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| 1 | Essential oils as alternatives to antibiotics in swine production显示文摘This review article summarizes the efficacy, feasibility and potential mechanisms of the application of essential oils as antibiotic alternatives in swine production.Although there are numerous studies demonstrating that essential oils have several properties, such as antimicrobial, antioxidative and antiinflammatory effects, feed palatability enhancement and improvement in gut growth and health, there is still a need of further investigations to elucidate the mechanisms underlying their functions.In the past,the results has been inconsistent in both laboratory and field studies because of the varied product compositions, dosages, purities and growing stages and conditions of animals.The minimal inhibitory concentration(MIC) of essential oils needed for killing enteric pathogens may not ensure the optimal feed intake and the essential oils inclusion cost may be too high in swine production.With the lipophilic and volatile nature of essential oils, there is a challenge in effective delivery of essential oils within pig gut and this challenge can partially be resolved by microencapsulation and nanotechnology.The effects of essential oils on inflammation, oxidative stress, microbiome, gut chemosensing and bacterial quorum sensing(QS) have led to better production performance of animals fed essential oils in a number of studies.It has been demonstrated that essential oils have good potential as antibiotic alternatives in feeds for swine production.The combination of different essential oils and other compounds(synergistic effect) such as organic acids seems to be a promising approach to improve the efficacy and safety of essential oils in applications.High-throughput systems technologies have been developed recently,which will allow us to dissect the mechanisms underlying the functions of essential oils and facilitate the use of essential oils in swine production. | Faith A.Omonijo Liju Ni Joshua Gong Qi Wang Ludovic Lahaye Chengbo Yang | 2018 | Animal Nutrition2018，，2： | 24 |
| 2 | NUMERICAL SIMULATIONS OF HIGHLY NONLINEAR STEADY AND UNSTEADY FREE SURFACE FLOWS显示文摘A numerical simulation model based on an open source Computational Fluid Dynamics (CFD) package-Open Field Operation and Manipulation (OpenFOAM) has been developed to study highly nonlinear steady and unsteady free surface flows. A two-fluid formulation is used in this model and the free surface is captured using the classical Volume Of Fluid (VOF) method. The incompressible Euler/Navier-Stokes equations are solved using a finite volume method on unstructured polyhedral cells. Both steady and unsteady free surface flows are simulated, which include: (1) a submerged NACA0012 2-D hydrofoil moving at a constant speed, (2) the Wigley hull moving at a constant speed, (3) numerical wave tank, (4) green water overtopping a fixed 2-D deck, (5) green water impact on a fixed 3-D body without or with a vertical wall on the deck. The numerical results obtained have been compared with the experimental measurements and other CFD results, and the agreements are satisfactory. The present numerical model can thus be used to simulate highly nonlinear steady and unsteady free surface flows. | YANG Chi HUANG Fuxin WANG Lijue WAN De-cheng | 2011 | Journal of Hydrodynamics2011，23，6： | 5 |
| 3 | Inhibitory effects of nisin-coated multi-walled carbon nanotube sheet on biofilm formation from Bacillus anthracis spores显示文摘Multi-walled carbon nanotube(MWCNT)sheet was fabricated from a drawable MWCNT forest and then deposited on poly(methyl methacrylate)film.The film was further coated with a natural antimicrobial peptide nisin.We studied the effects of nisin coating on the attachment of Bacillus anthracis spores,the germination of attached spores,and the subsequent biofilm formation from attached spores.It was found that the strong adsorptivity and the super hydrophobicity of MWCNTs provided an ideal platform for nisin coating.Nisin coating on MWCNT sheets decreased surface hydrophobicity,reduced spore attachment,and reduced the germination of attached spores by 3.5 fold,and further inhibited the subsequent biofilm formation by 94.6%compared to that on uncoated MWCNT sheet.Nisin also changed the morphology of vegetative cells in the formed biofilm.The results of this study demonstrated that the anti-adhesion and antimicrobial effect of nisin in combination with the physical properties of carbon nanotubes had the potential in producing effective anti-biofilm formation surfaces. | Xiuli Dong Eric McCoy Mei Zhang Liju Yang | 2014 | Journal of Environmental Sciences2014，26，12： | 4 |
