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| 1 | Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China显示文摘Objective: Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus(HPV) infection in China and the vision of screen-and-treat strategies in low-and middleincome countries(LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China.Methods: A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction(PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus(HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method.Results: A total of 22.2%(2,112/9,526) of women were HR-HPV positive and HPV52(21.7%) was the most common HR-HPV genotype, followed by HPV58(18.2%), HPV53(18.2%) and HPV16(16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia(CIN)1 were HPV16(36.7%), HPV58(20.4%), HPV56(15.3%). Among CIN2+, the most frequent genotypes were HPV16(75.6%), HPV52(17.8%),HPV58(16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions,and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions.Conclusions: The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population. | Shuang Zhao Xuelian Zhao Shangying Hu Jessica Lu Xianzhi Duan Xun Zhang Feng Chen Fanghui Zhao | 2019 | Chinese Journal of Cancer Research2019，31，4： | 30 |
| 2 | Effects of dietary Clostridium butyricum supplementation on growth performance,intestinal development,and immune response of weaned piglets challenged with lipopolysaccharide显示文摘Background: Weanling pigs, with immature immune system and physiological function, usually experience postweaning diarrhea. This study determined the effects of dietary Clostridium butyricum supplementation on growth performance, diarrhea, and immunity of weaned pigs challenged with lipopolysaccharide(LPS).Methods: In Experiment(Exp.) 1,144 weaned piglets were weaned at 21 d and randomly assigned to six groups,with six replicates per group and four pigs per replicate, receiving a control diet(CON) or diet supplemented with antibiotics(AB) or C. butyricum(CB)(0.1%, 0.2%, 0.4%, or 0.8%), respectively. All diets in Exp. 1 were a highly digestible basal diet, with 3,000 mg/kg zinc oxide supplied in the first 2 wk only. In Exp. 2, 180 piglets were weaned at 21 d and randomly assigned to five groups, with six replicates per group and six pigs per replicate, receiving CON, AB, or CB(0.2%, 0.4%, or 0.6%) diets. The digestibility of diets was lower than those in Exp. 1, and did not include zinc oxide. At 36 d of Exp. 2, 12 piglets were selected from each of the CON and 0.4% CB groups, six piglets were intraperitoneally injected with LPS(50 μg/kg body weight) and the other six piglets with normal saline;animals were killed at 4 h after injection to collect blood, intestine, and digesta samples for biochemical analysis.Results: In Exp. 1, CB and AB diets had no effect on growth performance of piglets. In Exp. 2, 0.4% CB decreased feed-gain ratio(P < 0.1), diarrhea score(P < 0.05), and increased duodenal, jejunal, and ileal villus height and jejunal villus height/crypt depth(P < 0.05). The 0.4% CB decreased the plasma tumor necrosis factor(TNF) α(P < 0.05) but increased ileal mucosa IL-10 and TLR2 mRNA expression(P < 0.05). Furthermore, 0.4% CB altered the microbial profile, with Bacillus and Ruminococcaceae UGG-003 at genus level and Lactobacillus casei and Parasutterella secunda at species level were higher than CON in colonic content(P < 0.05).Conclusions: Dietary C. butyricum supplementation had positive effects on growth of weaned piglets with less digestible diets. There was a tendency to reduce the feed-gain ratio, which could reduce feed costs in pig production. Moreover, C. butyricum