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| 1 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 2 | BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis显示文摘冷应力是不利地影响植物生长和开发的一个主要环境因素。C 重复有约束力的 factor/DRE 绑定因素 1 (CBF/DREB1 ) 规章的串联被显示出在对的植物反应起重要作用的 transcriptional 冷。这里,我们证明发信号的 brassinosteroid (BR ) 的二个关键部件调制 Arabidopsis 植物的结冰忍耐。象 GSK3 一样 kinases 的 loss-of-function 异种在 BR 发信号包含了, bin2-3 bil1 bil2,显示出的增加的结冰公差,而 BIN2 的 overexpression 导致了超敏性到结冰,在 non-acclimated 和 acclimated 下面的应力调节。由对比,显示的抄写因素 BZR1 和 BES1 的 gain-of-function 异种提高了结冰忍耐,和一致地冷的处理能导致 dephosphorylated BZR1 的累积。生物化学、基因的分析证明 BZR1 行动 CBF1 和 CBF2 到在上游直接调整他们的表示。而且,我们发现 BZR1 也调整了另外的英国管基因与 CBF 解开了例如 WKRY6, PYL6, SOC1, JMT,和 SAG21,种反应调制到冷应力。一致地, wrky6 异种显示出减少的结冰忍耐。一起拿,我们的结果显示 BZR1 断然调制通过 CBF 依赖、 CBF 独立的小径冻结忍耐的植物。 | Hui Li Keyi Ye Yiting Shi Jinkui Cheng Xiaoyan Zhang Shuhua Yang | 2017 | Molecular Plant2017，10，4： | 37 |
| 3 | Insights into the regulation of C-repeat binding factors in plant cold signaling显示文摘Cold temperatures, a major abiotic stress,threaten the growth and development of plants, worldwide. To cope with this adverse environmental cue, plants from temperate climates have evolved an array of sophisticated mechanisms to acclimate to cold periods,increasing their ability to tolerate freezing stress. Over the last decade, significant progress has been made in determining the molecular mechanisms underpinning cold acclimation, including following the identification of several pivotal components, including candidates for cold sensors, protein kinases, and transcription factors. With these developments, we have a better understanding of the CBF-dependent cold-signaling pathway. In this review,we summarize recent progress made in elucidating the cold-signaling pathways, especially the C-repeat binding factor-dependent pathway, and describe the regulatory function of the crucial components of plant cold signaling.We also discuss the unsolved questions that should be the focus of future work. | Jingyan Liu Yiting Shi Shuhua Yang | 2018 | Journal of Integrative Plant Biology2018，60，9： | 36 |
| 4 | Molecular Regulation of Plant Responses to Environmental Temperatures显示文摘Temperature is a key factor governing the growth and development,distribution,and seasonal behavior of plants.The entireplant life cycle is affected by environmental temperatures.Plants grow rapidly and exhibit specific changes in morphology under mild average temperature conditions,a response termed thermomorphogenesis.When exposed to chilling or moist chilling low temperatures,flowering or seed germination is accelerated in some plant species;these processes are known as vernalization and cold stratification,respectively.Interestingly,once many temperate plants are exposed to chilling temperatures for some time,they can acquire the ability to resist freezing stress,a process termed cold acclimation.In the face of global climate change,heat stress has emerged as a frequent challenge,which adversely affects plant growth and development.In this review,we summarize and discuss recent progress in dissecting them olecular mechanism sregulating plant thermomorphogenesis,vernalization,and responses to extreme temperatures.We also discuss the remaining issues that are crucial for understanding the interactions between plants and temperature. | Yanglin Ding Yiting Shi Shuhua Yang | 2020 | Molecular Plant2020，13，4： | 40 |
| 5 | The Antagonistic Action of Abscisic Acid and Cytokinin Signaling Mediates Drought Stress Response in Arabidopsis显示文摘 | Xiaozhen Huang Lingyan Hou Jingjing Meng Huiwen You Zhen Li Zhizhong Gong Shuhua Yang Yiting Shi | 2018 | Molecular Plant2018，11，7： | 15 |
