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| 1 | Energy metabolism disorders and potential therapeutic drugs in heart failure显示文摘Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy supply.This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of heart.Current HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the disease.Drugs aimed at cardiac energy metabolism have not yet been developed.In this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy metabolism.Finally,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF. | Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 11 |
| 2 | Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo显示文摘尽管表明小径的原子 factor-kappaB (NF-B ) 的组成的激活在多重不同人的肿瘤被报导了,在食道的有鳞的房间癌(ESCC ) 的 NF-B 小径的角色留下不清楚。丰富的来源提供了有趣的卓见进化疗和 chemopreventive 在癌症上完成的 curcumin 可以由调停的多重机制。在这研究,我们首先在二 ESCC 房间线 Eca109 和 EC9706 分析了 NF-B 小径的地位,然后进一步调查了 curcumin 是否能独自或在有 5 氟尿嘧啶(5-FU ) 的联合在 vitro 并且在 vivo 调制 NF-B 小径。结果证明 NF-B 发信号小径组成地在 ESCC 房间线被激活。Curcumin 经由 IB phosphorylation,和 downregulated 的抑制压制了 NF-B 的激活在 ESCC 房间线的 Bcl-2 和 CyclinD1 的表情。与 5-FU 相结合的 Curcumin 比独自对待的 5-FU 导致了更低的房间生存能力和更高的 apoptosis。在一个人的 ESCC 异种皮移植模型, curcumin 或 5-FU 独自减少了肿瘤体积,但是他们的联合有最强壮的 anticancer 效果。而且, curcumin 能也禁止在 vivo 通过 IB phosphorylation 和房间 apoptosis 的正式就职的 downregulation 表明小径的 NF-B。总的来说,我们的结果显示组成地激活的 NF-B 发信号小径在二个 ESCC 房间存在, curcumin 的 chemopreventive 效果与表明小径和它的下游的基因的 NF-B 的 downregulation 被联系。 | Fang Tian Tianli Fan Yan Zhang Yanan Jiang Xiaoyan Zhang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，10： | 10 |
| 3 | Heavy mineral assemblage characteristics and the Cenozoic paleogeographic evolution in southwestern Qaidam Basin显示文摘Based on the analysis of heavy mineral assemblages in Cenozoic southwestern Qaidam Basin, we found that different areas have variable heavy mineral assemblage characteristics, which suggested that there were two source areas—the Altyn Mountains and the Qimen Tagh-East Kunlun Mountains. In Ganchaigou-Shizigou-Huatugou(Area A), which was mainly source from the Altyn Mountains, its heavy minerals were mainly composed of zircon, Ti-oxides, and wollastonite in the Paleoceneearly Eocene and mainly of unstable minerals, especially amphibole, in the middle Eocene-Oligene. Since the late OligoceneMiocene, the heavy minerals were still mainly unstable minerals, but the content of epidote increased and the content of amphibole decreased. In Qigequan-Hongliuquan(Area B), which was the mixed source from the Altyn Mountains and the Qimen Tagh-East Kunlun Mountains, its heavy minerals were mainly garnet, epidote, and amphibole. The source of LücaotanDongchaishan-Kunbei(Area C) was mainly from the Qimen Tagh-East Kunlun Mountains, heavy minerals in the sediments in Area C were mainly zircon and Ti-oxides in Paleogene and garnet, epidote, and amphibole in Neogene. In Yuejin-Youshashan(Area D), where the stable minerals and unstable minerals were present simultaneously, the heavy mineral assemblages was controlled by multi-direction source. The variation of heavy mineral assemblages in southwestern Qaidam Basin shows that Altyn Mountains was of low-lying topographic relief in Paleocene-early Eocene, and the rapid uplift of Altyn Mountains started from the middle Eocene. In Paleogene, the Altyn Tagh Fault had a slow strike-slip velocity, but the strike-slip velocity increased greatly since the late Oligocene, leading to a strike-slip displacement above 300 km since Neogene. Meanwhile, the Qimen Tagh-East Kunlun fault zone was under a stable tectonic stage in Paleogene with the Qimen Tagh Mountain being lowlying hills; since the late Oligocene, the fault zone started to activate and the Qimen Tagh Mountain began to uplift rapidly. | LI LinLin GUO ZhaoJie GUAN ShuWei ZHOU SuPing WANG MingZhen FANG YaNan ZHANG ChenChen | 2015 | Science China Earth Sciences2015，58，6： | 6 |
