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| 1 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 2 | Phase Ⅱ open-label study of recombinant circularly permuted TRAIL as a single-agent treatment for relapsed or refractory multiple myeloma显示文摘Background: Despite the recent development of new therapies, multiple myeloma(MM) remains an incurable disease. Thus, new, efective treatments are urgently needed, particularly for relapsed or refractory MM(RRMM). In an earlier phase I study, a novel form of recombinant human Apo2L/tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) that is currently in clinical development for the treatment of hematologic malignancies, i.e., circularly permuted TRAIL(CPT), was well tolerated at a dose of 2.5 mg/kg per day and showed promising preliminary activity in patients with RRMM. This phase II, open-label, multicenter study further investigated the eicacy and safety of 2.5-mg/kg per day CPT as single-agent therapy for patients with RRMM.Methods: Patients with RRMM were treated once daily with CPT(2.5 mg/kg, intravenously) for 14 consecutive days for each 21-day cycle. Clinical response and toxicity were assessed after each treatment cycle.Results: Twenty-seven patients received CPT. Using the European Group for Blood and Marrow Transplantation criteria, we calculated the overall response rate of 33.3% with 1 near-complete response(n CR) and 8 partial responses(PRs). The clinical beneit rate(48.1%) included 1 nCR, 8 PRs, and 4 minimal responses. The most common treatmentrelated adverse events(TRAEs) were fever, aspartate aminotransferase elevation, alanine aminotransferase elevation, leucopenia, rash, neutropenia, and thrombocytopenia. We graded toxicity using the Common Toxicity Criteria for Adverse Events, version 3.0, and determined that 37.0% of patients had at least 1 grade 3–4 TRAE.Conclusions: CPT as a single agent can elicit a response in patients with RRMM and is well tolerated. Further clinical investigation is warranted. | Yun Leng Lugui Qiu Jian Hou Yaozhong Zhao Xuejun Zhang Shifang Yang Hao Xi Zhongxia Huang Ling Pan Wenming Chen | 2016 | Chinese Journal of Cancer2016，35，12： | 4 |
| 3 | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair显示文摘Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people.However,both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably,and new strategies for integrative cartilage repair are needed.Gene therapy provides local production of therapeutic factors,especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes,achieve accurate spatiotemporally release of gene products,thus provideing long-term treatment for cartilage repair.The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices.Among them,polymeric biomaterials are particularly attractive due to their tunable physiochemical properties,as well as excellent adaptive performance.This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair,with an emphasis on the important role of polymeric biomaterials in delivery systems. | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan | 2020 | Bioactive Materials2020，5，4： | 3 |
| 4 | Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a late onset neurodegenerative disease with fast progression.ALS has heavy genetic components in which a series of genetic mutations have been identified.In 2013,Mutations of the CREST gene(also known as SS18L1),which functions as a calcium-regulated transcriptional activator,were found in sporadic ALS patients.However,the pathogenic causality and mechanisms of ALS-associated mutations of CREST remain to be determined.Methods:In this study,we constructed CREST knockout and Q394X knock-in mice with CRISPR/Cas9 system.Using biochemical and imaging tools,we illustrated core pathological phenotypes in CREST mutant mice and claimed the possible pathogenic mechanisms.Furthermore,we also observed locomotion defects in CREST mutant mice with behavioural tests.Results:We demonstrate that ALS-related CREST-Q388X mutation exhibits loss-of-function effects.Importantly,the microglial activation was prevalent in CREST haploinsufficiency mice and Q394X mice mimicking the human CREST Q388X mutation.Furthermore,we showed that both CREST haploinsufficiency and Q394X mice displayed deficits in motor coordination.Finally,we identified the critical role of CREST-BRG1 complex in repressing the expression of immune-related cytokines including Ccl2 and Cxcl10 in neurons,via histone deacetylation,providing the molecular mechanisms underlying inflammatory responses within mice lack of CREST.Conclusion:Our findings indicate that elevated inflammatory responses in a subset of ALS may be caused by neuron-derived factors,suggesting potential therapeutic methods through inflammation pathways. | Cheng Cheng Kan Yang Xinwei Wu Yuefang Zhang Shifang Shan Aaron Gitler Anirvan Ghosh Zilong Qiu | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 5 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 6 | Effects of ovarian hormone loss on neuritic plaques and autophagic flux in the brains of adult female APP/PS1 double-transgenic mice显示文摘流行病的研究证明了女人们说明疾病(广告) 案例,在传播 gonadal 荷尔蒙的衰落为被认为是专业之一冒险的三分之二 Alzheimers 因素。另外,卵巢的荷尔蒙缺乏可以影响淀粉的(A) 免职,它与 autophagic 流动有一种靠近的关系。在这研究,我们在二个老鼠模型,上调查了短期或长期的卵巢的荷尔蒙剥夺的影响非转基因(野类型) 并且 APP/PS1 双 transgenic | Qiuhui Yao Min Feng Bo Yang Zhimin Long Shifang Luo Min Luo Guiqiong He Kejian Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 2 |