decreased post-weaning diarrhea by improving the intestinal morphology,intestinal microflora profile, and immune function. | Ling Chen Shuang Li Jie Zheng Wentao Li Xuemei Jiang Xilun Zhao Jian Li Lianqiang Che Yan Lin Shengyu Xu Bin Feng Zhengfeng Fang De Wu | 2018 | Journal of Animal Science and Biotechnology2018，9，4： | 26 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | Additive and Over-dominant Effects Resulting from Epistatic Loci Are the Primary Genetic Basis of Heterosis in Rice显示文摘A set of 148 F9 recombinant inbred lines(RILs) was developed from the cross of an indica cultivar 93-11 and japonica cultivar DT713,showing strong F1 heterosis.Subsequently,two backcross F1(BCF1) populations were constructed by backcrossing these 148 RILs to two parents,93-11 and DT713.These three related populations(281BCF1 lines,148 RILs) were phenotyped for six yield-related traits in two locations.Significant inbreeding depression was detected in the population of RILS and a high level of heterosis was observed in the two BCF1 populations.A total of 42 main-effect quantitative trait loci(M-QTLs) and 109 epistatic effect QTL pairs(E-QTLs) were detected in the three related populations using the mixed model approach.By comparing the genetic effects of these QTLs detected in the RILs,BCF1 performance and mid-parental heterosis(HMP),we found that,in both BCF1 populations,the QTLs detected could be classified into two predominant types:additive and over-dominant loci,which indicated that the additive and over-dominant effect were more important than complete or partially dominance for M-QTLs and E-QTLs.Further,we found that the E-QTLs detected collectively explained a larger portion of the total phenotypic variation than the M-QTLs in both RILs and BCF1 populations.All of these results suggest that additive and over-dominance resulting from epistatic loci might be the primary genetic basis of heterosis in rice. | Xiaojin Luo Yongcai Fu Peijiang Zhang Shuang Wu Feng Tian Jiayong Liu Zuofeng Zhu Jinshui Yang Chuanqing Sun | 2009 | Journal of Integrative Plant Biology2009，51，4： | 20 |
| 5 | Flavonoids from Heartwood of Dalbergia cochinchinensis显示文摘Objective To study the flavonoids from the heartwood of Dalbergia cochinchinensis. Methods The chemical constituents were isolated and purified by combination of silica gel, macroporous resin, Sephadex LH-20, and ODS column chromatography. Their structures were identified by means of spectral analysis. Results Fifteen flavonoids were isolated and identified as pinocembrin(1), liquiritigenin(2), galangin(3), 7-hydroxy-6-methoxyflavone(4), naringenin(5), alpinetin(6), 2,3-dimethoxyxanthone(7), 6,4′-dihydroxy-7-methoxy-flavan(8), mucronulatol(9), 7,8-dihydroxyflavanone(10), 5,7,3′,5′-tetrahydroxyflavanone(11), 4,2′,5′-trihydroxy-4′-methoxychalcone(12), isoliquiritigenin(13), butein(14), and 3′,5′,5,7-tetrahydroxy-6-C-β-D-glucopyranosylflavanone(15), respectively. Conclusion Compounds 7, 8, 10, and 15 are isolated from the plants of Dalbergia L. f. for the first time, and compounds 1, 3, 5, 6, 9, 11, 12, and 14 are isolated from this plant for the first time. | Rong-hua Liu Xin-chao Wen Feng Shao Pu-zhao Zhang Hui-lian Huang Shuang Zhang | 2016 | Chinese Herbal Medicines2016，8，1： | 18 |
