 647 host species(68 families and 231 gen era)parasitized by 41 species of Old Word cuckoos(1 family and 11 gen era)across Asia,Europe,Africa,and Australia.The diversity of parasitic cuckoos differs among continents,reflecting the continent-specific intensities of parasitic selection pressure on hosts.Therefore,host egg polymorphism is expected to evolve more frequently on continents with higher cuckoo diversity.We identified egg polymorphism in 24.1%of all host species and 47.6%of all host families.The common cuckoo Cuculus canorus utilized 184 hosts(28.4%of all host species).Hosts of the common cuckoo and of Chrysococcyx species were more likely to have polymorphic eggs than hosts parasitized by other cuckoos.Both the number of host species and the host families targeted by the cuckoo species were positively correlated with the frequency of host egg polymorphism.Most host species and most hosts exhibiting egg color polymorphism were located in Asia and Africa.Host egg polymorphism was observed less frequently in Australia and Europe.Our results also suggested that egg polymorphism tends to occur more frequently in hosts that are utilized by several cuckoo species or by generalist cuckoo species.We suggest that selecti on pressure on hosts from a given contin ent in creases proportionally to the number of cuckoo species,and that this selection pressure may,in turn,favor the evolution of host egg polymorphism. | Canchao Yang Xingfeng Si Wei Liang Anders Pape Moller | 2020 | Current Zoology2020，66，5： | 2 |
| 6 | TIPE-mediated up-regulation of MMP-9 promotes colorectal cancer invasion and metastasis through MKK-3/p38/NF-κB pro-oncogenic signaling pathway显示文摘Dear Editor,Colorectal cancer(CRC)is the third most common malignant tumor in human,ranking third in cancer-related mortality.1 Most colon cancer patients die of metastasis.2 Intriguingly,the deregulation of tumor necrosis factorα‑induced protein 8(TIPE)has been shown to play a vital regulatory role in tumor cell growth,proliferation,invasion,and metastasis.3 TIPE is a kind of cytoplasmic protein of 23 kDa.A large number of studies have shown that TIPE is closely related to the development of colon cancer.4 In addition,decreased expression of TIPE was linked to down-regulation of matrix metallopeptidase-1(MMP-1),MMP-9,and vascular endothelial growth factor receptor-2 in breast cancer. | Huiyu Chen Yuhan Ye Yan Yang Mengya Zhong Lei Gu Zhaopu Han Jinhua Qiu Zhongchen Liu Xingfeng Qiu Guohong Zhuang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 7 | Protective effects of probucol in rats with postoperative acute renal failure显示文摘Objective We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries(IRIs) after surgery.Methods Forty male Sprague-Dawley rats were randomly divided into a sham operation group(S group), ischemia reperfusion group(IR group), probucol low-dose treatment group(probucol + IR group 1, P+ IR1 group; probucol 250 mg/kg intragastric administration daily), and probucol high-dose treatment group(P + IR2 group; probucol 500 mg/kg intragastric administration daily). Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase(SOD), and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.Results Twenty-four-hour urinary protein excretion, urinary NAGase, Cys C, blood urea nitrogen(BUN), and creatinine were significantly lower in the P + IR1 and P + IR2 groups than in the IR group(P < 0.05). Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly(P < 0.05), renal pathological injury was alleviated, and the kidney index improved significantly(P < 0.05).Conclusion Probucol can relieve various types of acute renal failure in postoperative rats. | Cheng Yang Jun Peng Xingfeng Ren | 2018 | Oncology and Translational Medicine2018，4，2： | 0 |
| 8 | Primary cardiac CIC-rearranged undifferentiated sarcoma in an infant显示文摘Introduction:Cardiac neoplasms are particularly rare in children,and the majority of these tumors are benign.Approximately 10%of cardiac neoplasms are malignant,including soft tissue sarcomas and lymphomas.Cardiac tumors could also be metastases.Primitive EWSR1-negative round or spindle cell undifferentiated sarcoma harboring CIC gene translocation is a highly aggressive malignancy mainly occurring in soft tissues.However,it has not yet been described in the heart.Case presentation:We report a sarcoma that arose from the right ventricle in a 1-year-old girl.Histologically,it was composed of closely arranged small round or oval undifferentiated cells with fibrovascular separation,hyaline degeneration,and geographical necrosis.Immunohistochemically,the neoplastic cells exhibited focal membrane positivity for CD99 and diffuse positivity for WT1 and ETV4.Fluorescent in situ hybridization analysis showed EWSR1-negative but CIC-positive split signals.The breakpoint was also confirmed by whole genome sequencing.Conclusion:Based on morphological,immunohistochemical and molecular findings,this cardiac mass was diagnosed as CIC-rearranged sarcoma. | Meng Zhang Yeran Yang Xiaoxing Guan Xingfeng Yao Yongli Guo Lejian He | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 9 | Spatial scaling of soil microbial co-occurrence networks in a fragmented landscape显示文摘Impact statement Habitat loss has been a primary threat to biodiversity.However,species do not function in isolation but often associate with each other and form complex networks.Thus,revealing how the network complexity and stability scale with habitat area will give us more insights into the effects of habitat loss on ecosystems.In this study,we explored the relationships between the island area and the network complexity and stability of soil microbes.We found that the complexity and stability of soil microbial co‐occurrence networks scale positively with island area,indicating that habitat loss will potentially simplify and destabilize soil microbial networks. | Pandeng Wang Shao-Peng Li Xian Yang Xingfeng Si Wen-Jun Li Wensheng Shu Lin Jiang | 2023 | mLife2023，2，2： | 0 |
| 10 | Drying kinetics of soy protein isolate-corn starch film during preparation and its moisture adsorption characteristics during storage显示文摘To better understand the mass transfer process of moisture in the soy protein isolate-corn starch(SPI-CS)films during preparation and storage process,the drying kinetics model of SPI-CS films with different formation conditions during the drying process and the moisture adsorption characteristics of the SPI-CS films under different humidity conditions were investigated.Within the range of experimental conditions,the moisture migration rule in the SPI-CS films during the drying preparation was combined with the Page model which was expressed as MR=exp(-kt^(n)).It was found that the adsorption equilibrium needed shorter time(about 3 h)when the SPI-CS films existed in the environment with lower humidity(RH<54%).Additionally,the secondorder adsorption kinetic equation was successful to describe the moisture adsorption characteristic of the SPICS films during storage under different humidity conditions. | Tingwei Zhu Jinyu Yang Wanting Qin Yadong Tian Yingying Wang Xingfeng Guo | 2023 | Grain & Oil Science and Technology2023，6，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员