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| 1 | The mixing of multi-source fluids in the Wusihe Zn–Pb ore deposit in Sichuan Province, Southwestern China显示文摘The Sichuan-Yunnan-Guizhou(SYG)metallogenic province of southwest China is one of the most important Zn-Pb ore zones in China,with^200 Mt ZnPb ores at mean grades of 10 wt.%Zn and 5 wt.%Pb.The source and mechanism of the regional Zn-Pb mineralization remain controversial despite many investigations that have been conducted.The Wusihe Zn-Pb deposit is a representative large-scale Zn-Pb deposit in the northern SYG,which mainly occurs in the Dengying Formation and yields Zn-Pb resources of^3.7 Mt.In this paper,Zn and S isotopes,and Fe and Cd contents of sphalerite from the Wusihe deposit were investigated in an attempt to constrain the controls on Zn and S isotopic variations,the potential sources of ore-forming components,and the possible mineralization mechanisms.Both theδ66Zn andδ34S values in sphalerite from the Wusihe deposit increase systematically from the bottom to the top of the strata-bound orebodies.Such spatial evolution inδ66Zn andδ34S values of sphalerite can be attributed to isotopic Rayleigh fractionation during sphalerite precipitation with temperature variations.The strong correlations between the Zn-S isotopic compositions and Fe-Cd concentrations in sphalerite suggest that their variations were dominated by a similar mechanism.However,the Rayleigh fractionation mechanism cannot explain the spatial variations of Fe and Cd concentrations of sphalerite in this deposit.It is noted that the bottom and top sphalerites from the strata-bound orebodies document contrasting Zn and S isotopic compositions which correspond to the Zn and S isotopic characteristics of basement rocks and host rocks,respectively.Therefore,the mixing of two-source fluids with distinct Zn-S isotopic signatures was responsible for the spatial variations of Zn-S isotopic compositions of sphalerite from the Wusihe deposit.The fluids from basement rocks are characterized by relatively lighter Zn(~0.2‰)and S(~5‰)isotopic compositions while the fluids from host rocks are marked by relatively heavier Zn(~0.6‰)and S(~15‰)isotopic compositions. | Hongjie Zhang Haifeng Fan Chaoyi Xiao Hanjie Wen Lin Ye Zhilong Huang Jiaxi Zhou Qingjun Guo | 2019 | Acta Geochimica2019，38，5： | 6 |
| 2 | A theranostic agent for cancer therapy and imaging in the second nearinfrared window显示文摘Thera no stic nano particles are integrated systems useful for simulta neous diag nosis and imaging guided delivery of therapeutic drugs, with wide ranging pote ntial applicati ons in the clinic. Here we developed a thera no stic nan oparticle (~24 nm size by dynamic light scatteri ng) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-Ⅱ) window and an an ti-ca ncer drug paclitaxel. Folic acid (FA) was conjugated to the nan oparticles to afford specific binding to molecular folate receptors on muri ne breast can cer 4T1 tumor cells. In vivo, the nan oparticles accumulated in 4T1 tumor through both passive and active targeting effect. Under an 808 nm laser excitation, fluorescence detection above 1,300 nm afforded a large Stokes shift, allowing targeted molecular imaging tumor with high signal to background ratios, reaching a high tumor to normal tissue signal ratio (T/NT) of (20.0±2.3). Further, 4T1 tumors on mice were completed eradicated by paclitaxel released from p-FE-PTA-FA within 20 days of the first injection. Pharmacokinetics and histology studies indicated p-FE-PTX-FA had no obvious toxic side effects to major organs. This represented the first NIR-Ⅱ theranostic age nt developed. | Zhuoran Ma Hao Wan Weizhi Wang Xiaodong Zhang Takaaki Uno Qianglai Yang Jingying Yue Hongpeng Gao Yeteng Zhong Ye Tian Qinchao Sun Yongye Liang Hongjie Dai | 2019 | Nano Research2019，12，2： | 4 |
