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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Altered regional homogeneity in post-traumatic stress disorder: a resting-state functional magnetic resonance imaging study显示文摘Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD. | Yan Yin Changfeng Jin Lisa T. Eyler Hua Jin Xiaolei Hu Lian Duan Huirong Zheng Bo Feng Xuanyin Huang Baoci Shan Qiyong Gong Lingjiang Li | 2012 | Neuroscience Bulletin2012，28，5： | 9 |
| 3 | Heat transfer enhancement in a tube fitted with helical blade rotors with grooves显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Hua Yan | 2013 | Experimental Thermal and Fluid Science2013，，： | 4 |
| 4 | Heat transfer enhancement in the tube fitted with Left–Right helical blade rotors显示文摘 | Zhen Zhang Hua Yan Weimin Yang Yinpeng Zhou Yumei Ding Changfeng Guan | 2013 | Applied Thermal Engineering (-)2013，，1： | 4 |
| 5 | Heat transfer enhancement in double-pipe heat exchanger by means of rotor-assembled strands显示文摘 | Zhen Zhang Yumei Ding Changfeng Guan Hua Yan Weimin Yang | 2012 | Chemical Engineering & Processing: Process Intensification2012，，： | 4 |
| 6 | Soluble, Antibaterial, and Anticorrosion Studies of Sulfonated Polystyrene/Polyaniline/Silver Nanocomposites Prepared with the Sulfonated Polystyrene Template显示文摘 | Guangfu Liao Yan Gong Changfeng Yi Zushun Xu | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 7 | Experimental investigation on flow characteristics in circular tube inserted with rotor-assembled strand using PIV显示文摘Rotor-assembled strand works as a typical tube insert to achieve heat transfer augmentation and scale inhibition in a heat exchanger.In this work, the PIV experiment regarding the flow fields in a circular tube inserted with rotor-assembled strand was conducted and the flow characteristics on transverse section and longitudinal section were analyzed.The results showed that swirling flow was produced in the tube inserted with rotors and it was particularly strong within the swing diameter of the rotor on the section that contains the rotor;the average turbulence intensity and the radial velocity were improved notably; the velocity vectors on the longitudinal section remained along the direction of a straight line; both the swirling flow and average turbulence intensity were higher for the rotor with three blades than for the rotor with two blades except that the radial velocity was approximate, but they were all reduced by enlarging the lead of the rotor.Characterization of the flow patterns in a circular tube contributes to understanding the heat transfer efficiency and scale inhibition performance of the rotor-assembled strand and provides guidance for its application. | Lichen He Weimin Yang Changfeng Guan Hua Yan Lin Zheng Xiahua Zuo | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 3 |
| 8 | Numerical study on thermo-hydraulic characteristics of turbulent flow in a circular tube fitted with helical blade rotors显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Hua Yan | 2013 | International Journal of Heat and Mass Transfer2013，，： | 3 |
| 9 | Heat transfer and friction characteristics of turbulent flow through plain tube inserted with rotor-assembled strands显示文摘 | Zhen Zhang Weimin Yang Changfeng Guan Yumei Ding Fengxiang Li Hua Yan | 2011 | Experimental Thermal and Fluid Science2011，，： | 3 |
| 10 | Crack propagation mechanism of γ-TiAl alloy with pre-existing twin boundary显示文摘The deformation and failure mechanisms of γ-TiAl alloy with pre-existing crack and twin boundary are investigated by using molecular dynamics simulation. The effects of the crack position on the deformation and failure mechanisms of γ-TiAl specimen are analysed through the snapshots of crack propagation, microstructure of crack tip and stress-strain curves. The simulation results show that the dislocation motion is impeded, the good ductility can be maintained and the strength would be improved simultaneously by the twin boundary. The microstructure evolution of crack tip would change with crack positions. Essentially,the deformation behaviour mainly results from the reaction of dislocation-dislocation, dislocation-twin and twin-twin. Besides,the hierarchical twin is a main plastic deformation mechanism leading to strength of γ-TiAl specimen enhancement with noncompromising ductility and strain hardening. Based on