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| 1 | Different Dosages of Intravitreal Triamcinolone Acetonide Injections for Macular Edema Secondary to Central Retinal Vein Occlusion显示文摘Purpose:.To study the effect of intravitreal injections of triamcinolone acetonide (TA) for the treatment of macular edema secondary to central retinal vein occlusion.(CRVO).in a sample of Chinese patients from Shaanxi province. Methods:.The 50 eyes from 50 patients were separated into three TA treatment groups:.17 patients were given 4 mg/0.1 ml,.19 patients were given 8 mg/0.2 ml,.and 14 patients were given 16 mg/0.4 ml. Patients were followed up for 12 months. Foveal thickness, intraocular pressure (IOP), and best-corrected visual acuity (BCVA) were measured. Results:.Macular edema responded well both anatomically and functionally to the TA injections. After the initial intravitreal injection,.macular edema recurred at 2-4 months in the low-dose group.(4 mg),.at 3-5 months in the medium-dose group (8 mg), and at 6-9 months in the high-dose group (16 mg)..No significant difference in BCVA or in foveal thickness were observed between the first intravitreal injection and the re-injection. There was no increase in IOP after re-injection of 16 mg TA,.if the patient did not have an elevated IOP after the initial intravitreal injection of 4/8 mg TA. Conclusion: A low dosage of TA (4 mg) administered via intravitreal injection might be useful as an initial treatment for macular edema secondary to CRVO..A higher dosage of TA (16mg) can be used if there is no IOP elevation with the initial TA injection. | Yong Wei Huaizhou Wang Fenghua Chen Zhongqiao Zu Chuncao Bi Xinguang Yang | 2012 | Eye Science2012，27，3： | 6 |
| 2 | National guidelines for diagnosis and treatment of breast cancer 2022 in China(English version)显示文摘Contents 1. Breast cancer screening 1.1 Recommendations for females at normal risk 1.1.1 Age 20-39 years old 1.1.2 Age 40-69 years old 1.1.3 Age≥70 years old 1.2 Recommendations for females at increased risk 2. Diagnosis of breast cancer 2.1 Clinical manifestations 2.1.1 Breast lump 2.1.2 Nipple discharge 2.1.3 Skin changes 2.1.4 Abnormalities in nipple and areola 2.1.5 Enlarged axillary lymph nodes。 | 无 Xinguang Wang Xue Chen Dongfeng Niu Yang Yang Jingyi Zhao | 2022 | Chinese Journal of Cancer Research2022，34，3： | 5 |
| 3 | Effect of thermal exposure on the microstructure and creep properties of a fourth-generation Ni-based single crystal superalloy显示文摘The effect of thermal exposure on microstructure and creep properties of a fourth-generation nickelbased single crystal superalloy was investigated.The thermal exposure of samples after the full heat treatment was carried out at 1000℃,1100℃ and 1140℃ for 100 h and 200 h.The γ’ coarsening,γ’ rafting and γ channel widening were observed in samples after thermal exposure.When the thermal exposure time was constant,the morphology of γ’ phase in the alloy evolved significantly with increasing aging temperature.The interracial dislocation networks in aged samples after creep ruptured gradually became irregular and sparse with the increase of exposure temperature.When the higher exposure temperature was used,enla rgement of the defect pores was observed in samples,the microcracks were more likely to initiate and propagate at the corner of these pores.After aging at 1000℃ for 100 h,the creep life at 1140℃/137 MPa was slightly longer than that of heat-treated sample,which could be attributed to the slightly coarsened γ’ phase,homogenization of refractor elements.In contrast,the creep life of sample exposed at 1140℃ for 100 h was greatly decreased.The decrease of creep life was dominated by the rafting of γ’phase,the irregular interfacial dislocation networks as well as the enlargement of homogenization pores. | Yeshun Huang Xinguang Wang Chuanyong Cui Zihao Tan Jinguo Li Yanhong Yang Jinlai Liu Yizhou Zhou Xiaofeng Sun | 2021 | Journal of Materials Science & Technology2021，，10： | 4 |
