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| 1 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 2 | Study on Occupational Health Surveillance System Usedduring Construction of Qinghai-Tibet Railway显示文摘To prevent the occupational altitude disease and other occupational disease during construction, occupational health surveillance system is established used for the Qinghai-Tibet railway construction. This system is composed of three parts, labor environment monitoring system, occupational disease monitoring system and information managing system for health surveillance. The objective disease of surveillance is altitude disease, pneumoconiosis, occupational poisoning, ultraviolet radiation damage and occupational hearing damage. The surveillance period is 3 month. In addition, two systems, including information managing system and evaluation reporting system used for health surveillance, and a computer information managing software of health surveillance used during Qinghai-Tibet railway construction is developed. The computer managing software has three main functions, basic database, statistics database and output of evaluating report. | Shi Hongsheng Ren Anxu Zhao Yalin Ye Yuhua | 2006 | 工程科学(英文版)2006，4，2： | 0 |
| 3 | Preliminary Study on Development and Calibration of Standard Source of 133Ba Filter Box显示文摘In order to achieve the value transfer system K=EBa/EI,and use 133Ba filter box body source for the field calibration of iodine monitor,the research on the development of the transmission standard source of 133Ba filter box,the test of homogeneity of body source and the accurate determination of the fixed value were carried out. | SONG Xinpeng YE Hongsheng XIA Wen XU Lijun LI Ming CHEN Kesheng LUO Rui CHEN Yizhen ZHANG Weidong | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 4 | Establishment of Preparation Device for Reference Tritium Gas显示文摘There are a variety of influencing factors in the real-time monitoring of tritium in the air,such as low-energy characteristics of itsβ-particle,the background ofγray and interference of radioactive inert gas.It is said that the same kind of source should be applied in the calibration of tritium monitor in the regulation of GB/T 7165.5- | XU Lijun LUO Rui YE Hongsheng LI Ming ZHANG Weidong LIN Min LYU Xiaoxia SONG Xinpeng XIA Wen CHEN Kesheng CHEN Yizhen | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 5 | The preparation of Garcinia Glycosides solid dispersion and intestinal absorption by rat in situ single pass intestinal perfusion显示文摘Garcinia Glycosides is a candidate drug obtained by structural modification of Gambogic Acid (GA), which was acquired through High Throughput Screening(HTS). As Garcinia Glycosides is an effective but insoluble anti-tumor drug, the aim of this study was to obtain a solid dispersion form Garcinia Glycosides by using solvent-melt method so that improve the solubility and dissolution rate. The solid dispersion was characterized by High Performance Liquid Chromatography (HPLC), infrared spectroscopy and evaluated the intestinal absorption of the drug by rat in situ single pass intestinal perfusion. The results showed the increase of solubility, dissolution velocity and absorption compared to other forms. This indicated that solid dispersion could greatly improve the relative bioavailability of Garcinia Glycosides in vivo. | Shengnan Li Jingchao Ji Yinghui Chen Ye Chen Ju Liu Yang Wang Hongsheng Liu | 2019 | Journal of Pharmaceutical and Biopharmaceutical Research2019，1，1： | 0 |
| 6 | Preliminary Study on Absolute Measurement of Absorbed Dose of Electron Beam Based on Calorimetry显示文摘The preliminary study on absolute measurement of absorbed dose of electron beam was carried out at irradiation processing grade.Two type of calorimeters,graphite and polystyrene,which were made in RISO Laboratory,were used to do dynamic irradiation experiments at the energy of 10 MeV.This research was about dose response,repeatability,value transfer method,and so on.The results show that the absorbed dose measured by calorimeters was only connected with electron beam intensity during irradiation.The relationship of absorbed dose and electron beam intensity is shown in Fig.1.The absorbed dose was proportional to the beam intensity at the range of 1-50kGy. | LUO Rui ZHANG Weidong CHEN Kesheng CHEN Yizhen LIN Min YE Hongsheng XU Lijun | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 7 | Study on Heat Treatment of Radiochromic Film in Radiation Processing显示文摘Radiochromic film dosimeters for radiation processing were established in the laboratory,including FJL-02 and FJL-03 with the dose range of 0.05-210 kGy.The radiochromic film dosimeters were mass-produced.In the post irradiation stability study,it was found that the coloration of FJL-02/FJL-03radiochromic film material may continue to develop for some period of time after irradiation,generally several hours or even longer.In order to make the radiochromic film dosimeters better used in radiation processing and improve work efficiency,FJL-02/FJL-03radiochromic film dosimeters were properly heat treated after irradiation to promote rapid color stabilization for fast measurement. | CHEN Yizhen CHEN Kesheng ZHANG Weidong LUO Rui XU Lijun CUI Ying LIN Min YE Hongsheng | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 8 | Full-parameter omnidirectional transformation optical devices显示文摘Transformation optics(TO)provides an unprecedented technique to control electromagnetic(EM)waves by engineering the constitutive parameters of the surrounding medium