| 3 | Technique for Advanced Electrochemical Oxidation Treatment of Nanofiltration Concentrate of Landfill Leachate显示文摘Landfill leachate treated with combined process of 'pretreatment +biological treatment +advanced treatment(NF)' to produce nanofiltration concentrate, which bio-chemical ratio(B/C) is less than 0.1 and CODcr concentration is 2 000-2 500 mg/L, high salt content. Which cannot be discharged under existing environmental standards. According to analysis based on electrochemical advanced oxidation mechanism, a two-step electrochemical technique was recommended. In the first step, a pulse electrochemical technique was adopted. With Fe as consumption electrode and current density of 10 mA/cm2, the pollutants were removed by means of Fenton reaction, electroflotation and electrocoagulation. In the second step, a double function electrode was used to perform electrocatalytic oxidation by means of titanium metallic oxidates. In the condition that current density being 12.5 mA/cm2, the pollutants were further removed by oxidation and electrolytic deposition. Result shows that the removing rate of CODcr, NH3-N and Cl- were 70%-85%, 90% and 25%, respectively; average value of B/C ratio increased from 0.09 to 0.38 and conductivity reduced by 10%. | XIONG Changgui LI Guang ZHANG Zhiliang XIA Zhengwu LI Jian YE Hongji | 2014 | Wuhan University Journal of Natural Sciences2014，19，4： | 4 |
| 4 | Adsorption Kinetics of 2,2′,4,4′-Tetrabromodiphenyl Ether(BDE-47) on Maize Straw-Derived Biochars显示文摘The chars in the natural environment can affect the migration of polybrominated diphenyl ethers(PBDEs). However, there is insufficient research relating to the adsorption behavior and mechanisms of PBDEs on biochars. This study examined the adsorption kinetics of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) on maize straw-derived biochars(MSBCs) pyrolyzed at four different temperatures via batch experiments. The biochar samples were characterized using Fourier transform infrared(FTIR) spectroscopy,Raman spectra, and elemental analysis. A two-compartment first-order model and pseudo-second-order model exhibited a better fit compared to a pseudo-first-order model in describing the BDE-47 adsorption on biochars, which was dominated by a slow adsorption compartment and chemisorption. The MSBC pyrolyzed at 600 °C had the highest BDE-47 adsorption capacity owing to its relatively large specific surface area and relatively high aromaticity compared with the other three MSBCs pyrolyzed at 300, 400, and 500 ℃.However, there was no significant difference in adsorption capacity among the other three biochars. The organic functional groups coupled with the graphene structures of biochars and the hydrophobic effect of the functional groups promoted the adsorption of BDE-47. Pore diffusion was not the sole rate-limiting step;film diffusion was also involved in the adsorption process of BDE-47 on biochars. The overall results demonstrate the transport and potential treatment of PBDEs using biochars. | LIU Guangxia SONG Yang SHENG Hongjie YE Mao Robert DSTEDTFELD BIAN Yongrong GU Chenggang JIANG Xin WANG Fang | 2019 | Pedosphere2019，29，6： | 3 |
| 5 | Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction显示文摘 | Hongjie Liu Zhaoting Wu Xianle Shi Wenzhi Li Chang Liu Dekun Wang Xiaoying Ye Lin Liu Jie Na Hong Cheng Lingyi Chen | 2013 | Developmental Biology2013，，1： | 1 |
| 6 | Poroupyr amids structured silicon surface with low reflectance over a broad band by electrochemical etching 显示文摘 | Lv Hongjie Shen Honglie Jiang Ye | 2012 | Applied Surface Science2012，258，54： | 1 |
| 7 | Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging显示文摘 | Mingzhou Ye Yue Qian Jianbin Tang Hongjie Hu Meihua Sui Youqing Shen | 2013 | Journal of Controlled Release2013，，： | 1 |
| 8 | Optimal Power Flow Calculation of Active Distribution Network Based on Improved Comprehensive Technology显示文摘Comprehensive unified power flow controller(UPFC)technology can calculate voltage control parameters of UPFC,but it increases the nonlinearity of Newton power flow calculation.When the comprehensive technology is combined with the intelligent algorithm,the control parameters can only be optimized through the active and reactive power of UPFC on the branch,which makes the optimization convergence worse.Therefore,an optimal power flow calculation method for active distribution network based on improved comprehensive technology is proposed.First,based on the analysis of the influence of UPFC on branch power flow,an improved UPFC model is proposed.The accuracy of UPFC control parameters is enhanced by adjusting the voltage phase angle and regulation radius of series side transformer.Second,the optimal control model considering UPFC is established.Finally,the corresponding self-admittance and mutual admittance elements are extracted from the constructed UPFC model and introduced into the Jacobian matrix,so that while the comprehensive technology maintains the dimension of the Jacobian matrix,the intelligent algorithm can directly optimize the control parameters to reduce the search space.The IEEE33 bus system is used for example simulation,the results before and after the improvement are compared,and the Monte Carlo method is used to calculate the two algorithms 50 times respectively based on the installation number of UPFC,which verifies that the proposed optimization method has better convergence and operation speed. | CAO Hongji LIU Daobing LI Shichun JIN Zitong YUAN Ye XU Songlin | 2022 | Wuhan University Journal of Natural Sciences2022，27，2： | 1 |