| 6 | Cold-Induced CBF–PIF3 Interaction Enhances Freezing Tolerance by Stabilizing the phyB Thermosensor in Arabidopsis显示文摘Growth inhibition and cold-acclimation strategies help plants withstand cold stress,which adversely affects growth and survival.PHYTOCHROME B(phyB)regulates plant growth through perceiving both light and ambient temperature signals.However,the mechanism by which phyB mediates the plant response to cold stress remains elusive.Here,we show that the key transcription factors mediating cold acclimation,C-REPEAT BINDING FACTORs(CBFs),interact with PHYTOCHROME-INTERACTING FACTOR 3(PIF3)under cold stress,thus attenuating the mutually assured destruction of PIF3–phyB.Cold-stabilized phyB acts downstream of CBFs to positively regulate freezing tolerance by modulating the expression of stress-responsive and growth-related genes.Consistent with this,phyB mutants exhibited a freezing-sensitive phenotype,whereas phyB-overexpression transgenic plants displayed enhanced freezing tolerance.Further analysis showed that the PIF1,PIF4,and PIF5 proteins,all of which negatively regulate plant freezing tolerance,were destabilized by cold stress in a phytochrome-dependent manner.Collectively,our study reveals that CBFs–PIF3–phyB serves as an important regulatory module for modulating plant response to cold stress. | Bochen Jiang Yiting Shi Yue Peng Yuxin Jia Yan Yan Xiaojing Dong Hui Li Jie Dong Jigang Li Zhizhong Gong Michael F.Thomashow Shuhua Yang | 2020 | Molecular Plant2020，13，6： | 13 |
| 7 | COLD1: a cold sensor in rice显示文摘Rice(Oryza sativa L.)is one of the most important food crops in the world.Originating in tropical and subtropical regions,rice cultivars are grouped into two major subspecies,indica(O.sativa ssp.indica)and japonica(O.sativa ssp.japonica).indica cultivars grown in low latitude | SHI YiTing YANG ShuHua | 2015 | Science China(Life Sciences)2015，58，4： | 11 |
| 8 | Survey on deep learning for pulmonary medical imaging显示文摘As a promising method in artificial intelligence,deep learning has been proven successful in several domains ranging from acoustics and images to natural language processing.With medical imaging becoming an important part of disease screening and diagnosis,deep learning-based approaches have emerged as powerful techniques in medical image areas.In this process,feature representations are learned directly and automatically from data,leading to remarkable breakthroughs in the medical field.Deep learning has been widely applied in medical imaging for improved image analysis.This paper reviews the major deep learning techniques in this time of rapid evolution and summarizes some of its key contributions and state-of-the-art outcomes.The topics include classification,detection,and segmentation tasks on medical image analysis with respect to pulmonary medical images,datasets,and benchmarks.A comprehensive overview of these methods implemented on various lung diseases consisting of pulmonary nodule diseases,pulmonary embolism,pneumonia,and interstitial lung disease is also provided.Lastly,the application of deep learning techniques to the medical image and an analysis of their future challenges and potential directions are discussed. | Jiechao Ma Yang Song Xi Tian Yiting Hua Rongguo Zhang Jianlin Wu | 2020 | Frontiers of Medicine2020，14，4： | 5 |
| 9 | Integration of light and temperature signaling pathways in plants显示文摘As two of the most important environmental factors,light and temperature regulate almost all aspects of plant growth and development.Under natural conditions,light is accompanied by warm temperatures and darkness by cooler temperatures,suggesting that light and temperature are tightly associated signals for plants.Indeed,accumulating evidence shows that plants have evolved a wide range of mechanisms to simultaneously perceive and respond to dynamic changes in light and temperature.Notably,the photoreceptor phytochrome B(phy B)was recently shown to function as a thermosensor,thus reinforcing the notion that light and temperature signaling pathways are tightly associated in plants.In this review,we summarize and discuss the current understanding of the molecular mechanisms integrating light and temperature signaling pathways in plants,with the emphasis on recent progress in temperature sensing,light control of plant freezing tolerance,and thermomorphogenesis.We also discuss the questions that are crucial for a further understanding of the interactions between light and temperature signaling pathways in plants. | Lijuan Qi Yiting Shi William Terzaghi Shuhua Yang Jigang Li | 2022 | Journal of Integrative Plant Biology2022，64，2： | 4 |