| 4 | Urban structure and the risk of influenza A(H1N1) outbreaks in municipal districts显示文摘Changsha was one of the most affected areas during the 2009 A(H1N1)influenza pandemic in China.Here,we analyze the spatial–temporal dynamics of the 2009 pandemic across Changsha municipal districts,evaluate the relationship between case incidence and the local urban spatial structure and predict high-risk areas of influenza A(H1N1).We obtained epidemiological data on all cases of influenza A(H1N1)reported across municipal districts in Changsha during period May 2009–December 2010 and data on population density and basic geographic characteristics for 239 primary schools,97 middle schools,347 universities,96 malls and markets,674 business districts and 121 hospitals.Spatial–temporal K functions,proximity models and logistic regression were used to analyze the spatial distribution pattern of influenza A(H1N1)incidence and the association between influenza A(H1N1)cases and spatial risk factors and predict the infection risks.We found that the 2009 influenza A(H1N1)was driven by a transmission wave from the center of the study area to surrounding areas and reported cases increased significantly after September 2009.We also found that the distribution of influenza A(H1N1)cases was associated with population density and the presence of nearest public places,especially universities(OR=10.166).The final predictive risk map based on the multivariate logistic analysis showed high-risk areas concentrated in the center areas of the study area associated with high population density.Our findings support the identification of spatial risk factors and highrisk areas to guide the prioritization of preventive and mitigation efforts against future influenza pandemics. | Hong Xiao Xiaoling Lin Gerardo Chowell Cunrui Huang Lidong Gao Biyun Chen Zheng Wang Liang Zhou Xinguang He Haining Liu Xixing Zhang Huisuo Yang | 2014 | Chinese Science Bulletin2014，59，5： | 1 |
| 5 | Power-scalable sub-100-fs Tm laser at 2.08μm显示文摘We report on a power-scalable sub-100-fs laser in the 2-μm spectral range using a Tm;-doped‘mixed’(Lu,Sc);O;sesquioxide ceramic as an active medium.Pulses as short as 58 fs at 2076 nm with an average output power of 114 mW at a pulse repetition rate of approximately 82.9 MHz are generated by employing single-walled carbon nanotubes as a saturable absorber.A higher average power of 350 m W at 2075 nm is obtained at the expense of the pulse duration(65 fs).A maximum average power of 486 mW is achieved for a pulse duration of 98 fs and an optical conversion efficiency of 22.3%,representing the highest value ever reported from sub-100-fs mode-locked Tm lasers. | Li Wang Weidong Chen Yongguang Zhao Hanlin Yang Wei Jing Zhongben Pan Hui Huang Jiachen Liu Ji Eun Bae Fabian Rotermund Pavel Loiko Xavier Mateos Zhengping Wang Xinguang Xu Uwe Griebner Valentin Petrov | 2021 | High Power Laser Science and Engineering2021，9，4： | 1 |
| 6 | A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression显示文摘 | Xing-dong Xiong Miook Cho Xiu-ping Cai Jie Cheng Xia Jing Jin-ming Cen Xinguang Liu Xi-li Yang Yousin Suh | 2014 | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2014，，： | 1 |
| 7 | Influence of Ta/Al ratio on the microstructure and creep property of a Ru-containing Ni-based single-crystal superalloy显示文摘Two alloys with different Ta and Al contents were applied to study the influence of Ta/Al ratio on the microstructural evolution and creep deformation under high temperature.The increase of Ta/Al ratio made theγ/γ'lattice misfit more negative and enhanced the volume fraction ofγ'phase,which produced cubic and smallγ'phase in the initial microstructures.These initial tinyγ'phases impeded the dislocations movement and delayed the course of complete raftedγ'phase during the origination of creep deformation,which prolonged the time of the primary creep stage.Moreover,the increase of Ta/Al ratio and addition of Ru produced the denser and stable dislocation networks,the high APB energy and better solution strengthening,which hindered the climbing and sliding of dislocations,and restrained the formation of superdislocations in theγ'precipitate.The second creep stage was extended,and the minimum creep rate was reduced.Hence,the increase of whole creep life of the alloy containing high Ta/Al ratio was attributed to the prolongation