| 7 | Short-cut nitrification in biological aerated filters with modified zeolite and nitrifying sludge显示文摘 | Qiang Li Shifang Sun Tingfeng Guo Chao Yang Cunjiang Song Weitao Geng Wei Zhang Jun Feng Shufang Wang | 2013 | Bioresource Technology2013，，： | 1 |
| 8 | Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications显示文摘Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections. | Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan | 2020 | Journal of Materials Science & Technology2020，59，24： | 1 |
| 9 | Effects of algae contamination on the hydrophobicity of high-voltage composite insulators显示文摘Algae colonisation has been observed on silicone rubber insulators around the world especially in a subtropical climate because the moderate temperature and moisture could aggravate the growth of algae upon silicone rubber material.The surface of these insulators easily forms a water film,and the originally excellent hydrophobicity is decreased or even destroyed.This study explores the regularity of the hydrophobicity changes and the underlying mechanism.Based on the solid layer method,silicone rubber samples were found with algae and inorganics quantitatively,and their contact angles were measured after reservation under different humidity levels.The results showed that although inorganic ash could accelerate the hydrophobic recovery process,algae colonisation decisively decreased the hydrophobicity,especially in moist climates.After an extensive investigation of biological contaminants,it was found that the appearance of algae was independent of inorganics,but algae could accelerate the accumulation of inorganics through water absorptivity and the viscosity of secretions.The water absorption ability of algae was compared with that of inorganic ash and sugar,and their difference was deduced to be due to the environmental adaptability of the algae organisms,which was reflected mainly in a dry climate.The microscopy analysis of bio-contaminants was conducted through SEM. | Shifang Yang Zhidong Jia Xiaogang Ouyang | 2019 | High Voltage2019，4，3： | 1 |
| 10 | Molecular Detection of TYLCV Isolates from Xinjiang Autonomous Region of China and Analysis of Its DNA-A Genome Sequences显示文摘In 2012,the symptoms of dwarf plants,yellowed and curled leaves were observed in tomato,pepper,eggplant,datura,poinsettia,florists cyclamen and anthurium in Kashi,Tulufan and Yili regions of Xinjiang autonomous region in China.The results showed that all of the above seven species of plants could be infected by Tomato yellow leaf curl virus(TYLCV).We obtained the full-length DNA-A genome sequences of the virus isolate that KSCTo4,KSCTo16, KZPTo18 and KYCTo20 from tomato,KSCPe6 and KSCPe7 from pepper,KSCEg1from eggplant and KSCDa from datura.Each isolate had all of the characteristic features of Begomovirus genome.Virus isolate collected from different hosts had little difference in sequence,and shared the similarity of 99.0%-99.8% with each other.These isolate shared the similarity of 98.6%-99.5% with TYLCV isolate SH3,ZJ6,SD2A-7,HNSQ and HBBD reported in China. | Ding Yingna Li Shifang Zhang Sheng Cui Yuanyu Yang Hua He Wei Sun Xiaojun | 2013 | Plant Diseases and Pests2013，4，6： | 1 |
| 11 | Melting evolution and diffusion behavior of vanadium nanoparticles显示文摘 | Wangyu Hu Shifang Xiao Jianyu Yang Zhi Zhang | 2005 | The European Physical Journal B2005，，4： | 1 |
| 12 | Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid显示文摘 | Li Liu Shifang Yuan Yin Long Zhenjun Guo Yang Sun Yuhua Li Yinbo Niu Chen Li Qibing Mei | 2009 | International Immunopharmacology2009，，13： | 1 |
| 13 | Sulfonated poly (phenylene oxide) membranes as romising materials for new proton ex change membranes 显示文摘 | Yang Shifang Gong Chunli | 2006 | Polymers for Adwanced Technologies2006，17，： | 1 |