| 4 | Two soybean homologues of TERMINAL FLOWER 1 control flowering time under long day conditions显示文摘Flowering time is a key agronomic trait that directly affect the adaptation and yield of soybean.After whole genome duplications,about 75%of genes being represented by multiple copies in soybean.There are four TERMINAL FLOWER 1(TFL1)genes in soybean,and the TFL1b(Dt1)has been characterized as the determinant of stem growth habit.The function of other TFL1 homologs in soybean is still unclear.Here,we generated knockout mutants by CRISPR/Cas9 genome editing technology and found that the tfl1c/tfl1d double mutants flowered significantly earlier than wild-type plants.We investigated that TFL1c and TFL1d could physically interact with the b ZIP transcription factor FDc1 and bind to the promoter of APETALA1a(AP1a).RNA-seq and q RT-PCR analyses indicated that TFL1c and TFL1d repressed the expressions of the four AP1 homologs and delayed the flowering time in soybean.The two genes play important roles in the regulation of flowering time in soybean and mainly act as the flowering inhibitors under long-day conditions.Our results identify novel components in the flowering-time regulation network of soybean and will be invaluable for molecular breeding of improved soybean yield. | Lingshuang Wang Chun Lin Bohui Li Tong Su Shichen Li Haiyang Li Fanglei He Chuanjie Gou Zheng Chen Yanan Wang Jun Qin Baohui Liu Fanjiang Kong Lin Yue Sijia Lu Chao Fang | 2023 | The Crop Journal2023，11，3： | 3 |
| 5 | Identification of reversible insertion-type lithium storage reaction of manganese oxide with long cycle lifespan显示文摘Recently,MnO2 has gained attention as an electrode material because of its very high theoretical capacity and abundant availability.However,the very high volumetric change caused by its conversion-type reaction results in bad reversibility of charge-discharge.In this study,δ-MnO2 of thickness 8 nm anchored on the surface of carbon nanotubes(CNT)by Mn-O-C chemical bonding is synthesized via a facile hydrothermal method.Numerous ex-situ characterizations of the lithium storage process were performed.Furthermore,density functional theory(DFT)calculations indicated thatδ-MnO2(012)thermodynamically prefers bonding with CNTs.Moreover,the interfacial interaction reinforces the connection of Mn-O and reduces the bond strength of Li-O in lithiated MnO2,which could facilitate an intercalation-type lithium storage reaction.Consequently,the as-synthesizedδ-MnO2 retains an excellent reversible capacity of 577.5 mAh g-1 in 1000 cycles at a high rate of 2 A g-1 between 0.1 V and 3.0 V.The results of this study demonstrate the possibility of employing the cost-effective transition metal oxides as intercalation lithium storage dominant electrodes for advanced rechargeable batteries. | Yuxuan Zhang Fang Lian Jianhao Lu Laijun Ma Ning Chen Yanan Chen Dingguo Xia | 2020 | Journal of Energy Chemistry2020，29，7： | 3 |
| 6 | Density estimated physicochemical properties of alanine-based ionic liquid [C_7mim][Ala] and its application in selective transesterification of soybean oil显示文摘Amino acid ionic liquid (AAIL) based on alanine, 1-n-heptyl-3-methylimidazolium alanine ([C7mim][Ala]), has been prepared and characterized. Since the IL can form strong hydrogen bonds with water, trace amount of water is a problematic impurity in the IL. Using the standard addition method (SAM), the densities were measured in the temperature range from 293.15 to 343.15±0.05 K. On the basis of the experimental data of density, the surface tension , molar volume, and the molecular volume Vm, molar enthalpy of vaporization lgHm0, and the thermal expansion coefficients , for [C7mim][Ala] were estimated using semi-empirical methods. Also the interstice model has been verified with good accordance. Then the [C7mim][Ala] was taken as catalyst in the transesterification reaction with fatty acid, where soybean oil was used as raw material and methanol as reactant. The amount of catalyst, alcohol consumption, reaction time, temperature and other factors of the reaction were investigated. Using GC determination, the conversions were calculated by the internal standard method. The main ingredients of the products were identified by GC-MS as palm methyl ester and linoleic acid methyl ester only, which showed high selectivity in palmitic acid and linoleic acid. | FANG DaWei LI Meng GE RiLe ZANG ShuLiang YANG JiaZhen GAO YanAn | 2012 | Science China Chemistry2012，55，8： | 2 |
| 7 | Low-dose intravenous tissue plasminogen activator for acute ischaemic stroke: an alternative or a new standard?显示文摘Background:With the recent publication of a large clinical trial on the use of a lower dose of intravenous(IV)tissue plasminogen activator(tPA)for acute ischaemic stroke(AIS),the concept of using a different dose has been debated.We intend to review the literature on using a lower dose of IV tPA and gain a better understanding of the impact of different IV doses on the treatment of patients with AIS.Methods:A comprehensive literature search of the related topics in PubMed,EMBASE,Web of Science and MEDLINE was carried out.Key words used include low dose IV tPA,thrombolysis,Alteplace and tPA for AIS.Findings were tabulated according to the size of the cohort studied,outcome,adverse event and level of evidence.The results of all studies using lower doses were analysed for efficacy and adverse events.Results:From 1992 to 2016,there were 23 trials that included 10950 patients published on the use of lower doses of IV tPA for AIS.Doses ranged from 0.5,0.6,0.75 to 0.85 mg/kg.Most were observational,retrospective and registry studies.One was a prospective open-label randomised controlled trial.13 trials combined lower doses of IV tPA with a glycoprotein IIb/IIIa inhibitor or thrombectomy.Patients treated with lower doses of IV tPA showed a trend of lower rate of symptomatic intracranial haemorrhage and mortality at 3 months but slightly more disability.Conclusions:Lower doses of IV tPA showed less haemorrhagic events but were not more effective compared with the standard dose.The optimal low dose of IV tPA remains unclear.Patients with AIS with a high risk of developing sypmtomatic intracranial haemorrhage might benefit from lower dose IV tPA,such as 0.6 mg/kg. | Yi Dong Wenjie Cao Xin Cheng Kun Fang Fei Wu Lumeng Yang Yanan Xie Qiang Dong | 2016 | Stroke & Vascular Neurology2016，1，3： | 2 |
| 8 | Growth Rates of Fine Aerosol Particles at a Site near Beijing in June 2013显示文摘Growth of fine aerosol particles is investigated during the Aerosol–CCN–Cloud Closure Experiment campaign in June2013 at an urban site near Beijing. Analyses show a high frequency(~ 50%) of fine aerosol particle growth events, and show that the growth rates range from 2.1 to 6.5 nm h^(-1) with a mean value of ~ 5.1 nm h^(-1). A review of previous studies indicates that at least four mechanisms can affect the growth of fine aerosol particles: vapor condensation, intramodal coagulation,extramodal coagulation, and multi-phase chemical reaction. At the initial stage of fine aerosol particle growth, condensational growth usually plays a major role and coagulation efficiency generally increases with particle sizes. An overview of previous studies shows higher growth rates over megacity, urban and boreal forest regions than over rural and oceanic regions. This is most likely due to the higher condensational vapor, which can cause strong condensational growth of fine aerosol particles.Associated with these multiple factors of influence, there are large uncertainties for the aerosol particle growth rates, even at the same location. | Chuanfeng ZHAO Yanan LI Fang ZHANG Yele SUN Pucai WANG | 2018 | Advances in Atmospheric Sciences2018，35，2： | 2 |
