|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 3 | Atomization Inhalation of Terbutaline and Budesonide Efficiently Improved Immunity and Lung Function of AECOPD Patients显示文摘Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic progressive airflow limitation as a result of chronic inflammation of the airways and lung parenchyma. COPD patients always have airway hyperreactivity (AHR),so how to reduce AHR becomes the key purpose of clinical treatment. It is hypothesized that combined inhalation of corticosteroids and β2-agonists can reduce the AHR in COPD. In this study,atomization inhalation of budesonide and terbutaline plus conventional therapies was applied to treat AECOPD (acute exacerbation of chronic obstructive pulmonary disease) patients for two weeks. The results showed that additional inhalation of budesonide and terbutaline could upregulate serum IL-2 levels,the percentages of CD3+ T and CD4+ T cells,and CD4/CD8 ratio,and decrease eosinophils and serum CRP level more efficiently than conventional treatment in patients with AECOPD. And the lung function of the atomization inhalation group was improved more obviously after the treatment compared with the conventional treatment group. Thus,atomization inhalation of terbutaline and budesonide can control AECOPD effectively,and has wide clinical perspective in controlling and preventing the exacerbation of COPD. | Guilan Xiong Lijun Xu Liu Wei Xiaodan Li | 2008 | Cellular & Molecular Immunology2008，5，4： | 30 |
| 4 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 5 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 28 |
| 6 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 7 | Electrochemical behavior of zirconium in molten NaCl-KCl-K_2ZrF_6 system显示文摘The electrochemical reduction of Zr4+(complex) ions in NaCl-KCl-K2ZrF6 molten salt on Pt electrode was investigated using cyclic voltammetry and square wave voltammetry at 1023 K.Two cathodic reduction peaks related to Zr4+/Zr2+ and Zr2+/Zr steps were observed in the cyclic voltammograms.The result was also confirmed by square wave voltammetry.The diffusion coefficient of Zr4+(complex) ions at 1023 K in NaCl-KCl-K2ZrF6 melt,measured by cyclic voltammetry,is about 4.22×10-6 cm2/s.The characterization of the deposits obtained by potentiostatic electrolysis at different potentials was investigated by XRD,and the results were well consistent with the electrochemical reduction mechanism of Zr4+(complex) ions. | WU Yanke XU Zhigao CHEN Song WANG Lijun LI Guoxun | 2011 | Rare Metals2011，30，1： | 16 |
| 8 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 9 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 10 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 11 | Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields. | Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai | 2018 | Journal of Environmental Sciences2018，30，2： | 12 |
| 12 | Immunotherapeutical Potential of Mycobacterium Vaccae on M. Tuberculosis Infection in Mice显示文摘Tuberculosis remains the worldwide infectious disease. To identify the therapeutic potential of M. vaccae in treating tuberculosis,M. vaccae was injected into Mycobacterium tuberculosis(M. tuberculosis) infected mice. The optimal dose of M. vaccae(22.5 μg/mouse) treated mice showed lower pathological change index,spleen weight index,lung weight index and vital M. tuberculosis count than those of the untreated group. Treatment with M. vaccae enhanced the percentages of CD3+ and CD4+ T cells,IFN-γ+CD4+ T cells,innate immune cells including NK cells,NK1.1+ T cells and γδ T cells,and reduced the percentage of IL-4+CD4+ T cells. Therefore,M. vaccae could protect the mice from M. tuberculosis infection and improved mouse innate and adaptive cell-mediated immunity,suggesting that M. vaccae is a potential immunotherapeutic agent in pulmonary tuberculosis. | Lijun Xu Yanyan Wang Xiaodong Zheng Xiangdong Gui Lifeng Tao Haiming Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 11 |