| 6 | The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review显示文摘The clinical treatment of joint contracture due to immobilization remains difficult.The pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis.The proteolytic pathways involved in disuse muscle atrophy include the ubiquitin-proteasome-dependent pathway,caspase system pathway,matrix metalloproteinase pathway,Ca2+-dependent pathway and autophagy-lysosomal pathway.The important biological processes involved in skeletal muscle fibrosis include intermuscular connective tissue thickening caused by transforming growth factor-β1 and an anaerobic environment within the skeletal muscle leading to the induction of hypoxia-inducible factor-1α.This article reviews the progress made in understanding the pathological processes involved in immobilization-induced muscle contracture and the currently available treatments.Understanding the mechanisms involved in immobilization-induced contracture of muscle tissue should facilitate the development of more effective treatment measures for the different mechanisms in the future. | Feng Wang Quan-Bing Zhang Yun Zhou Shuang Chen Peng-Peng Huang Yi Liu Yuan-Hong Xu | 2019 | Chinese Journal of Traumatology2019，22，2： | 15 |
| 7 | Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence显示文摘The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century.Mammalian sirtuin 1(SIRT1) has been shown to decrease high-glucose-induced endothelial cell senescence in vitro and prevent hyperglycemia-induced vascular dysfunction.However,a role for SIRT1 in prevention of hyperglycemia-induced vascular cell senescence in vivo remains unclear.We used endothelium-specific SIRT1 transgenic(SIRT1-Tg) mice and wild-type(WT) mice to construct a 40-week streptozotocin(STZ)-induced diabetic mouse model.In this mode,42.9% of wild-type(WT) mice and 38.5% of SIRT1-Tg mice were successfully established as diabetic.Forty weeks of hyperglycemia induced significant vascular cell senescence in aortas of mice,as indicated by upregulation of expression of senescence-associated markers including p53,p21 and plasminogen activator inhibitor-1(PAI-1).However,SIRT1-Tg diabetic mice displayed dramatically decreased expression of p53,p21 and PAI-1 compared with diabetic WT mice.Moreover,manganese superoxide dismutase expression(MnSOD) was significantly downregulated in the aortas of diabetic WT mice,but was preserved in diabetic SIRT1-Tg mice.Furthermore,expression of the oxidative stress adaptor p66Shc was significantly decreased in aortas of SIRT1-Tg diabetic mice compared with WT diabetic mice.Overall,these findings suggest that SIRT1-mediated inhibition of hyperglycemia-induced vascular cell senescence is mediated at least partly through the reduction of oxidative stress. | CHEN HouZao WAN YanZhen ZHOU Shuang LU YunBiao ZHANG ZhuQin ZHANG Ran CHEN Feng HAO DeLong ZHAO Xiang GUO ZhiChen LIU DePei LIANG ChihChuan | 2012 | Science China(Life Sciences)2012，55，6： | 14 |
| 8 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 9 | Prognostic value of M30/M65 for outcome of hepatitis B virus-related acute-on-chronic liver failure显示文摘AIM:To determine the prognostic value of circulating indicators of cell death in acute-on-chronic liver failure(ACLF)patients with chronic hepatitis B virus(HBV)infection as the single etiology.METHODS:Full length and caspase cleaved cytokeratin 18(detected as M65 and M30 antigens)represent circulating indicators of necrosis and apoptosis.M65and M30 were identified by enzyme-linked immunosorbent assay in 169 subjects including healthy controls(n=33),patients with chronic hepatitis B(CHB,n=55)and patients with ACLF(n=81).According to the 3-mo survival period,ACLF patients were defined as having spontaneous recovery(n=33)and non-spontaneous recovery which included deceased patients and those who required liver transplantation(n=48).RESULTS:Both biomarker levels significantly increased gradually as liver disease progressed(for M65:P<0.001 for all;for M30:control vs CHB,P=0.072;others:P<0.001 