| 10 | The direct targets of CBFs:In cold stress response and beyond显示文摘Cold acclimation in Arabidopsis thaliana triggers a significant transcriptional reprogramming altering the expression patterns of thousands of cold-responsive(COR) genes. Essential to this process is the C-repeat binding factor(CBF)-dependent pathway, involving the activity of AP2/ERF(APETALA2/ethylene-responsive factor)-type CBF transcription factors required for plant cold acclimation. In this study, we performed chromatin immunoprecipitation assays followed by deep sequencing(ChIP-seq) to determine the genomewide binding sites of the CBF transcription factors. Cold-induced CBF proteins specifically bind to the conserved C-repeat(CRT)/dehydrationresponsive elements(CRT/DRE;G/ACCGAC) of their target genes. A Gene Ontology enrichment analysis showed that 1,012 genes are targeted by all three CBFs. Combined with a transcriptional analysis of the cbf1,2,3 triple mutant, we define 146 CBF regulons as direct CBF targets. In addition, the CBF-target genes are significantly enriched in functions associated with hormone, light,and circadian rhythm signaling, suggesting that the CBFs act as key integrators of endogenous and external environmental cues. Our findings not only define the genome-wide binding patterns of the CBFs during the early cold response, but also provide insights into the role of the CBFs in regulating multiple biological processes of plants. | Yue Song Xiaoyan Zhang Minze Li Hao Yang Diyi Fu Jian Lv Yanglin Ding Zhizhong Gong Yiting Shi Shuhua Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 3 |
| 11 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 12 | Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift显示文摘Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin. | TIAN Xingwang LIU Guangdi LUO Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG Yunlong SUN Yiting DOU Shuang | 2022 | Acta Geologica Sinica(English Edition)2022，96，4： | 2 |
| 13 | Fine-tuning inverse metal-support interaction boosts electrochemical transformation of methanol into formaldehyde based on density functional theory显示文摘Different from traditional metal-support heterogenous catalysts,inverse heterogeneous catalysts,in which the surface of metal is decorated by metal oxide,have recently attracted increasing interests owing to the unique interracial effect and electronic structure.However,a deep insight into the effect of metaloxide interaction on the catalytic performance still remains a great challenge.In our work,an inverse hematite/palladium(Fe_(2) O_(3)/Pd) hybrid nanostructure,i.e.,the active Fe_(2) O_(3) ultrathin oxide layers partially covering on the surface of Pd nanoparticles(NPs),exhibited superior electrocatalytic performance towards methanol oxidation reaction(MOR) as compared to the bare Pd NPs based on density functional theory calculation.The charge could transfer from Pd to Fe_(2) O_(3) driven by the built-in potential at the interface of Pd and Fe_(2) O_(3),which favors the downshift of d band center of Pd.With the assistance of interfacial hydroxyl OH*,the cleavage of O—H and C—H in CH_(3) OH could take place much easily with lower barrier ene rgy on Fe_(2) O_(3)/Pd than that on pure Pd via two electrons transferring reaction pathways.Our results highlight that the syne rgy of Pd and Fe_(2) O_(3) at the interface could facilitate the electrochemical transformation of methanol into formaldehyde assisted with interfacial hydroxyl OH*. | Wenjuan Yang Junjun Li Xiaoya Cui Chenhuai Yang Yiting Liu Xianwei Zeng Zhicheng Zhang Qitao Zhang | 2021 | Chinese Chemical Letters2021，32，8： | 2 |
| 14 | Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis显示文摘Protein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses.In addition,phospho-regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants.However,it is less well known that a regulatory feedback loop is formed by the protein kinase and the protein phosphatase in plant responses to cold stress.Here,we report that OPEN STOMATA 1(OST1)and PROTEIN PHOSPHATASE 2C G GROUP 1(PP2CG1)reciprocally regulate the activity during the cold stress response.The interaction of PP2CG1 and OST1 is inhibited by cold stress,which results in the release of OST1 at the cytoplasm and nucleus from suppression by PP2CG1.Interestingly,cold-activated OST1 phosphorylates PP2CG1 to suppress its phosphatase activity,thereby amplifying cold signaling in plants.Mutations of PP2CG1 and its homolog PP2CG2 enhance freezing tolerance,whereas overexpression of PP2CG1 decreases freezing tolerance.Moreover,PP2CG1 