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| 1 | Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach显示文摘Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last decade.There has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control HFMD.Methods:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and 2015.Distributed lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and holidays.Results:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age groups.HFMD incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,Shanghai.This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions. | Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 17 |
| 2 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 3 | Techno-Economic Challenges of Fuel Cell Commercialization显示文摘随着资源稀缺、气候变化加剧以及污染程度上升等问题的凸显,经济增长需要依赖更加环保、高效的生产过程。燃料电池具有高效和环保的特点,是内燃机和锅炉的理想替代品,也是通向绿色工业的途径。然而,作为一种新的能源技术,燃料电池的市场渗透率仍然不高。本文通过研究生命周期和价值链活动,对燃料电池系统进行了技术经济和环境方面的分析。首先,我们研究了燃料电池的发展进程,根据其生命周期活动、价值链活动以及最终用户验收标准确定了下一阶段需要采取的行动。然后,我们统一了解了燃料电池商业化的制度障碍。最终用户的主要验收标准是功能、价格和可靠性,比起其他同类产品,如内燃机和电池,燃料电池需要在这些标准上有所提升,以凸显其竞争优势。燃料电池的维修和保养费用可能会使成本大幅增加并减小可用性(由于可靠性较低),而成本和可用性是最终用户能否接受的主要因素。因此,为了克服可靠性的障碍,燃料电池产业面临着巨大的挑战。本文深入洞察了过去几年燃料电池商业化面临的主要障碍,讨论了燃料电池在未来绿色低碳经济中的潜在关键作用。文中还提出了未来低碳经济的必要性,并指出了相关的研究方向。以燃料电池为配置的绿色能源可以真正作为未来的商业模式。通过采取绿色公众投资、实行政策举措,为经济增长提供一条更加持续的发展道路,鼓励更多的环保产业投资。 | Junyewang Hualin Wang Yi Fan | 2018 | Engineering2018，4，3： | 11 |
| 4 | Genome-wide comprehensive analysis of transcriptomes and small RNAs offers insights into the molecular mechanism of alkaline stress tolerance in a citrus rootstock显示文摘Alkaline stress has serious-negative effects on citrus production.Ziyang xiangcheng(Citrus junos Sieb.ex Tanaka)(Cj)is a rootstock that is tolerant to alkaline stress and iron deficiency.Trifoliate orange(Poncirus trifoliata(L.)Raf.)(Pt),the most widely used rootstock in China,is sensitive to alkaline stress.To investigate the molecular mechanism underlying the tolerance of Cj to alkaline stress,next-generation sequencing was employed to profile the root transcriptomes and small RNAs of Cj and Pt seedlings that were cultured in nutrient solutions along a three pH gradient.This two-level regulation data set provides a system-level view of molecular events with a precise resolution.The data suggest that the auxin pathway may play a central role in the inhibitory effect of alkaline stress on root growth and that the regulation of auxin homeostasis under alkaline stress is important for the adaptation of citrus to alkaline stress.Moreover,the jasmonate(JA)pathway exhibits the opposite response to alkaline stress in Cj and Pt and may contribute to the differences in the alkaline stress tolerance and iron acquisition between Cj and Pt.The dataset provides a wealth of genomic resources and new clues to further study the mechanisms underlying alkaline stress resistance in Cj. | Juxun Wu Junying Cao Mei Su Guizhi Feng Yanhui Xu Hualin Yi | 2019 | Horticulture Research2019，6，1： | 4 |
| 5 | ERF4 affects fruit ripening by acting as a JAZ interactor between ethylene and jasmonic acid hormone signaling pathways显示文摘The regulation of apple(Malus domestica)fruit texture during ripening is complex and a fundamental determinant of its commercial quality.In climacteric fruit,ripening-related processes are regulated by ethylene(ET),and jasmonate(JA)is also involved in the ethylene biosynthesis pathway,mainly through the transcription factor MYC2.However,the molecular genetic mechanism for fruit ripening processes between the JA and ET signaling pathways still needs to be elucidated.In order to explore how JA regulates apple fruit ripening through ERF4,we used’Gala’and’Ralls Janet’fruit at different developmental stages as experimental materials to determine the fruit firmness and related gene expression analysis.Meanwhile,we carried out different hormone treatments on’Gala’fruit at ripening stage.Here,we show that ERF4 is a core JA signaling hub protein JASMONATE ZIM-DOMAIN(JAZ)interactor that affects ethylene signaling pathways.During fruit development,ERF4 represses the expression of ACS1 and ACO1 by interacting with JAZ,as well as with the JA-activated transcription factor MYC2.Ripening is promoted in JAZ-suppressed apples.Thus,ERF4 acts as a molecular link between ethylene and JA hormone signals,and the natural variation of the ERF4Ethylene-responsive binding factor-associated amphiphilic repression(EAR)motif decreases repression of ethylene biosynthesis genes. | Yanan Hu Hualin Sun Zhenyun Han Shuai Wang Ting Wang Qiqi Li Ji Tian Yi Wang Xinzhong Zhang Xuefeng Xu Zhenhai Han Ting Wu | 2022 | Horticultural Plant Journal2022，8，6： | 2 |