of the primary and second creep stages,and the low minimum creep rate.The appearance of the topological inversion phenomenon during the tertiary creep stage was the primary cause for the sudden increase of the creep strain rate of the alloy containing low Ta/Al ratio.However,the high creep strain rate of the alloy containing high Ta/Al ratio during the tertiary creep stage was related to the occurrence and extending of the cracks near the voids.Both alloys would lose efficacy within 20 h-30 h. | Wei Song Xinguang Wang Jinguo Li Jie Meng Yanhong Yang Jinlai Liu Jide Liu Yizhou Zhou Xiaofeng Sun | 2021 | Journal of Materials Science & Technology2021，，30： | 1 |
| 8 | Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria显示文摘 | Baohua Liu Shrestha Ghosh Xi Yang Huiling Zheng Xinguang Liu Zimei Wang Guoxiang Jin Bojian Zheng Brian K. Kennedy Yousin Suh Matt Kaeberlein Karl Tryggvason Zhongjun Zhou | 2012 | Cell Metabolism2012，，6： | 1 |
| 9 | Global existence and exponential stability for a ld compressible and radiative MHD flow显示文摘 | Qin Yuming Liu Xin Yang Xinguang | 2012 | J Dif- ferential Equations2012，253，5： | 1 |
| 10 | BKM's Criterion of Weak Solutions for the 3D Boussinesq Equations显示文摘 | YANG Xinguang ZHANG Lingrui | 2014 | Journal of Partial Differential Equations2014，27，1： | 1 |
| 11 | Evolution of TCP Phase During Long Term Thermal Exposure in Several Re-Containing Single Crystal Superalloys显示文摘The application and component designs of single crystal superalloys are restricted by the precipitation of topologically closed packed(TCP)phases,which can deteriorate the microstructural stability of the alloys severely.Limited researches concerning the type and morphology evolution of TCP phases under elevated temperature conditions have been reported previously.In the present work,three Re-containing single crystal alloys were designed to investigate TCP phase evolution via long term isothermal exposure tests at 1120℃while the effects of Re on the microstructural characteristic and elements segregation were also clarified.The results showed that the addition of Re increased the instability of the alloys and the volume fraction of the TCP phases exceeded 5 vol%when the Re content reached 3 wt%.The increasing Re content had also raised the precipitation temperature of TCP phases but it did not change the type of them after long term aging;all the TCP particles were identified asμphase in this study.Moreover,the elements segregation became considerably serious as Re addition increased constantly,which brought about various morphologies of theμphase in the experimental alloys.In particular,the rod-like and needle-likeμphases demonstrated the typical orientation withinγmatrix while the blockyμphase was dispersedly distributed in the space.No specific orientation relationship could be observed in theμphase when the addition of Re exceeded certain threshold value. | Zihao Tan Lin Yang Xinguang Wang Yunling Du Lihua Ye Guichen Hou Yanhong Yang Jinlai Liu Jide Liu Jinguo Li Yizhou Zhou Xiaofeng Sun | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 1 |
| 12 | Ultra-thin robust CNT@GC film integrating effective electromagnetic shielding and flexible Joule heating显示文摘The demand for lightweight,thin electromagnetic interference(EMI)shielding film materials with high shielding effectiveness(SE),excellent mechanical properties,and stability in complex environments is particularly pronounced in the realm of flexible and portable electronic products.Here,we developed an ultra-thin film(CNT@GC)in which the glassy carbon(GC)layer wrapped around and welded carbon nanotubes(CNTs)to form a core-shell network structure,leading to exceptional tensile strength(327.2 MPa)and electrical conductivity(2.87×10^(5) S·m^(−1)).The CNT@GC film achieved EMI SE of 60 dB at a thickness of 2µm after post-acid treatment and high specific SE of 3.49×10^(5) dB·cm^(2)·g^(−1),with comprehensive properties surpassing those of the majority of previous shielding materials.Additionally,the CNT@GC film exhibited Joule heating capability,reaching a surface temperature of 135℃at 3 V with a fast thermal response of about 0.5 s,enabling anti-icing/de-icing functionality.This work presented a methodology for constructing a robust CNT@GC film with high EMI shielding performance and exceptional Joule heating capability,demonstrating immense potential in wearable devices,defense,and aerospace applications. | Ding Zhang Chunhui Wang Meng Li Weixue Meng Shipeng Zhang Mengdan Yang Xinguang Huang Yingjiu Zhang Yuanyuan Shang Anyuan Cao | 2024 | Nano Research2024，17，5： | 0 |