for all).In contrast,the M30/M65 ratio was significantly higher in controls compared with CHB patients(P=0.010)or ACLF patients(P<0.001).In addition,the area under receiver operating characteristic curve(AUC)analysis demonstrated that both biomarkers had diagnostic value(AUC≥0.80)in identifying ACLF from CHB patients.Interestingly,it is worth noting that the M30/M65 ratio was significantly different between spontaneous and non-spontaneous recovery in ACLF patients(P=0.032).The prognostic value of the M30/M65 ratio was compared with the Model for End-Stage Liver Disease(MELD)and Child-Pugh scores at the 3-mo survival period,the AUC of the M30/M65ratio was 0.66 with a sensitivity of 52.9%and the highest specificity of 92.6%(MELD:AUC=0.71;sensitivity,79.4%;specificity,63.0%;Child-Pugh:AUC=0.77;sensitivity,61.8%;specificity,88.9%).CONCLUSION:M65 and M30 are strongly associated with liver disease severity.The M30/M65 ratio may be a potential prognostic marker for spontaneous recovery in patients with HBV-related ACLF. | Su-Jun Zheng Shuang Liu Mei Liu Malcolm A McCrae Jun-Feng Li Yuan-Ping Han Chun-Hui Xu Feng Ren Yu Chen Zhong-Ping Duan | 2014 | World Journal of Gastroenterology2014，20，9： | 13 |
| 10 | Metamorphic Characteristics and Tectonic Implications of the Kadui Blueschist in the Central Yarlung Zangbo Suture Zone,Southern Tibet显示文摘The Kadui blueschist is located in the central section of Yarlung Zangbo suture zone(YZSZ), southern Tibet, and has been subjected to the subduction of the Neo-Tethyan Ocean below the Asian Plate and provides important clues for better understanding the evolution of the India-Asia convergence zone. In this paper, the systematical petrographic and mineral chemical studies were carried out on the Kadui blueschist, which reveal a mineral assemblage of sodic amphibole, chlorite, epidote, albite and quartz with accessory minerals of titanite, calcite and zircon. Electron microprobe analyses demonstrate that amphibole shows zoned from actinolite core to ferrowinchite/riebeckite rim composition indicating that the sodic amphibole has formed during a prograde metamorphic event. The protolith of the blueschist is an intermediate-basic pyroclastic rock. The calculated pseudosection indicates a clockwise P-T path and constrains peak metamorphic conditions of about 5.9 kbar at 345 ℃. This condition is transitional between pumpellyite-actinolite, greenschist and blueschist facies with a burial depth of 20–22 km and a thermal gradient of 15–16 ℃/km. This thermal gradient belongs to high pressure intermediate P/T facies series and is possibly related to a warm subduction setting of young oceanic slabs. Our new findings indicate that the Kadui blueschist in the central part of YZSZ experienced a rapid subduction and exhumation process as a response to a northward subduction of the Neo-Tethyan oceanic lithosphere during the initial India-Asia collision stage. | Guangming Sun Xu-Ping Li WenYong Duan Shuang Chen Zeli Wang Lingquan Zhao Qingda Feng | 2018 | Journal of Earth Science2018，29，5： | 12 |
| 11 | Metamorphic Evolution and Zircon U-Pb Ages of the Nanshankou Mafic High Pressure Granulites from the Jiaobei Terrane, North China Craton显示文摘Petrological analysis and LA-ICP-MS zircon U-Pb dating were conducted on high-pressure mafic granulites, which occured as xenolith within TTG gneisses, from the Nanshankou Village of the Jiaobei terrane, Shandong Peninsula in the north-eastern part of the North China Craton(NCC). The mafic HP granulite is composed of garnet, clinopyroxene, orthopyroxene, amphibole and symplectitic clinopyroxene, orthopyroxene, plagioclase, ilmente and