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| 1 | Cationic content effects of biodegradable amphoteric chitosan-based flocculants on the flocculation properties显示文摘A series of biodegradable amphoteric chitosan-based flocculants(3-chloro-2-hydroxypropyl trimethyl ammonium chloride(CTA) modified carboxymethyl chitosan,denoted as CMC-CTA) with different substitution degrees of CTA were prepared successfully.The content of carboxymethyl groups in each CMC-CTA sample was kept almost constant.The solubility of the various flocculants showed that,higher cationic content of flocculants caused a better solubility.The flocculation experiments using kaolin suspension as synthetic water at the laboratory scale indicated that the substitution degree of CTA was one of the key factors for the flocculation properties.With the increase of cationic content,the flocculants were demonstrated better flocculation performance and lower dosage requirement.Flocculation kinetics model of particles collisions combining zeta potential and turbidity measurements was employed to investigate the effects of the cationic content of the flocculants on the flocculation properties from the viewpoint of flocculation mechanism in detail.Furthermore,flocculation performance using raw water from Zhenjiang part of Yangtze River at the pilot scale showed the similar effects to those at the laboratory scale. | Zhen Yang Yabo Shang Xin Huang Yichun Chen Yaobo Lu Aimin Chen Yuxiang Jiang Wei Gu Xiaozhi Qian Hu Yang Rongshi Cheng | 2012 | Journal of Environmental Sciences2012，24，8： | 8 |
| 2 | Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19显示文摘Silent hypoxia has emerged as a unique feature of coronavirus disease 2019(COVID-19).In this study,we show that mucins are accumulated in the bronchoalveolar lavage fluid(BALF)of COVID-19 patients and are upregulated in the lungs of severe respiratory syndrome coronavirus 2(SARS-CoV-2)-infected mice and macaques.We find that induction of either interferon(IFN)-P or IFN-y upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor(AhR)signaling through an IDO-Kyn-dependent pathway,leading to transcriptional upregulation of the expression of mucins,both the secreted and membrane-bound,in alveolar epithelial cells.Consequently,accumulated alveolar mucus affects the blood-gas barrier,thus inducing hypoxia and diminishing lung capacity,which can be reversed by blocking AhR activity.These findings potentially explain the silent hypoxia formation in COVID-19 patients,and suggest a possible intervention strategy by targeting the AhR pathway. | Yuying Liu Jiadi Lv Jiangning Liu Man Li Jing Xie Qi Lv Wei Deng Nannan Zhou Yabo Zhou Jiangping Song Peng Wang Chuan Qin Wei-Min Tong Bo Huang | 2020 | Cell Research2020，30，12： | 5 |
| 3 | Mn atomic layers under inert covers of graphene and hexagonal boron nitride prepared on Rh(111)显示文摘进 graphene 和它的支持的底层的接口的金属原子的置闰为削弱联合并且构造金属的接口的缘故成为了一个吸引人的话题在惰性的封面下面的原子层。然而,这新奇行为很少在类似的六角形的硼氮化物(h-BN ) 上被报导了在金属底层上综合了。这里,我们描述 Mn 置闰的比较研究进 graphene/Rh (111 ) 和 h-BN/Rh (111 ) 的接口,由使用解决 atomically 的扫描通道显微镜学(STM ) 和密度功能的理论(DFT ) 计算。置闰被退火执行同样扔的 Mn 簇,和进 h-BN/Rh (111 ) 的 Mn 置闰的开始的温度被发现是 80 瑩 ?? 数歡瀠睯牥搠湥楳祴漠 ??? ″坭洯吗? | Yu Zhang Yanfeng Zhang Donglin Ma Qingqing Ji Wei Fang Jianping Shi Teng Gao Mengxi Liu Yabo Gao Yubin Chen Limei Xu Zhongfan Liu | 2013 | Nano Research2013，6，12： | 2 |
| 4 | High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients显示文摘The outbreak of coronavirus disease 2019(COVID-19)caused by the new virus SARS-CoV-2 has been announced as a public health emergency of international concern.1–3 The clinical features of patients with COVID-19 range from common fever and cough to other rare symptoms,such as diarrhea and nausea.This disease can progress quickly,and 2–3%of patients die within a short time,which is generally due to multiple organ failure.4–7 Clinically,COVID-19 patients are classified into mild,moderate,severe,and critical cases.5–7 The immune response against SARS-CoV-2 is probably linked to the severity of disease.Recently,Zheng et al.8 showed that elevated levels of T-cell exhaustion and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients;however,a more comprehensive understanding of the pathology of SARS-CoV-2 infection remains to be delineated.Here,we profiled immune cellular components using mass cytometry(CyTOF)to analyze the peripheral blood mononuclear cells(PBMCs)from patients with differences in disease progression by comparing with the PBMCs from healthy donors(HDs). | Wenjing Wang Bin Su Lijun Pang Luxin Qiao Yingmei Feng Yabo Ouyang Xianghua Guo Hongbo Shi Feili Wei Xiaogang Su Jiming Yin Ronghua Jin Dexi Chen | 2020 | Cellular & Molecular Immunology2020，17，6： | 2 |
