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| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | Modelling urban expansion using a multi agentbased model in the city of Changsha显示文摘Although traditional urban expansion simulation models can simulate dynamic features, these models fail to address complex changes produced by different agents' behaviors. The paper has built up a set of spatial-temporal land resource allocation rules and developed a dynamic urban expansion model based on a multi-agent system, which can simulate the interaction among different agents, such as residents, peasants, and governments. This model is applied to simulate urban expansion process taking Changsha City, in China as a study area. The results show that this model can not only reflect basic characteristics of urban expansion, but also help explain the reasons for urban expansion process and understand the effect of agents' behavior on the expansion process, and provide insights into the causing factors behind the expansion. In addition, in contrast to simulation results with land use classification map from remote sensing images, the precision of the simulation reached over 68% with higher precision than cellular automata model according to the cell-by-cell comparison. The results suggest that the model can help to provide land use decision making support to government and urban planners. | ZHANG Honghui ZENG Yongnian BIAN Ling YU Xijun | 2010 | Journal of Geographical Sciences2010，20，4： | 11 |
| 3 | Temperature pattern dynamics in shocked porous materials显示文摘The physical fields in porous materials under strong shock wave reaction are very complicated. We simulate such systems using the grain contact material point method. The complex temperature fields in the material are treated with the morphological characterization. To compare the structures and evolution of characteristic regimes under various temperature thresholds, we introduce two concepts, structure similarity and process similarity. It is found that the temperature pattern dynamics may show high similarity under various conditions. Within the same material, the structures and evolution of high-temperature regimes may show high similarity if the shock strength and temperature threshold are chosen appropriately. For process similarity in materials with high porosity, the required temperature threshold increases parabolically with the impact velocity. When the porosity becomes lower, the increasing rate becomes higher. For process similarity in different materials, the required temperature threshold and the porosity follow a power-law relationship in some range. | XU AiGuo*, ZHANG GuangCai, LI Hua, YING YangJun, YU XiJun & ZHU JianShi National Key Laboratory of Computational Physics, Institute of Applied Physics and Computational Mathematics, Beijing 100088, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，8： | 7 |
| 4 | A conservative local discontinuous Galerkin method for the solution of nonlinear Schrdinger equation in two dimensions显示文摘In this study, we present a conservative local discontinuous Galerkin(LDG) method for numerically solving the two-dimensional nonlinear Schrdinger(NLS) equation. The NLS equation is rewritten as a firstorder system and then we construct the LDG formulation with appropriate numerical flux. The mass and energy conserving laws for the semi-discrete formulation can be proved based on different choices of numerical fluxes such as the central, alternative and upwind-based flux. We will propose two kinds of time discretization methods for the semi-discrete formulation. One is based on Crank-Nicolson method and can be proved to preserve the discrete mass and energy conservation. The other one is Krylov implicit integration factor(IIF) method which demands much less computational effort. Various numerical experiments are presented to demonstrate the conservation law of mass and energy, the optimal rates of convergence, and the blow-up phenomenon. | ZHANG RongPei YU XiJun LI MingJun LI XiangGui | 2017 | Science China Mathematics2017，60，12： | 5 |