magnetite which were formed after the decomposition of porphyroblastic garnet and clinopyroxene. Four stages of metamorphic mineral assemblages for the mafic HP granulites were constrained by detail petrological and mineralogical investigations. The early prograde assemblage is represented by the mineral inclusions within garnet and clinopyroxene porphyroblasts(Opx_1+Pl_1+Qtz_1), recording the metamorphic conditions at ~754–757 ℃, 0.63–0.71 GPa; peak metamorphic conditions were determined at ~874–891 ℃, 1.32–1.35 GPa with the mineral assemblage of Grt_2+Cpx_2+Amp_2+Pl_2+Qtz_2. Retrograde minerals derived from symplectitic assemblage Opx_3+Cpx_3+Amp_3+Pl_3+Qtz_3+Ilm_3±Mag_3 were formed at 693–796 ℃, 0.60–0.84 GPa. A final greenschist to sub-greenschist facies event was recorded by the exsolution of actinolite and albite within a retrograded clinopyroxene, as well as the occurrence of prehnite, chlorite and calcite minerals. Accordingly, a clockwise P-T path was concluded on the basis of the different stages of mineral asseblage. Cathodoluminescence imaging, trace element and U-Pb dating of zircons from the mafic HP granulites recorded similar charactistics for three episodes of Paleo–Meso Proterozoic metamorphic events. These are the metamorphic events preserved in mafic and pelitic granulites in the Jiao-Liao-Ji belt(JLJB) with ^(207)Pb/^(206)Pb ages of 2.0-1.9 Ga for peak metamorphism and of 1.86-1.84 Ga for decomposing process, followed by a retrograde amphibolite facies metamorphic event related to the post-orogenic extension at the age of 1.76-1.74 Ga, resulting the exhumation of the granulite to the upper crust level. | Shuang Chen Xu-Ping Li Fanmei Kong Qingda Feng | 2018 | Journal of Earth Science2018，29，5： | 12 |
| 12 | Quantitative evaluation of benign meningioma and hemangiopericytoma with peritumoral brain edema by 64-slice CT perfusion imaging显示文摘背景 Hemangiopericytomas ( HPC )为本地复发和转移有一个无情的趋势,在外科为计划的两治疗和这研究的预后 appraisal.The 目的是重要的以前,在良性的 meningiomas 和 HPC 之间区分是在外科手术前地区分良性的 meningiomas 和 HPCs.Methods 在额外轴的肿瘤和 CT 灌注成像的可能的角色评估在 CT 灌注参数和 microvessel 密度( MVD )之间的关联十七 | REN Guang CHEN Shuang WANG Yin ZHU Rui-jiang GENG Dao-ying FENG Xiao-yuan | 2010 | Chinese Medical Journal2010，，15： | 11 |
| 13 | QAAR exploration on pesticides with high solubility:An investigation on sulfonylurea herbicide dimers formed through π–π stacking interactions显示文摘Bioactive compounds could form aggregates that influence the bio-interactive processes. In this letter,based on p–p stacking models, quantitative aggregation–activity relationship(QAAR) studies were carried out on a series of sulfonylurea herbicides with good solubility. Four QAAR/QSAR models were constructed, which indicated that the bioactivity may strongly depend on both the characters of the dimeric aggregates and the monomer. The QAAR approach based on dimer-aggregates was also applicable for the highly water-soluble sulfonylurea herbicides that can form p–p stacking interactions.It was expected that the QAAR studies based on molecular aggregation state would be applied to other pesticide systems. | Shuang Xia Yue Feng Jia-Gao Cheng Hai-Bin Luo Zhong Li Zheng-Ming Li | 2014 | Chinese Chemical Letters2014，25，7： | 10 |
| 14 | LSD1 coordinates with the SIN3A/HDAC complex and maintains sensitivity to chemotherapy in breast cancer显示文摘 | Yang Yang Wei Huang Rongfang Qiu Ruiqiong Liu Yi Zeng Jie Gao Yu Zheng Yongqiang Hou Shuang Wang Wenqian Yu Shuai Leng Dandan Feng Yan Wang | 2018 | Journal of Molecular Cell Biology2018，10，4： | 10 |