| 5 | ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques显示文摘During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains unclear.As the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial cells.As an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 infection.However,the molecular mechanism regulating ACE2 expression remains unclear. | Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu Nannan Zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo Zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 6 | Investigation on the rapid degradation of congo red catalyzed by activated carbon powder under microwave irradiation显示文摘 | Zhaohong Zhang Yabo Shan Jun Wang Hongjie Ling Shuliang Zang Wei Gao Zhe Zhao Huachun Zhang | 2007 | Journal of Hazardous Materials2007，，1： | 1 |
| 7 | Distributed Space-Frequency Coding for Cooperative Diversity in Broadband Wireless Ad Hoe Networks 显示文摘 | Zhang Wei Li Yabo | 2008 | IEEE Transactions on Wireless Communications2008，7，3： | 1 |
| 8 | SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages显示文摘Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 infection.Intranasally administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for degradation.This pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal acidification.In addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side effects.These findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future. | Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang | 2022 | Cellular & Molecular Immunology2022，19，2： | 1 |
| 9 | Establishment of image-guided radiotherapy of orthotopic hepatocellular carcinoma mouse model显示文摘Background:Hepatocellular carcinoma(HCC)is the most common type of liver cancer.Recently,developments in radiotherapy technology have led to radiotherapy becoming one of the main therapeutics of HCC.Therefore,a suitable animal model for radiotherapy of the orthotopic HCC mouse model is urgently needed.Methods:In the present study,Hepa1-6 cells were injected into the liver of C57BL/6 mice in situ to mimic the pathological characteristics of the original HCC.Tumor formation was monitored by applying magnetic resonance imaging techniques and verified by H&E histopathological staining,AFP staining,and Ki67 staining.A single dose of 10 Gy X-ray was applied to simulate clinical radiotherapy plans using image-guided radiotherapy(IGRT)equipment.The efficiency of radiotherapy was then assessed by examining tumor size and weight one week after radiation.Cleaved-caspase3 staining and TUNEL were used to assess apoptosis in tumor tissues.Results:Intrahepatic tumor development was detected in the liver according using MRI.A high-density shadow could be seen 10 days after cell injection,which indicated the formation of HCC in vivo.The tumors grew steadily bigger,and underwent precision radiotherapy 20 days after injection.The typical pathological characteristics of HCC,such as large,deeply stained nuclei and irregular cell size,were visible with H&E staining.After radiotherapy,significantly higher expression of the immunohistochemical markers Ki67 and AFP were detected in tumor tissue than in the nearby normal tissue.Compared with the control group,the tumor volume(p=0.05)and weight(p<0.05)of the irradiated group were significantly reduced.In addition,a higher frequency of apoptosis was identified in irradiated HCC tumor tissue using the TUNEL and cleaved-caspase3 staining assay.Conclusions:In a well-established orthotopic HCC model,MRI was utilized to monitor the formation of tumors,and IGRT was used to simulate clinical radiotherapy.The present study could provide a suitable preclinical system for HCC radiotherapyrelated studies. | Kaixiao Zhou Yabo Jiang Shuang Feng Wei Mo Jing Nie Jianping Cao Yang Jiao | 2023 | Animal Models and Experimental Medicine2023，6，5： | 0 |