| 9 | Prediction of Polycyclic Aromatic Hydrocarbon Bioaccessibility to Earthworms in Spiked Soils by Composite Extraction with Hydroxypropyl-β-Cyclodextrin and Organic Acids显示文摘Traditional exhaustive extraction methods often overestimate the risk of polycyclic aromatic hydrocarbon(PAH) bioaccessibility to biota. Therefore, reliable assessment methods need to be established. In this study, a composite extraction with hydroxypropyl-β-cyclodextrin(HPCD) and three low-molecular-weight organic acids, oxalic acid(OA), malic acid(MA), and citric acid(CA), was used to predict the PAH bioaccessibility to earthworms, subjecting to two soils(red soil and yellow soil) spiked with selected PAHs,phenanthrene, pyrene, chrysene, benzo(a)anthracene, benzo(b)fluoranthene, benzo(k)fluoranthene, and benzo(a)pyrene. For both soils,concentrations of PAHs by composite extraction using HPCD-OA(R^2= 0.89–0.92, slope = 1.89–2.03; n = 35), HPCD-MA(R^2=0.92–0.96, slope = 1.43–1.67; n = 35), and HPCD-CA(R^2= 0.92–0.96, slope = 1.26–1.56; n = 35) were significantly correlated with PAH accumulation in the Eisenia fetida earthworms. Moreover, the HPCD-CA-and HPCD-MA-extracted PAH concentrations were closer to the earthworm-accumulated PAH concentration than the extraction using just HPCD. The results indicated that the composite extraction could improve the prediction of PAH bioaccessibility, and therefore can serve as a reliable chemical method to predict PAH bioaccessibility to earthworms in contaminated soils. | ZHANG Yanan YANG Xinglun GU Chenggang BIAN Yongrong LIU Zongtang JIA Mingyun WANG Fang WANG Daizhang JIANG Xin | 2017 | Pedosphere2017，27，3： | 2 |
| 10 | CmBES1 is a regulator of boundary formation in chrysanthemum ray florets显示文摘Chrysanthemum(Chrysanthemum morifolium)is an ideal model species for studying petal morphogenesis because of the diversity in the flower form across varieties;however,the molecular mechanisms underlying petal development are poorly understood.Here,we show that the brassinosteroid transcription factor BRI1-EMS-SUPPRESSOR 1(CmBES1)in chrysanthemum(C.morifolium cv.Jinba)is important for organ boundary formation because it represses organ boundary identity genes.Chrysanthemum plants overexpressing CmBES1 displayed increased fusion of the outermost ray florets due to the loss of differentiation of the two dorsal petals,which developed simultaneously with the ventral petals.RNA-seq analysis of the overexpression lines revealed potential genes and pathways involved in petal development,such as CUP-SHAPED COTYLEDON(CUC2),CYCLOIDEA 4(CYC4),genes encoding MADS-box transcription factors and homeodomain-leucine zippers(HD-Zips)and auxin pathway-related genes.This study characterizes the role of CmBES1 in ray floret development by its modulation of flower development and boundary identity genes in chrysanthemum. | Peilei Cheng Yanan Liu Yiman Yang Hong Chen Hua Cheng Qian Hu Zixin Zhang Jiaojiao Gao Jiaxin Zhang Lian Ding Weimin Fang Sumei Chen Fadi Chen Jiafu Jiang | 2020 | Horticulture Research2020，7，1： | 2 |
| 11 | The over-expression of a chrysanthemum gene encoding an RNA polymerase II CTD phosphatase-like 1 enzyme enhances tolerance to heat stress显示文摘The enzyme RNAPII CTD phosphatase-like 1 is known as a transcriptional regulator of the plant response to various abiotic stresses.Here,the isolation of CmCPL1,a chrysanthemum(Chrysanthemum morifolium)gene encoding this enzyme is described.Its predicted 955 residue gene product includes the FCPH catalytic domain,two double-stranded RNA binding motifs,and a nuclear localization signal.A sub-cellular localization assay confirmed that CmCPL1 was expressed in the nucleus.CmCPL1 transcription was shown to be significantly inducible by heat stress.The over-expression and knockdown of CmCPL1,respectively,increased and diminished the tolerance of chrysanthemum to heat stress,which maybe dependent on the regulation of CmCPL1 and on the expression of downstream heat stress-responsive genes. | Yuying Qi Yanan Liu Zixin Zhang Jiaojiao Gao Zhiyong Guan Weimin Fang Sumei Chen Fadi Chen Jiafu Jiang | 2018 | Horticulture Research2018，5，1： | 2 |