| 15 | Hydrochemical Characteristics and Solute Dynamics of Meltwater Runoff of Urumqi Glacier No.1,Eastern Tianshan,Northwest China显示文摘Hydrochemical characteristics and solute dynamics of bulk meltwater draining from Urumqi Glacier No.1 were investigated in years 2006 and 2007.The glacial meltwater was slightly alkaline with the mean pH of 7.64 and 7.61 in 2006 and 2007,respectively.In the meltwater,the dominant anions were the bicarbonate and sulphate,and the dominant cation was calcium.The concentration of major cations were varied as c(Ca2+) > c(Mg2+) > c(K+) > c(Na+),while the order for the cations was c(HCO3) > c(SO42) > c(NO3) > c(Cl).The total dissolved solids(TDS) in meltwater had inverse relationships with the diurnal discharge.The major ion composition of meltwater was mainly controlled by rock weathering as inferred from the Gibbs model.Furthermore,the ion ratios and Piper diagram indicated that the main processes controlling the meltwater chemistry were carbonate weathering,pyrite weathering and feldspar weathering in rocks,and Ca2+ and HCO3 were the dominant ions during the carbonate weathering process.Solute flux calculation at Glacier No.1 station suggested that chemical denudation rates were 11.46 and 13.90 ton.km 2.yr 1 in 2006 and 2007,respectively. | FENG Fang LI Zhongqin JIN Shuang DONG Zhiwen WANG Feiteng | 2012 | Journal of Mountain Science2012，9，4： | 10 |
| 16 | Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB显示文摘背景象 CKLF 一样奇迹 transmembrane 包含域的家庭(CMTM ) 蛋白质的一个新奇家庭正在连接 chemokines 和 TM4SF。不同成员展出多样的生物功能。在这研究,调整人的免疫不全病毒 type-1 (HIV-1 ) 上的细胞内部的 CMTM2 的效果抄写是 evaluated.Methods 调整全身的 HIV-1 provirus 和 HIV-1 上的 CMTM2 的效果渴望终端重复(LTR ) 指导了抄写被酶试金估计。抄写因素试金用 AP-1 的酶记者 plasmids, CRE,和 NF-B 被进行探索可以被 CMTM2 调整的发信号的小径。在 CMTM2 和抄写因素 AP-1 之间的潜在的关系被西方的弄污进一步分析当 HIV-1 transcription.CMTM2 的一个否定管理者在两全身的 HIV-1 provirus 和 HIV-1 上施加了一个镇压行动,在从水流的结果学习的 导致PMA 的 ERK1/2 phosphorylation.Results 上调查 CMTM2 的效果的分析表明 CMTM2 行动 指导LTR transcription.Transcription 因素试金证明 CMTM2 有选择地禁止了基础 AP-1 和 CREB 交流 HIV-1 的合作表示梭织,有势力 AP-1 和 CREB 使活跃之物,不能颠倒 调停CMTM2 的 AP-1 和 CREB 抑制,在否定地调整细胞内部的 CMTM2 能否定地调整的这二发信号的 pathways.Conclusion 上建议一个有势力和 CMTM2 的特定的效果 HIV-1 抄写,至少部分地,由指向 AP-1 和 CREB 小径。进一步探索机制可以导致新方法控制 HIV-1 复制。 | SONG Hong-shuo SHI Shuang LU Xiao-zhi GAO Feng YAN Ling WANG Ying ZHUANG Hui | 2010 | Chinese Medical Journal2010，，17： | 9 |
| 17 | Discriminated sgRNAs-Based SurroGate System Greatly Enhances the Screening Efficiency of Plant Base-Edited Cells显示文摘The development of CRISPR/Cas9-mediated base editing has made genomic modification more efficient. However, selection of genetically modified cells from millions of treated cells, especially plant cells, is still challenging. In this study, an efficient surrogate reporter system based on a defective hygromycin resistance gene was established in rice to enrich base-edited cells. After step-by-step optimization, the Discriminated sgRNAs-based SurroGate system (DisSUGs) was established by artificially differentiating the editing abilities of a wild-type single guide RNA (sgRNA) targeting the surrogate reporter gene and an enhanced sgRNA targeting endogenous sites. The DisSUGs enhanced the efficiency of screening base-edited cells by 3- to 5-fold for a PmCDA1-based cytosine-to-tyrosine base editor (PCBE), and 2.5- to 6.5-fold for an adenine base editor (ABE) at endogenous targets. These targets showed editing efficiencies of <25% in the conventional systems. The DisSUGs greatly enhanced the frequency of homozygous substitutions and expanded the activity window slightly for both a PCBE and an ABE. Analyses of the total number of single-nucleotide variants from whole-genome sequencing revealed that, compared with the no-enrichment PCBE strategy, the DisSUGs did not alter the frequency of genome-wide sgRNA-independent off-target mutations, but slightly increased the frequency of target-dependent off-target mutations. Collectively, the DisSUGs developed in this study greatly enhances the efficiency of screening plant base-edited cells and will be a useful system in future applications. | Wen Xu Yongxing Yang Ya Liu Guiting Kang Feipeng Wang Lu Li Xinxin Lv Si Zhao Shuang Yuan Jinling Song Ying Wu Feng Feng Xiaoqing He Chengwei Zhang Wei Song Jiuran Zhao Jinxiao Yang | 2020 | Molecular Plant2020，13，1： | 8 |
