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| 1 | Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia显示文摘Nitric oxide(NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique and adaptive physiological change in highland Tibetans. However, there has been lack of NO data from Tibetans living at low altitude and lowlander immigrants living at high altitude, which is crucial to test this hypothesis. Here, through cross-altitude(1990–5018 m) and cross-population(Tibetans and Han Chinese) analyses of serum NO metabolites(NOx) of 2086 individuals, we demonstrate that although Tibetans have a higher serum NOx level compared to lowlanders, Han Chinese immigrants living at high altitude show an even higher level than Tibetans. Consequently, our data contradict the previous proposal of increased NO signaling as the unique adaptive strategy in Tibetans.Instead, Tibetans have a relatively lower circulating NOx level at high altitude. This observation is further supported by data from the hypoxic experiments using human umbilical vein endothelial cells and gene knockout mice. No difference is detected between Tibetans and Han Chinese for endothelial nitric oxide synthase(e NOS), the key enzyme for circulating NO synthesis, suggesting that e NOS itself is unlikely to be the cause. We show that other NO synthesis-related genes(e.g. GCH1) carry Tibetan-enriched mutations significantly associated with the level of circulating NOx in Tibetans. Furthermore, gene network analysis revealed that the downregulation and upregulation of NOx is possibly achieved through distinct pathways.Collectively, our findings provide novel insights into the physiological and genetic mechanisms of the evolutionary adaptation of Tibetans to high-altitude hypoxia. | Yaoxi He Xuebin Qi Ouzhuluobu Shiming Liu Jun Li Hui Zhang Baimakangzhuo Caijuan Bai Wangshan Zheng Yongbo Guo Duojizhuoma Baimayangji Dejiquzong Bianba Gonggalanzi Yongyue Pan Qula Kangmin Cirenyangji Wei Guo Yangla Yi Peng Xiaoming Zhang Kun Xiang Zhaohui Yang Liangbang Wang Gengdeng Yanfeng Zhang Tianyi Wu Bing Su Chaoying Cui | 2018 | National Science Review2018，5，4： | 7 |
| 2 | Arc corrosion behavior of Cu-Ti_3AlC_2 composites in air atmosphere显示文摘The arc corrosion evolution of Cu-20 vol.% Ti_3 AlC_2 cathodes is presented here. After eroded by 3, 4, 5, 6, 7, 8, 9, 10 kV DC voltage, respectively, the surface morphologies were characterized by field emission scanning electron microscope with craters and protrusions. Compared to small craters and dense protrusions of the morphology by high voltage, the eroded surface was covered with bigger craters and sparse protrusions at low voltage. No crack was discovered on the surface even at 10 kV. By means of energy dispersive spectroscopy and Raman spectroscopy, the decomposition of Cu-20 vol.% Ti_3 AlC_2 cathode to CuO,Al__2 O_3 and TiO_2 were proved. Meanwhile, W anode is oxidized to WO_2. The peak current increases with the increasing breakdown voltage, which is recorded by a digital memory oscilloscope. | HUANG XiaoChen FENG Yi QIAN Gang ZHAO Hao SONG ZhaoKun ZHANG JingCheng ZHANG XueBin | 2018 | Science China(Technological Sciences)2018，61，4： | 6 |
| 3 | Effect of current polarity on electrical sliding wear behavior of Cu-WS_2-graphite-WS_2 nanotube composites in air and vacuum conditions显示文摘In this paper Cu-WS2-graphite-WS2nanotube composites were fabricated by powder metallurgy hot pressing method.The effect of current polarity on the wear rates and contact voltage drops of the composites were investigated using a brush-on-slip ring tribometer rubbing against Cu-5 wt.%Ag alloy ring in air and vacuum,respectively.The worn surfaces of the composites were analyzed by scanning electron microscopy(SEM)and X-ray photoelectron spectroscopy(XPS).Surface profile curves of the worn tracks were measured using the surface profiler.The results demonstrated that the current polarity has a significant effect on the wear rates and contact voltage drops of the composites in both air and vacuum conditions.Positive brush possesses a higher wear rate compared with the negative brush in the air atmosphere since the electrical field direction activates oxidation at the positive brush surface while inhibits oxidation at the negative brush surface.Except for the regular wear losses,the combined effect of molten metal bridge erosion and arc erosion cause the positive brush to lose extra material and the negative brush to gain extra material,so the positive brush shows a higher wear rate in the vacuum condition.The contact voltage drop of the positive brush is lower than that of the negative brush in the air atmosphere,but contrarily,the positive brush shows a higher contact voltage drop in the vacuum condition. | QIAN Gang FENG Yi CHEN FanYan LIU WenHong ZHANG XueBin LIU YanFang | 2013 | Science China(Technological Sciences)2013，56，11： | 5 |