| 5 | Microbial community functional structure in response to micro-aerobic conditions in sulfate-reducing sulfur-producing bioreactor显示文摘Limited oxygen supply to anaerobic wastewater treatment systems had been demonstrated as an effective strategy to improve elemental sulfur(S0) recovery, coupling sulfate reduction and sulfide oxidation. However, little is known about the impact of dissolved oxygen(DO) on the microbial functional structures in these systems. We used a high throughput tool(GeoChip) to evaluate the microbial community structures in a biological desulfurization reactor under micro-aerobic conditions(DO: 0.02–0.33 mg/L). The results indicated that the microbial community functional compositions and structures were dramatically altered with elevated DO levels. The abundances of dsrA/B genes involved in sulfate reduction processes significantly decreased(p < 0.05, LSD test) at relatively high DO concentration(DO: 0.33 mg/L). The abundances of sox and fccA/B genes involved in sulfur/sulfide oxidation processes significantly increased(p < 0.05, LSD test) in low DO concentration conditions(DO: 0.09 mg/L) and then gradually decreased with continuously elevated DO levels. Their abundances coincided with the change of sulfate removal efficiencies and elemental sulfur(S0) conversion efficiencies in the bioreactor. In addition, the abundance of carbon degradation genes increased with the raising of DO levels, showing that the heterotrophic microorganisms(e.g., fermentative microorganisms) were thriving under micro-aerobic condition. This study provides new insights into the impacts of micro-aerobic conditions on the microbial functional structure of sulfatereducing sulfur-producing bioreactors, and revealed the potential linkage between functional microbial communities and reactor performance. | Hao Yu Chuan Chen Jincai Ma Xijun Xu Ronggui Fan Aijie Wang | 2014 | Journal of Environmental Sciences2014，26，5： | 4 |
| 6 | Sulfonic acid-based metal organic framework functionalized magnetic nanocomposite combined with gas chromatography-electron capture detector for extraction and determination of organochlorine显示文摘The metal organic framework functionalized with sulfonic acid was combined with magnetic nanoparticles to fabricate a new nanocomposite(denoted as Fe3O4@PDA@Zr-SO3H).By combining with gas chromatography-electron capture detector,the resulting Fe3O4@PDA@Zr-SO3H nanocomposite was successfully used as a high-efficiency adsorbent for pre-concentrating eight organochlorine pesticides from water sample in environment.Apart from the ability of fast separation,the as-prepared Fe3O4@PDA@Zr-SO3H nanocomposite also exhibited high adsorption capacity for organochlorine pesticides.With the use of optimal experimental conditions,the linear relationship can be obtained in the range of 0.05~300μg/L,the correlation coefficient was over 0.9978,and the relative standard deviation was located in 2.5%-7.7%.Moreover,the limit of detection and quantification was between0.005-0.016μg/L and 0.017~0.050μg/L.Finally,the nanocomposite was used for the determination of organochlorine pesticides from environmental water samples,and displayed the recovery of 82%-118%. | Ying Wang Qing Ye Menghuan Yu Xijun Zhang Chunhui Deng | 2020 | Chinese Chemical Letters2020，31，7： | 3 |
| 7 | H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells显示文摘The H7N9 influenza virus emerged in China in 2013,causing more than 1560 human infections,39% of which were fatal.A ‘cytokine storm’ in the lungs of H7N9 patients has been linked to a poor prognosis and death;however,the underlying mechanism that triggers the cytokine storm is unknown.Here,we found that efficient replication of the H7N9 virus in mouse lungs activates gasdermin E(GSDME)-mediated pyroptosis in alveolar epithelial cells,and that the released cytosolic contents then trigger a cytokine storm.Knockout of Gsdme switched the manner of death of A549 and human primary alveolar epithelial cells from pyroptosis to apoptosis upon H7N9 virus infection,and Gsdme knockout mice survived H7N9 virus lethal infection.Our findings reveal that GSDME activation is a key and unique mechanism for the pulmonary cytokine storm and lethal outcome of H7N9 virus infection and thus opens a new door for the development of antivirals against the H7N9 virus. | Xiaopeng Wan Jiqing Li Yupeng Wang Xiaofei Yu Xijun He Jianzhong Shi Guohua Deng Xianying Zeng Guobin Tian Yanbing Li Yongping Jiang Yuntao Guan Chengjun Li Feng Shao Hualan Chen | 2022 | National Science Review2022，9，1： | 3 |