| 18 | CIVB flashback analysis of hydrogen flame based on azimuthal vorticity at mixing zone exit显示文摘Swirl-premixed combustion systems exhibit potential to meet future regulations on pollution emissions. However, combustion induced vortex breakdown(CIVB) flashback is frequently observed in these systems, especially for high hydrogen content fuel. In this study, a swirl-premixed burner with diverging centerbody was used to investigate CIVB flashback based on azimuthal vorticity at mixing zone exit. Through 2D axisymmetric model, it was found that there was a maximal azimuthal vorticity at mixing zone exit for each equivalence ratio. The physical meaning of these maximal azimuthal vorticity values was the minimally required azimuthal vorticity to trigger CIVB flashback. At the same time, the required azimuthal vorticity declined with the increase of equivalence ratio since turbulent burning velocity started to control flashback. Nevertheless, azimuthal vorticity offered by heat release increased with the increase of equivalence ratio, which promoted flame propagating upstream continually. | TIAN Xiao Jing XING Shuang Xi CUI Yu Feng FANG Ai Bing NIE Chao Qun | 2014 | Science China(Technological Sciences)2014，57，12： | 7 |
| 19 | Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway显示文摘oncostatin M (OSM ) 能在 vivo 并且在 vitro 开始 cardiomyocyte dedifferentiation,这被报导了。导致 OSM 的 cardiomyocyte dedifferentiation 可能是为糖尿病的心肌症(DCM ) 的处理的一个新目标。这研究被设计在 cardiomyocyte dedifferentiation 和 DCM 的前进决定 OSM 的角色。一个老鼠 DCM 模型被建立在 vivo 评估 OSM 的效果。Echocardiography 被使用决定心脏的功能。染色的天狼星红被用来检测纤维变性区域。传播电子显微镜学被用来评估线粒体缺陷。实时聚合酶链反应和西方的污点分析被执行检测相对 mRNA 表情和 cardiomyocyte dedifferentiation 相关的蛋白质表情分别地。OSM 处理导致了类似的损害心脏的功能和心脏的超微结构缺陷到在 DCM 鼠标检测的那些。cardiomyocyte 的 dedifferentiation 标记的表达式(Runx1,和 -SM-actin) 与在控制组的那些相比在对待 OSM 的鼠标是起来调整的。为了推进,表明 OSM 的重要角色, OSM 受体大美人(O ko ) 老鼠被使用。在 O ko 老鼠, c 工具包的 cardiomyocytes dedifferentiation 标记, Runx1,和 atrial natriuretic 肽是下面调整的,与稀释 DCM 损害和废除 OSM/B-Raf/Mek/Erk 发信号小径。在结论,导致 OSM 的 cardiomyocyte dedifferentiation 在 DCM 的前进起一个关键作用。导致 OSM 的 cardiomyocyte dedifferentiation 的机制与通过 OSM 受体 O 表明小径的 B-Raf/Mek/Erk 被联系。 | Xiaotian Zhang Sai Ma Ran Zhang Shuang Li Di Zhu Dong Han Xiuiuan Li Congye Li Wei Yan Dongdong Sun Bin Xu Yabin Wang Feng Cao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 7 |
| 20 | Spatial Distribution of Liver Cancer Incidence in Shenqiu County,Henan Province,China:a Spatial Analysis显示文摘Liver cancer is a common and leading cause of cancer death in China.We used the cancer registry data collected from 2009 to 2011 to describe the spatial distribution of liver cancer incidence at village level in Shengqiu county,Henan province,China.Spatial autocorrelation analysis was employed to detect significant differences from a random spatial distribution of liver cancer incidence.Spatial scan statistics were used to detect and evaluate the clusters of liver cancer cases. | SUN Jie HUANG Hui XIAO Ge Xin FENG Guo Shuang YU Shi Cheng XUE Yu Tang WAN Xia YANG Gong Huan SUN Xin | 2015 | Biomedical and Environmental Sciences2015，28，3： | 7 |
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