| 12 | Surface modification with oxygen vacancy in Li-rich layered oxide Li1.2Mn0.54Ni0.13Co0.13O2 for lithium-ion batteries显示文摘A couple of layered Li-rich cathode materials Li1.2Mn0.54Ni0.13Co0.13O2 without any carbon modification are successfully synthesized by solvothermal and hydrothermal methods followed by a calcination process. The sample synthesized by the solvothermal method(S-NCM) possesses more homogenous microstructure, lower cation mixing degree and more oxygen vacancies on the surface, compared to the sample prepared by the hydrothermal method(H-NCM). The S-NCM sample exhibits much better cycling performance, higher discharge capacity and more excellent rate performance than H-NCM. At 0.2 C rate,the S-NCM sample delivers a much higher initial discharge capacity of 292.3 mAh g^-1 and the capacity maintains 235 m Ah g^-1 after 150 cycles(80.4% retention), whereas the corresponding capacity values are only 269.2 and 108.5 m Ah g^-1(40.3% retention) for the H-NCM sample. The S-NCM sample also shows the higher rate performance with discharge capacity of 118.3 mAh g^-1 even at a high rate of 10 C, superior to that(46.5 m Ah g^-1) of the H-NCM sample. The superior electrochemical performance of the S-NCM sample can be ascribed to its well-ordered structure, much larger specific surface area and much more oxygen vacancies located on the surface. | Bozhou Chen Bangchuan Zhao Jiafeng Zhou Zhitang Fang Yanan Huang Xuebin Zhu Yuping Sun | 2019 | Journal of Materials Science & Technology2019，35，6： | 2 |
| 13 | SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis显示文摘Dear Editor,The SARS-CoV-2 Omicron variant has rapidly displaced the Delta variant and spread across the world.The Omicron variant harbors over 60 mutations,and 15 of the mutations are located in the receptor-binding domain(RBD).1 Compared with parental virus and previous variants,the Omicron variant is characterized by decreased hospitalization rates and less severe disease in patients. | Yanan Zhang Ting Zhang Yihui Fang Jie Liu Qinong Ye Lihua Ding | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 14 | NAD^(+) salvage governs the immunosuppressive capacity of mesenchymal stem cells显示文摘Mesenchymal stem/stromal cells(MSCs)possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders.This capacity is not innate but is activated or‘licensed’by inflammatory cytokines.The licensing mechanism remains unclear.Here,we examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity.In response to stimulation by inflammatory cytokines,MSCs exhibited a dramatic increase in the consumption of glucose,which was accompanied by an enhanced use of nicotinamide adenine dinucleotide(NAD^(+))and increased expression of nicotinamide phosphoribosyltransferase(NAMPT),a central enzyme in the salvage pathway for NAD^(+) production.When NAD^(+) synthesis was blocked by inhibiting or depleting NAMPT,the immunosuppressive function of MSCs induced by inflammatory cytokines was greatly attenuated.Consequently,when NAD^(+) metabolism in MSCs was perturbed,their therapeutic benefit was decreased in mice suffering from inflammatory bowel disease and acute liver injury.Further analysis revealed that NAMPT-driven production of NAD^(+) was critical for the inflammatory cytokine-induced increase in glycolysis in MSCs.Furthermore,the increase in glycolysis led to succinate accumulation in the tricarboxylic acid cycle,which led to hypoxia-inducible factor 1α(HIF-1α)stabilization and subsequently increased the transcription of key glycolytic genes,thereby persistently maintaining glycolytic flux.This study demonstrated that unlike its proinflammatory role in immune cells,NAD^(+) metabolism governs the anti-inflammatory function of MSCs during inflammation. | Jiankai Fang Pengbo Hou Shisong Liu Muqiu Zuo Zhanhong Liu Wangwang Chen Yuyi Han Yanan Li Tingting Wang Chao Feng Peishan Li Changshun Shao Yufang Shi | 2023 | Cellular & Molecular Immunology2023，20，10： | 1 |