negatively regulates protein levels of C-REPEAT BINDING FACTORs(CBFs)under cold stress.Our results uncover a phosphor/dephosphor-regulatory feedback loop mediated by PP2CG1 phosphatase and OST1 protein kinase in plant cold responses. | Jian Lv Jingyan Liu Yuhang Ming Yiting Shi Chunpeng Song Zhizhong Gong Shuhua Yang Yanglin Ding | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 15 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 16 | High-resolution Simulation of an Extreme Heavy Rainfall Event in Shanghai Using the Weather Research and Forecasting Model: Sensitivity to Planetary Boundary Layer Parameterization显示文摘In this study,an extreme rainfall event that occurred on 25 May 2018 over Shanghai and its nearby area was simulated using the Weather Research and Forecasting model,with a focus on the effects of planetary boundary layer(PBL)physics using double nesting with large grid ratios(15:1 and 9:1).The sensitivity of the precipitation forecast was examined through three PBL schemes:the Yonsei University Scheme,the Mellor−Yamada−Nakanishi Niino Level 2.5(MYNN)scheme,and the Mellor−Yamada−Janjic scheme.The PBL effects on boundary layer structures,convective thermodynamic and large-scale forcings were investigated to explain the model differences in extreme rainfall distributions and hourly variations.The results indicated that in single coarser grids(15 km and 9 km),the extreme rainfall amount was largely underestimated with all three PBL schemes.In the inner 1-km grid,the underestimated intensity was improved;however,using the MYNN scheme for the 1-km grid domain with explicitly resolved convection and nested within the 9-km grid using the Kain−Fritsch cumulus scheme,significant advantages over the other PBL schemes are revealed in predicting the extreme rainfall distribution and the time of primary peak rainfall.MYNN,with the weakest vertical mixing,produced the shallowest and most humid inversion layer with the lowest lifting condensation level,but stronger wind fields and upward motions from the top of the boundary layer to upper levels.These factors all facilitate the development of deep convection and moisture transport for intense precipitation,and result in its most realistic prediction of the primary rainfall peak. | Rui WANG Yiting ZHU Fengxue QIAO Xin-Zhong LIANG Han ZHANG Yang DING | 2021 | Advances in Atmospheric Sciences2021，38，1： | 1 |
| 17 | Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1 , in Barrett’s Esophagus and Esophageal Adenocarcinoma显示文摘 | Wenjing Wu Tushar D. Bhagat Xue Yang Jee Hoon Song Yulan Cheng Rachana Agarwal John M. Abraham Sariat Ibrahim Matthias Bartenstein Zulfiqar Hussain Masako Suzuki Yiting Yu Wei Chen Charis Eng John Greally Amit Verma Stephen J. Meltzer | 2013 | Gastroenterology2013，，5： | 1 |
| 18 | Sharp bounds for the general Randic index显示文摘 | LI XUELIANG YANG YITING | 2004 | Match Commun Math Compt Chem2004，，51： | 1 |
| 19 | Analysis of the formation process and performance of magnetic Fe_3O_4@Poly(4-vinylpyridine) absorbent prepared by in-situ synthesis显示文摘The morphology evolution of the mesoporous magnetic composite nanospheres Fe_3O_4@Poly(4-vinylpyridine) during the formation process and its absorption property of Congo red were studied in this study. A simple solvothermal method was applied for the fabrication of Fe_3O_4@Poly(4-vinylpyridine)composites with regular structure and uniform size distribution in the presence of 4-vinylpyridine as the structure inducer. The morphology, structure and magnetism performance were characterized and the adsorption model and mechanism were discussed. The results showed that the Fe_3O_4@Poly(4-vinylpyridine) composites were efficient adsorbent for the removal of Congo red from water and it could be reused by a magnetic separation. The adsorption isotherm of Congo red on Fe_3O_4@Poly(4-vinylpyridine) composites was fitted well with the Langmuir adsorption model. | Birong Zeng Li Yang Wei Zheng Jihong Zhu Xiaojun Ma Xinyu Liu Conghui Yuan Yiting Xu Lizong Dai | 2018 | Journal of Materials Science & Technology2018，34，6： | 1 |
| 20 | Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge显示文摘 | ShuangCheng Ma YiTing Yang | 2002 | Journal of Ethnopharmacology2002，79，3： | 1 |
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