| 4 | Effects of strain rates on dynamic deformation behavior of Cu-20Ag alloy显示文摘Copper alloy is widely used in high-speed railway,aerospace and other fields due to its excellent electrical conductivity and mechanical properties.High speed deformation and dynamic loading under impact load is a complex service condition,which widely exists in the field of national defense,military and industrial application.Therefore,the dynamic deformation behavior of the Cu-20Ag alloy was investigated by Split Hopkinson Pressure Bar(SHPB)with the strain rates of 1000-25000 s^(-1),high-speed hydraulic servo material testing machine with the strain rates of 1-500 s^(-1).The effect of strain rate on flow stress and adiabatic shear sensitivity was analyzed.The results show that the increase of strain rate will increase the flow stress and critical strain,that is to say,the increase of strain rate will reduce the adiabatic shear sensitivity of the Cu-20Ag alloy.The Cu-Ag interface has obvious orientation relationship with;(111)_(Cu)//(111)_(Ag):(^(-)111)_(Cu)//(^(-)111)_(Ag):(^(-)200)_(Cu)//(^(-)200)_(Ag) and [0^(-)11]_(Cu)//[0^(-)11]_(Ag) with the increase of strain rate.The increase of strain rate promotes the precipitation of Ag and increases the number of interfaces in the microstructure,which hinders the movement of dislocations and improves the stress and yield strength of the Cu-20Ag alloy.The concentration and distribution density of dislocations and the precipitation of Ag were the main reasons improve the flow stress and yield strength of the Cu-20Ag alloy. | Kexing Song Yongfeng Geng Yijie Ban Yi Zhang Zhou Li Xujun Mi Jun Cao Yanjun Zhou Xuebin Zhang | 2021 | Journal of Materials Science & Technology2021，，20： | 3 |
| 5 | Prior information based channel estimation for millimeter-wave massive MIMO vehicular communications in 5G and beyond显示文摘Millimeter wave(mm Wave) has been claimed as the viable solution for high-bandwidth vehicular communications in 5 G and beyond. To realize applications in future vehicular communications, it is important to take a robust mm Wave vehicular network into consideration. However, one challenge in such a network is that mm Wave should provide an ultra-fast and high-rate data exchange among vehicles or vehicle-to-infrastructure(V2 I). Moreover,traditional real-time channel estimation strategies are unavailable because vehicle mobility leads to a fast variation mm Wave channel. To overcome these issues, a channel estimation approach for mm Wave V2 I communications is proposed in this paper. Specifically, by considering a fast-moving vehicle secnario, a corresponding mathematical model for a fast time-varying channel is first established. Then, the temporal variation rule between the base station and each mobile user and the determined direction-of-arrival are used to predict the time-varying channel prior information(PI). Finally, by exploiting the PI and the characteristics of the channel, the time-varying channel is estimated. The simulation results show that the scheme in this paper outperforms traditional ones in both normalized mean square error and sum-rate performance in the mm Wave time-varying vehicular system. | Zhao YI Weixia ZOU Xuebin SUN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，6： | 2 |
| 6 | Effects of different atmospheres on the arc erosion behaviors of Ti_(3)SiC_(2)cathodes显示文摘The effects of ambient atmospheres on the arc erosion behaviors of Ti_(3)SiC_(2)cathodes were investigated at 5.5 kV in argon,nitrogen,air,and oxygen.The mass loss of the cathodes increased in the order of argon,nitrogen,air,and oxygen and the morphologies were measured by 3D laser scanning confocal microscope with a gradual blooming phenomenon.Raman spectroscopy,X-ray diffraction,and X-ray photoelectron spectroscopy were employed to detect the components of erosion regions.The erosion-chemical products mainly consisted of TiNx in nitrogen,TiN_(x),TiO_(2)and SiO_(2)in air,TiO_(2)and SiO_(2)in oxygen.The arc energy was responsible for the arc erosion characteristics in different atmospheres. | ZHOU ZiJue FENG Yi ZHAO Hao QIAN Gang ZHANG JingCheng ZHANG XueBin HUANG XiaoChen | 2021 | Science China(Technological Sciences)2021，64，3： | 2 |
| 7 | Effect of relative stress on post - peak uniaxial compression fracture energy of concrete显示文摘 | Wang Xuebin Pan Yi -shan | 2003 | Journal of Wuhan University of Technology - Materials Science Edition2003，18，4： | 1 |