| 4 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 5 | Electrical/electrochemical impedance for rapid detection of foodborne pathogenic bacteria显示文摘 | Liju Yang Rashid Bashir | 2007 | Biotechnology Advances2007，，2： | 2 |
| 6 | Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation显示文摘The COVID-19 pandemic poses a global threat to public health and economy.The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines.In this study,we identified that EK1 and cholesterol-coupled derivative of EK1,EK1C4,as pan-CoV fusion inhibitors,exhibit potent antiviral activity against SARS-CoV-2 infection in both lung-and intestine-derived cell lines(Calu-3 and Caco2,respectively).They are also effective against infection of pseudotyped SARS-CoV-2 variants B.1.1.7(Alpha)and B.l.1.248(Gamma)as well as those with mutations in S protein,including N417T,E484K,N501Y,and D614G,which are common in South African and Brazilian variants.Crystal structure revealed that EK1 targets the HR1 domain in the SARS-CoV-2 S protein to block virus-cell fusion and provide mechanistic insights into its broad and effective antiviral activity.Nasal administration of EK1 peptides to hACE2 transgenic mice significantly reduced viral titers in lung and intestinal tissues.EK1 showed good safety profiles in various animal models,supporting further clinical development of EK1-based pan-CoV fusion inhibitors against SARS-CoV-2 and its variants. | Shuai Xia Qiaoshuai Lan Yun Zhu Chao Wang Wei Xu Yutang Li Lijue Wang Fanke Jiao Jie Zhou Chen Hua Qian Wang Xia Cai Yang Wu Jie Gao Huan Liu Ge Sun Jan Munch Frank Kirchhoff Zhenghong Yuan Youhua Xie Fei Sun Shibo Jiang Lu Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 2 |
| 7 | Simultaneous detection of Escherichia coli O157:H7 and Salmonella typhimurium using quantum dots asfluorescence labels显示文摘 | YANG Liju LI Yanbin | 2006 | Analyst2006，131，3： | 1 |
| 8 | Inactivation of bacterial pathogens by carbon nanotubes in suspensions显示文摘 | ARIAS L R YANG Liju | 2009 | Langmuir2009，25，5： | 1 |
| 9 | AFM and impedance spectroscopy characterization of the immobilization of Ab on indium-tin oxide electrode through self-assembled monolayer of epoxysilane and their capture of Escherichia coli O157:H7显示文摘 | YANG Liju LI Yanbin | | 0，，07： | 1 |
| 10 | Magnetic nanoparticle-antibody conjugates for the separation of Escherichia coli O157:H7 in ground beef显示文摘 | Madhukar Varshney Liju Yang Li Suxiao | | 0，，9： | 1 |
| 11 | Diagnostic value of anti-cyclic citrullinated peptide antibodies in northern Chinese Han patients with rheumatoid arthritis and its correlation with disease activity显示文摘 | Li Hui Song Wuqi Li Yang Liu Yanhong Bai Jing Li Xiu Mu Fengyun Wang Yao Zhang Fengshan Su Liju Zhang Fengmin | 2010 | Clinical Rheumatology2010，，4： | 1 |
| 12 | A nanoparticle ampli?cation based quartz crystal microbalance DNA sensor for detectionof Escherichiacoli 0157:H7显示文摘 | Mao Xiaole Yang Liju Su Xiaoli | 2006 | Biosens Bioelectron2006，21，： | 1 |
| 13 | Electrical / electrochemical impedance for rapid detection of foodbome pathogenic bacteria 显示文摘 | Liju Yang Rashid Bashir | 2008 | Biotechnology Advances2008，26，： | 1 |
| 14 | Electrical/electrochemical impedance for rapid detection of foodborne pathogenic bacteria显示文摘 | Liju Yang Rashid Bashir | 2007 | Biotechnology Advances2007，，2： | 1 |
| 15 | Detection of viable Salmonella typhimurium by impedance measurement of electrode capacitance and medium resistance显示文摘 | Yang Liju Ruan Chuanmin Li Yanbin | 2003 | Biosens Bioelectron2003，19，5： | 1 |
| 16 | A Review of Multifunctions of Dielectrophoresis in Biosensors and Biochips for Bacteria Detection显示文摘 | Liju Yang | 2012 | 2012 (2-3)2012，，2： | 1 |
| 17 | Immunobiosensor chips for detection of Escherichia coli O157:H7 using electrochemical impedance spectroscopy显示文摘 | RUAN Chuanmin YANG Liju LI Yanbin | 2002 | Anal Chem2002，74，18： | 1 |
| 18 | Interdigitated microelectrode (IME) impedance sensor for the detection of viable Salmonella typhimurium显示文摘 | Liju Yang Yanbin Li Carl L Griffis Michael G Johnson | 2003 | Biosensors and Bioelectronics2003，，10： | 1 |
| 19 | Rapid detection of viable Salmonella typhimurium in a selective medium by monitoring oxygen consumption with electrochemical cyclic voltammetry显示文摘 | RUAN Chuanmin YANG Liju LI Yanbin | 2002 | Journal of Electroanalytical Chemistry2002，519，12： | 1 |
| 20 | A nanoparticleamplification based quartz crystal microbalance DNA sen-sor for detection of Escherichia coli O157∶H7显示文摘 | Mao Xiaole Yang Liju Su Xiaoli | 2006 | Bio-sens Bioelectron2006，21，： | 1 |
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