stress-strain curves, it can be concluded that the yield strength varies with crack positions. They are the determinant factors for variation of the yield strength with different crack positions such as dislocation behaviour, stacking fault and hierarchical twin. The ductile-brittle transition associated with the dislocation motion and the decohesion failure of crack tip atom can be observed from the lower boundary crack and the center crack models. The crack propagation caused by the coalescent of the void and the crack tip is the main failure mechanism of γ-TiAl specimen. In addition, the results reveal that the mechanism of crack propagation would be influenced by pre-existing twin boundary which can prevent the crack propagation and improve the fracture toughness. | CAO Hui RUI ZhiYuan CHEN WenKe FENG RuiCheng YAN ChangFeng | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
| 11 | Surface defect-rich ceria quantum dots anchored on sulfur-doped carbon nitride nanotubes with enhanced charge separation for solar hydrogen production显示文摘Designing defect-engineered semiconductor heterojunctions can effectively promote the charge carrier separation.Herein,novel ceria(CeO2) quantum dots(QDs) decorated sulfur-doped carbon nitride nanotubes(SCN NTs) were synthesized via a thermal polycondensation coupled in situ depositionprecipitation method without use of template or surfactant.The structure and morphology studies indicate that ultrafine CeO2 QDs are well distributed inside and outside of SCN NTs offering highly dispersed active sites and a large contact interface between two components.This leads to the promoted formation of rich Ce^(3+) ion and oxygen vacancies as confirmed by XPS.The photocatalytic performance can be facilely modulated by the content of CeO2 QDs introduced in SCN matrix while bare CeO2 does not show activity of hydrogen production.The optimal catalyst with 10% of CeO2 loading yields a hydrogen evolution rate of 2923.8 μmol h-1 g-1 under visible light,remarkably higher than that of bare SCN and their physical mixtures.Further studies reveal that the abundant surface defects and the created 0 D/1 D junctions play a critical role in improving the separation and transfer of charge carriers,leading to superior solar hydrogen production and good stability. | Mengru Li Changfeng Chen Liping Xu Yushuai Jia Yan Liu Xin Liu | 2021 | Journal of Energy Chemistry2021，30，1： | 1 |
| 12 | Applied research of fracture for brass in extra-low cycle inverse rotating bending fatigue 显示文摘 | Li Youtang Yan Changfeng Ma Ping | 2005 | Key Engineering Materials2005，298，2： | 1 |
| 13 | Applied inves- tigation of fracture for middle carbon steel in extra-low cycle inverse rotating bending fatigue 显示文摘 | Li Youtang Yan Changfeng Wei Yaobing | 2004 | Key Engineering Mate- rials2004，261，1： | 1 |
| 14 | The applied re- search investigation of fracture for low carbon steel in extra- low cycle rotating bending fatigue 显示文摘 | Li Youtang Rui Zhiyuan Yan Changfeng | 2004 | Key Engineering Materials2004，274，1： | 1 |
| 15 | Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder; A functional magnetic resonance imaging study显示文摘 | Yin Yan Jina Changfeng Hu Xiaolei | 2011 | Brail Research2011，1411，9： | 1 |
| 16 | Performance assessment in a tube with rotor-assembled strands mixed by spiral slot rotor and low flow resistance rotor显示文摘 | Peng Jiang Weimin Yang Hua Yan Changfeng Guan | 2013 | Applied Thermal Engineering2013，，1： | 1 |
| 17 | The Applied Research of Fracture in Three-point Bending to Blanking of Bearing Steel显示文摘The application of fracture in three-point bending to blanking of bearing steel is studied in this paper. Several mechanical models of stress blanking are discussed at first. And then the experiments have been made in special equipment of three-point bending designed by us. Several problems, such as the suitable span, the relations between bending and tension bending complex, the ratio of blanking length to the diameter, the relations of blank length to force, the feature of fracture, are studied through the experiments. The suitable parameters of three-point bending to blanking, depth and tip radius of notch and the ratio between blanking length and stick diameter have been proposed. | Youtang Li Ping Ma Changfeng Yan | 2004 | 上海交通大学学报2004，38，z2： | 0 |
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