| 15 | Combined Hyste- rolaparoscopy for the Diagnosis of Famale Infertility: a Retro-spective Study of 132 Patients in china显示文摘 | Erhong Zhang Yanan Zhang Li Fang | 2014 | Mater Sociomed2014，26，3： | 1 |
| 16 | Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells显示文摘γδ T cells are heterogeneous lymphocytes located in various tissues.However,a systematic and comprehensive understanding of the origins of γδ T cell heterogeneity and the extrathymic developmental pathway associated with liver γδ T cells remain largely unsolved.In this study,we performed single-cell RNA sequencing(scRNA-seq)to comprehensively catalog the heterogeneity of γδ T cells derived from murine liver and thymus samples.We revealed the developmental trajectory of γδ T cells and found that the liver contains γδ T cell precursors(pre-γδ T cells).The developmental potential of hepatic γδ T precursor cells was confirmed through in vitro coculture experiments and in vivo adoptive transfer experiments.The adoptive transfer of hematopoietic progenitor Lin^(-)Sca-1^(+)Mac-1^(+)(LSM)cells from fetal or adult liver samples to sublethally irradiated recipients resulted in the differentiation of liver LSM cells into pre-γδ T cells and interferon-gamma^(+)(IFN-γ^(+))but not interleukin-17a^(+)(IL-17a^(+))γδ T cells in the liver.Importantly,thymectomized mouse models showed that IFN-γ-producing γδ T cells could originate from liver LSM cells in a thymus-independent manner.These results suggested that liver hematopoietic progenitor LSM cells were able to differentiate into pre-γδ T cells and functionally mature γδ T cells,which implied that these cells are involved in a distinct developmental pathway independent of thymus-derived γδ T cells. | Yuan Hu Keke Fang Yanan Wang Nan Lu Haoyu Sun Cai Zhang | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 17 | Propelling polysulfide redox by Fe_(3)C-FeN heterostructure@nitrogendoped carbon framework towards high-efficiency Li-S batteries显示文摘Lithium-sulfur(Li-S) batteries hold great promise in next-generation high-energy-density energy storage systems,but the intractable shuttle effect and the sluggish redox kinetics of polysulfides hinder the practical implementation of Li-S batteries.Here,heterostructured Fe_(3)C-FeN nanoparticles dotted in the threedimensional-ordered nitrogen-doped carbon framework(Fe_(3)C-FeN@NCF) were synthesized by molecular engineering combined with heterointerface engineering,and were applied to regulate the immobilization-diffusion-conversion behavior of polar polysulfides.It is experimentally and theoretically demonstrated that the heterointerface between Fe_(3)C and FeN exhibits high sulfiphilicity and high electronic/ionic conductivity,thus effectively capturing polysulfides and accelerating the bidirectional conversion of sulfur species.Meanwhile,the holey carbon framework functions as the scaffold to highly disperse binary nanoparticles,ensuring the sufficient exposure of active sites and the easy accessibility for lithium ions and electrons.By virtue of these synergistic merits,the Li-S batteries based on Fe_(3)CFeN@NCF-modified separators afford excellent electrochemical performances including a high rate capacity of 858 mA h g^(-1)at 2 C and a low capacity decay rate of 0.07% per cycle after 800 cycles at 1C This work provides inspiration for the design of heterostructured compounds and sheds light on the potential of heterostructure in high-efficiency Li-S batteries. | Mengdi Zhang Jiawei Mu Yanan Li Yuanyuan Pan Zhiliang Dong Bei Chen Shiwei Guo Wenhan Yuan Haiqiu Fang Han Hu Mingbo Wu | 2023 | Journal of Energy Chemistry2023，，3： | 1 |