through a proper spatial transformation.In general,ideal transformation optical devices require simultaneous electric and magnetic responses along all three dimensions.To ease the practical implementation,previous studies usually made use of reduced parameters or other simplified approaches,which inevitably introduce extra reflection or unwanted phase shift.Up to today,experimental realizations of full-parameter transformation optical devices in free space are still quite limited.Here,a general design strategy is proposed to solve this problem.As a specific example,a full-parameter spatial-compression TO medium with constitutive parameters taking the diagonal form diag(a,a,1/a)for the TM wave incidence was designed and realized experimentally.Such spatial-compression TO media were then applied to the implementation of an ideal omnidirectional invisibility cloak capable of concealing a large-scale object over a wide range of illumination angles.Both the simulation and experiment confirm that the cloak allows for nearly unity transmission of EM waves in the forward direction without introducing extra scattering or phase shift.This work constitutes an important stepping stone for future practical implementation of arbitrary full-parameter omnidirectional transformation optical devices. | Yuan Gao Yu Luo Jingjing Zhang Zhengjie Huang Bin Zheng Hongsheng Chen Dexin Ye | 2024 | National Science Review2024，11，3： | 0 |
| 9 | Aβ-ketoacyl-CoA Synthase OsCUT1 Confers Increased Drought Tolerance in Rice显示文摘Drought stress is one of the major environmental factors affecting crop growth and productivity.Cuticular wax plays essential roles in protecting plants from environmental stress via forming a hydrophobic barrier on leaf epidermis.In this study,we analyzed nine members(OsCUT1‒OsCUT9)ofβ-ketoacyl-CoA synthase,the rate-limiting key enzyme for cuticular wax synthesis in rice by homology search and domain prediction.The expression levels of OsCUT genes under different abiotic stresses were investigated and OsCUT1 down-regulated by abiotic stress was selected for further function validation.Compared to the wild type,overexpression of OsCUT1(OX-OsCUT1)exhibited significantly increased drought resistance.Epicuticular wax was increased on the leaf surface of OX-OsCUT1 and the chlorophyll leaching experiment showed that the cuticular permeability was decreased in the OX-OsCUT1 plants.Moreover,overexpression of OsCUT1 didn’t result in the significant changes of major agronomic traits.In total,these results suggested that OsCUT1 is a promising gene for engineering rice plants with enhanced drought tolerance. | GAO Xiuying ZHANG Ye ZHANG Hongsheng HUANG Ji | 2022 | Rice science2022，29，4： | 0 |
| 10 | Revealing the Transformation Invariance of Full-Parameter Omnidirectional Invisibility Cloaks显示文摘Searching for an optimal solution among many nonunique answers provided by transformation optics is critical for many branches of research,such as the burgeoning research on invisibility cloaks.The past decades have witnessed rapid development of transformation optics,and different kinds of invisibility cloaks have been designed and implemented.However,the available cloaks realized thus far have been mostly demonstrated with reduced parameters,which greatly impact the predefined cloaking performance.Here,we report a general design strategy to realize full-parameter omnidirectional cloaks that can hide arbitrarily shaped objects in free space.Our approach combines a singular transformation with transformation-invariant metamaterials.The cloaking device with extreme parameters is implemented using a metallic array structure.In the experiment,two cloak samples are designed and fabricated,one with nondiscrete cloaking regions and the other with separated hidden regions.Near-unit transmission of electromagnetic waves with arbitrary incident angles is experimentally demonstrated along with significantly suppressed scattering.Our work challenges the prevailing paradigms of invisibility cloaks and provides deep insight into how transformation optics could be harnessed to obtain easily-accessible metadevices. | Bin Zheng Huan Lu Chao Qian Dexin Ye Yu Luo Hongsheng Chen | 2023 | Electromagnetic Science2023，1，2： | 0 |
| 11 | Chimeric antigen receptor T-cell therapy: a promising treatment modality for relapsed/refractory mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a distinct histological type of B-cell lymphoma with a poor prognosis.Several agents,such as proteasome inhibitors,immunomodulatory drugs,and inhibitors of B cell lymphoma-2 and Bruton’s tyrosine kinase have shown efficacy for relapsed or refractory(r/r)MCL but often have short-term responses.Chimeric antigen receptor(CAR)T-cell therapy has emerged as a novel treatment modality for r/r non-Hodgkin’s lymphoma.However,long-term safety and tolerability associated with CAR T-cell therapy are not defined well,especially in MCL.In this report,we described a 70-year-old patient with r/r MCL with 48-month duration of follow-up who achieved long-term remission after CAR T-cell therapy.CAR T-cell-related toxicities were also mild and tolerated well even in this elderly patient.This report suggested that CAR T-cell therapy is a promising treatment modality for patients with MCL,who are generally elderly and have comorbid conditions. | Ping Li Ningxin Dong Yu Zeng Jie Liu Xiaochen Tang Junbang Wang Wenjun Zhang Shiguang Ye Lili Zhou Alex Hongsheng Chang Aibin Liang | 2020 | Frontiers of Medicine2020，14，6： | 0 |
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