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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 3 | Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants显示文摘AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF survival and overall survival. Among patients received CRT, overall survival was significantly longer in patients with negative than positive surgical margin(27.7 mo vs 22.4 mo, P = 0.016) in the overallstudy population, while time of radiotherapy initiation had no significant impact on survival times. Nodal stage was determined to be independent predictor of LRF survival in the overall study population with 4.959 fold(P = 0.042) increase in mortality in patients with nodal stage N2 compared to patients with nodal stage N0, and independent predictor of overall survival with 5.132 fold(P = 0.006), 5.263 fold(P = 0.027) and 4.056 fold(P = 0.009) increase in the mortality in patients with nodal stage N3a(before 2008), N3b(before 2008) and N2(overall study population) when compared to patients with N0 stage, respectively.CONCLUSION: Our findings emphasize the likelihood of postoperative adjuvant CRT to have a survival benefit in patients with resectable gastric carcinoma. | Sevgi Ozden Zerrin Ozgen Hazan Ozyurt Cengiz Gemici Gokhan Yaprak Huseyin Tepetam Alpaslan Mayadagli | 2015 | World Journal of Gastroenterology2015，21，4： | 7 |
| 4 | Role of pre-transplant 18F-FDG PET/CT in predicting hepatocellular carcinoma recurrence after liver transplantation显示文摘The last two decades have seen a paradigm shift in the selection of patients with hepatocellular carcinoma(HCC)for liver transplantation.Microvascular invasion and differentiation have been the most significant factors affecting post-transplant recurrence;however,because of inherent disadvantages of pre-transplant biopsy,histological criteria never gained popularity.Recently,the selection criteria evolved from morphological to biological criteria,such as biomarkers and response to loco-regional therapy.With the introduction of multimodality imaging,combination of computed tomography with nuclear medicine imaging,particularly,18F-fluorodeoxyglucose positron emission tomography fulfilled an unmet need and rapidly became a critical component of HCC management.This review article will focus on the use of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in the pre-transplant evaluation of HCC patients with special discussion on its ability to predict HCC recurrence after liver transplantation. | Onur Yaprak Sencan Acar Gokhan Ertugrul Murat Dayangac | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 4 |
| 5 | Major complications of adult right lobe living liver donors显示文摘BACKGROUND:The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease.It is important to know the preoperative factors relating to the major postoperative complications.We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.METHODS:Data from 378 donors who had undergone | Necdet Guler Onur Yaprak Yusuf Gunay Murat Dayangac Murat Akyildiz Fisun Yuzer Yildiray Yuzer Yaman Tokat | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 6 | Living donor liver hilar variations: surgical approaches and implications显示文摘BACKGROUND: Varied vascular and biliary anatomies are common in the liver. Living donor hepatectomy requires precise recognition of the hilar anatomy. This study was undertaken to study donor vascular and biliary tract variations, surgical approaches and implications in living liver transplant patients. METHODS: Two hundred living donor liver transplantations were performed at our institution between 2004 and 2009. All donors were evaluated by volumetric computerized tomography (CT), CT angiography and magnetic resonance cholangiography in the preoperative period. Intraoperative ultrasonography and cholangiography were carried out. Arterial, portal and biliary anatomies were classified according to the Michels, Cheng and Huang criteria. RESULTS: Classical hepatic arterial anatomy was observed in 129 (64.5%) of the 200 donors. Fifteen percent of the donors had variation in the portal vein. Normal biliary anatomy was found in 126 (63%) donors, and biliary tract variation in 70% of donors with portal vein variations. In recipients with single duct biliary anastomosis, 16 (14.4%) developed