| 9 | A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females显示文摘 | Yubei Huang Xiaoliang Zhang Weiqin Li Fengju Song Hongji Dai Jing Wang Ying Gao Xueou Liu Chuan Chen Ye Yan Yaogang Wang Kexin Chen | 2014 | Cancer Causes & Control2014，，2： | 1 |
| 10 | Requirements model driven adaption and evolution of Internetware显示文摘Today’s software systems need to support complex business operations and processes.The development of the web-based software systems has been pushing up the limits of traditional software engineering methodologies and technologies as they are required to be used and updated almost real-time,so that users can interact and share the same applications over the internet as needed.These applications have to adapt quickly to the diversified and dynamic changing requirements in the physical,technological,economical and social environments.As a consequence,we are expecting a major paradigm shift in software engineering to reflect such changes in computing environment in order to better address the fundamental needs of organisations in this new era.Existing software technologies,such as model driven development,business process engineering,online(re-)configuration,composition and adaptation of managerial functionalities are being repurposed to reduce the time taken for software development by reusing software codes.The ability to dynamically combine contents from numerous web sites and local resources,and the ability to instantly publish services worldwide have opened up entirely new possibilities for software development.In retrospect to the ten years applied research on Internetware,we have witnessed such a paradigm shift,which brings about many changes to the developmental experience of conventional web applications.Several related technologies,such as cloud computing,service computing,cyber-physical systems and social computing,have converged to address this emerging issue with emphasis on different aspects.In this paper,we first outline the requirements that the Internetware software paradigm should meet to excel at web application adaptation;we then propose a requirement model driven method for adaptive and evolutionary applications;and we report our experiences and case studies of applying it to an enterprise information system.Our goal is to provide high-level guidelines to researchers and practitioners to meet the challenges of building adaptive industrial-strength applications with the spectrum of processes,techniques and facilities provided within the Internetware paradigm. | LIU Lin YANG Chen WANG JianMin YE XiaoJun LIU YingBo YANG HongJi LIU XiaoDong | 2014 | Science China(Information Sciences)2014，57，6： | 1 |
| 11 | Targeted biodegradable dendritic MRI contrast agent for enhanced tumor imaging显示文摘 | Mingzhou Ye Yue Qian Jianbin Tang Hongjie Hu Meihua Sui Youqing Shen | 2013 | Journal of Controlled Release2013，，3： | 1 |
| 12 | Porous-pyramids structured silicon surface with low reflectance over a broad band by electrochemical etching显示文摘 | Hongjie Lv Honglie Shen Ye Jiang Chao Gao Han Zhao Jiren Yuan | 2012 | Applied Surface Science2012，，14： | 1 |
| 13 | Dynamic human retinal pigment epithelium(RPE)and choroid architecture based on single-cell transcriptomic landscape analysis显示文摘The retinal pigment epithelium(RPE)and choroid are located behind the human retina and have multiple functions in the human visual system.Knowledge of the RPE and choroid cells and their gene expression profiles are fundamental for understanding retinal disease mechanisms and therapeutic strategies.Here,we sequenced the RNA of about 0.3 million single cells from human RPE and choroids across two regions and seven ages,revealing regional and age differences within the human RPE and choroid.Cell–cell interactions highlight the broad connectivity networks between the RPE and different choroid cell types.Moreover,the transcription factors and their target genes change during aging.The coding of somatic variations increases during aging in the human RPE and choroid