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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | lonization and dissociation of acetonitrile by intense femtosecond laser pulse显示文摘Photoionization and photodissociation of CH3CN were studied by a linear time of flight mass spectrometer coupled with 800 nm, 50 fs laser pulses at intensities of 6.3×1013-1.2×1014 W/cm2. The laser power dependences for principal ions CH3CN+, CH2CN+, CHCN+ and CCN+ were measured, which are consistent with the numbers of photons required to produce the ions via multiphoton ionization and dissociation. The results show that eight-photon non-resonant multiphoton ionization is the main photoionization mechanism of the parent ion CH3CN+, while the fragment ions were produced through the dissociation of the molecules in the super-excited states. | WU Chengyin, XIONG Yijia, GAO Zhen, KONG Fan’ao, LU Haihe, YANG Xiaodong & XU ZhizhanInstitute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China Correspondence should be addressed to Kong Fan’ao | 2000 | Chinese Science Bulletin2000，45，21： | 3 |
| 3 | A new approach to dissecting complex traits by combining quantitative trait transcript (QTT) mapping and diallel cross analysis显示文摘A promising way to uncover the genetic architectures underlying complex traits may lie in the ability to recognize the genetic variants and expression transcripts that are responsible for the traits' inheritance.However,statistical methods capable of investigating the association between the inheritance of a quantitative trait and expression transcripts are still limited.In this study,we described a two-step approach that we developed to evaluate the contribution of expression transcripts to the inheritance of a complex trait.First,a mixed linear model approach was applied to detect significant trait-associated differentially expressed transcripts.Then,conditional analysis were used to predict the contribution of the differentially expressed genes to a target trait.Diallel cross data of cotton was used to test the application of the approach.We proposed that the detected differentially expressed transcripts with a strong impact on the target trait could be used as intermediates for screening lines to improve the traits in plant and animal breeding programs.It can benefit the discovery of the genetic mechanisms underlying complex traits. | YANG DaiGang YE ChengYin MA XiongFeng ZHU ZhiHong ZHOU XiaoJian WANG HaiFeng MENG QingQin PEI XiaoYu YU ShuXun ZHU Jun | 2012 | Chinese Science Bulletin2012，57，21： | 3 |
| 4 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 5 | Insight into the formation of hollow silver nanoparticles using a facile hydrothermal strategy显示文摘 | Chengyin Li Hui Liu Penglei Cui Feng Ye Jun Yang | 2016 | Particuology2016，14，1： | 1 |
| 6 | 显示文摘 | QU Qishu ZHANG Xinxin SHEN Ming LIU Yin HU Xiaoya YANG Gongjun WANG Chengyin ZHANG Yukui YAN Chao | 2008 | Electrophoresis2008，29，4： | 1 |
| 7 | Flexible sodium-ion capacitors boosted by high electrochemicallyreactive and structurally-stable Sb_(2)S_(3)nanowire/Ti_(3)C_(2)Tx MXene film anodes显示文摘The rapid development of portable,foldable,and wearable electronic devices requires flexible energy storage systems.Sodiumion capacitors(SICs)combining the high energy of batteries and the high power of supercapacitors are promising solutions.However,the lack of flexible and durable electrode materials that allow fast and reversible Na+storage hinders the development of flexible SICs.Herein,we report a high-capacity,free-standing and flexible Sb2S3/Ti_(3)C_(2)Tx composite film for fast and stable sodium storage.In this hybrid nano-architecture,the Sb_(2)S_(3)nanowires uniformly anchored between Ti_(3)C_(2)Tx nanosheets not only act as sodium storage reservoirs but also pillar the two-dimensional(2D)Ti_(3)C_(2)Tx to form three-dimensional(3D)channels benefiting for electrolyte penetration.Meanwhile,the highly conductive Ti_(3)C_(2)Tx nanosheets provide rapid electron transport pathways,confine the volume expansion of Sb_(2)S_(3)during sodiation,and restrain the dissolution of discharged sodium polysulfides through physical constraint and chemical absorption.Owing to the synergistic effects of the one-dimensional(1D)Sb_(2)S_(3)nanowires and 2D MXenes,the resultant composite anodes exhibit outstanding rate performance(553 mAh·g−1 at 2 A·g−1)and cycle stability in sodium-ion batteries.Moreover,the flexible SICs using Sb2S3/Ti_(3)C_(2)Tx anodes and active carbon/reduced graphene oxide(AC/rGO)paper cathodes deliver a superior energy and power density in comparison with previously reported devices,as well as an excellent cycling performance with a high capacity retention of 82.78%after 5,000 cycles.This work sheds light on the design of next-generation low-cost,flexible and fast-charging energy storage devices. | Jian Yang Tianyi Wang Xin Guo Xiaoxue Sheng Jiabao Li Chengyin Wang Guoxiu Wang | 2023 | Nano Research2023，16，4： | 0 |