| 6 | RAPD-based genetic analysis of offsprings from the sexual cross using allotetraploid citrus somatic hybrid as pollen parent显示文摘Thirty-one polymorphic decamer primers were selected to genotype 92 progenies from the cross be- tween Yiben No.4, a monoembryonic diploid F1 hybrid of Citrus reticulata Blanco cv Huanongbendizao tangerine and C. ichangensis Swingle, and [Hamlin sweet orange + Rough lemon], an allotetraploid somatic hybrid of Citrus sinensis Osbeck cv. Hamlin and C. jambhiri Lush cv. Rough Lemon. χ2 (Chi-square) analysis of RAPD markers in the progenies indicated they were randomly transmitted from the four donor parents, without significant difference between the diploids and triploids. However, these progenies were clustered into three major groups using dendrogram constructed by UPGMA, skewed to three parents in certain degrees, 15 (13 triploids and 2 diploids) to Hamlin, 16 (9 and 7) to Yiben No. 4, and 61 (57 and 4) to [Hamlin sweet orange + Rough Lemon] from which genomic contribu- tion was predominant in progenies, respectively. | YI HuaLin & DENG XiuXin State Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, National Center of Citrus Breeding, Huazhong Agricultural University, Wuhan 430070, China | 2007 | Science China(Life Sciences)2007，50，3： | 2 |
| 7 | Simultaneous estimation of genetic linkage and preferential pairing factor for a triploid population with unphased markers显示文摘Triploids,recognized to occur more frequently in natural and experimental populations of many species than previously appreciated,display important economic and biological values.Despite this,however,linkage analysis for triploids has not been well explored.We develop a statistical model for estimating and testing the linkage between molecular markers in a triploid population derived from a tetraploid and diploid parent.The model incorporates one important meiotic feature of tetraploids by which more homologous chromosomes pair with a greater likelihood than less homologous chromosomes.By implementing the EM algorithm within the maximum likelihood framework,the model provides a procedure for simultaneous estimation of the linkage and preferential pairing factor.The model accommodates the segregating patterns of pseudotest markers and intercross markers with different amounts of informativeness.The utility of the model was validated through a real data analysis and simulation studies.The model provides a statistical tool for linkage analysis in a triploid population by taking into account meiotic behavior of tetraploids.Results from the model will help to shed light on the genetic diversity and origin of a polyploid population. | WANG JianXin DONG XiaoLi PANG XiaoMing LV YaFei YI HuaLin YANG XiaoXia WANG Zhong WU Song WU RongLing | 2012 | Chinese Science Bulletin2012，57，21： | 1 |
| 8 | Transferability, polymorphism and effectiveness for genetic mapping of the Pummelo ( Citrus grandis Osbeck) EST-SSR markers显示文摘 | Lijun Chai Manosh Kumar Biswas Hualin Yi Wenwu Guo Xiuxin Deng | 2013 | Scientia Horticulturae2013，，： | 1 |
| 9 | Solid/liquid separation performance of hydrocyclones with different cone combi- nations显示文摘 | YANG QIANG WANG HUALIN LIU YI | 2010 | Separation and Purification Technology2010，6，： | 1 |
| 10 | Solid/liquid separationperformance of hydrocyclones with different cone combinations显示文摘 | Yang Qiang Wang Hualin Liu Yi | 2010 | Separation and Purification Technology2010，74，3： | 1 |
| 11 | Microwave-assisted Synthesis of CdTe Quantum Dots Using 3-Mercaptopropionic Acid as Both a Reducing Agent and a Stabilizer显示文摘 | HUANG Yantao LAN Yuwei YI Qilei HUANG Hualin WANG Yilin LU Jianping | 2016 | Chemical Research in Chinese Universities2016，32，1： | 0 |