| 14 | The impact of Typhoon Lekima (2019) on East China: a postevent survey in Wenzhou City and Taizhou City显示文摘Typhoon Lekima(2019)struck Zhejiang Province on 10 August 2019 as a supertyphoon,which severely impacted Zhejiang Province.The typhoon killed 45 people and left three others missing,and the total economic loss reached 40.71 billion yuan.This paper reports a postdisaster survey that focuses on the storm precipitation,flooding,landslides,and weather services associated with Typhoon Lekima(2019)along the southeastern coastline of Zhejiang Province.The survey was conducted by a joint survey team from the Shanghai Typhoon Institute and local meteorological bureaus from 26 to 28 August,2019,approximately two weeks after the disaster.Based on this survey and subsequent analyses of the results,we hope to develop countermeasures to prevent future tragedies. | Cong ZHOU Peiyan CHEN Shifang YANG Feng ZHENG Hui YU Jie TANG Yi LU Guoming CHEN Xiaoqing LU Xiping ZHANG Jing SUN | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 15 | Experiences and Lessons of Combating COVID-19 that Chinese Experts Shared with the World显示文摘At the end of 2019,a novel viral pneumonia was detected in Wuhan City(1)and has spread rapidly throughout 215 countries,areas,and territories with more than 3.8 million cases and over 260,000 deaths as of May 8,2020.This pneumonia,later named coronavirus disease 2019(COVID-19),has become a global public security challenge. | Tao Liu Jiufeng Sun Miaoyun Wen Youping Zhang Xiaodan Luo Xiangxin Liu Shifang Yang Jun Li | 2020 | China CDC weekly2020，2，43： | 1 |
| 16 | St-BA copolymer emulsions prepared by using novel cationic maleic dialkyl polymerizable emulsifier显示文摘 | Yang Shifang Xiong Pingting Gong Tao | 2005 | European Polymer Journal2005，41，： | 1 |
| 17 | Anti-osteosarcoma Effects and Mechanisms of 4-o-amino-phenol-4' - demethylepipodophyllotoxin Ether显示文摘 | Yang Tuanmin Guo Shifang Zhang Xiaoyu Li Wenguang Bai Decheng | 2010 | 美中国际创伤杂志2010，9，1： | 0 |
| 18 | Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a highly infectious respiratory disease that continues to pose a serious global public health emergency.The disease shows a high infection rate,long incubation period,and rapidly emerging variants,which have led to its rapid spread worldwide(Krammer 2020).Many vaccines have been developed for the control of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the virus responsible for COVID-19,including vaccines based on messenger RNA(mRNA)(Polack et al.2020),viral vectors(Zhu et al.2020),recombinant proteins(Yang et al.2020),and inactivated SARS-CoV-2(Zhang et al.2021). | Dali Tong Mei Zhang Yunru Yang Han Xia Haiyang Tong Huajun Zhang Weihong Zeng Muziying Liu Yan Wu Huan Ma Xue Hu Weiyong Liu Yuan Cai Yanfeng Yao Yichuan Yao Kunpeng Liu Shifang Shan Yajuan Li Ge Gao Weiwei Guo Yun Peng Shaohong Chen Juhong Rao Jiaxuan Zhao Juan Min Qingjun Zhu Yanmin Zheng Lianxin Liu Chao Shan Kai Zhong Zilong Qiu Tengchuan Jin Sandra Chiu Zhiming Yuan Tian Xue | 2023 | Protein & Cell2023，14，1： | 0 |
| 19 | Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer显示文摘Circularly permuted TRAIL(CPT),a novel recombinant TRAIL mutant,is a potent antitumor agent.However,its efficacy in triple-negative breast cancer(TNBC)remains unclear.Treatment with CPT alone and in combination with doxorubicin(Dox)is explored for its effects on the proliferation and apoptosis of MDA-MB-231(MB231)and MDAMB-436(MB436)breast cancer cells in vitro and in vivo.Here,we show that CPT combined with Dox exhibits timeand dose-dependent synergy to inhibit cell viability and enhance apoptosis of MB231 and MB436 cells.Combined treatment substantially increases caspase-8,caspase-3,and PARP cleavage in both cell lines and significantly suppresses tumor growth in nude mice bearing MB231 xenografts.Collectively,our findings demonstrate that treatment with CPT in combination with Dox exerts synergistic antitumor effects through activation of the caspase cascade pathway,a mechanism that is partly dependent on the Dox-induced upregulation of death receptor 4 and death receptor 5.Therefore,CPT combined with Dox may be a feasible therapeutic strategy for the management of TNBC. | Jia Liu Tienian Zhu Jiankun Liu Yujie Cui Shifang Yang Ruijing Zhao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 20 | Application of 3-D numerical simulation software SRIFCAST to produce ductile iron castings显示文摘Based on a method using numerical simulation equations and their solution schemes for liquid metal flows andheat transfer during mold filling and the solidification process of casting, 3-D numerical simulation software SRIFCAST wascreated. This includes enmeshment of casting; velocity and temperature fields calculation; displaying iso-temperature lines;velocity vectors and 3-D temperature fields on a Windows 9x operating system. SRIFCAST was applied to produce soundcastings of automobile and diesel engines, and also to connect with microstructure simulation for ductile iron castings. | Junqing WANG Xun SUN Shifang SU Baozhi LI Jun YANG | 2005 | China Foundry2005，2，3： | 0 |
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