5篇
您的检索式：作者名="Zhixiong Long"
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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Mode and modulation characteristics for microsquare lasers with a vertex output waveguide显示文摘The mode and high-speed modulation characteristics are investigated for a microsquare laser with a side length of 16 ?m and a 2-?m-wide output waveguide connected to one vertex. The longitudinal and transverse mode characteristics are analyzed by numerical simulation and light ray model, and compared with the lasing spectra for the microsquare laser. Up to the fifth transverse mode is observed clearly from the lasing spectra. Single mode operation with the side mode suppression ratio of 41 d B is realized at the injection current of 24 m A, and the maximum output power of 0.53(0.18) m W coupled into the multiple(single) mode fiber is obtained at the current of 35 m A, for the microsquare laser at the temperature of 288 K. Furthermore, a flat small-signal modulation response is reached with the 3-d B bandwidth of 16.2 GHz and the resonant peak of 3.6 d B at the bias current of 34 m A. The K-factor of 0.22 ns is obtained by fitting the damping factor versus the resonant frequency, which implies a maximum intrinsic 3-d B bandwidth of 40 GHz. | LONG Heng HUANG YongZhen YANG YueDe ZOU LingXiu XIAO JinLong XIAO ZhiXiong | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 4 |
| 3 | Facile Synthesis and Charaterization of Silica Nanoscale Ionic Materials显示文摘A series of silica nanoscale materials(NIMs) were prepared through a facile acid-base neutralization. These silica derivatives consist of a nanosilica core, a charged corana(sulfonic acid SIT) attatched to the core, and an oppositely charged canopy (PEG-substituted tertiary amines) to balance the corona. By selecting proper canopy such as surface-functionalized, silica can behave viscous liquid in the absence of any solvent at room temperature. DSC results indicated the melting temperature and glass transition of the derivatives were slightly lower than those of the neat polymer canopy, indicating strong interaction between the core and PEG-substituted tertiary amine. | 王雁冰 LI Wenjing LONG Juan HUANG Zhixiong | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，4： | 0 |
| 4 | Simulation of ECCD and ECRH for SUNIST显示文摘 | WANG Zhongtian LONG Yongxing DONG Jiaqi HE Zhixiong Zonca F. Fu G. Y. | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 5 | Pomalidomide improves the function of CD133-or HER2-specific CAR T cells显示文摘Chimeric antigen receptor(CAR)T-cell therapy is mostly limited to hematological malignancies and has a poor effect on solid tumors.CAR T cells as a kind of immune cell may be affected by some immunomodulatory drugs such as pomalidomide,so the use of pomalidomide may improve the effect of CAR T cells on solid tumors.In this study,CD133-or HER2-specific CAR T cells were chosen to investigate whether pomalidomide can regulate the function of CAR T cells in vitro.We found that pomalidomide can significantly enhance the ability of CD133-CAR T cells and HER2-CAR T cells to kill tumor cells and increase the cytokine secretion of CD133-CAR T cells and HER2-CAR T cells.Also,pomalidomide was shown to induce down-regulation of protein levels of IL-2 transcriptional repressors Aiolos and Ikaros in CAR T cells.This study suggests that the combination of pomalidomide and CAR T cells may be a new strategy for the treatment of solid tumors. | ZHIXIONG WANG NA RISU JIAYU FU HUI LIU GUOMIN ZHOU QIAN LIU YAN ZOU JIAXING TANG LONG LI XUEKAI ZHU | 2021 | BIOCELL2021，45，1： | 0 |
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