at the single-cell level.Moreover,we identified ELN as a candidate for improving RPE degeneration and choroidal structure during aging.The mapping of the molecular architecture of the human RPE and choroid improves our understanding of the human vision support system and offers potential insights into the intervention targets for retinal diseases. | Lulin Huang Lin Ye Runze Li Shanshan Zhang Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Bo Gong Zheng Li Hongjie Yang Man Yu Yi Shi Changguan Wang Wei Chen Zhenglin Yang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 14 | Effects of Different Eelectron-withdrawing Moieties on the General Photoelectric Properties of Fluorene-based Dimers显示文摘Here,9,9.9'-tris(4-butoxyphenyl)-9H-9'Hl-2,2'-difluorene(DF)was synthesized as a reference for compa rison,and diphenyl sulfone and triphenylphosphine oxygen were introduced to the 9-position of fluorene througha C-H coupling reaction to produce two fluorene-based oligomers 9′,9′″-sulfonylbis(4.1-phenylene)bis9,9′,9′tris(4-butoxyphenyl)-9H,9'H-2.2'-bifluorene(DF)SOz and phenylbis(4-{9.9,9-tris(4-butoxyphenyl)-9H,9'H-12.2-bif-luorenel-9-yl} phenyl)phosphine oxidel(DF)2POI.Solid powders of all the three compounds exhibit excellent therma stability with thermal temperature at 5%mass loss of 375,429 and 383 C for(DF)2SO2,(DF)PO and DF.In addition,owing to the distorted molecular structure and weak electron-absorbing ability of the acceptor,(DF)Soz and(DF)2PO do not have obvious intramolecular charge transfer characteristics.and exhibit stable localized 394 nm/375 nm fluorescence emission peaks in different polar solvents.The absolute luminescence quantumefficiencies of(DF)2S02,(DF)PO and DF solid powders are 20.83%,10.03%and 59.46%,Compound DF has the highest quantum yield as an electron donor.The chromaticity coordinates of the blue OLED devices based on DF and DF2SO2 fabricated by solution spin coating were(0.19.0.10)and(0.19.0.11).which were closest to the deep blue region,and the corresponding maximum external quantum efficiencies are 1.45%and 0.87%,respectively,which are higher than that of(DF)2PO(0.25%)and consistent with the difference in the solid-state quantum efficiency between them. | YUAN Xinlei LI Jie LU Zhiwei YE Shanghui JIANG Hongji | 2020 | Chemical Research in Chinese Universities2020，36，6： | 0 |
| 15 | Visible-Light-Promoted Formation of C-C and C-P Bonds Derived from Evolution of Bromoalkynes under Additive-Free Conditions:Synthesis of 1,1-Dibromo-1-en-3-ynes and Alkynylphosphine Oxides显示文摘Main observation and conclusion The controllable achievement of C-C and C-P bond formations is developed via visible-light-promoted bromoalkyne dimerization or its further transformation with secondary phosphine oxides.The 1,1-dibromo-1-en-3-ynes are formed when bromoalkyne is exposed to visible-light.While alkynylphosphine oxides are generated when bromoalkynes are mixed with secondary phosphine oxides. | Hailong Xu Rui Chen Hongjie Ruan Ruyi Ye Ling-Guo Meng | 2021 | Chinese Journal of Chemistry2021，39，4： | 0 |
| 16 | Deep Sc-RNA sequencing decoding the molecular dynamic architecture of the human retina显示文摘The human retina serves as a light detector and signals transmission tissue.Advanced insights into retinal disease mechanisms and therapeutic strategies require a deep understanding of healthy retina molecular events.Here,we sequenced the m RNA of over 0.6 million single cells from human retinas across six regions at nine different ages.Sixty cell sub-types have been identified from the human mature retinas with unique markers.We revealed regional and age differences of gene expression profiles within the human retina.Cell-cell interaction analysis indicated a rich synaptic connection within the retinal cells.Gene expression regulon analysis revealed the specific expression of transcription factors and their regulated genes in human retina cell types.Some of the gene’s expression,such as DKK3,are elevated in aged retinas.A further functional investigation suggested that over expression of DKK3 could impact mitochondrial stability.Overall,decoding the molecular dynamic architecture of the human retina improves our understanding of the vision system. | Lulin Huang Runze Li Lin Ye Shanshan Zhang Huaping Tian Mingyan Du Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Ling Zhong Hongjie Yang Man Yu Yi Shi Changguan Wang Houbin Zhang Wei Chen Zhenglin Yang | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 17 | Micro pore and throat characteristics and origin of tight sandstone reservoirs: A case study of the Triassic Chang 6 and Chang 8 members in Longdong area, Ordos Basin, NW China显示文摘The microstructure differences of the Triassic Chang 6 and Chang 8 members tight reservoirs in the Longdong area of Ordos Basin were compared by means of cast thin sections, scanning electron microscope, X-ray diffraction, and constant rate mercury injection. Their pore evolution models were established, and the effects of main diagenesis on densification were examined. The throat is the main factor controlling the physical properties of the Chang 6 and Chang 8 members reservoirs: The lower the permeability, the smaller and the more concentrated the throat radius and the larger the proportion of the throats in the effective storage space. There are several obvious differences between Chang 6 and Chang 8 members:(1) with the increase of permeability, the contribution of the relative large throats to the permeability in the Chang 8 member reservoir is more than that in the Chang 6 member reservoir;(2) the control effect on pore-throat ratio of the nano-throats in the Chang 6 member reservoir is more significant. The sedimentary action determines the primary pore structure of the Chang 6 and Chang 8 members sand bodies, and the diagenesis is the main factor controlling the densification of the reservoirs. Because of the difference in rock fabrics and the chlorite content of Chang 6 and Chang 8, the strong compaction resulted in less porosity reduction(17%) of the Chang 81 reservoir with larger buried depth and larger ground temperature than the Chang 63 reservoir(19%). The siliceous, calcareous and clay minerals cement filling the pores and blocking the pore throat, which is the key factor causing the big differences between the reservoir permeability of Chang 6 and Chang 8 members. | LIU Hanlin YANG Youyun WANG Fengqin DENG Xiuqin LIU Ye NAN Junxiang WANG Jin ZHANG Hongjie | 2018 | Petroleum Exploration and Development2018，45，2： | 0 |
| 18 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
| 19 | Synthesis and Properties of a Biodegradable Dendritic Magnetic Resonance Imaging Contrast Agent显示文摘新奇可被细菌破坏的树枝状的对比代理人(DCA ) 基于聚酯 dendrimers 被综合并且描绘。DCA 在生理的 pH 很快在酸的 pH,而是 hydrolyzed 是稳定的,它象小分子 CA 的一样使 DCA 的长期的 Gd3+ 保留变为低。他们 10.2 ~ 17.5 L 祬的纵的 relaxivities?? | Tingting Li Yue Qian Mingzhou Ye Jianbin Tang Hongjie Hu Youqing Shen | 2014 | Chinese Journal of Chemistry2014，32，1： | 0 |
| 20 | Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate in water显示文摘Accompanying an annual increase in cancer incidence,the global use of anticancer drugs has remarkably increased with their worldwide environmental prevalence and ecological risks.In this study,the oxidation of methotrexate(MTX),a typical anticancer drug with ubiquitous occurrence and multi-endpoint toxicity,by ferrate(VI)(Fe(VI))and permanganate(Mn(VII)))was investigated in water.Fe(VI)exhibited a higher reactivity with MTX(93.34 M^(−1) s^(−1))than Mn(VII)(3.01 M^(−1) s^(−1)) at pH 8.0.The introduction of Cu(II)and Fe(III)at 1.0 mM improved the removal efficiency of 5.0μM MTX by 100.0μM Fe(VI)from 80%to 95%and 100%after 4 min,respectively.Seven oxidized products(OPs)were identified during oxidative treatments,while OP-191 and OP-205 were characterized as specific products for Fe(VI)oxidation.Initial ketonization of the L-glutamic acid moiety and cleavage of the peptide bond of MTX were proposed.Additionally,a multi-endpoint toxicity evaluation indicated no genotoxicity,neurotoxicity,or endocrine-disrupting effects of MTX and its OPs.Particularly,serious developmental toxicity in zebrafish larvae was observed in the treated MTX solutions.Based on the acute and chronic aquatic toxicity prediction,OP-190,OP-192,OP-206,and OP-208 were deemed toxic or very toxic compared to harmful MTX.Furthermore,the reduced biodegradability index from 0.15(MTX)to−0.5 to−0.2(OP-192,OP-206,and OP-468)indicated the formation of lower biodegradable OPs.Overall,this study suggests that Fe(VI)and Mn(VII)oxidation are promising treatments for remediating anticancer drug-contaminated water.However,the environmental risks associated with these treatments should be considered in the evaluation of water safety. | Shengqi Zhang Chengsong Ye Wenjun Zhao Lili An Xin Yu Lei Zhang Hongjie Sun Mingbao Feng | 2022 | Frontiers of Environmental Science & Engineering2022，16，7： | 0 |
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