| 13 | Inhibition of bromophenols against PTP1B and anti-hyperglycemic effect of Rhodomela confervoides extract in diabetic rats显示文摘Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways. PTP1B is an effective target for the treatment of type 2 diabetes mellitus. Four bromophenol derivatives from red algae Rhodomela confervoides, 2,2′,3,3′-tetrabromo-4,4′,5,5′-tetra- hydroxydiphenyl methane (1), 3-bormo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl) pyrocatechol (2), bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (3) and 2,2′,3-tribromo-3′,4,4′,5-tetrahydroxy-6′-ethyloxy- methyldiphenylmethane (4) showed significant inhibitory activity against PTP1B (IC50 were 2.4, 1.7, 1.5 and 0.84 μmol/L, respectively) as potential therapeutical agents for the treatment of type 2 diabetes mellitus. The anti-hyperglycemic effects of the ethanol extracts from R. confervoides on streptozoto- cin-induced diabetes (STZ-diabetes) in male Wistar rats fed with high fat diet were investigated. The STZ-diabetic rats treated with medium-dose and high-dose alga extracts showed remarkable reductions in fasting blood glucose (FBG) as compared with the STZ-diabetic control. The results indicate that the in vivo anti-hyperglycemic activity of the R. confervoides extracts can be partially attributed to the in- hibitory actions against PTP1B of the bromophenol derivatives and that may be of clinical importance in improving the management of type 2 diabetes mellitus. | SHI DaYong XU Feng HE Juan LI Jing FAN Xiao HAN LiJun | 2008 | Chinese Science Bulletin2008，53，16： | 11 |
| 14 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 15 | Subduction tectonics vs.plume tectonics——Discussion on driving forces for plate motion显示文摘Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half a century ago,considerable debates have remained regarding the driving forces for plate motion.The early'Bottom up'view,i.e.,the convecting mantledriven mechanism,states that mantle plumes originating from the core-mantle boundary act at the base of plates,accelerating continental breakup and driving plate motion.Toward the present,however,the'Top down'idea is more widely accepted,according to which the negative buoyancy of oceanic plates is the dominant driving force for plate motion,and the subducting slabs control surface tectonics and mantle convection.In this regard,plate tectonics is also known as subduction tectonics.'Top down'tectonics has received wide supports from numerous geological and geophysical observations.On the other hand,recent studies indicate that the acceleration/deceleration of individual plates over the million-year timescale may reflect the effects of mantle plumes.It is also suggested that surface uplift and subsidence within stable cratonic areas are correlated with plumerelated magmatic activities over the hundred-million-year timescale.On the global scale,the cyclical supercontinent assembly and breakup seem to be coupled with superplume activities during the past two billion years.These correlations over various spatial and temporal scales indicate the close relationship and intensive interactions between plate tectonics and plume tectonics throughout the history of the Earth and the considerable influence of plumes on plate motion.Indeed,we can acquire a comprehensive understanding of the driving forces for plate motion and operation mechanism of the Earth's dynamic system only through joint analyses and integrated studies on plate tectonics and plume tectonics. | Ling CHEN Xu WANG Xiaofeng LIANG Bo WAN Lijun LIU | 2020 | Science China Earth Sciences2020，63，3： | 10 |
| 16 | Spatial and temporal variations of coastlines in northern China (2000-2012)显示文摘This study examined the spatial distribution of the continent coastline in northern China using remote sensing and GIS techniques,and calculated the fractal dimension of the coastline by box-counting method,with a time span from 2000 to 2012.Moreover,we analyzed the characteristics of spatial-temporal changes in the coastline's length and fractal dimension,the relationship between the length change and fractal dimension change,and the driving forces of coastline changes in northern China.During the research period,the coastline of the study area increased by 637.95 km,at a rate of 53.16 km per year.On the regional level,the most significant change in coastline length was observed in Tianjin and Hebei.Temporally,the northern China coastline grew faster after 2008.The most dramatic growth was found between 2010 and 2011,with an increasing rate of 2.49% per year.The fractal dimension of the coastline in northern China was increasing during the research period,and the most dramatic increase occurred in Bohai Rim.There is a strong-positive linear