| 8 | Interface Engineering of Fe_(7)S_(8)/FeS_(2) Heterostructure in situ Encapsulated into Nitrogen‑Doped Carbon Nanotubes for High Power Sodium‑Ion Batteries显示文摘Heterostructure engineering combined with carbonaceous materials shows great promise toward promoting sluggish kinetics,improving electronic conductivity,and mitigating the huge expansion of transition metal sulfide electrodes for high-performance sodium storage.Herein,the iron sulfide-based heterostructures in situ hybridized with nitrogen-doped carbon nanotubes(Fe_(7)S_(8)/FeS_(2)/NCNT)have been prepared through a successive pyrolysis and sulfidation approach.The Fe_(7)S_(8)/FeS_(2)/NCNT heterostructure delivered a high reversible capacity of 403.2 mAh g^(−1) up to 100 cycles at 1.0 A g^(−1) and superior rate capability(273.4 mAh g^(−1) at 20.0 A g^(−1))in ester-based electrolyte.Meanwhile,the electrodes also demonstrated long-term cycling stability(466.7 mAh g^(−1) after 1,000 cycles at 5.0 A g^(−1))and outstanding rate capability(536.5 mAh g^(−1) at 20.0 A g^(−1))in ether-based electrolyte.This outstanding performance could be mainly attributed to the fast sodium-ion diffusion kinetics,high capacitive contribution,and convenient interfacial dynamics in ether-based electrolyte. | Penghao Song Jian Yang Chengyin Wang Tianyi Wang Hong Gao Guoxiu Wang Jiabao Li | 2023 | Nano-Micro Letters2023，15，8： | 0 |
| 9 | Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)C_(2)T_(x) heterojunction with robust sodium storage at low temperature显示文摘Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also challenging.Besides,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold climates.Herein,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical activity.Particularly,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous interface.Besides,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure coupling.Consequently,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained. | Jiabao Li Shaocong Tang Jingjing Hao Quan Yuan Tianyi Wang Likun Pan Jinliang Li Shenbo Yang Chengyin Wang | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 10 | In the Teaching-Learning-Assessment of Effective Classroom From the Perspective of Alignment A Case Study of the Review Course of Organic Chemistry Reaction显示文摘 | Yang Chengyin Li Yalin Yang Fan | 2017 | US-China Education Review(A)2017，7，11： | 0 |
| 11 | Construction and investigation of photo-switch property of azobenzene-bridged pillar[5]arene-based[3]rotaxanes显示文摘Series of azobenzene-bridged pillar[5]arene-based [3]rotaxanes with different alkyl chain length of guest molecules were constructed by threading-endcapping method with alkylenetriazole as axile and tetrahydrochromene as endcapping group.The encapsulation of pillar[5]arenes were proved by highresolution mass,^(1) H NMR and NOESY spectra.The photo-responsive property were examined by irradiation of the synthesized [3]rotaxanes with 365 nm and blue light LED,which caused trans to cis and cis to trans isomerization,respectively.Irradiation of corresponding model guest compounds without pillar[5]arene encapsulation resulted in near completely trans to cis and cis to trans isomerization,indicating the existence of pillar[5]arenes is the determining factor for the comprised photo isomerization efficiency. | Hui Chong Cuiyun Nie Lihong Wang Sicong Wang Ying Han Yang Wang Chengyin Wang Chaoguo Yan | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 12 | MXene:An efficient hemoperfusion sorbent for the removal of uremic toxins显示文摘MXene,a family of two-dimensional(2D)transition metal carbides and nitrides have attracted extensive interests for many biochemical applications,including tumour elimination,biosensors,and magnetic resonance imaging(MRI).In this article,we firstly discovered