| 13 | Dynamical behaviors of non-autonomous fractional FitzHugh-Nagumo system driven by additive noise in unbounded domains显示文摘The regularity of random attractors is considered for the non-autonomous fractional stochastic FitzHugh-Nagumo system.We prove that the system has a pullback random attractor that is compact in Hs(R^(n))×L^(2)(R^(n))and attracts all tempered random sets of L^(2)(R^(n))×L^(2)(R^(n))in the topology of Hs(R^(n))×L^(2)(R^(n))with s∈(0,1).By the idea of positive and negative truncations,spectral decomposition in bounded domains,and tail estimates,we achieved the desired results. | Chunxiao GUO Yiju CHEN Ji SHU Xinguang YANG | 2021 | Frontiers of Mathematics in China2021，16，1： | 0 |
| 14 | Conductive hydrogels incorporating carbon nanoparticles:A review of synthesis,performance and applications显示文摘As one of the most rapidly expanding materials,hydrogels have gained increasing attention in a variety of fields due to their biocompatibility,degradability and hydrophilic properties,as well as their remarkable adhesion and stretchability to adapt to different surfaces.Hydrogels combined with carbon-based materials possess enhanced properties and new functionalities,in particular,conductive hydrogels have become a new area of research in the field of materials science.This review aims to provide a comprehensive overview and up-to-date examination of recent developments in the synthesis,properties and applications of conductive hydrogels incorporating several typical carbon nanoparticles such as carbon nanotubes,graphene,carbon dots and carbon nanofibers.We summarize key techniques and mechanisms for synthesizing various composite hydrogels with exceptional properties,and represented applications such as wearable sensors,temperature sensors,supercapacitors and human-computer interaction reported recently.The mechanical,electrical and sensing properties of carbon nanoparticles conductive hydrogels are thoroughly analyzed to disclose the role of carbon nanoparticles in these hydrogels and key factors in the microstructure.Finally,future development of conductive hydrogels based on carbon nanoparticles is discussed including the challenges and possible solutions in terms of microstructure optimization,mechanical and other properties,and promising applications in wearable electronics and multifunctional materials. | Shipeng Zhang Bo Zhao Ding Zhang Mengdan Yang Xinguang Huang Lei Han Kun Chen Xinjian Li Rui Pang Yuanyuan Shang Anyuan Cao | 2023 | Particuology2023，，12： | 0 |
| 15 | Yangqing Chenfei formula(养清尘肺方)alleviates crystalline silica induced pulmonary inflammation and fibrosis by suppressing macrophage polarization显示文摘OBJECTIVE:To explore the underlying mechanisms of the effects of Yangqing Chenfei formula(养清尘肺方,YCF) on inflammation and fibrosis in silicosis via inhibition of macrophage polarization.METHODS:A silicotic rat model was established via a single intratracheal instillation of silica particles on the first day of week 0.Subsequently,YCF was administered intragastrically to silicotic rats during weeks 0-2 and 5-8 twice daily.The mouse-derived alveolar macrophage cell line was used to investigate the mechanisms of YCF in M1/M2 polarization.RESULTS:YCF treatment effectively inhibited lung pathological changes,including inflammatory cell infiltration and tissue damage,and increased the forced expiratory volume in the first 0.3 s,functional residual capacity,and maximal mid-expiratory flow in weeks 2 and 8.Furthermore,the treatment improved lung functions by upregulating tidal volume,pause increase,and expiratory flow at 50% tidal volume from weeks 5 to 8.Moreover,YCF could significantly suppressed the progression of inflammation and fibrosis,by reducing the levels of