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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Controllable chrominance and highly improvedluminescent quantum yield of YV1-xPxO4:Tm,Dy,Eu inverse opal white light phosphors显示文摘 | ZHOU Pingwei ZHU Yongsheng XU Wen | 2013 | Optics Express2013，21，25： | 1 |
| 3 | 320-fold luminescence enhancement of [Ru(dpp)3]Cl2 dispersed on PMMA opal photonic crystals and highly improved oxygen sensing performance显示文摘Ru complexes([Ru(dpp)3]Cl2)were spin coated on poly(methyl methacrylate)(PMMA)opal photonic crystals(PhCs),and a,320-fold luminescence enhancement was observed compared to that on glass,which is the largest luminescence enhancement of dye molecules by the modulation of three-dimensional(3D)PhCs reported until now.The enhancement mechanism was carefully examined and it was shown that the luminescence of[Ru(dpp)3]Cl2 depended on the molecule concentration and temperature.It can be concluded that the suppressed non-radiative relaxation among the molecules and the field enhancement both contribute significantly to the luminescence enhancement.The PMMA PhC/Ru complex composites were then tested for their intracellular oxygen sensing and cell imaging properties;these composites effectively improved the limit of detection(LOD)and the brightness of the cell images. | Pingwei Zhou Donglei Zhou Li Tao Yongsheng Zhu Wen Xu Sai Xu Shaobo Cui Lin Xu Hongwei Song | 2014 | Light(Science & Applications)2014，3，1： | 1 |
| 4 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 5 | Synthesis and characterization of hollow glass–ceramics microspheres显示文摘 | Nan Xu Jinhui Dai Zhibin Zhu Xiang Huang Pingwei Wu | 2012 | Composites Science and Technology2012，，4： | 1 |
| 6 | Microparticles released by Listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity显示文摘在在为 T 房间有免疫力的回答处理和细菌的抗原的表示的巨噬细胞和树枝状的房间之间的相互影响仍然保持糟糕理解。用 Listeria monocytogenes (Lm ) 感染模型,我们证明树枝状的房间(DC ) 要求巨噬细胞的支持对 Lm 感染得到保护的免疫。DC 自己在收起 Lm 是低效的但是能够收起感染 Lm 的巨噬细胞释放的 microparticles (MP ) 。这些 MP 把 Lm 抗原转移了到 DC,允许 DC 介绍 Lm 抗原给受动器 T 房间。调停 MP 的 Lm 抗原转移要求了 MHC 一级参予,自从在巨噬细胞的 MHC 一级缺乏导致了 T 房间激活的重要减小。而且,有从感染 Lm 的巨噬细胞的 MP 的老鼠的种痘对 Lm 感染生产了强壮的保护的免疫。我们这里在 Lm 感染期间识别在巨噬细胞和 DC 之间的一个内在的抗原转移节目,并且强调巨噬细胞也在得到 DC 的 Lm 特定的 T 房间回答起一个必要作用。 | Yi Zhang Ruihua Zhang Huafeng Zhang Jing Liu Zhuoshun Yang Pingwei Xu Wenqian Cai Geming Lu Miao Cui Reto A Schwendener Huang-Zhong Shi Huabao Xiong Bo Huang | 2012 | Cellular & Molecular Immunology2012，9，6： | 1 |
| 7 | Synthesis and characterization of hollow glass–ceramics microspheres显示文摘 | Nan Xu Jinhui Dai Zhibin Zhu Xiang Huang Pingwei Wu | 2011 | Ceramics International2011，，7： | 1 |
| 8 | Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1显示文摘Macrophages in tumors(tumor-associated macrophages,TAMs),a major population within most tumors,play key homeostatic functions by stimulating angiogenesis,enhancing tumor cell growth,and suppressing antitumor immunity.Resetting TAMs by simple,efficacious and safe approach(s)is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy.Previously,we used tumor cell-derived microparticles to package chemotherapeutic drugs(drug-MPs),which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments,implicating that drug-MPs might reset TAMs,considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation.Here,we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-βrelease.Mechanistically,drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases,resulting in superoxide anion formation,which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2.Consequently,lysosomal Ca^(2+)signaling is activated,thus polarizing macrophages towards M1.Meanwhile,the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-βproduction.This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity.These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages.This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade. | Keke Wei Huafeng Zhang Shuaishuai Yang Yuxiao Cui Bingxia Zhang Jincheng Liu Liang Tang Yaoyao Tan Simin Liu Shiqi Chen Wu Yuan Xiao Luo Chen Chen Fei Li Junwei Liu Jie Chen Pingwei Xu Jiadi Lv Ke Tang Yi Zhang Jingwei Ma Bo Huang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 9 | Supramolecular G-quadruplex hydrogels:Bridging fabrication to biomedical application显示文摘G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine derivatives.As a biomimetic hydrogel,G-quadruplex hydrogels demonstrate wide biomedical applications,such as drug delivery,tissue engineering,and biosensing.The advantages of using G-quadruplex hydrogels include adequate biocompatibility and biodegradability,tunable multifunctionality,and cost-effective and large-scalable fabrication process.In this review,we focus on recent progress in the fabrication and characterization of G-quadruplex hydrogels to help readers understand the principles of G-quadruplex hydrogel formation.Meanwhile,the applications of G-quadruplex hydrogels in the biomedical area are discussed,aiming to pave the way for downward clinical or industry translation.The development of G-quadruplex hydrogel is still in its infancy.We hope this review will boost the development of this area and that more applications of G-quadruplex hydrogel will be developed. | Yuanfeng Li Junjie Chi Pingwei Xu Xing Dong Anh-Tuan Le Keqing Shi Yong Liu Jian Xiao | 2023 | Journal of Materials Science & Technology2023，，24： | 0 |
| 10 | Mechanical Test and Meso-Model Numerical Study of Composite Rubber Concrete under Salt-Freezing Cycle显示文摘A composite rubber concrete(CRC)was designed by combining waste tire rubber particles with particle sizes of 3~5 mm,1~3 mm and 20 mesh.Taking the rubber content of different particle sizes as the influencing factors,the range and variance analysis of the mechanical and impermeability properties of CRC was carried out by orthogonal test.Through analysis,it is concluded that the optimal proportion of 3~5 mm,1~3 mm,and 20 mesh particle size composite rubber is 1:2.5:5.5 kinds of CRC and 3 kinds of ordinary single-mixed rubber concrete(RC)with a total content of 10%~20%were designed under this ratio,and the salt-freezing cycle test was carried out with a concentration of 5%Na 2 SO4 solution.The physical and mechanical damage laws during 120 salt-freezing cycles are obtained,and the corresponding damage prediction model is established according to the experimental data.The results show that:on the one hand,the composite rubber in CRC produces a more uniform“graded”structure,forms a retractable particle group,and reduces the loss of mechanical properties of CRC.On the other hand,colloidal particles with different particle sizes are used as air entraining agent to improve the pore structure of concrete and introduce evenly dispersed bubbles,which fundamentally improves the durability of concrete.Under the experimental conditions,the CRC performance is the best when the overall content of composite rubber is 15%. | Mingkai Sun Yanan Wang Pingwei Jiang Zerong Song Zhan Gao Jiaming Xu | 2023 | Journal of Renewable Materials2023，11，2： | 0 |
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