| 8 | High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome as potential targets for evaluating the therapeutic effects and mechanism of geniposide显示文摘High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitative and quantitative analysis of metabolites.This study used the established Yang Huang syndrome(YHS)mouse model to evaluate the efficacy of geniposide(GEN).Urine metabolic data were quantified by ultraperformance liquid chromatography-tandem mass spectrometry.The non-target screening of the massive biological information dataset was performed,and a total of 33 metabolites,including tyramine glucuronide,aurine,and L-cysteine,were identified relating to YHS.These differential metabolites directly participated in the disturbance of phase I reaction and hydrophilic transformation of bilirubin.Interestingly,they were completely reversed by GEN.While,as the auxiliary technical means,we also focused on the molecular prediction and docking results in network pharmacological and integrated analysis part.We used integrated analysis to communicate the multiple results of metabolomics and network pharmacology.This study is the first to report that GEN indirectly regulates the metabolite“tyramine glucuronide”through its direct effect on the target heme oxygenase 1 in vivo.Meanwhile,heme oxygenase-1,a prediction of network pharmacology,was the confirmed metabolic enzyme of phase I reaction in hepatocytes.Our study indicated that the combination of high-throughput metabolomics and network pharmacology is a robust combination for deciphering the pathogenesis of the traditional Chinese medicine(TCM)syndrome. | Heng Fang Aihua Zhang Xiaohang Zhou Jingbo Yu Qi Song Xijun Wang | 2020 | Frontiers of Medicine2020，14，5： | 3 |
| 9 | DC-field in- duced synthesis of ZnO nanowhiskers in water-in-oil mi- croemulsions 显示文摘 | Lu Hongxia Yu Xijun Zeng Zhaohuan | 2011 | Ceramics International2011，37，1： | 1 |
| 10 | Spatial and temporal dynamics of urban sprawl along two urban-rural transects: A case study of Guangzhou, China显示文摘 | YU Xijun NG C N | 2007 | Landscape and Urban Planning2007，79，： | 1 |
| 11 | Spatial and temporal dynamics of urban sprawl along two urban-rural transects:A case study of Guangzhou,China显示文摘 | Yu xijun Cho Nam Ng | 2007 | Landscape and Urban Planning2007，79，1： | 1 |
| 12 | Interface engineering for composite cathodes in sulfide-based all-solid-state lithium batteries显示文摘All-solid-state lithium battery(ASLB)based on sulfide-based electrolyte is considered to be a candidate for the next-generation high-energy storage system.Despite the high ionic conductivity of sulfide solid electrolyte,the poor interfacial stability(mechanically and chemically)between active materials and sulfide solid electrolytes in composite cathodes leads to inferior electrochemical performances,which impedes the practical application of sulfide electrolytes.In the past years,various of strategies have been carried out to achieve an interface with low impedance in the composite cathodes.Herein,a review of recent progress of composite cathodes for all-solid-state sulfide-based lithium batteries is summarized,including the interfacial issues,design strategies,fabrication methods,and characterization techniques.Finally,the main challenges and perspectives of composite cathodes for high-performance all-solidstate batteries are highlighted for future development. | Yu Li Dechao Zhang Xijun Xu Zhuosen Wang Zhengbo Liu Jiadong Shen Jun Liu Min Zhu | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 13 | Spatial and temporal dynamics of urban dynamics of urban sprawl along two urban-rural transects: a case study of Guangzhou, China显示文摘 | YU Xijun NG C N | 2007 | Landscape and Urban Planning2007，79，： | 1 |