relationship between the historical coastline length and fractal dimension(the correlation coefficient was 0.9962).Through statistical analysis of a large number of local coastline changes,it can be found that the increase(or decrease) of local coastline length will,in most cases,lead to the increase(or decrease) of the whole coastline fractal dimension.Civil-coastal engineering construction was the most important factor driving the coastline change in northern China.Port construction,fisheries facilities and salt factories were the top three construction activities.Compared to human activities,the influence of natural processes such as estuarine deposit and erosion were relatively small. | XU Jinyong ZHANG Zengxiang ZHAO Xiaoli WEN Qingke ZUO Lijun WANG Xiao YI Ling | 2014 | Journal of Geographical Sciences2014，24，1： | 10 |
| 17 | Deformation Compensation of Ram Components of Super-heavy-duty CNC Floor Type Boring and Milling Machine显示文摘Ram is a very important component of super-heavy-duty computer numerical control (CNC) floor type boring-milling machine, and deformation of ram is a significant source causing errors in machining process. To compensate the deformation error of super-heavy-duty CNC floor type boring-milling machine, based on force analysis theory, the law and compensation measures of deformation of ram are researched. Based on the principle of torque (force) balance of the ram components, the formulas of compensation forces and compensation torques are derived, the relations between compensation forces (compensation torques) and the stroke distance of the ram are given. According to theoretical analysis results and the structural characteristics of super-heavy-duty CNC floor type boring and milling machine of TK6932, rods compensation, hydrostatic pressure compensation and wire rope compensation measures are taken to compensate the deformation error of ram. The experiments and computer simulation results show that the straightness of the ram at its overhanging end meets the national machinery industry standards. | WU Fenghe QIAO Lijun XU Yaoling | 2012 | Chinese Journal of Aeronautics2012，25，2： | 9 |
| 18 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 19 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 20 | Correlation of CD105 and Vascular Endothelial Growth Factor in Laser-induced Choroidal Neovascularization in Rats显示文摘Purpose: Choroidal neovascularization (CNV) plays an important role in pathogenesis of age-related macular degeneration (AMD), ocular histoplasmosis syndrome (OHS) and so on. However, mechanisms of CNV formation are not fully understood. The aim of this study is to investigate the correlation between expressions of CD105 and vascular endothelial growth factor (VEGF) in experimental laser-induced CNV in rats. Methods: CNV model was established by 532 nm laser photocoagulation in Brown-Norway rats. The expression of CD105 and VEGF in CNV was observed by immunohistochemistry at 3, 7, 14, 21, 28 and 56 days after laser photocoagulation. The image analysis was performed with the professional software of Image-Pro Plus. Results: Fluorescein angiography showed fluorescein leakage in CNV from days 7 to 56 after photocoagulation. VEGF expression was mainly observed in vascular endothelial cells, ganglion cells, inner nuclear layers and retinal pigment epithelial cells in normal retina and vascular endothelial cells in normal choroid of the rats. On day 3 after photocoagulation, VEGF began to express in laser-induced lesions. VEGF was strongly expressed in CNV after 7 days (P<0.05) and decreased after 14 days (P>0.05). CD105 was initially presented in CNV at 7 days and obviously expressed at 14 days after photocoagulation (P<0.05). Four weeks later, when angiogenesis tended toward inactive status, expression of CD105 was markedly decreased (P>0.05). There was notablely direct correlation between CD105-positive-microvessel density and positively semiquantitative scoring of VEGF in the CNV(r=0.989, P<0.01). Conclusions: There is direct correlation between the expression of CD105 and VEGF in the laser-induced CNV in rat. It suggests that CD105 and VEGF might participate in the new blood vessel formation and promote the growth of CNV. | Jianfeng Xu Yusheng Wang Xiumei Yang Peng Zhang Lijun Chen | 2006 | 眼科学报2006，22，3： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员