3篇
您的检索式：作者名="Yan Tongjun"
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| 1 | Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer显示文摘Colorectal 癌症(CRC ) 是在西方的世界上的癌症相关的死亡的第三个领先的原因。在这研究,我们计算了矩阵 metalloproteinase 的表达式在 CRC 的 2 基因(MMP2 ) 并且与 clinicopathological 特征分析了它的关联。我们发现 MMP2 的表示比在 colorectal 纸巾在 CRC 纸巾是显著地更高的。另外, MMP2 蛋白质的高水平断然与肿瘤尺寸,淋巴节点转移,远转移,公爵阶段,和肿瘤侵略的地位被相关。而且,有更高的 MMP2 层次的病人与低 MMP2 层次比那些有显著地更短的全面幸存。Multivariate 分析结果建议 MMP2 表示的水平是为有 CRC 的病人的幸存的独立预示的指示物。在有调停 lentiviral 的 shRNA 的 CRC 房间线的 Silencing MMP2 表示显著地压制了房间增长,殖民地形成,和侵略。而且,我们观察到那个脉管的 endothelial 生长因素(VEGF ) 和膜打 1 (MT1 )-MMP 蛋白质层次在 MMP2-down-regulated colorectal 细胞被减少。因此,我们的学习证明 MMP2 是与 CRC 的 carcinogenesis 和转移有关的一个重要因素,并且 MMP2 由起来调整的 VEGF 和 MT1-MMP 表示支持 CRC 房间生长和侵略,它为癌症治疗使这条小径成为一个潜在的目标。 | Wei Dong Hong Li Yan Zhang Heng Yang Min Guo Li Li Tongjun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 10 |
| 2 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 3 | 6-27 Structural Design of ADS-L60 Superconducting Magnets显示文摘Accelerator driven system (ADS) is the effective tool for transmuting the long-lived transuranic radionuclidesinto shorter-lived radionuclides. A project called C-ADS is being studied at the Chinese Academy of Sciences.Injector II prototype of C-ADS which is in charge of by the Institute of Modern Physics has already gained agood progress so far. Two superconducting solenoids with the effective length of 150 mm have been designed andfabricated by Magnet and Mechanical Group of IMP and installed into the testing cryomodule[1]. | Mei Enming Wu Wei Wu Beimin Yan Tongjun | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
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