| 14 | Synthesis of selenium-doped carbon from glucose:An efficient antibacterial material against Xcc显示文摘Se/C as a novel carbon-based biomaterial was prepared by using cheap and abundant glucose as the carbon source.It was highly active and could well restrain Xanthomonas campestris pv.campestris(EC50=4.7403 μg/mL),a very harmful germ causing the devastating cabbage black rot disease and resulting in huge economic losses.As a type of carbon material insoluble in wate r,Se/C is bio-compatible and can adhere onto the leaves of the plants to allow a slow and sustained release of its efficacy,affording an efficient method for the cabbage black rot disease prevention and cure.This work as the first report on the bioactivity studies of Se/C significantly expands the application scopes of the selenium-containing materials and may draw continuous attentions from a broad field. | Hongen Cao Yufan Yang Xijun Chen Jian Liu Chao Chen Shuzhong Yuan Lei Yu | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 15 | A Runge Kutta Discontinuous Galerkin Method for Lagrangian Compressible Euler Equations in Two-Dimensions显示文摘This paper presents a new Lagrangian type scheme for solving the Euler equations of compressible gas dynamics.In this new scheme the system of equations is discretized by Runge-Kutta Discontinuous Galerkin(RKDG)method,and the mesh moves with the fluid flow.The scheme is conservative for the mass,momentum and total energy and maintains second-order accuracy.The scheme avoids solving the geometrical part and has free parameters.Results of some numerical tests are presented to demonstrate the accuracy and the non-oscillatory property of the scheme. | Zhenzhen Li Xijun Yu Jiang Zhu Zupeng Jia | 2014 | Communications in Computational Physics2014，15，4： | 1 |
| 16 | Spatial and Temporal Dynamics of Urban Sprawl along Two Urban-rural Transects: A Case Study of Guangzhou, China 显示文摘 | YU Xijun | 2007 | Landscape and Urban Planning2007，79，： | 1 |
| 17 | The new nu- merical method for solving the system of two-dimensional Burgers' equations 显示文摘 | Zhao Guozhong Yu Xijun Zhang Rongpei | 2011 | Computers and Mathematics with Applications2011，62，8： | 1 |
| 18 | Modified Burgers’equation by the local discontinuous Galerkin method显示文摘 | Zhang Rongpei Yu Xijun Zhao Guozhong | 2013 | Chin Phys B2013，22，3： | 1 |
| 19 | Single-Cell Microwell Platform Reveals Circulating Neural Cells as a Clinical Indicator for Patients with Blood-Brain Barrier Breakdown显示文摘Central nervous system diseases commonly occur with the destruction of the blood-brain barrier.As a primary cause of morbidity and mortality,stroke remains unpredictable and lacks cellular biomarkers that accurately quantify its occurrence and development.Here,we identify NeuN^(+)/CD45^(−)/DAPI^(+)phenotype nonblood cells in the peripheral blood of mice subjected to middle cerebral artery occlusion(MCAO)and stroke patients.Since NeuN is a specific marker of neural cells,we term these newly identified cells as circulating neural cells(CNCs).We find that the enumeration of CNCs in the blood is significantly associated with the severity of brain damage in MCAO mice(p<0:05).Meanwhile,the number of CNCs is significantly higher in stroke patients than in negative subjects(p<0:0001).These findings suggest that the amount of CNCs in circulation may serve as a clinical indicator for the real-time prognosis and progression monitor of the occurrence and development of ischemic stroke and other nervous system disease. | Yu Zhang Antony R.Warden Khan Zara Ahmad Yanlei Liu Xijun He Minqiao Zheng Xinlong Huo Xiao Zhi Yuqing Ke Hongxia Li Sijia Yan Wenqiong Su Deng Cai Xianting Ding | 2021 | Research2021，，1： | 0 |
| 20 | A SINGLESTEP CHARACTERISTIC FINITE DIFFERENCE METHOD FOR TWO-DIMENSIO NALNON LINEAR CONVECTION-DIFFUSIONPROBLEMS显示文摘A singlestep characteristic finite difference method is given based on the linear and quadratic interpolations for solving two-dimensional nonlinear convection-diffusionproblems. The convergence of approximate solutions is obtained in L2 under milder restrictions in the temporal stepsize and spatial stepsize than those required in [1]. | YU Xijun(Laboratory of Computational Physics, Institute of Applied Physics and ComputationalMathematics, Beijing 100088, China) | 1999 | Systems Science and Mathematical Sciences1999，12，S1： | 0 |
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