| 18 | FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe显示文摘A ratiometric fluorescent hybrid nanoprobe CDs-1 for arginine(Arg),exhibiting high sensitivity(the limit of detection,LOD,being 6.5×10^-8 mol/L) and excellent selectivity and anti-interference ability,was fabricated through fluorescence resonance energy transfer(FRET) and the electrostatic attraction between positively-charged hemicyanine molecules and negatively-charged carbon dots(CDs).Arg can be quantitatively detected in the concentration range from 6.0×10^-5 mol/L to 2.7×10^-4 mol/L.Further,due to its ability to target mitochondrion and low cytotoxicity,intracellular Arg was succes s fully tracked through ratiometric fluorescence imaging. | Yueyue Li Yanan Ban Ruihui Wang Zheng Wang Zhanxian Li Chenjie Fang Mingming Yu | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
| 19 | On Consistency in AHP and Fuzzy AHP显示文摘The analytic hierarchy process(AHP) is used widely for analyzing decisions made in various real-world applications. Its basic idea is to construct a hierarchy of concepts encountered in a given decision problem and to choose the best alternative according to pairwise comparison matrices given by the decision maker. Under the assumption of fully rational economics, a reasonable decision should be consistent. It becomes an important issue on how to analyze and ensure the consistency of comparison matrices together with the judgments of the decision maker. The main objectives of the present paper are threefold. First, we review the basic idea and methods used to define the consistency and the transitivity of multiplicative reciprocal matrices, additive reciprocal matrices and comparison matrices with fuzzy interval and triangular fuzzy numbers. The existing controversy behind the applications of fuzzy set theory to the AHP in the literature is presented. Second, the consistency of the collective comparison matrices in group decision making based on AHP and fuzzy AHP is further analyzed. We point out that the weak consistency of preference relations with fuzzy numbers in fuzzy AHP and group decision making should be investigated comprehensively. Third, under the consideration of the vagueness in the process of evaluating the judgements, a new concept of fuzzy consistency of comparison matrices in the AHP is given. | Fang LIU Yanan PENG Weiguo ZHANG Witold PEDRYCZ | 2017 | Journal of Systems Science and Information2017，8，2： | 1 |
| 20 | Analysis and control for a bioinspired multi-legged soft robot显示文摘Untethered soft miniature robots are considered to have a wide range of applications in biomedical field.However,researchers today still have not reached a consensus on its configuration design and actuation method.Here,inspired by the tentacles of a certain kind of echinodermata,we propose a soft multi-legged robot with a total weight of 0.26 g capable of multiple locomotion modes.Based on the magnetic field distribution of a square permanent magnet,we qualitatively analyze the motion mechanism of the robot.Finally,we carried out relevant experimental research.The research shows that the robot can move forward,backward,steering and cross obstacles under the control of the magnetic field,and can combine these abilities to navigate the maze. | Danying Sun Jingyu Zhang Qin Fang Pingyu Xiang Yanan Xue Yue Wang Rong Xiong Haojian Lu | 2022 | Biomimetic Intelligence & Robotics2022，2，1： | 1 |
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