that Ti3C2Tx MXene exhibited a highly efficient adsorption capability as hemoperfusion absorbent towards middle-molecular mass and protein bound uremic toxins in the end stage of renal disease(ESRD)treatment.Molecular scale investigations reveal that the high efficiency of MXene for the removal of uremic toxins could be attributed to synergistic effects of physical/chemical adsorption,electrostatic interaction surface of 2D MXene,and transformation of protein secondary structure.2D MXene materials could be used as a new hemoperfusion sorbent with ultrahigh efficiency for removing uremic toxins during the treatment of kidney disease. | Tianyi Wang Wei Gu Lu Yu Xin Guo Jian Yang Xiaoyu Sun Jun Guan Lin Zhou Chengyin Wang Hang Yao Xiuyun Zhang Guoxiu Wang | 2023 | Journal of Materiomics2023，9，6： | 0 |
| 13 | Three-dimensional crosslinked nanoarchitectonics of CoP@NC anchored on Ti_(3)C_(2)Tx with high ionic diffusion and enhanced sodium storage performance显示文摘Transition metal phosphides(CoP,etc.),featuring rich natural abundance and remarkable theoretical capacity,suffer from extremely poor rate capability and severe energy decay for sodium storage due to their huge volume change and low electronic conductivity.Herein,an elaborate hierarchical superstructure,nitrogen-doped carbon wrapped CoP in-situ anchored on Ti_(3)C_(2)Tx MXene(CoP@NC/Ti_(3)C_(2)Tx),was fabricated by crosslinking ZIF-67 on Ti_(3)C_(2)Tx flakes followed by successive carbonization and phosphorization.In principle,the dual modification for CoP nanoparticles through NC coating and Ti_(3)C_(2)Tx support can dramatically accelerate the ionic/electronic transportation and alleviate the structure change upon repeated sodiation/desodiation,thus leading to superior electrode integrity,modified ohmic polarization,and excellent electrochemical reversibility.Consequently,the elaborated hierarchical superstructure delivers impressive sodium storage performances with large capacity(396.06 mA$h/g at 0.1 A/g up to 100 cycles),robust rate performance(237.8 mA$h/g at 2.0 A/g),and satisfied cyclability(capacity retention of 81.3%at 1.0 A/g after 1,200 cycles).In principle,systematic electrochemical and characterizations measurements manifest that the high pseudocapacitive effect to charge storage,enhanced ionic diffusion kinetics,and remarkable electrochemical reversibility contribute to the impressive sodium storage performance of target CoP@NC/Ti_(3)C_(2)Tx.Importantly,the unique modification strategy reported in this study paves a way to fabricate high-performance electrode for SIBs. | Zhihao Gu Jiabao Li Penghao Song Yu Wang Jian Yang Tianyi Wang Chengyin Wang | 2023 | Journal of Materiomics2023，9，6： | 0 |
| 14 | Detection of avian influenza virus H9N_(2) based on self-driving and self-sensing microcantilever piezoelectric sensor显示文摘In this article, we used the self-excitation and self-inductance characteristics of polyvinylidene fluoride(PVDF) piezoelectric materials, combined with the powerful signal processing and calculation analysis capabilities of integrated circuits, for the first time to explore a set of microcantilever sensor 'readout system' without additional driver(self-driving) and can realize self-sensing external signal(self-sensing).It was successfully applied to the unlabeled detection of avian influenza virus(AIV) H9N_(2). The specific force of the antigen-antibody complexes on the surface of the microcantilever leads to the change of the stress of the cantilever, which drives the constructed detection device, and does not require an additional excitation source to drive it, that is, the self-driving part. At the same time, due to the movement of piezoelectric charges in the film caused by the positive piezoelectric effect of the PVDF film, self-inductive charges are generated on the surface of the sensor dielectric. The charge signal is converted into a voltage signal, and the sensing part is completed, that is, self-sensing. The immunosensor has a linear range of100-1000 ng/m L with a detection limit of 2.9 ng/m L. The method will also open up a new avenue for the detection of other analytes based on antigen-antibody responses. | Yawen Zhang Feng Shi Chenguang Zhang Xin Sheng Yunhao Zhong Hui Chong Zhanjun Yang Chengyin Wang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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