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| 1 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 2 | Research on rotary forming mechanism of cartridge bottom by FEM显示文摘 | LIU Gang YAO Youliang HUANG Shaodong | 2003 | Journal Of Harbin Institude of Technology2003，10，1： | 1 |
| 3 | Mapping a stable adult-plant stripe rust resistance QTL on chromosome 6AL in Chinese wheat landrace Yibinzhuermai显示文摘Stripe rust,caused by Puccinia striiformis f.sp.tritici(Pst),is one of the most important diseases threatening the yield and stability of wheat production in China and many other countries.Identification and utilization of new genes for durable stripe rust resistance are important for ongoing control of this disease.The objectives of this study were to identify quantitative trait loci(QTL)associated with adult-plant stripe rust resistance in the Chinese wheat landrace Yibinzhuermai(YBZR)and to provide wheat breeders with new sources of potentially durable resistance.A total of 117 recombinant inbred lines(RILs)(F5:8)derived from a cross between YBZR and highly susceptible cultivar Taichung 29(TC29)were assessed for stripe rust severity in field experiments at Wenjiang in 2016 and 2017 and Chongzhou in 2016,2017,2018,and 2019 in Sichuan following inoculation with a mixture of current Pst races.The RILs were genotyped using the Wheat55K single nucleotide polymorphism(SNP)array.Three QTL were identified on chromosome arms 6AL,5BL and 7DS.QYr.YBZR-6AL and QYr.YBZR-7DS conferred major effects in all field environments,explaining 10.6%to 14.7%and 11.5%to 21.2%of phenotypic variation,respectively.The QTL on 5BL and 7DS likely correspond to previously known QTL,whereas QYr.YBZR-6AL is probably novel.Haplotype analysis revealed that the resistance allele at QYr.YBZR-6AL was present in 2.8%of 324 Chinese wheat landraces.SNP markers closely linked with QYr.YBZR-6AL were converted to kompetitive allele-specific PCR markers and validated in the RIL population and a subset of 92 wheat cultivars.QYr.YBZR-6AL and its markers should be useful in breeding programs to improve the level and durability of stripe rust resistance. | Mei Deng Li Long Yukun Cheng Fangjie Yao Fangnian Guan Yuqi Wang Hao Li Zhien Pu Wei Li Qiantao Jiang Yuming Wei Jian Ma Houyang Kang Pengfei Qi Jirui Wang Youliang Zheng Yunfeng Jiang Guoyue Chen | 2022 | The Crop Journal2022，10，4： | 0 |
| 4 | Prospective study on observations of γ-ray sources in the Galaxy using the HADAR experiment显示文摘The High Altitude Detection of Astronomical Radiation(HADAR)experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique.It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energyγ-rays and cosmic rays.With the advantages of a large field-of-view(FOV)and low energy threshold,the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources.This study presents the prospects of using the HADAR experiment for the sky survey of TeVγ-ray sources from TeVCat and provids a one-year survey of statistical significance.Results from the simulation show that a total of 23 galactic point sources,including five supernova remnant sources and superbubbles,four pulsar wind nebula sources,and 14 unidentified sources,were detected in the HADAR FOV with a significance greater than 5 standard deviations(σ).The statistical significance for the Crab Nebula during one year of operation reached 346.0σand the one-year integral sensitivity of HADAR above 1 TeV was~1.3%–2.4%of the flux from the Crab Nebula. | Xiangli Qian Huiying Sun Tianlu Chen Danzengluobu Youliang Feng Qi Gao Quanbu Gou Yiqing Guo Hongbo Hu Mingming Kang Haijin Li Cheng Liu Maoyuan Liu Wei Liu Bingqiang Qiao Xu Wang Zhen Wang Guangguang Xin Yuhua Yao Qiang Yuan Yi Zhang | 2022 | Frontiers of physics2022，17，6： | 0 |
| 5 | Study on the efficiency of the underground muon detectors in YangBaJing Hybrid Array显示文摘Purpose Theγ-ray astronomy at 100 TeV is important to unravel the puzzles related to the origin and acceleration of the Galactic cosmic rays up to PeV energy.The YangBaJing Hybrid Array(YBJ-HA),about 2%the scale of LHAASO-KM2A,is such a kind of detection instrument capable of detecting 100 TeVγ-rays.And the muon detection efficiency stability of the MD array in YBJ-HA is crucial for high qualityγ-ray observation.To measure and monitor the muon detection efficiency,we develop a method in this work.Methods We develop a muon bundle method to measure and monitor the efficiency of each muon detector.In this method,muon detection efficiency of the target MD unit is calculated based on the surrounding MD units and the MC simulation.Results The average actual muon detection efficiency of the 16 MD units is up to 83.4%during 4 years’observation.Conclusions The muon detection efficiency of each MD unit is found to be stable during 4 years’operation.In the future,a similar method may be applicable to the muon detection efficiency study for LHAASO. | Zhen Wang Youliang Feng Cheng Liu Yiqing Guo Hongbo Hu Tianlu Chen Danzeng Luobu Jiancheng He Yuhua Yao Yi Zhang | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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