| 8 | Chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells in type I collagen-hydrogel for cartilage engineering显示文摘 | Xuebin Chen Fang Zhang Xinhong He Yinsheng Xu Zhiping Yang Li Chen Shaomei Zhou Yishu Yang Zhixiang Zhou Wang Sheng Yi Zeng | 2012 | Injury2012，，： | 1 |
| 9 | Size-induced effect on cathode luminescence spectra of CsI(Na) and CsI(Tl) crystals显示文摘We investigated the cathode luminescence characteristics of CsI(Na)and CsI(Tl)crystals by the spectrum and structure properties at room temperature.We fabricated three different sizes of CsI(Na)and CsI(Tl)crystals and measured their luminescence spectra under cathode rays.We found that CsI(Na)cathode luminescence peaks appear at 420 and 305 nm,and CsI(Tl)cathode luminescence peaks are 540 and 410 nm,the grain size affects CsI(Na)luminescence significantly,and the Na-related420 nm luminescence intensified relatively when the average grain size reaches^20μm,which becomes weak when the grain size is down to nano-scale.But the cathode luminescence spectra of CsI(Tl)crystals with different size have no obvious changes.Our explanations for these phenomena are that the different impurities in the same host material CsI lead to different luminescence mechanisms.These cathode luminescence characteristics indicate the suitability of CsI(Na)and CsI(Tl)crystals to match photomultiplier tube for large area crystal detector development. | LIU Fang OUYANG XiaoPing LIU Bin LIU JinLiang CHEN Liang ZHANG ZhongBing ZHANG XueBin FENG Yi | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，9： | 1 |
| 10 | Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic显示文摘In early 2020,the COVID-19 outbreak complicated the diagnosis,treatm ent and rehabilitation of patients with substance use disorders and increased the risks of substance abuse and addictive behaviours,such as online gaming disorders,in the general public.Substance use disorder is a chronic recurrent brain disease characterised by strong cravings,high recurrence rates,and a high proportion of comorbidity of mental and physical disorders.1 Therefore,regular long-term therapeutic interventions are critical to preventing dm g relapses while maintaining withdrawal. | Jiang Du Ni Fan Min Zhao Wei Hao Tieqiao Liu Lin Lu Jie Shi Haifeng Jiang Na Zhong Xiaochang Lan Shichao Xu Hongxian Chen Xiaojun Xiang Xuyi Wang Hongqiang Sun Bing Li Yu-Ping Ning Jing Li Wanjun Guo Yajuan Niu Lixia Sheng Yi Li Xuebin Liu Xuhui Zhou Mincai Qian Wenhua Zhou Ruiling Zhang Hongxing Hu Yan Xia Zhonghua Su Ruimin Zhang Mei Yang Fen Liu Wei Yuan | 2020 | General Psychiatry2020，33，4： | 1 |
| 11 | Resource Dependence Relationship between Grass-roots Government and Farmers' Specialized Cooperatives显示文摘Based on theories of resource dependence and government functions,this paper analyzed benefit interaction between grass-roots government and farmers' specialized cooperatives in Hubei Province. It was intended to make clear the path dependence relationship between grassroots government and farmers' specialized cooperatives and find out problems in between. Besides,from the perspective of grass-roots government and farmers' specialized cooperatives,it came up with corresponding recommendations,to promote constant improvement of farmers' specialized cooperatives,and help them to become key forces of leading farmers to get rich,pull agricultural economic development,and promote new socialist countryside construction. | Xuebin SHEN Yi CAI | 2016 | Asian Agricultural Research2016，8，1： | 0 |
| 12 | Analysis of Ground-state Zero-field Splitting for Mn^(2+) Ions in[Co(H_(2)O)]XY_(6) (X=Si,Sn,Pt;Y=F,Cl)显示文摘The electron paramagnetic spectra of trigonal Mn^(2+) centers in[Co(H_(2)O)_(6)]SiF6,[Co(H_(2)O)_(6)]SnF6,and[Co(H_(2)O)_(6)]PtCl6 crystals were studied on the basis of the complete energy matrices for a d5 configuration ion in a trigonal ligand field.When Mn^(2+) is doped in the[Co(H_(2)O)_(6)]SiF6,[Co(H_(2)O)_(6)]SnF6,and[Co(H_(2)O)_(6)]PtCl6 crystals crystals,there is a similar local distortion.The experimental results show that the local lattice structure around a trigonal Mn^(2+) center has an elongation distortion along the crystalline C3 axis.From the EPR calculation,the local lattice structure parameters R=2.278A,θ=52.6406? for[Co(H_(2)O)_(6)]SiF6,R=2.280,θ=52.4936° for[Co(H_(2)O)_(6)]SnF6 and R=2.244A,θ=53.0616? for[Co(H_(2)O)_(6)]PtCl6 were determined. | 李菊芬 SU Juan YI Xuebin TANG Bin WU Xinhui ZHONG Shuirong | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，4： | 0 |
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