| 10 | Bioinspired iron porphyrins with appended poly-pyridine/amine units for boosted electrocatalytic CO_(2) reduction reaction显示文摘Developing highly efficient electrocatalysts for the CO_(2) reduction reaction(CO_(2)RR)has attracted increasing interest in the past decade.Herein,we report on the design and synthesis of Fe porphyrin 1 with an appended N,N-di(2-picolyl)ethylenediamine(DPEN)unit that boosts electrocatalytic activity for CO_(2)-to-CO conversion in acetonitrile with water as the proton source.By mimicking carbon monoxide dehydrogenase(CODH),1 has poly-pyridine/amine units located at the active site to form hydrogen-bonded water-containing networks that enable fast proton transfer.The protonated and positively charged DPEN unit can also stabilize CO_(2) reduction intermediates through electrostatic and hydrogen-bonding interactions.These factors make 1 a highly active electrocatalyst for the CO_(2)RR by achieving a TOFmax of 5.0×10^(4)s^(−1) with water providing the protons.These critical roles of the DPEN unit in the CO_(2)RR are further supported by theoretical studies.This work is significant to highlight the benefits of using molecular catalysts to elucidate structural effects. | Jinxiu Han Ni Wang Xialiang Li Haitao Lei Yabo Wang Hongbo Guo Xiaotong Jin Qingxin Zhang Xinyang Peng Xue-Peng Zhang Wei Zhang Ulf-Peter Apfel Rui Cao | 2022 | eScience2022，2，6： | 0 |
| 11 | Advances in artificial intelligence techniques drive the application of radiomics in the clinical research of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)remains the most common malignancy to threaten public health globally.With advances in artificial intelligence techniques,radiomics for HCC management provides a novel perspective to solve unmet needs in clinical settings,and reveals pixel-level radiological information for medical imaging big data,correlating the radiological phenotype with targeted clinical issues.Conventional radiomics pipelines depend on handcrafted engineering features,and further deep learning-based radiomics pipelines are supplemented with deep features calculated via self-learning strategies.During the past decade,radiomics has been widely applied in accurate diagnoses and pathological or biological behavior evaluation,as well as in prognosis prediction.In this review,we systematically introduce the main pipelines of artificial intelligence-based radiomics and their efficacy in the clinical studies of HCC. | Jingwei Wei Meng Niu Ouyang Yabo Yu Zhou Xiaoke Ma Xue Yang Hanyu Jiang Hui Hui Hongyi Cao Binwei Duan Hongjun Li Dawei Ding Jie Tian | 2022 | iLIVER2022，1，1： | 0 |
| 12 | Photovoltaic Properties of the Modified n-Si(111) Electrodes with Ethyl and Carboxyls显示文摘n-Si (111 ) 表面跟踪 -C2H5,-C2H4COOH,-C2H2COOH 被反应在 Si-H 之中准备到 ethyl-Grignard,甲基压克力吃了,丙酸乙酯,和 carboxyls 在 trifluoroacetic 酸的存在下面被形成。合成 n-Si (lll ) 电极被扔磅 nanodots 获得,为这些电极的光电的特征在 I^-/I_3^- 氧化还原作用电解质被学习。到在太阳的照明下面的电极的相片电压和光电流密度的行为与一些 -C2H2COOH>-C2H4COOH>-H>-C2H5.The 相片电压和电极的光电流密度一起定期改变了的 j-U (相片水流密度潜力) 跟踪了 -C2H2COOH 分别地,是 -0.641 V 和 5.25 mA/cm2 比那些更否定非结合的修正。 | Yuxue ZHAO Yabo WEI Wensheng YANG Pudun ZHANG Xin ZHOU Qinghong XU | 2008 | Journal of Materials Science & Technology2008，24，2： | 0 |
| 13 | Tuning Electronic Structures of Covalent Co Porphyrin Polymers for Electrocatalytic CO_(2) Reduction in Aqueous Solutions显示文摘Improving the selectivity of the electrocatalytic CO_(2) reduction reaction(CO_(2)RR)over hydrogen evolution in aqueous solutions is required but challenging because the two reactions occur at close thermodynamic potentials and compete with each other.Herein,we report on the selective CO_(2)RR in aqueous solutions utilizing covalent Co porphyrin polymers with fine-tuned electronic structures. | Yabo Wang Xue-Peng Zhang Haitao Lei Kai Guo Gelun Xu Lisi Xie Xialiang Li Wei Zhang Ulf-Peter Apfel Rui Cao | 2022 | CCS Chemistry2022，4，9： | 0 |
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