inflammatory cytokines,as well as collagen-Ⅰ and Ⅲ.YCF treatment also decreased the numbers of macrophages and M1/M2 macrophages and the level of transforming growth factor-β(TGF-β).Additionally,YCF5,the effective substance in YCF,decreased lipopolysaccharide and interferon-γ-induced M1 macrophage polarization in a concentration-dependent manner.The mechanism of anti-M1 polarization might be related to a decrease in extracellular signal-regulated kinase,c-JUN N-terminal kinase,P38,and P65 phosphorylation.Furthermore,YCF5 inhibited interleukin-4-induced M2 macrophages by decreasing the protein and m RNA expressions of arginase-1 and CD206 as well as the levels of profibrotic factors,such as TGF-β and connective tissue growth factor.The mechanisms underlying the anti-M2 polarization of YCF5 were primarily associated with the inhibition of the nuclear translocation of phosphorylated signal transducer and activator of transcription 6(pSTAT6).CONCLUSION:YCF significantly inhibits inflammation and fibrosis in silicotic rats probably via the suppression of M1/M2 macrophage polarization mediated by the inhibition of mitogen-activated protein kinase and nuclear factor kappa B signaling pathways and Janus kinase/STAT6 pathways. | TIAN Xinrong HOU Runsu LIU Xinguang ZHAO Peng TIAN Yange LI Jiansheng | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 16 | Current state and future of co-inhibitory immune checkpoints for the treatment of glioblastoma显示文摘In the interaction between a tumor and the immune system,immune checkpoints play an important role,and in tumor immune escape,co-inhibitory immune checkpoints are important.Immune checkpoint inhibitors(ICIs)can enhance the immune system's killing effect on tumors.To date,impressive progress has been made in a variety of tumor treatments;PD1/PDL1 and CTLA4 inhibitors have been approved for clinical use in some tumors.However,glioblastoma(GBM)still lacks an effective treatment.Recently,a phase III clinical trial using nivolumab to treat recurrent GBM showed no significant improvement in overall survival compared to bevacizumab.Therefore,the use of immune checkpoints in the treatment of GBM still faces many challenges.First,to clarify the mechanism of action,how different immune checkpoints play roles in tumor escape needs to be determined;which biomarkers predict a benefit from ICIs treatment and the therapeutic implications for GBM based on experiences in other tumors also need to be determined.Second,to optimize combination therapies,how different types of immune checkpoints are selected for combined application and whether combinations with targeted agents or other immunotherapies exhibit increased efficacy need to be addressed.All of these concerns require extensive basic research and clinical trials.In this study,we reviewed existing knowledge with respect to the issues mentioned above and the progress made in treatments,summarized the state of ICIs in preclinical studies and clinical trials involving GBM,and speculated on the therapeutic prospects of ICIs in the treatment of GBM. | Shaoping Shen Ling Chen Jialin Liu Lin Yang Mengna Zhang Lingxiong Wang Rong Zhang Yasushi Uemura Qiyan Wu Xinguang Yu Tianyi Liu | 2020 | Cancer Biology & Medicine2020，17，3： | 0 |
| 17 | CACA guidelines for holistic integrative management of glioma显示文摘Glioma of the brain is a kind of tumor originating from neuroglial cells.It is the most common primary intracranial tumor,accounting for~30%of all central nervous system tumors and 80% of malignant brain tumors.Glioma is characterized by high disability and recurrence rates.The disease seriously threatens the life of patients,afects their quality of life,and brings a heavy economic and psychological burden to patients,families,and society.With the progression of molecular genetic testing technology and the completion of various clinical trials,the classifcation scheme for glioma is increasingly well established.Diagnosis and treatment regimens,including traditional and new regimens,are becoming increasingly specialized and standardized.The purpose is to develop a clinical diagnosis and treatment guideline for glioma in the Chinese population