biliary leak, and 9 (8.1%) developed biliary stricture; however more than one biliary anastomosis increased recipient biliary complications. Donor vascular variations did not increase recipient vascular complications. Variant anatomy was not associated with an increase in donor morbidity. CONCLUSIONS: Living donor liver transplantation provides information about variant hilar anatomy. The success of the procedure depends on a careful approach to anatomical variations. When the deceased donor supply is inadequate living donor transplantation is a life-saving alternative and is safe for the donor and recipient, even if the donor has variant hilar anatomy. | Onur Yaprak Tolga Demirbas Cihan Duran Murat Dayangac Murat Akyildiz Yaman Tokat Yildiray Yuzer | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 2 |
| 7 | Determination of Some Trace Metals in Environmental Samples by Flame AAS Following Solid Phase Extraction with Amberlite XAD-2000 Resin after Complexing with 8-Hydroxyquinoline显示文摘为 Mn ( II )的 preconcentration 的一个过程, Fe ( II ),公司( II ), Cu ( II ), Cd ( II ), Zn ( II ), Pb ( II )和 Ni ( II )被火焰 AAS 为环境样品的分析基于他们有在列的 Amberlite XAD-2000 树脂上的 8-hydroxyquinoline ( HQ )的建筑群的保留建议。象 pH, eluent 类型,卷,集中,流动率和样品答案的体积那样的各种各样的参数,和金属离子的保留上的矩阵干扰效果被调查。为在问题的金属建筑群的保留的最佳 pHs 除了为其价值是 8 的 Mn2+ 是大约 6。为从在最佳条件下面的树脂的这些金属和他们的恢复的吸附物的装载能力在范围是 6.829.26 | DURAN, Celal SENTURK, H. Basri GUNDOGDU, Ali BULUT, V. Numan EICi, Latif SOYLAK, Mustafa TUFEKCI, Mehmet UYGUR, Yaprak | 2007 | Chinese Journal of Chemistry2007，25，2： | 2 |
| 8 | Association of Helicobacter pylori infection with systemic inflammation in preeclampsia显示文摘 | Yusuf üstün Yaprak Engin-üstün Esra ?zkaplan Bari? Otlu Mehmet Sait Tekereko?lu | 2010 | Journal of Maternal-Fetal and Neonatal Medicine2010，，4： | 2 |
| 9 | Alliance Orientation:Conceptualization,Measurement,and Impact on Market Performance显示文摘 | KANDEMIR YAPRAK CAVUSGIL | 2006 | Journal of the Academy of Marketing Science2006，34，3： | 1 |
| 10 | Role of surface functional groups in the adsorption kinetics of water vapor on microporous activated carbons显示文摘 | Ashleigh J F Yaprak U K Mark T | 2007 | Physical Chemistry2007，111，： | 1 |
| 11 | Alliance Orientation: Conceptualization, Measurement and Impact on Market Perform- ance显示文摘 | Kandemir D Yaprak A Cavusgil S T | 2006 | Journal of the Academy of Marketing Science2006，34，3： | 1 |
| 12 | Determination ot sodium, magnesium, aluminium, silicon, potassium, chloride, calcium and iron in cigarette tobacco by fast neutron activation analysis 显示文摘 | Cam NF Yaprak G Erduran MN | 1999 | J Radioanal NuelChem1999，242，2： | 1 |
| 13 | A Cross- National Comparison of Consumer Research Measures 显示文摘 | Parameswaran R Yaprak A | 1987 | Journal of International Business Studies1987，18，1： | 1 |
| 14 | Determination of changes in some physical and chemical properties of soybean oil during hydrogenation 显示文摘 | Karabuluta Y Kayahanb M Yaprak S | 2003 | Food Chemistry2003，81，： | 1 |
| 15 | 用低能γ闪烁能谱法直接测量地质样品的^(238)U含量和不平衡状态显示文摘提出了一种用低能γ闪烁能谱法测定地质样品的铀含量和不平衡状态的厅法。制备了不同含量的放射性平衡的矿石标准,并与同含量的化学铀标准比较了低能谱.用X射线荧光能谱仪和高分辨γ能谱仪仔细地分析了这些标准的铀含量。将矿石谱中63keV光电峰和93keV光电峰形成的复合峰的计数,与化学油标准谱的相应道的计数进行了比较。发现,对于平衡的标准,复合峰下(26±2)%计数来自于^(234)Th;^(234)Th(63keV+93keV)计数与^(210)Pb(47keV)计数之间存在着常数关系。这种技术曾应用于以前在同一实验室用高能γ能谱法测定过当量铀含量的地质样品。 | Günseli Yaprak Güngr Yener 张瑞增 | 1992 | 国外铀金地质1992，，3： | 1 |
| 16 | Growth performance of Awassi lambs fed calf milk replacer显示文摘 | Emsen E M Yaprak M Bilgin O C | 2004 | Small Ruminant Re search2004，53，： | 1 |
| 17 | Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer显示文摘 | Cengiz Gemici Mehmet Sargin Oya Uygur-Bayramicli Alpaslan Mayadagli Gokhan Yaprak Resat Dabak Mihriban Kocak | 2013 | Radiotherapy and Oncology2013，，2： | 1 |
| 18 | Cross-national development and validation of an international business measurement scale: the COISCALE显示文摘 | Gary A. Knight Richard A. Spreng Attila Yaprak | 2003 | International Business Review2003，，5： | 1 |
| 19 | Growthper formance of Awassilambs fed calf milk replacer 显示文摘 | Emsen EM Yaprak M Bilgin OC | 2004 | Sm all Ruminant Research2004，53，： | 1 |
| 20 | Acute endophthalmitis after 25-gauge sutureless vitrectomy显示文摘 | Nur Acar Yaprak Banu Unver Tu?rul Altan Ziya Kapran | 2007 | International Ophthalmology2007，，6： | 1 |
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