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| 1 | Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model显示文摘Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer. | Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，12： | 2 |
| 2 | 共面转换液晶显示器中获得对比度高于1:600的新技术显示文摘薄膜晶体管液晶电视(TFT-LCDTV)因为具有薄、轻、紧凑和可随意放置的特点,已经占据了大部分电视机市场。除了这些物理特性以外,最重要的特性是已具有了良好像质的对比度。为了将对比度提高到1:600以上,对偏振片膜、背光源板、滤色片树脂、电极锥角和摩擦条件等都进行了研究。优化的背光板组合,光滑的电极锥角和摩擦方法的控制是提高对比度的主要控制因素。应用新开发的滤色片树脂,对获得高对比度最为有效。 | Jae Hyun Kim Joun Ho Lee Ji Chul Lim Chang Hoon Lee Moo Hyoung Song Ju Yeon Yoon Hee Dong Choi Jeom Jae Kim Chang Ho Oh Sang Deog Yeo 李路海 | 2004 | 现代显示2004，，5： | 1 |
| 3 | Hair condi- tioning effect of amino silicone softeners in varied treatment conditions 显示文摘 | YEON HEE LIM CHUNG HEE PARK JOOYOUN KIM | 2010 | Fibers and Polymers2010，11，3： | 1 |
| 4 | S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial显示文摘 | Yong Sang Hong Young Suk Park Ho Yeong Lim Jeeyun Lee Tae Won Kim Kyu-pyo Kim Sun Young Kim Ji Yeon Baek Jee Hyun Kim Keun-Wook Lee Ik-Joo Chung Sang-Hee Cho Kyung Hee Lee Sang Joon Shin Hye Jin Kang Dong Bok Shin Sook Jung Jo Jae Won Lee | 2012 | Lancet Oncology2012，，11： | 1 |
| 5 | Resting-state regional homogeneity as a biological marker for patients with Internet gaming disorder: A comparison with patients with alcohol use disorder and healthy controls显示文摘 | Heejung Kim Yu Kyeong Kim Ah Reum Gwak Jae-A Lim Jun-Young Lee Hee Yeon Jung Bo Kyung Sohn Sam-Wook Choi Dai Jin Kim Jung-Seok Choi | 2015 | Progress in Neuropsychopharmacology & Biological2015，，： | 1 |
| 6 | Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11 C-methionine positron emission tomography显示文摘 | Jeehun Lee Bo Lyun Lee Keon Hee Yoo Ki Woong Sung Hong Hoe Koo Su Jin Lee Joon Young Choi Kyung-Han Lee Jung Il Lee Hyung-Jin Shin Ji Hye Kim Yeon Lim Suh Ke Hyang Lee Munhyang Lee | 2009 | Child’s Nervous System2009，，1： | 1 |
| 7 | Melatonin modulates adiponectin expression on murine colitis with sleep deprivation显示文摘AIM To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation.METHODS The following five groups of C57BL/6 mice were used in this study:(1) group Ⅰ,control;(2) group Ⅱ,2% DSS induced colitis for 7 d;(3) group Ⅲ,2% DSS induced colitis and melatonin treatment;(4) group Ⅳ,2% DSS induced colitis with sleep deprivation(SD) using specially designed and modified multiple platform water baths; and(5) group V,2% DSS induced colitis with SD and melatonin treatment. Melatonin(10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures,levels of serum cytokines were measured by ELISA. RESULTS Sleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury,but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis,with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly(P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection. CONCLUSION This study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated antiinflammatory effects on colitis with sleep deprivation. | Tae Kyun Kim Young Sook Park Haing-Woon Baik Jin Hyun Jun Eun Kyung Kim Jae Woong Sull Ho Joong Sung Jin Woo Choi Sook Hee Chung Myung Chan Gye Ju Yeon Lim Jun Bong Kim Seong Hwan Kim | 2016 | World Journal of Gastroenterology2016，22，33： | 1 |
| 8 | miR‐206 regulates brain‐derived neurotrophic factor in Alzheimer disease model显示文摘 | Soon‐Tae Lee Kon Chu Keun‐Hwa Jung Jin Hee Kim Ji‐Young Huh Hyejin Yoon Dong‐Kyu Park Ji‐Yeon Lim Jeong‐Min Kim Daejong Jeon Hoon Ryu Sang Kun Lee Manho Kim Jae‐Kyu Roh | 2012 | Ann Neurol2012，，2： | 1 |
| 9 | Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-κB through Akt and p38 inhibition in RAW 264.7 macrophage cells显示文摘 | Ho Gyoung Kim Bhushan Shrestha So Yeon Lim Deok Hyo Yoon Woo Chul Chang Dong-Jik Shin Sang Kuk Han Sang Min Park Jung Hee Park Hae Il Park Jae-Mo Sung Yangsoo Jang Namsik Chung Ki-Chul Hwang Tae Woong Kim | 2006 | European Journal of Pharmacology2006，，2： | 1 |
| 10 | Diagnostic performance of 64-section CT using CT gastrography in preoperative T staging of gastric cancer according to 7th edition of AJCC cancer staging manual显示文摘 | Jin Woong Kim Sang Soo Shin Suk Hee Heo Yoo Duk Choi Hyo Soon Lim Young Kyu Park Chang Hwan Park Yong Yeon Jeong Heoung Keun Kang | 2012 | European Radiology2012，，3： | 1 |
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