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| 1 | Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome显示文摘INTRODUCTIONNuclearpseudogenesofmitochondrial(mt)DNAwereinitiallydiscoveredintheearly80's[1--6].However,mechanismsforthegenerationofmtDNApseudogenesarestillnotclearandmayvaryindifferentcases.BothRNA--[7--8]andDNAmediated[9--11]processeshavebeensugges... | YUAN JIN DUO JIN XIU SHI GUANG XUNMENG LI GUO AN GENG XI HU( Shanghai Institute of Cell Biology and the ShanghaiLife Science Center, Chinese Academy of Sciences,320 Yue Yang Road, Shanghai 200031, China)( Department of Biology, Shandong Normal Univers | 1999 | Cell Research1999，9，4： | 3 |
| 2 | High H_(2) selective performance of Ni-Fe-Ca/H-Al catalysts for steam reforming of biomass and plastic显示文摘The development of a selective catalyst for the conversion of biomass and plastics into H2by steam reforming can combat the energy crisis and global warming.In this work,support Ni-Fe-Ca/H-Al bifunctional catalysts were prepared by loading Ni and Fe into pretreatment CaO/Al_(2)O_(3)(Ca/H-Al)carriers and showed high catalytic activity for the steam reforming of biomass and plastic.Moreover,the idea of bidirectional degradation was exploited to strengthen the pyrolysis of plastic with a high H/C and biomass with a high O/C.Interestingly,the products presented high H2selective(1302.10 m L/g)and low CO_(2)yield(120.23 m L/g)in 7Ni-5Fe-Ca/H-Al(2:4)catalyst compared with current reports.Here,the abundant oxygen vacancies(Ov)in the H-Al carrier exhibited an electron-deficient nature,providing active sites for anchoring Ni O.Meanwhile,Ni O interacted with Ca_(2)Fe_(2)O_(5)to produce more defective Ovsites,which stabilized the NiO particles in the 7Ni-5Fe-Ca/H-Al(2:4)catalyst,and the interaction between the catalyst and the carrier was enhanced,leading to the reduction of weakly basic sites,this property promoted the strong adsorption of CO_(2)and H2O by the catalyst,contributing to the enhancement of efficient steam conversion and the promotion of conversion of by-products to H2.Notably,7Ni-5Fe-Ca/H-Al(2:4)catalysts maintained structural integrity after regeneration and exhibited excellent regenerability in H2selection and CO_(2)adsorption.The work provides a new idea for the study of efficient H2production from steam reforming of biomass and plastics. | Jin Deng Lingshuai Meng Duo Ma Yujie Zhou Xianyang Wang Xiaodong Luo Shenfu Yuan | 2023 | Journal of Energy Chemistry2023，，5： | 2 |
| 3 | High production of fatty alcohols in Yarrowia lipolytica by coordination with glycolysis显示文摘Fatty alcohol biosynthesis by oleaginous microbes was a promising alternative to the petroleum or other non-renewable resources-based process. However, low titer and yield hamper the further industrial and commercial applications. Here, we developed an efficient strategy to coordinate fatty alcohol with glycolysis which achieved a ‘pull-and-push’ effect to improve fatty alcohol production. Transcript profiling indicated that genes in carbohydrate metabolism were up-regulated significantly in response to high fatty alcohol production. Based on it, 11 glycolysis promoters were screening to express fatty acyl-CoA reductase(FAR) to relate the fatty alcohol production with the up-regulated carbohydrate metabolism, and the fatty alcohol production reached 557 mg/L when FAR was expressed by the promoter of PFBAin. RNA-seq and qRT-PCR analysis demonstrated that a ‘pull-and-push’ effect caused by the coordination system dynamically enhanced the product synthesis flux from top to bottom, which was also testified and intensified by doubled glucose concentration. After manipulating structural and regulatory genes of lipid metabolism, the final strain achieved up to 5.75 g/L fatty alcohol production from modified YPD medium(containing 91 g/L glucose) in shake flasks, which represented the highest titer reported to date. This work offered a feasible and effective reference for dynamic manipulation of fatty acid-derived chemicals synthesis. | Jin-Lai Zhang Ying-Xiu Cao Yang-Zi Peng Cong-Cong Jin Qiu-Yan Bai Ruo-Si Zhang Duo Liu Ying-Jin Yuan | 2019 | Science China Chemistry2019，62，8： | 2 |
| 4 | Systemic delivery of microRNA for treatment of brain ischemia显示文摘Brain ischemia is the second leading cause of death and the third leading cause of disability in the world.Systemic delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ischemia.However,their therapeutic efficacy has been hampered by poor delivery efficiency of microRNA.We report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the brain.Exemplified by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity. | Chaoyong Liu Jing Wen Dai Li Hongzhao Qi Lina Nih Jialin Zhu Duo Xu Yu Ren Shanshan Zhang Donglin Han Huanhuan Jia Junhu Zhou Meng Qin Jialing Wu Xubo Yuan Ji Liu Jin Zhao Chunsheng Kang Yunfeng Lu | 2021 | Nano Research2021，14，9： | 0 |
| 5 | SCRaMbLE drive application of synthetic yeast genome显示文摘The Synthetic Yeast Genome Project (Sc2.0)consortium has recently published a collection of seven reports on the development of Synthetic Chromosome Rearrangement and Modification by LoxP-Mediated Evolution (SCRaM- bLE)system that set the stage for the application of synthetic yeast genome.Scientists of synthetic genomics have worked on de novo genome synthesis from viruses, bacteria to eukaryote [1-12].What can we do with these synthetic genomes?The JCVI-syn3.0contains 473genes with 531kbp which minimized from 1079kbp synthetic genome of Mycoplasma myeoides JCVI-synl.0.This minimal bacterial genome will be a new platform for investigating the core function of cell [3].The rE.coli-57 project aims to synthetize a 3.97Mbp 57-codon Escherichia coli genome which could produce a virus-resistant, biocontained bacterium for industrial applications,though only individually recoded segments were tested [4]. | Jin Jin Yuan Ma Duo Liu | 2018 | Frontiers of Chemical Science and Engineering2018，12，4： | 0 |
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