suitable for Chinese doctors and the general population based on domestic and international glioma research progress.Thus,domestic practitioners in the feld can obtain current information and provide better service to patients with glioma,promoting the development of domestic clinical medicine and basic research on glioma. | Daiming Fan Tao Jiang Wenbin Ma Chuanlu Jiang Yongping You Ying Mao Xiaoguang Qiu Chunsheng Kang Gang Li Qing Mao Xuejun Yang Zhiyong Qin Zhixiong Liu Weimin Wang Xinting Wei Wenbin Li Yunhui Liu Rutong Yu Xinguang Yu Dezhi Kang Yonggao Mou Lei Wang Wei Zhang Zhaoshi Bao Ruichao Chai Baoshi Chen Xing Fan Shengyu Fang Guanzhang Li Lianwang Li Shouwei Li Xing Liu Yanwei Liu Xia Shan Liang Wang Yinyan Wang Yu Wang Zheng Wang Zhiliang Wang Chenxing Wu Wei Yan Pei Yang Gan You Chuanbao Zhang Zhong Zhang Zheng Zhao | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 18 | A nomogram predicting atrial fibrillation in patients with dilated cardiomyopathy显示文摘To the Editor:Dilated cardiomyopathy(DCM)is a type of primary myocardial disease with unknown etiology.[1]It is a disorder of the heart muscle mainly characterized by left ventricular dilation and systolic dysfunction,resulting from the response of the myocardium to genetic and environmental insults.The clinical manifestations arc progressive heart failure,arrhythmia,thromboembolism,and even sudden death. | Yangming Mao Yanmin Liu Jian Zhang Yeqian Zhu Xinguang Chen Ling Sun Yao Lu Hongwu Chen Weizhu Ju Gang Yang Pengcheng Zhao Minglong Chen Fengxiang Zhang | 2022 | Chinese Medical Journal2022，，8： | 0 |
| 19 | Method to Appraise Dangerous Class of Building Masonry Component Based on DC-YOLO Model显示文摘This DC-YOLO Model was designed in order to improve the efficiency for appraising dangerous class of buildings and avoid manual intervention,thereby making the appraisal results more objective.It is an automated method designed based on deep learning and target detection algorithms to appraise the dangerous class of building masonry component.Specifically,it(1)adopted K-means clustering to obtain the quantity and size of the prior boxes;(2)expanded the grid size to improve identification to small targets;(3)introduced in deformable convolution to adapt to the irregular shape of the masonry component cracks.The experimental results show that,comparing with the conventional method,the DC-YOLO model has better recognition rates for various targets to different extents,and achieves good effects in precision,recall rate and F1 value,which indicates the good performance in classifying dangerous classes of building masonry component. | Hongrui Zhang Wenxue Wei Xinguang Xiao Song Yang Wanlu Shao | 2020 | Computers, Materials & Continua2020，，4： | 0 |
| 20 | A survey on deep learning for textual emotion analysis in social networks显示文摘Textual Emotion Analysis(TEA)aims to extract and analyze user emotional states in texts.Various Deep Learning(DL)methods have developed rapidly,and they have proven to be successful in many fields such as audio,image,and natural language processing.This trend has drawn increasing researchers away from traditional machine learning to DL for their scientific research.In this paper,we provide an overview of TEA based on DL methods.After introducing a background for emotion analysis that includes defining emotion,emotion classification methods,and application domains of emotion analysis,we summarize DL technology,and the word/sentence representation learning method.We then categorize existing TEA methods based on text structures and linguistic types:text-oriented monolingual methods,text conversations-oriented monolingual methods,text-oriented cross-linguistic methods,and emoji-oriented cross-linguistic methods.We close by discussing emotion analysis challenges and future research trends.We hope that our survey will assist readers in understanding the relationship between TEA and DL methods while also improving TEA development. | Sancheng Peng Lihong Cao Yongmei Zhou Zhouhao Ouyang Aimin Yang Xinguang Li Weijia Ji Shui Yu | 2022 | Digital Communications and Networks2022，8，5： | 0 |
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