| 12 | Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes显示文摘Dear Editor,Aquatic birds are thought to be the main reservoir for avian influenza viruses(AIVs)(Olsen et al.2006).Pandemic emergences caused by these viruses threaten the international poultry industry giving rise to enormous economic losses.In addition,more and more reported cases of birdto-human transmission alert us the importance of | Yi Li Longquan Ni Jianjun Chen Juan Yang Fei Deng Hualin Wang | 2018 | Virologica Sinica2018，33，1： | 0 |
| 13 | Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives显示文摘Tissue engineering aims to offer large-scale replacement of damaged organs using implants with the com-bination of cells,growth factors and scaffolds.However,the intra/peri-implant region is exposed to se-vere hypoxic stress and oxidative stress during the early stage of implantation with bone graft materials,which endangers the survival,proliferation and differentiation of seed cells within the implants as well as the host cells surrounding the implants.If the bone graft material could spontaneously and intelligently regulate the hypoxic stress and oxidative stress to a moderate level,it will facilitate the vascularization of the implants and the rapid regeneration of the bone tissue.In this review,we will first introduce the signaling pathways of cellular response under hypoxic stress and oxidative stress,then present the clas-sical material designs and examples in response to hypoxic stress and oxidative stress.And finally,we will address the important role of epigenetic mechanisms in the regulation of hypoxic stress and oxida-tive stress and describe the potential applications and prospective smart bone graft materials based on novel epigenetic factors against hypoxic stress and oxidative stress in bone repair.The main content of this review is summarized in the following graphical abstract. | Hao Hu Xiao Liu Jun Chen Shangbin Cui Hualin Yi Gang Wang Renxian Wang Tiansheng Zheng Ben Wan Zhiyu Zhou Yong Wan Manman Gao Dafu Chen Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
| 14 | Genomic and transcriptomic analyses of Citrus sinensis varieties provide insights into Valencia orange fruit mastication trait formation显示文摘Valencia orange(Citrus sinensis Osbeck)(VO)is a type of late-ripening sweet orange whose ripening occurs 4 to 5 months later than that of the mid-ripening common sweet orange(CO).Notably,the mastication trait of VO fruit is inferior to that of CO fruit.To date,how inferior pulp mastication trait forms in VO has not been determined.In this study,13 VO varieties and 12 CO varieties were subjected to whole-genome resequencing.A total of 2.98 million SNPs were identified from 25 varieties,and a SNP molecular marker was developed to distinguish VO and CO.Moreover,144 and 141 genes identified by selective sweep analysis were selected during VO and CO evolution,respectively.Based on gene functional enrichment analysis,most of the selected VO genes were related to the stress response and lignin biosynthesis.Simultaneously,we comparatively analyzed the transcriptome profiles of peel and pulp tissues among three VO varieties and three CO varieties,and the results demonstrated differences in lignin biosynthesis between VO and CO fruits.Furthermore,coexpression network analysis was performed to identify hub genes of lignin-related and variety-specific networks,which included CsERF74,CsNAC25,CsHSFB3,CsSPL4/13,etc.Overall,this study provides important insights into the mastication trait formation of Valencia orange fruit. | Guizhi Feng Xiu Ai Hualin Yi Wenwu Guo Juxun Wu | 2021 | Horticulture Research2021，8，1： | 0 |
| 15 | A cloud of laser cooled ^(40)Ca^+ in a linear ion trap显示文摘A cloud of 40Ca+is successfully trapped and cooled using the radiation of a red-detuned 397 nm laser beam and a resonant 866 nm laser beam in our prototype linear ion trap,which was designed and constructed for studying quantum information processing.We have characterized the size of the ion cloud,estimating the temperature to be in the order of milli-Kelvins. | ZHOU Fei XU YouYang XIE Yi GUO Bin SHU HuaLin LI JiaoMei HUANG XueRen FENG Mang | 2010 | Chinese Science Bulletin2010，55，27： | 0 |
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